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  1. Book ; Conference proceedings: Kline Festschrift Symposium on Nerves

    Kline, David G.

    [held in New Orleans in October 2007]

    (Neurosurgery ; 65,4, Suppl.)

    2009  

    Event/congress 2-Day International Symposium on Nerve (2007, NewOrleansLa.)
    Series title Neurosurgery ; 65,4, Suppl.
    Collection
    Language English
    Size N4, A234 S. : Ill., graph. Darst.
    Publisher Lippincott Williams & Wilkins
    Publishing place Hagerstown, Md
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT016105726
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 1424 -65,4,Suppl.- not available for loan Zeitschriften-Lesesaal

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  2. Book: Atlas of peripheral nerve surgery

    Kim, Daniel H. / Hudson, Alan R. / Kline, David G.

    (Expert consult)

    2013  

    Author's details Daniel H. Kim ; Alan R. Hudson ; David G. Kline
    Series title Expert consult
    Keywords Peripheral Nerves / surgery ; Atlases
    Language English
    Size XI, 274 S. : zahlr. Ill.
    Edition 2. ed.
    Publisher Elsevier Saunders
    Publishing place Philadelphia, Pa. u.a.
    Publishing country United States
    Document type Book
    Accompanying material Zugang zur Internetausgabe über Code
    HBZ-ID HT017570627
    ISBN 978-1-4557-0988-5 ; 1-4557-0988-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2013 C 5 order for loan Magazin
    Zugang zur Internetausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  3. Article ; Online: The role of astrocytes in the nucleus tractus solitarii in maintaining central control of autonomic function.

    Martinez, Diana / Kline, David D

    American journal of physiology. Regulatory, integrative and comparative physiology

    2021  Volume 320, Issue 4, Page(s) R418–R424

    Abstract: The nucleus tractus solitarii (nTS) is the first central site for the termination and integration of autonomic and respiratory sensory information. Sensory afferents terminating in the nTS as well as the embedded nTS neurocircuitry release and utilize ... ...

    Abstract The nucleus tractus solitarii (nTS) is the first central site for the termination and integration of autonomic and respiratory sensory information. Sensory afferents terminating in the nTS as well as the embedded nTS neurocircuitry release and utilize glutamate that is critical for maintenance of baseline cardiorespiratory parameters and initiating cardiorespiratory reflexes, including those activated by bouts of hypoxia. nTS astrocytes contribute to synaptic and neuronal activity through a variety of mechanisms, including gliotransmission and regulation of glutamate in the extracellular space via membrane-bound transporters. Here, we aim to highlight recent evidence for the role of astrocytes within the nTS and their regulation of autonomic and cardiorespiratory processes under normal and hypoxic conditions.
    MeSH term(s) Animals ; Astrocytes/metabolism ; Astrocytes/pathology ; Autonomic Nervous System/physiopathology ; Cardiovascular System/innervation ; Glutamic Acid/metabolism ; Hemodynamics ; Humans ; Hypoxia/metabolism ; Hypoxia/pathology ; Hypoxia/physiopathology ; Neuronal Plasticity ; Respiration ; Respiratory System/innervation ; Sensory Receptor Cells/metabolism ; Sensory Receptor Cells/pathology ; Solitary Nucleus/metabolism ; Solitary Nucleus/pathology ; Solitary Nucleus/physiopathology ; Synaptic Transmission
    Chemical Substances Glutamic Acid (3KX376GY7L)
    Language English
    Publishing date 2021-01-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 603839-6
    ISSN 1522-1490 ; 0363-6119
    ISSN (online) 1522-1490
    ISSN 0363-6119
    DOI 10.1152/ajpregu.00254.2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Nucleus tractus solitarii is required for the development and maintenance of phrenic and sympathetic long-term facilitation after acute intermittent hypoxia.

    Ostrowski, Daniela / Heesch, Cheryl M / Kline, David D / Hasser, Eileen M

    Frontiers in physiology

    2023  Volume 14, Page(s) 1120341

    Abstract: Exposure to acute intermittent hypoxia (AIH) induces prolonged increases (long term facilitation, LTF) in phrenic and sympathetic nerve activity (PhrNA, SNA) under basal conditions, and enhanced respiratory and sympathetic responses to hypoxia. The ... ...

    Abstract Exposure to acute intermittent hypoxia (AIH) induces prolonged increases (long term facilitation, LTF) in phrenic and sympathetic nerve activity (PhrNA, SNA) under basal conditions, and enhanced respiratory and sympathetic responses to hypoxia. The mechanisms and neurocircuitry involved are not fully defined. We tested the hypothesis that the nucleus tractus solitarii (nTS) is vital to augmentation of hypoxic responses and the initiation and maintenance of elevated phrenic (p) and splanchnic sympathetic (s) LTF following AIH. nTS neuronal activity was inhibited by nanoinjection of the GABA
    Language English
    Publishing date 2023-02-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1120341
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Use of a Robotic Walking Device for Home and Community Mobility in Parkinson Disease: A Randomized Controlled Trial.

    Kegelmeyer, Deb A / Minarsch, Raquel / Kostyk, Sandra K / Kline, David / Smith, Rachel / Kloos, Anne D

    Journal of neurologic physical therapy : JNPT

    2024  Volume 48, Issue 2, Page(s) 102–111

    Abstract: Background/purpose: Gait impairments in Parkinson disease (PD) contribute to decreased quality of life. This randomized controlled trial examined immediate- and longer-term effects of a single joint robotic exoskeleton device (EXOD), the Honda Walking ... ...

    Abstract Background/purpose: Gait impairments in Parkinson disease (PD) contribute to decreased quality of life. This randomized controlled trial examined immediate- and longer-term effects of a single joint robotic exoskeleton device (EXOD), the Honda Walking Assist device, on gait.
    Methods: Participants (n = 45) with PD (Hoehn and Yahr stages 1-3) were randomized to a robotic-assisted gait training (RAGT) group (n = 23) or control (CON) group (n = 22). The RAGT group was tested with and without the EXOD at baseline and then received supervised in-home and community training with the EXOD twice weekly for 8 weeks. The CON group received no interventions. Outcome measures included gait speed (primary), gait endurance (6-minute walk test), perceived ease of walking, and questionnaires and logs assessing performance of daily activities, freezing of gait, and daily activity levels.
    Results: Forty participants completed the study. No significant immediate impact of EXOD usage on participants' gait measures was found. Differences in gait speed and secondary outcome measures postintervention were not significantly different between the RAGT and CON groups. Participants with greater disease severity (worse baseline motor scores) had greater improvements in stride length during unassisted walking after the intervention than those with lower severity (mean difference: 3.22, 95% confidence interval: 0.05-6.40; P = 0.04).
    Discussion and conclusions: All RAGT participants could use the EXOD safely. The RAGT treatment used in this mostly low impairment population of people with PD may be ineffective and/or was insufficiently dosed to see a positive treatment effect. Our findings suggest that RAGT interventions in PD may be more effective in individuals with greater motor impairments.
    MeSH term(s) Humans ; Parkinson Disease ; Gait Disorders, Neurologic/etiology ; Quality of Life ; Robotic Surgical Procedures ; Gait ; Walking ; Exercise Therapy
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2276921-3
    ISSN 1557-0584 ; 1557-0576 ; 1085-049X
    ISSN (online) 1557-0584
    ISSN 1557-0576 ; 1085-049X
    DOI 10.1097/NPT.0000000000000467
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6541: Show issues Location:
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  6. Book: Kline and Hudson's nerve injuries

    Kline, David G. / Kim, Daniel H. / Hudson, Alan R.

    operative results for major nerve injuries, entrapments, and tumors

    2008  

    Title variant Kline & Hudson's nerve injuries ; Nerve injuries
    Author's details Daniel H. Kim
    Keywords Nervous System / injuries
    Language English
    Size XIII, 505 S. : zahlr. Ill., graph. Darst.
    Edition 2. ed.
    Publisher Elsevier Saunders
    Publishing place Philadelphia, Pa. u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT015380223
    ISBN 0-7216-9537-X ; 978-0-7216-9537-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2008 A 1282 on loan 0 Vormerkungen

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  7. Article ; Online: Tuning excitability of the hypothalamus via glutamate and potassium channel coupling.

    Kline, David D

    The Journal of physiology

    2017  Volume 595, Issue 14, Page(s) 4583–4584

    MeSH term(s) Glutamic Acid ; Hypothalamus ; N-Methylaspartate ; Potassium Channels ; Supraoptic Nucleus
    Chemical Substances Potassium Channels ; Glutamic Acid (3KX376GY7L) ; N-Methylaspartate (6384-92-5)
    Language English
    Publishing date 2017-06-09
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP274446
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Corrigendum to "Exaggerated potassium current reduction by oxytocin in visceral sensory neurons following chronic intermittent hypoxia" [Auton Neurosci. 229 2020 Sep 28 102735].

    Dantzler, Heather A / Kline, David D

    Autonomic neuroscience : basic & clinical

    2020  Volume 230, Page(s) 102758

    Language English
    Publishing date 2020-12-05
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 2020105-9
    ISSN 1872-7484 ; 1566-0702
    ISSN (online) 1872-7484
    ISSN 1566-0702
    DOI 10.1016/j.autneu.2020.102758
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1533: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Cardiovascular deconditioning increases GABA signaling in the nucleus tractus solitarii.

    Lima-Silveira, Ludmila / Hasser, Eileen M / Kline, David D

    Journal of neurophysiology

    2022  Volume 128, Issue 1, Page(s) 28–39

    Abstract: The nucleus tractus solitarii (nTS) is the major integrative brainstem region for autonomic modulation and processing of cardiovascular reflexes. GABA and glutamate are the main inhibitory and excitatory neurotransmitters, respectively, within this ... ...

    Abstract The nucleus tractus solitarii (nTS) is the major integrative brainstem region for autonomic modulation and processing of cardiovascular reflexes. GABA and glutamate are the main inhibitory and excitatory neurotransmitters, respectively, within this nucleus. Alterations in the GABA-glutamate regulation in the nTS are related to numerous cardiovascular comorbidities. Bedridden individuals and people exposed to microgravity exhibit dysautonomia and cardiovascular deconditioning that are mimicked in the hindlimb unloading (HU) rat model. We have previously shown in the nTS that HU increases glutamatergic neurotransmission yet decreases neuronal excitability. In this study, we investigated the effects of HU on nTS GABAergic neurotransmission. We hypothesized that HU potentiates GABA signaling via increased GABAergic release and postsynaptic GABA receptor expression. Following HU or control postural exposure, GABAergic neurotransmission was assessed using whole cell patch clamp whereas the magnitude of GABA release was evaluated via an intensity-based GABA sensing fluorescence reporter (iGABASnFR). In response to GABA interneuron stimulation, the evoked inhibitory postsynaptic current (nTS-IPSC) amplitude and area, as well as iGABASnFR fluorescence, were greater in HU than in control. HU also elevated the frequency but not the amplitude of spontaneous miniature IPSCs. Picoapplication of GABA produced similar postsynaptic current responses in nTS neurons of HU and control. Moreover, HU did not alter GABA
    MeSH term(s) Animals ; Cardiovascular Deconditioning ; Cardiovascular Diseases/metabolism ; Glutamic Acid/metabolism ; Humans ; Rats ; Rats, Sprague-Dawley ; Receptors, GABA-A/metabolism ; Solitary Nucleus/physiology ; Synaptic Transmission/physiology ; gamma-Aminobutyric Acid/metabolism
    Chemical Substances Receptors, GABA-A ; Glutamic Acid (3KX376GY7L) ; gamma-Aminobutyric Acid (56-12-2)
    Language English
    Publishing date 2022-06-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 80161-6
    ISSN 1522-1598 ; 0022-3077
    ISSN (online) 1522-1598
    ISSN 0022-3077
    DOI 10.1152/jn.00102.2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Exaggerated potassium current reduction by oxytocin in visceral sensory neurons following chronic intermittent hypoxia.

    Dantzler, Heather A / Kline, David D

    Autonomic neuroscience : basic & clinical

    2020  Volume 229, Page(s) 102735

    Abstract: Oxytocin (OT) from the hypothalamus is increased in several cardiorespiratory nuclei and systemically in response to a variety of stimuli and stressors, including hypoxia. Within the nucleus tractus solitarii (nTS), the first integration site for ... ...

    Abstract Oxytocin (OT) from the hypothalamus is increased in several cardiorespiratory nuclei and systemically in response to a variety of stimuli and stressors, including hypoxia. Within the nucleus tractus solitarii (nTS), the first integration site for cardiorespiratory reflexes, OT enhances synaptic transmission, action potential (AP) discharge, and cardiac baroreflex gain. The hypoxic stressor obstructive sleep apnea, and its CIH animal model, elevates blood pressure and alters heart rate variability. The nTS receives sensory input from baroafferent neurons that originate in the nodose ganglia. Nodose neurons express the OT receptor (OTR) whose activation elevates intracellular calcium. However, the influence of OT on other ion channels, especially potassium channels important for neuronal activity during CIH, is less known. This study sought to determine the mechanism (s) by which OT modulates sensory afferent-nTS mediated reflexes normally and after CIH. Nodose ganglia neurons from male Sprague-Dawley rats were examined after 10d CIH (6% O
    MeSH term(s) Animals ; Baroreflex/physiology ; Disease Models, Animal ; Electrophysiological Phenomena/physiology ; Hypoxia/metabolism ; Hypoxia/physiopathology ; Male ; Nodose Ganglion/metabolism ; Nodose Ganglion/physiology ; Oxytocin/metabolism ; Patch-Clamp Techniques ; Potassium Channels/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Oxytocin/metabolism ; Signal Transduction/physiology ; Sleep Apnea Syndromes/metabolism ; Sleep Apnea Syndromes/physiopathology ; Visceral Afferents/physiology
    Chemical Substances Potassium Channels ; Receptors, Oxytocin ; oxytocin receptor, rat ; Oxytocin (50-56-6)
    Language English
    Publishing date 2020-09-28
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2020105-9
    ISSN 1872-7484 ; 1566-0702
    ISSN (online) 1872-7484
    ISSN 1566-0702
    DOI 10.1016/j.autneu.2020.102735
    Database MEDical Literature Analysis and Retrieval System OnLINE

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