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Article ; Online: Proton versus photon comprehensive nodal breast irradiation.

McKenna, Kelly

Medical dosimetry : official journal of the American Association of Medical Dosimetrists

2023 Volume 48, Issue 4, Page(s) 312–314

Abstract: Comprehensive nodal breast irradiation is traditionally treated utilizing 3DCRT planning with a three or four field technique. While the three or four field photon technique may be the standard of care for comprehensive nodal breast treatment, the ... ...

Abstract	Comprehensive nodal breast irradiation is traditionally treated utilizing 3DCRT planning with a three or four field technique. While the three or four field photon technique may be the standard of care for comprehensive nodal breast treatment, the ipsilateral lung dose and heart mean can often be of concern dependent on patient's anatomy. Standard dose constraints (200cGy x25) per the Alliance A221505 trial strive to maintain the ipsilateral V20<35% and heart mean <3Gy. Double scattering proton therapy treatment has a significant advantage over photons in reducing the ipsilateral lung and heart dose due the Spread-Out Bragg Peak and rapid dose drop off. Proton therapy in comprehensive nodal breast irradiation can be beneficial when dose constraints are exceeding in a photon plan or in the re-irradiation setting. Within this study, a comparison of ipsilateral lung and heart mean doses will be evaluated using both photon three/four field technique and double scattering proton therapy technique. A decreased ipsilateral lung V20 can be correlated to all proton plans that were conducted in the study. In all but one patient there was a decrease in the heart mean as well, which was due to patient anatomy.
MeSH term(s)	Humans ; Female ; Protons ; Radiotherapy Planning, Computer-Assisted/methods ; Radiotherapy, Conformal/methods ; Proton Therapy/methods ; Radiotherapy Dosage ; Breast Neoplasms/radiotherapy
Chemical Substances	Protons
Language	English
Publishing date	2023-09-15
Publishing country	United States
Document type	Case Reports
ZDB-ID	645065-9
ISSN	1873-4022 ; 0958-3947 ; 0739-0211
ISSN (online)	1873-4022
ISSN	0958-3947 ; 0739-0211
DOI	10.1016/j.meddos.2023.08.005
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Zs.A 2448: Show issues

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Article ; Online: A systematic review of social determinants of health in pediatric organ transplant outcomes.

Rea, Kelly E / West, Kara B / Dorste, Anna / Christofferson, Elizabeth S / Lefkowitz, Debra / Mudd, Emily / Schneider, Lauren / Smith, Courtney / Triplett, Kelli N / McKenna, Kristine

Pediatric transplantation

2022 Volume 27, Issue 1, Page(s) e14418

Abstract: Background: Equitable access to pediatric organ transplantation is critical, although risk factors negatively impacting pre- and post-transplant outcomes remain. No synthesis of the literature on SDoH within the pediatric organ transplant population has ...

Abstract	Background: Equitable access to pediatric organ transplantation is critical, although risk factors negatively impacting pre- and post-transplant outcomes remain. No synthesis of the literature on SDoH within the pediatric organ transplant population has been conducted; thus, the current systematic review summarizes findings to date assessing SDoH in the evaluation, listing, and post-transplant periods. Methods: Literature searches were conducted in Web of Science, Embase, PubMed, and Cumulative Index to Nursing and Allied Health Literature databases. Results: Ninety-three studies were included based on pre-established criteria and were reviewed for main findings and study quality. Findings consistently demonstrated disparities in key transplant outcomes based on racial or ethnic identity, including timing and likelihood of transplant, and rates of rejection, graft failure, and mortality. Although less frequently assessed, variations in outcomes based on geography were also noted, while findings related to insurance or SES were inconsistent. Conclusion: This review underscores the persistence of SDoH and disparity in equitable transplant outcomes and discusses the importance of individual and systems-level change to reduce such disparities.
MeSH term(s)	Child ; Humans ; Social Determinants of Health ; Organ Transplantation ; Risk Factors
Language	English
Publishing date	2022-11-01
Publishing country	Denmark
Document type	Systematic Review ; Journal Article
ZDB-ID	1390284-2
ISSN	1399-3046 ; 1397-3142
ISSN (online)	1399-3046
ISSN	1397-3142
DOI	10.1111/petr.14418
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Zs.A 4947: Show issues

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Article ; Online: Non-surgical management of metacarpal fractures.

Neumeister, Michael W / Webb, Kelli / McKenna, Kate

Clinics in plastic surgery

2014 Volume 41, Issue 3, Page(s) 451–461

Abstract: Metacarpal fractures are among the most common fractures of the upper extremity. Surgical management is generally offered for unstable or significantly displaced fractures. A more conservative, nonsurgical approach, however, may provide safe, rapid ... ...

Abstract	Metacarpal fractures are among the most common fractures of the upper extremity. Surgical management is generally offered for unstable or significantly displaced fractures. A more conservative, nonsurgical approach, however, may provide safe, rapid recovery while maintaining normal active range of motion. This article reviews the nonsurgical approach, protocols, and outcomes of metacarpal fractures.
MeSH term(s)	Fracture Healing ; Fractures, Bone/therapy ; Humans ; Metacarpal Bones/injuries ; Orthopedic Procedures/methods
Language	English
Publishing date	2014-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	193117-9
ISSN	1558-0504 ; 0094-1298
ISSN (online)	1558-0504
ISSN	0094-1298
DOI	10.1016/j.cps.2014.03.008
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Article ; Online: Total Artificial Hearts-Past, Current, and Future.

Fox, Carson S / McKenna, Kelli L / Allaire, Paul E / Mentzer, Robert M / Throckmorton, Amy L

Journal of cardiac surgery

2015 Volume 30, Issue 11, Page(s) 856–864

Abstract: We present a review of the evolution of total artificial hearts (TAHs) and new directions in development, including the coupling of VADs as biventricular TAH support. ...

Abstract	We present a review of the evolution of total artificial hearts (TAHs) and new directions in development, including the coupling of VADs as biventricular TAH support.
MeSH term(s)	Heart Failure/therapy ; Heart, Artificial/trends ; Heart-Assist Devices/trends ; Humans
Language	English
Publishing date	2015-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	639059-6
ISSN	1540-8191 ; 0886-0440
ISSN (online)	1540-8191
ISSN	0886-0440
DOI	10.1111/jocs.12644
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Zs.A 2221: Show issues

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Article ; Online: A Systematic Review of Community Health Center Based Interventions for People with Diabetes.

Han, Hae-Ra / McKenna, Siobhan / Nkimbeng, Manka / Wilson, Patty / Rives, Sally / Ajomagberin, Olayinka / Alkawaldeh, Mohammad / Grunstra, Kelli / Maruthur, Nisa / Sharps, Phyllis

Journal of community health

2019 Volume 44, Issue 6, Page(s) 1253–1280

Abstract: Community health centers (CHCs) focus on serving socioeconomically disadvantaged populations with heightened chronic disease burden, making CHCs an ideal setting for implementing diabetes care programs that target vulnerable populations. We aimed to ... ...

Abstract	Community health centers (CHCs) focus on serving socioeconomically disadvantaged populations with heightened chronic disease burden, making CHCs an ideal setting for implementing diabetes care programs that target vulnerable populations. We aimed to synthesize evidence concerning the effects of CHC interventions in people with diabetes. To do this, four electronic databases were searched, including PubMed, EMBASE, CINAHL, and Scopus, and hand searches of reference collections were undertaken to identify intervention trials published in English. We screened 892 unique titles and abstracts. Two reviewers then independently evaluated 221 full-text articles. We discovered 29 articles met our eligibility criteria for inclusion. We found 27 unique studies with two companion articles. Seventeen studies were randomized controlled trials and the majority had a higher proportion of female and racial/ethnic minorities in the study sample. CHC interventions often involved either one-on-one or group education sessions supplemented by a phone follow-up that were delivered by health providers, nutritionists, or community health workers. CHC interventions using education sessions combined with follow up via phone generally resulted in significant improvements in hemoglobin A1C, while sole telephone-based education studies showed no significant improvements. CHC interventions had no significant effects on physical activity in all six studies that examined the outcome. Overall, we found that CHC interventions were in general effective in improving glucose control when using face-to-face interactions in low-income, underserved, and racial and ethnic minority patients with diabetes. Evidence was limited, however, in regards to other outcomes which suggests the need for continued evaluations of CHC intervention models.
MeSH term(s)	Chronic Disease ; Community Health Centers ; Delivery of Health Care ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/therapy ; Female ; Humans ; Male ; Vulnerable Populations
Keywords	covid19
Language	English
Publishing date	2019-07-06
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	426631-6
ISSN	1573-3610 ; 0094-5145
ISSN (online)	1573-3610
ISSN	0094-5145
DOI	10.1007/s10900-019-00693-y
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Zs.A 1386: Show issues

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Article ; Online: The right not to know: Non-disclosure of primary genetic test results and genetic counselors' response.

Murphy, Claire / Sturm, Sarah / McKenna, Meghan Juliana / Ormond, Kelly E

Journal of genetic counseling

2023

Abstract: As part of clinical genetic counseling practice, patients may request that their primary genetic test results be disclosed to someone else, such as a relative or referring provider, or request that results be disclosed to no one (non-disclosure). In ... ...

Abstract	As part of clinical genetic counseling practice, patients may request that their primary genetic test results be disclosed to someone else, such as a relative or referring provider, or request that results be disclosed to no one (non-disclosure). In making these requests, patients employ the ethical principle of the "right not to know," which argues that autonomous individuals can choose not to know relevant health information. Although the right not to know has been well-studied in medicine in general, and in the return of genomic secondary findings, we are not aware of other studies that have explored the return of primary genetic test results when patients request non-disclosure or disclosure to another individual. This study aimed to describe common clinical scenarios in which these requests occur, how genetic counselors respond, and what ethical considerations they employ in their decision-making process. We recruited participants from the National Society of Genetic Counselors' (NSGC) "Student Research Surveys and Reminders" listserv and conducted semi-structured interviews with 11 genetic counselors in the United States who described genetic counseling cases where this occurred. Interviews were transcribed and coded inductively, and themes were identified. Case details varied, but in our study data the requests for non-disclosure were most commonly made by patients with poor, often oncologic, prognoses who requested their test results be disclosed to a family member instead of themselves. Genetic counselors considered similar factors in deciding how to respond to these requests: patient autonomy, medical actionability of results for the patient and family, the relationship between the patient and the person to whom results might be disclosed, and legal or practical concerns. Genetic counselors often made decisions on a case-by-case basis, depending on how relevant each of these factors were. This study adds to the growing body of literature regarding patients' "right not to know" and will hopefully provide guidance for genetic counselors who experience this situation in clinical practice.
Language	English
Publishing date	2023-09-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	1117799-8
ISSN	1573-3599 ; 1059-7700
ISSN (online)	1573-3599
ISSN	1059-7700
DOI	10.1002/jgc4.1797
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Zs.A 4263: Show issues

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Article ; Online: Pressure-Flow Experimental Performance of New Intravascular Blood Pump Designs for Fontan Patients.

Chopski, Steven G / Fox, Carson S / Riddle, Michelle L / McKenna, Kelli L / Patel, Jay P / Rozolis, John T / Throckmorton, Amy L

Artificial organs

2016 Volume 40, Issue 3, Page(s) 233–242

Abstract: An intravascular axial flow pump is being developed as a mechanical cavopulmonary assist device for adolescent and adult patients with dysfunctional Fontan physiology. Coupling computational modeling with experimental evaluation of prototypic designs, ... ...

Abstract	An intravascular axial flow pump is being developed as a mechanical cavopulmonary assist device for adolescent and adult patients with dysfunctional Fontan physiology. Coupling computational modeling with experimental evaluation of prototypic designs, this study examined the hydraulic performance of 11 impeller prototypes with blade stagger or twist angles varying from 100 to 600 degrees. A refined range of twisted blade angles between 300 and 400 degrees with 20-degree increments was then selected, and four additional geometries were constructed and hydraulically evaluated. The prototypes met performance expectations and produced 3-31 mm Hg for flow rates of 1-5 L/min for 6000-8000 rpm. A regression analysis was completed with all characteristic coefficients contributing significantly (P < 0.0001). This analysis revealed that the impeller with 400 degrees of blade twist outperformed the other designs. The findings of the numerical model for 300-degree twisted case and the experimental results deviated within approximately 20%. In an effort to simplify the impeller geometry, this work advanced the design of this intravascular cavopulmonary assist device closer to preclinical animal testing.
MeSH term(s)	Adolescent ; Adult ; Computer Simulation ; Fontan Procedure/instrumentation ; Heart Defects, Congenital/surgery ; Heart-Assist Devices ; Hemodynamics ; Humans ; Hydrodynamics ; Models, Cardiovascular ; Pressure ; Prosthesis Design
Language	English
Publishing date	2016-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	441812-8
ISSN	1525-1594 ; 0160-564X
ISSN (online)	1525-1594
ISSN	0160-564X
DOI	10.1111/aor.12549
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Zs.A 1463: Show issues

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Article ; Online: Physics-driven impeller designs for a novel intravascular blood pump for patients with congenital heart disease.

Chopski, Steven G / Fox, Carson S / McKenna, Kelli L / Riddle, Michelle L / Kafagy, Dhyaa H / Stevens, Randy M / Throckmorton, Amy L

Medical engineering & physics

2016 Volume 38, Issue 7, Page(s) 622–632

Abstract: Mechanical circulatory support offers an alternative therapeutic treatment for patients with dysfunctional single ventricle physiology. An intravascular axial flow pump is being developed as a cavopulmonary assist device for these patients. This study ... ...

Abstract	Mechanical circulatory support offers an alternative therapeutic treatment for patients with dysfunctional single ventricle physiology. An intravascular axial flow pump is being developed as a cavopulmonary assist device for these patients. This study details the development of a new rotating impeller geometry. We examined the performance of 8 impeller geometries with blade stagger or twist angles varying from 100° to 800° using computational methods. A refined range of blade twist angles between 300° and 400° was then identified, and 4 additional geometries were evaluated. Generally, the impeller designs produced 4-26mmHg for flow rates of 1-4L/min for 6000-8000 RPM. A data regression analysis was completed and found the impeller with 400° of blade twist to be the superior performer. A hydraulic test was conducted on a prototype of the 400° impeller, which generated measurable pressure rises of 7-28mmHg for flow rates of 1-4L/min at 6000-8000 RPM. The findings of the numerical model and experiment were in reasonable agreement within approximately 20%. These results support the continued development of an axial-flow, mechanical cavopulmonary assist device as a new clinical therapeutic option for Fontan patients.
Language	English
Publishing date	2016-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1181080-4
ISSN	1873-4030 ; 1350-4533
ISSN (online)	1873-4030
ISSN	1350-4533
DOI	10.1016/j.medengphy.2016.03.010
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Article ; Online: The benefits of implant-retained overdentures as a treatment modality for patients in primary care settings.

Kelly, Niamh / McKenna, Gerry

Evidence-based dentistry

2020 Volume 21, Issue 3, Page(s) 89

Abstract: Data sources Data was collected utilising Medline (OVID interface), Google Scholar and Cochrane Library. Systematic reviews with/without meta-analysis were selected which included patient satisfaction and oral health-related quality of life as outcome ... ...

Abstract	Data sources Data was collected utilising Medline (OVID interface), Google Scholar and Cochrane Library. Systematic reviews with/without meta-analysis were selected which included patient satisfaction and oral health-related quality of life as outcome measures. The literature search performed included systematic reviews with publication dates ranging from 1946 to 2018. PROSPERO was also used to incorporate systematic reviews that had been completed after the last search in August 2018.Study selection Studies were selected using the PICO model, selecting systematic reviews analysing adult edentulous patients with conventional complete dentures and/or implant-retained overdentures. The systematic reviews chosen assessed satisfaction and oral health-related quality of life, while comparing results to adult edentulous patients with no replacement teeth or prosthesis.Data extraction and synthesis All of the articles located from the database searches were uploaded to reference management software. Articles were screened independently by two authors to reduce bias and to assess the articles against the predetermined inclusion criteria. The EndNote filter Service was applied to avoid duplication of articles. Guidance from the Centre for Reviews and Dissemination (University of York) was incorporated to present data narratively, with text and tables. Eight reviews were included in data synthesis.Results Of the eight reviews included, six were systematic reviews without meta-analysis, one systematic review with meta-analysis was included and one was meta-analysis. Conclusions The results of this systematic review highlight the greater benefits of implant retained overdentures compared with conventional complete dentures when assessing patient satisfaction and oral health-related quality of life. The superiority of implant retained overdentures is most evident when patients cannot tolerate conventional complete dentures. However, consideration most be given to the adaptive capabilities of patients and the financial implications of implant-retained overdentures.
MeSH term(s)	Adult ; Dental Implants ; Dental Prosthesis, Implant-Supported ; Denture, Complete ; Denture, Overlay ; Humans ; Oral Health ; Patient Satisfaction ; Personal Satisfaction ; Primary Health Care ; Quality of Life
Chemical Substances	Dental Implants
Language	English
Publishing date	2020-09-26
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	1457588-7
ISSN	1476-5446 ; 1462-0049
ISSN (online)	1476-5446
ISSN	1462-0049
DOI	10.1038/s41432-020-0118-2
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Zs.A 4972: Show issues

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Article ; Online: Protocol for the systematic review of research on professional learning to promote implementation of a multitiered system of support in education.

Castillo, Jose M / Wolgemuth, Jennifer R / Ginns, Diana S / Latimer, Joseph / Scheel, Nicholas / McKenna, Meaghan / March, Amanda L / Moulton, Sara / Wang, Joy / Thoman, Sarah / Jenkins, Andrew / Henson, Kelli / Ferron, John M

BMJ open

2018 Volume 8, Issue 11, Page(s) e024057

Abstract: Introduction: A multitiered system of supports (MTSS) represents a widely adopted public health approach to education in the USA. Researchers agree professional learning is critical for educators to implement the critical components of MTSS; however, ... ...

Abstract	Introduction: A multitiered system of supports (MTSS) represents a widely adopted public health approach to education in the USA. Researchers agree professional learning is critical for educators to implement the critical components of MTSS; however, professional learning approaches vary in their designs and targeted outcomes. While researchers increasingly focus their inquiries on professional learning for MTSS, no systematic research review exists. Objectives: The primary objectives for this mixed-methods review are to (1) understand how professional learning focused on MTSS has been operationalised (2) determine the impact of professional learning on educator (eg, knowledge) and implementation (eg, data-based decision-making processes) outcomes and (3) understand the contextual variables that influence professional learning in the USA. We aim to determine which elements of professional learning improve educators' capacity to implement MTSS. Methods and analysis: We will include studies that use quantitative and qualitative methods. PsycInfo, PubMed, CIHAHL and ERIC will be the primary research databases used to search for studies published from January 1997 to May 2018. We also will search the US Institute for Educational Sciences and Office of Special Education Programs websites, ProQuest, Google Scholar, Science Watch and MSN. Finally, we will search the proceedings of relevant conferences, examine the reference lists of studies that pass full screening and contact authors for additional work. Data extraction will include participant demographics, intervention details, study design, outcomes, analyses and key findings. We will conduct a quality assessment and analyse the data using effect size and thematic analyses. Ethics and dissemination: Institutional review board or ethics approval is not needed for this review of already published works. We will disseminate the findings through presentations at state, national and international conferences; presentations to stakeholders and agencies; publication in peer-reviewed journals; and posts to organisational and agency websites.
MeSH term(s)	Decision Making ; Education, Nonprofessional ; Education, Professional ; Humans ; Learning ; Public Health ; Research Design ; School Teachers ; Schools ; Students ; Teaching ; United States ; Systematic Reviews as Topic
Language	English
Publishing date	2018-11-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2018-024057
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