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  1. Book: Macrophages

    Biswas, Subhra K. / Mantovani, Alberto

    biology and role in the pathology of diseases

    2015  

    Author's details Subhra K. Biswas ; Alberto Mantovani ed
    Language English
    Size IX, 615 S., Ill., graph. Darst.
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT018515021
    ISBN 978-1-4939-1310-7 ; 9781493913114 ; 1-4939-1310-7 ; 1493913115
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 A 251 available for loan (reading room) Lesesaal EG

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  2. Book ; Online: Tumor Microenvironment and Myelomonocytic Cells

    Biswas, Subhra K.

    2012  

    Keywords Oncology
    Size 1 electronic resource (312 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021050069
    ISBN 9789535169468 ; 9535169467
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Metabolic regulation of Cathepsin B in tumor macrophages drives their pro-metastatic function.

    Vidergar, Romana / Biswas, Subhra K

    Cancer cell

    2022  Volume 40, Issue 10, Page(s) 1079–1081

    Abstract: Tumor macrophages possess tumor-promoting functions, but the mechanism regulating such functions is poorly understood. Providing new insight into such mechanism, Shi et al. in this issue of Cancer Cell identify how metabolic regulation of Cathepsin B and ...

    Abstract Tumor macrophages possess tumor-promoting functions, but the mechanism regulating such functions is poorly understood. Providing new insight into such mechanism, Shi et al. in this issue of Cancer Cell identify how metabolic regulation of Cathepsin B and its O-GlcNAcylation by lysosomal O-GlcNAc transferase (OGT) in macrophages drives pro-metastatic function.
    MeSH term(s) Cathepsin B ; Humans ; Macrophages ; Neoplasms
    Chemical Substances Cathepsin B (EC 3.4.22.1)
    Language English
    Publishing date 2022-09-15
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2078448-X
    ISSN 1878-3686 ; 1535-6108
    ISSN (online) 1878-3686
    ISSN 1535-6108
    DOI 10.1016/j.ccell.2022.08.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5650: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 104: Show issues

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  4. Article ; Online: Metabolic Reprogramming of Immune Cells in Cancer Progression.

    Biswas, Subhra K

    Immunity

    2015  Volume 43, Issue 3, Page(s) 435–449

    Abstract: Immune cells play a key role in host defense against infection and cancer. Upon encountering danger signals, these cells undergo activation leading to a modulation in their immune functions. However, recent studies reveal that immune cells upon ... ...

    Abstract Immune cells play a key role in host defense against infection and cancer. Upon encountering danger signals, these cells undergo activation leading to a modulation in their immune functions. However, recent studies reveal that immune cells upon activation also show distinct metabolic changes that impact their immune functions. Such metabolic reprogramming and its functional effects are well known for cancer cells. Given that immune cells have emerged as crucial players in cancer progression, it is important to understand whether immune cells also undergo metabolic reprogramming in tumors and how this might affect their contribution in cancer progression. This emerging aspect of tumor-associated immune cells is reviewed here, discussing metabolic reprogramming of different immune cell types, the key pathways involved, and its impact on tumor progression.
    MeSH term(s) Animals ; Disease Progression ; Energy Metabolism/genetics ; Energy Metabolism/immunology ; Gene Expression Regulation, Neoplastic/immunology ; Humans ; Immune System/immunology ; Immune System/metabolism ; Immune System/pathology ; Metabolic Networks and Pathways/genetics ; Metabolic Networks and Pathways/immunology ; Models, Immunological ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/metabolism
    Language English
    Publishing date 2015-09-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2015.09.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4227: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 69: Show issues

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  5. Article ; Online: Information transmission in a two-step cascade: interplay of activation and repression.

    Roy, Tuhin Subhra / Nandi, Mintu / Biswas, Ayan / Chaudhury, Pinaki / Banik, Suman K

    Theory in biosciences = Theorie in den Biowissenschaften

    2021  Volume 140, Issue 3, Page(s) 295–306

    Abstract: We present an information-theoretic formalism to study signal transduction in four architectural variants of a model two-step cascade with increasing input population. Our results categorize these four types into two classes depending upon the effect of ... ...

    Abstract We present an information-theoretic formalism to study signal transduction in four architectural variants of a model two-step cascade with increasing input population. Our results categorize these four types into two classes depending upon the effect of activation and repression on mutual information, net synergy, and signal-to-noise ratio. Using the Gaussian framework and linear noise approximation, we derive the analytic expressions for these metrics to establish their underlying relationships in terms of the biochemical parameters. We also verify our approximations through stochastic simulations.
    MeSH term(s) Signal Transduction ; Stochastic Processes
    Language English
    Publishing date 2021-10-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1376847-5
    ISSN 1611-7530 ; 1431-7613
    ISSN (online) 1611-7530
    ISSN 1431-7613
    DOI 10.1007/s12064-021-00357-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Bonn / Germany

    Z 46/348: Show issues

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  6. Article ; Online: Tumor-Associated Neutrophils Show Phenotypic and Functional Divergence in Human Lung Cancer.

    Saha, Shilpi / Biswas, Subhra K

    Cancer cell

    2016  Volume 30, Issue 1, Page(s) 11–13

    Abstract: Studies in murine cancer models have demonstrated the phenotypic and functional divergence of neutrophils; however, their role in pro- or anti-tumor responses in human remains elusive. In this issue of Cancer Cell, Singhal et al. report the existence of ... ...

    Abstract Studies in murine cancer models have demonstrated the phenotypic and functional divergence of neutrophils; however, their role in pro- or anti-tumor responses in human remains elusive. In this issue of Cancer Cell, Singhal et al. report the existence of specialized subsets of neutrophils in human lung cancer with diverging functions.
    MeSH term(s) Animals ; Humans ; Lung Neoplasms ; Neutrophils
    Language English
    Publishing date 2016--11
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2078448-X
    ISSN 1878-3686 ; 1535-6108
    ISSN (online) 1878-3686
    ISSN 1535-6108
    DOI 10.1016/j.ccell.2016.06.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5650: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 104: Show issues

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  7. Article ; Online: Colonic Macrophages "Remote Control" Adipose Tissue Inflammation and Insulin Resistance.

    Biswas, Subhra K / Bonecchi, Raffaella

    Cell metabolism

    2016  Volume 24, Issue 2, Page(s) 196–198

    Abstract: The early events linking diet-induced adipose tissue inflammation and insulin resistance remain poorly understood. In this issue of Cell Metabolism, Kawano et al. (2016) show that infiltration of colonic pro-inflammatory macrophages orchestrated by the ... ...

    Abstract The early events linking diet-induced adipose tissue inflammation and insulin resistance remain poorly understood. In this issue of Cell Metabolism, Kawano et al. (2016) show that infiltration of colonic pro-inflammatory macrophages orchestrated by the intestinal CCL2/CCR2 axis kick-starts this process during high-fat-diet feeding.
    MeSH term(s) Adipose Tissue ; Humans ; Inflammation ; Insulin Resistance ; Macrophages ; Mice, Inbred C57BL ; Obesity
    Language English
    Publishing date 2016-08-24
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2016.07.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6169: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Rewiring macrophages for anti-tumour immunity.

    Lee, Yunqin / Biswas, Subhra K

    Nature cell biology

    2016  Volume 18, Issue 7, Page(s) 718–720

    Abstract: Tumour-associated macrophages facilitate cancer progression, but whether they can be reprogrammed to elicit an anti-tumour response remains unclear. Deletion of the microRNA-processing enzyme Dicer is now shown to rewire macrophages to an anti-tumour ... ...

    Abstract Tumour-associated macrophages facilitate cancer progression, but whether they can be reprogrammed to elicit an anti-tumour response remains unclear. Deletion of the microRNA-processing enzyme Dicer is now shown to rewire macrophages to an anti-tumour mode, leading to an enhanced response to immunotherapy and inhibition of tumour progression.
    MeSH term(s) Animals ; Cellular Reprogramming ; Disease Progression ; Humans ; Immunotherapy/methods ; Macrophages/immunology ; Neoplasms/diagnosis ; Neoplasms/immunology ; Neoplasms/therapy ; Ribonuclease III/immunology ; Ribonuclease III/metabolism
    Chemical Substances Ribonuclease III (EC 3.1.26.3)
    Language English
    Publishing date 2016-06-28
    Publishing country England
    Document type News
    ZDB-ID 1474722-4
    ISSN 1476-4679 ; 1465-7392
    ISSN (online) 1476-4679
    ISSN 1465-7392
    DOI 10.1038/ncb3384
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5169: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 12: Show issues

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  9. Book: Macrophages

    Biswas, Subhra K / Mantovani, Alberto

    biology and role in the pathology of diseases

    2014  

    Author's details Subhra K. Biswas, Alberto Mantovani, editors
    MeSH term(s) Macrophages
    Language English
    Size ix, 615 pages :, illustrations
    Document type Book
    ISBN 9781493913107 ; 9781493913114 ; 1493913107 ; 1493913115
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Article ; Online: Post-transcriptional regulatory feedback encodes JAK-STAT signal memory of interferon stimulation.

    Kalliara, Eirini / Kardynska, Malgorzata / Bagnall, James / Spiller, David G / Müller, Werner / Ruckerl, Dominik / Śmieja, Jarosław / Biswas, Subhra K / Paszek, Pawel

    Frontiers in immunology

    2022  Volume 13, Page(s) 947213

    Abstract: Immune cells fine tune their responses to infection and inflammatory cues. Here, using live-cell confocal microscopy and mathematical modelling, we investigate interferon-induced JAK-STAT signalling in innate immune macrophages. We demonstrate that ... ...

    Abstract Immune cells fine tune their responses to infection and inflammatory cues. Here, using live-cell confocal microscopy and mathematical modelling, we investigate interferon-induced JAK-STAT signalling in innate immune macrophages. We demonstrate that transient exposure to IFN-γ stimulation induces a long-term desensitisation of STAT1 signalling and gene expression responses, revealing a dose- and time-dependent regulatory feedback that controls JAK-STAT responses upon re-exposure to stimulus. We show that IFN-α/β1 elicit different level of desensitisation from IFN-γ, where cells refractory to IFN-α/β1 are sensitive to IFN-γ, but not
    MeSH term(s) Antiviral Agents ; Feedback ; Interferon-alpha/metabolism ; Janus Kinases/metabolism ; Protein Tyrosine Phosphatases/metabolism ; Protein-Tyrosine Kinases/metabolism ; RNA, Messenger ; STAT Transcription Factors/metabolism ; Transcription, Genetic
    Chemical Substances Antiviral Agents ; Interferon-alpha ; RNA, Messenger ; STAT Transcription Factors ; Protein-Tyrosine Kinases (EC 2.7.10.1) ; Janus Kinases (EC 2.7.10.2) ; Protein Tyrosine Phosphatases (EC 3.1.3.48)
    Language English
    Publishing date 2022-09-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.947213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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