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  1. Article: Discovery of New Ligand with Quinoline Scaffold as Potent Allosteric Inhibitor of HIV-1 and Its Copper Complexes as a Powerful Catalyst for the Synthesis of Chiral Benzimidazole Derivatives, and

    Azimi, Sabikeh G / Bagherzade, Ghodsieh / Saberi, Mohammad Reza / Amiri Tehranizadeh, Zeinab

    Bioinorganic chemistry and applications

    2023  Volume 2023, Page(s) 2881582

    Abstract: In this paper, the novel Schiff base ligand containing quinoline moiety and its novel copper chelate complexes were successfully prepared. The catalytic activity of the final complex in the organic reaction such as synthesis of chiral benzimidazoles and ... ...

    Abstract In this paper, the novel Schiff base ligand containing quinoline moiety and its novel copper chelate complexes were successfully prepared. The catalytic activity of the final complex in the organic reaction such as synthesis of chiral benzimidazoles and anti-HIV-1 activity of Schiff base ligand and the products of this reaction were investigated. In addition, green chemistry reactions using microwaves, powerful catalyst synthesis, green recovery and reusability, and separation of products with economic, safe, and clean methods (green chemistry) are among the advantages of this protocol. The potency of these compounds as anti-HIV-1 agents was investigated using molecular docking into integrase (IN) enzyme with code 1QS4 and the GROMACS software for molecular dynamics simulation. The final steps were evaluated in case of RMSD, RMSF, and Rg. The results revealed that the compound VII exhibit a good binding affinity to integrase (Δ
    Language English
    Publishing date 2023-04-21
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2213020-2
    ISSN 1687-479X ; 1565-3633
    ISSN (online) 1687-479X
    ISSN 1565-3633
    DOI 10.1155/2023/2881582
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  2. Article: An atypical presentation of hypothyroidism with extremely exaggerated functional impairment.

    Arezoumand, Alireza / Nazari, Sahar / Jazi, Kimia / Bagherzade, Mohammad / Riahi, Mohammad Mehdi / AkbariMehr, Melika / Kanganee, Narges / Masoumi, Maryam

    Clinical case reports

    2023  Volume 11, Issue 7, Page(s) e7708

    Abstract: Key clinical message: Myopathy-related symptoms are rare manifestations of hypothyroidism. Clinicians should consider hypothyroid myopathy as one of the possible diagnoses for patients with proximal weaknesses.: Abstract: Myopathy-related symptoms ... ...

    Abstract Key clinical message: Myopathy-related symptoms are rare manifestations of hypothyroidism. Clinicians should consider hypothyroid myopathy as one of the possible diagnoses for patients with proximal weaknesses.
    Abstract: Myopathy-related symptoms are rare manifestations of hypothyroidism. Clinicians should consider hypothyroid myopathy as one of the possible diagnoses for patients with proximal weaknesses. We report a 34-year-old woman, presenting with a new atypical musculoskeletal manifestation of hypothyroidism mimicking polymyositis.
    Language English
    Publishing date 2023-07-18
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.7708
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  3. Article: Plasmapheresis with corticosteroids and antiviral: a life-saving treatment for severe cases of Covid 19.

    Bagherzade, Mohammad / Parham, Mahmoud / Zohali, Somayeh / Molaei, Sedighe / Vafaeimanesh, Jamshid

    Caspian journal of internal medicine

    2021  Volume 11, Issue Suppl 1, Page(s) 572–576

    Abstract: Background: COVID-19 pandemic is a global concern. Unfortunately, there is no exclusive treatment for critical patients to survive. In this study, we suggest using a novel three-dimensional treatment mainly based upon immune system modulation to fix the ...

    Abstract Background: COVID-19 pandemic is a global concern. Unfortunately, there is no exclusive treatment for critical patients to survive. In this study, we suggest using a novel three-dimensional treatment mainly based upon immune system modulation to fix the virus chaos, through cytokine storm as the main character of COVID-19 infection scenario.
    Case presentation: A young man infected by SARS-CoV-2 who suffered from respiratory arrest and loss of consciousness, underwent cardiopulmonary resuscitation and endotracheal intubation. Following ICU administration and confirmed diagnosis of COVID-19, considering critical condition of the young patient, plasmapheresis was performed once on a daily basis, three doses of interferon beta(IFN-β-1b) was injected subcutaneously every other day and dexamethasone was given at a dose of 4 mg every 8 hours along with common antiviral regimen. After 2 days, the patient was extubated and transferred from the ICU to the ward where plasmapheresis was performed 4 times daily for 4 days. Finally, after 7 days of hospitalization, the patient was discharged with a good general condition.
    Conclusion: We modulated the immune system through plasmapheresis to sweep out the released cytokines. Also, corticosteroid along with interferon was added to common antiviral treatments. Our data suggest that this combined method is effective for critically ill COVID-19 patients.
    Language English
    Publishing date 2021-01-01
    Publishing country Iran
    Document type Case Reports
    ZDB-ID 2971933-1
    ISSN 2008-6172 ; 2008-6164
    ISSN (online) 2008-6172
    ISSN 2008-6164
    DOI 10.22088/cjim.11.0.572
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  4. Article ; Online: Sleep Duration as the Main Indicator of Self-Rated Wellness and Health among Healthcare Workers Involved in the COVID-19 Pandemic.

    Masoumi, Maryam / Shokraee, Kamyar / Mohammadi, Somayeh / Moradi, Soroush / Bagherzade, Mohammad / Balasi, Javad / Smiley, Abbas

    International journal of environmental research and public health

    2021  Volume 19, Issue 1

    Abstract: Objective: This study was performed during the COVID-19 pandemic to better understand the indicators of self-rated wellness and health among healthcare workers.: Methods: Sleep pattern, mood status, nutritional condition, physical activity, habits ... ...

    Abstract Objective: This study was performed during the COVID-19 pandemic to better understand the indicators of self-rated wellness and health among healthcare workers.
    Methods: Sleep pattern, mood status, nutritional condition, physical activity, habits and the subjective wellness and health index of the healthcare workers of a university affiliated hospital were surveyed. Paired
    Results: Of the 200 healthcare workers who participated in this study, 119 (60%) were female and 81 (40%) were male, with a mean (SD) age of 28.8 (5.9) years. We found that the COVID-19 pandemic significantly changed many lifestyle factors compared to the pre-pandemic states. The scores of sleep quality, mood status, pre-planned physical activity and social activity were reduced by 30%, 40%, 50% and 70%, respectively. The average night sleep duration before the pandemic was 7 h and 22 min, whereas during the pandemic it decreased to 6 h and 44 min, a debt of 38 min in sleep duration every night. As found by multivariable regression modelling, self-reported wellness and health before the pandemic period was associated with wake-up time, mood status, physical activity and diet. During the pandemic period, in addition to these variables, night sleep duration (β = 0.049,
    Conclusion: COVID-19 has detrimentally affected healthcare workers' well-being and quality of life. Sleep duration was the main factor correlated with subjective wellness and health index during the current COVID-19 pandemic.
    MeSH term(s) Adult ; COVID-19 ; Cross-Sectional Studies ; Female ; Health Personnel ; Humans ; Male ; Pandemics ; Quality of Life ; SARS-CoV-2 ; Sleep ; Sleep Quality
    Language English
    Publishing date 2021-12-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19010136
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  5. Article ; Online: Sleep Duration as the Main Indicator of Self-Rated Wellness and Health among Healthcare Workers Involved in the COVID-19 Pandemic

    Maryam Masoumi / Kamyar Shokraee / Somayeh Mohammadi / Soroush Moradi / Mohammad Bagherzade / Javad Balasi / Abbas Smiley

    International Journal of Environmental Research and Public Health, Vol 19, Iss 136, p

    2022  Volume 136

    Abstract: Objective: This study was performed during the COVID-19 pandemic to better understand the indicators of self-rated wellness and health among healthcare workers. Methods: Sleep pattern, mood status, nutritional condition, physical activity, habits and the ...

    Abstract Objective: This study was performed during the COVID-19 pandemic to better understand the indicators of self-rated wellness and health among healthcare workers. Methods: Sleep pattern, mood status, nutritional condition, physical activity, habits and the subjective wellness and health index of the healthcare workers of a university affiliated hospital were surveyed. Paired t -tests were performed to compare the participants’ quality of life before and after the outbreak of COVID-19. Multivariable linear regression models with a backward elimination stepwise process determined the parameters that significantly correlated with self-reported wellness and health. Results: Of the 200 healthcare workers who participated in this study, 119 (60%) were female and 81 (40%) were male, with a mean (SD) age of 28.8 (5.9) years. We found that the COVID-19 pandemic significantly changed many lifestyle factors compared to the pre-pandemic states. The scores of sleep quality, mood status, pre-planned physical activity and social activity were reduced by 30%, 40%, 50% and 70%, respectively. The average night sleep duration before the pandemic was 7 h and 22 min, whereas during the pandemic it decreased to 6 h and 44 min, a debt of 38 min in sleep duration every night. As found by multivariable regression modelling, self-reported wellness and health before the pandemic period was associated with wake-up time, mood status, physical activity and diet. During the pandemic period, in addition to these variables, night sleep duration (β = 0.049, p = 0.049) and nap duration (β = 0.009, p = 0.01) were left in the final multivariable model and correlated significantly with the wellness and health index. Conclusion: COVID-19 has detrimentally affected healthcare workers’ well-being and quality of life. Sleep duration was the main factor correlated with subjective wellness and health index during the current COVID-19 pandemic.
    Keywords COVID-19 ; pandemic ; healthcare workers ; lifestyle ; sleep ; Medicine ; R
    Subject code 796 ; 360
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  6. Article ; Online: Discharge of Confirmed COVID-19 Patients Based on WHO or Regional Criteria? A Cohort Study.

    Adeli, Seyed-Hasan / Parham, Mahmoud / Asghari, Akram / Bagherzade, Mohammad / Shajari, Rasoul / Tabarraii, Reihane / Shakeri, Masoumeh / Jabbari, Amir / Jafari, Saeede / Ahmadpour, Sajjad / Habibi, Mohammad Amin / Khodadai, Javad / Shafiee, Hamed / Eskandari, Narges / Dameshghi, Davoud Olad / Masoumi, Maryam / Ghomi, Seyed Yaser Foroghi / Ebrazeh, Ali / Vafaeimanesh, Jamshid

    Infectious disorders drug targets

    2023  Volume 23, Issue 1, Page(s) e150822207493

    Abstract: Background: Increasing the number of COVID-19 patients raises concerns about the capacity of the health care system. This issue emphasizes reducing the admission rate and expediting patient discharge.: Objective: This study aimed to develop a ... ...

    Abstract Background: Increasing the number of COVID-19 patients raises concerns about the capacity of the health care system. This issue emphasizes reducing the admission rate and expediting patient discharge.
    Objective: This study aimed to develop a discharge protocol for COVID-19 patients based on the existing capacity of the healthcare system and to assess its post-discharge outcomes.
    Methods: This is a multicenter cohort study. All COVID-19 patients referred to selected medical centers in Qom, Iran, from Feb. 19 to Apr. 19, 2020, were target populations. Eligible patients were classified into a) the criterion group and b) the non-criterion group. Patients were followed up daily for 14 days after discharge by phone, and the required data was gathered and recorded in follow-up form. Univariate (chi-square and t-tests) and multivariate multiple (multivariate probit regression) analysis were used.
    Results: A total of 2775 patients were included in the study (1440 people in the criterion group and 1335 in the non-criterion group). Based on multivariate probit regression, death was statistically associated with discharge outside our criteria (p<0.001), rising age (p<0.001), and being male (p=0.019), and readmission were associated with discharge outside our criteria (p<0.001), rising age (p=0.009), and having the history of underlying diseases (p=0.003). Furthermore, remission had statistically significant associations with discharge based on our criteria (p<0.001), decreasing age (p=0.001), and lack of a history of underlying diseases (p<0.001).
    Conclusion: Mortality and readmission were significantly lower according to our discharge criteria. Our designed criteria apply to less developed and developing countries due to the limited capacity and resources available in the health care system.
    MeSH term(s) Humans ; Male ; Female ; COVID-19 ; Patient Discharge ; SARS-CoV-2 ; Cohort Studies ; Aftercare ; World Health Organization
    Language English
    Publishing date 2023-02-06
    Publishing country United Arab Emirates
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2234298-9
    ISSN 2212-3989 ; 1871-5265
    ISSN (online) 2212-3989
    ISSN 1871-5265
    DOI 10.2174/1871526522666220815151958
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  7. Article ; Online: Comparing the Sensitivity and Specificity of Lung CT-scan with RT-PCR for Diagnosis of COVID-19.

    Asghari, Akram / Adeli, Seyed-Hasan / Parham, Mahmoud / Bagherzade, Mohammad / Ahmadpour, Sajjad / Shajari, Rasoul / Tabarrai, Reihane / Shakeri, Masoumeh / Habibi, Mohammad Amin / Jabbari, Amir / Jafari, Saeede / Razavinia, Fatemesadat / Foroghi Ghomi, Seyed Yaser / Ebrazeh, Ali / Vafaeimanesh, Jamshid

    Current medical imaging

    2022  Volume 19, Issue 4, Page(s) 327–332

    Abstract: Background: The lung is one of the major organs affected by the SARS-CoV-2 virus. Lung CT scan and RT-PCR are the most valuable diagnostic methods in the early diagnosis and management of COVID-19. Due to the possible inconsistency of the false-negative ...

    Abstract Background: The lung is one of the major organs affected by the SARS-CoV-2 virus. Lung CT scan and RT-PCR are the most valuable diagnostic methods in the early diagnosis and management of COVID-19. Due to the possible inconsistency of the false-negative results for the RT-PCR test, in our study, we aimed to evaluate the sensitivity and specificity of lung CT-scan as an accurate diagnostic method of COVID-19.
    Methods: In this cross-sectional study, patients suspected of COVID-19 and referred to Shahid Beheshti Hospital in Qom city from February 26 to April 13, 2020, were enrolled. For a definitive diagnosis of COVID-19, chest CT scan and RT-PCR testing was performed for 644 patients, and both sensitivity and specificity of lung CT scan were evaluated.
    Results: According to the findings, and comparing to the RT-PCR test as the gold standard, sensitivity, specificity as well as, positive predictive and negative predictive values of lung CT-scan were found as follow; 94.47% (95% CI: 90.73 - 97.02%), 24.71% (95% CI: 20.70 - 29.07%), 40.73% (95% CI: 36.58 - 44.99%), 89.08% (95% CI: 82.4 - 94.05%), respectively.
    Conclusion: According to the findings, the lung CT scan has a better diagnostic value than RTPCR in symptomatic patients who were referred to the hospital for COVID-19 diagnosis. Performing lung CT-scan in patients with negative RT-PCR tests should be assessed.
    MeSH term(s) Humans ; COVID-19/diagnostic imaging ; SARS-CoV-2 ; COVID-19 Testing ; Reverse Transcriptase Polymerase Chain Reaction ; Cross-Sectional Studies ; Lung/diagnostic imaging ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2022-07-14
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 1573-4056
    ISSN (online) 1573-4056
    DOI 10.2174/1573405618666220620141012
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  8. Article: Relationship between β-Thalassemia minor and

    Zamani, Mohammad / Vahedi, Amin / Tamaddoni, Ahmad / Bijani, Ali / Bagherzade, Mojgan / Shokri-Shirvani, Javad

    Caspian journal of internal medicine

    2017  Volume 9, Issue 1, Page(s) 54–59

    Abstract: Background: Until now, no study has been reported investigating the association between β-thalassemia minor and : Methods: A number of 100 β-thalassemia minor patients (50 males, 50 females) and 100 gender-matched healthy controls were prospectively ... ...

    Abstract Background: Until now, no study has been reported investigating the association between β-thalassemia minor and
    Methods: A number of 100 β-thalassemia minor patients (50 males, 50 females) and 100 gender-matched healthy controls were prospectively recruited in this study in a period of 3 months. The study population consisted of the people who referred to a health center in Babol, North of Iran, for premarital counseling.
    Results: The overall
    Conclusions: According to the results, it can be concluded that β-thalassemia minor patients are possibly more susceptible to
    Language English
    Publishing date 2017-12-28
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2971933-1
    ISSN 2008-6172 ; 2008-6164
    ISSN (online) 2008-6172
    ISSN 2008-6164
    DOI 10.22088/cjim.9.1.54
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  9. Article ; Online: Relationship between β-Thalassemia minor and Helicobacter pylori infection

    Mohammad Zamani / Amin Vahedi / Ahmad Tamaddoni / Ali Bijani / Mojgan Bagherzade / Javad Shokri-Shirvani

    Caspian Journal of Internal Medicine, Vol 9, Iss 1, Pp 54-

    2018  Volume 59

    Abstract: Background: Until now, no study has been reported investigating the association between β-thalassemia minor and Helicobacter pylori (H. pylori) infection. This study was designed to compare H. pylori infection rate between β-thalassemia minor patients ... ...

    Abstract Background: Until now, no study has been reported investigating the association between β-thalassemia minor and Helicobacter pylori (H. pylori) infection. This study was designed to compare H. pylori infection rate between β-thalassemia minor patients and healthy controls. Methods: A number of 100 β-thalassemia minor patients (50 males, 50 females) and 100 gender-matched healthy controls were prospectively recruited in this study in a period of 3 months. The study population consisted of the people who referred to a health center in Babol, North of Iran, for premarital counseling. H. pylori status was assessed by measuring the anti-H. pylori IgG antibodies using enzyme-linked immunosorbent assay. Demographic information and informed consent were collected from all participants. Results: The overall H. pylori infection rate was 43%. The infection was significantly more prevalent in thalassemia patients (53%) than in the controls (33%) in both univariate (OR=2.29, 95% CI: 1.3-4.06) and multivariable analyses (OR=2.05, 95% CI: 1.12-3.76). Age was the only significant factor which was positively correlated with the infection in β-thalassemia minor cases (OR=1.11, 95% CI: 1.02-1.2). Gender, blood groups, residency, and education level were not related to the infection. Conclusions: According to the results, it can be concluded that β-thalassemia minor patients are possibly more susceptible to H. pylori infection than healthy people. Further studies are needed to discover more about the exact mechanisms of increased susceptibility to H. pylori infection in β-thalassemia minor patients
    Keywords Helicobacter pylori ; thalassemia minor ; prevalence ; Internal medicine ; RC31-1245
    Subject code 616
    Language English
    Publishing date 2018-01-01T00:00:00Z
    Publisher Babol University of Medical Sciences
    Document type Article ; Online
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  10. Article ; Online: Objective and subjective assessments of lighting in a hospital setting: implications for health, safety and performance.

    Dianat, Iman / Sedghi, Ali / Bagherzade, Javad / Jafarabadi, Mohammad Asghari / Stedmon, Alex W

    Ergonomics

    2013  Volume 56, Issue 10, Page(s) 1535–1545

    Abstract: A field study was conducted to evaluate the illumination levels, to examine the effect of lighting conditions (including lighting characteristics and disturbances) on employee satisfaction, job performance, safety and health, and to compare the employees' ...

    Abstract A field study was conducted to evaluate the illumination levels, to examine the effect of lighting conditions (including lighting characteristics and disturbances) on employee satisfaction, job performance, safety and health, and to compare the employees' perception of lighting level with actual illuminance levels in a hospital setting using both questionnaire and physical illuminance measurements. The illumination levels varied across different locations within the hospital and were lower than standards for 52.2% of the workplaces surveyed. Most respondents indicated that at least one of the four lighting characteristics (i.e. light level, type of light sources, light colour and use of daylight) was inappropriate, and that at least one of the three lighting disturbances (i.e. flickering lights, glare and unwanted shadows) was a major disturbance to them. The employees' perceptions of illuminance generally reflected the actual illuminance levels. The more appropriate maintenance or installation of lighting fixtures was rated as the most appropriate for improving lighting. The findings suggest that environmental ergonomics should be given a more prominent role in hospital building and workplace design to support safer healthcare facilities (for staff and potentially for patients).
    Practitioner summary: Good lighting is essential to improve employee performance, health and safety. The findings suggest that quantitative physical measurements should be supplemented by qualitative subjective assessments to provide a more holistic approach where specific details about the lighting condition in each working environment are incorporated from the workers' perspective.
    MeSH term(s) Adult ; Attitude of Health Personnel ; Health Facility Environment ; Hospitals ; Humans ; Lighting/adverse effects ; Male ; Middle Aged ; Safety ; Young Adult
    Language English
    Publishing date 2013-07-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1920-3
    ISSN 1366-5847 ; 0014-0139
    ISSN (online) 1366-5847
    ISSN 0014-0139
    DOI 10.1080/00140139.2013.820845
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