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  1. Book ; Thesis: PKC Isoformen α und ζ als Mediatoren der ROS-induzierten exkretorischen Dysfunktion in der Leber

    Banz, Micha / Press, Adrian Tibor / Kahlert, Ulf D. / Zipprich, Alexander

    2023  

    Title variant alpha zeta
    Institution Friedrich-Schiller-Universität Jena
    Author's details von Micha Sebastian Banz
    Language German
    Size 78 Seiten, Illustrationen, Diagramme, 29,5 cm
    Publishing place Jena
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Friedrich-Schiller-Universität Jena, 2023
    Note Kumulative Dissertation, enthält Zeitschriftenaufsätze ; Tag der Verteidigung: 02.05.2023
    HBZ-ID HT030626282
    Database Catalogue ZB MED Medicine, Health

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    2024 E 83 order for loan Magazin

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  2. Book ; Thesis: Quantitative Untersuchung der Gefäßmaturation in malignen humanen Tumoren

    Kahlert, Sebastian

    2001  

    Author's details vorgelegt von Sebastian Kahlert
    Language German
    Size III, 75 Bl. : Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Göttingen, Univ., Diss., 2003
    HBZ-ID HT013834838
    Database Catalogue ZB MED Medicine, Health

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  3. Article: Why pledges alone will not get plastics recycled: Comparing recyclate production and anticipated demand

    Kahlert, Sebastian / Bening, Catharina R.

    Resources, conservation, and recycling. 2022 June, v. 181

    2022  

    Abstract: Scientific analysis and media coverage of rampant plastic pollution has taken a toll on the material's reputation in recent years, fueling talk of a “plastic crisis”. Brand owners have made ambitious pledges to overcome this crisis—but can voluntary ... ...

    Abstract Scientific analysis and media coverage of rampant plastic pollution has taken a toll on the material's reputation in recent years, fueling talk of a “plastic crisis”. Brand owners have made ambitious pledges to overcome this crisis—but can voluntary commitments turn the tide? In this paper, we analyze the current flow of polyethylene terephthalate (PET) from production to recycling in the European Union (EU). We show that the pledged volume for recycled PET (rPET) to be used in the EU in 2025 amounts to 2.066 m tons, requiring the annual recycling growth rate to double in the next years compared to 2014–2018. Our results indicate that even widespread adoption of deposit return systems for bottles will not suffice, especially when increasing demand from other industries drives the price above the packaging producers’ willingness to pay. To realize the pledges, substantial investments and a regulatory framework for the targeted and sensible use of PET recyclate are necessary.
    Keywords European Union ; pollution ; polyethylene terephthalates ; prices ; willingness to pay
    Language English
    Dates of publication 2022-06
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1498716-8
    ISSN 0921-3449
    ISSN 0921-3449
    DOI 10.1016/j.resconrec.2022.106279
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Plastics recycling after the global pandemic: resurgence or regression?

    Kahlert, Sebastian / Bening, Catharina R

    Resources, conservation, and recycling

    2020  Volume 160, Page(s) 104948

    Keywords covid19
    Language English
    Publishing date 2020-05-16
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1498716-8
    ISSN 0921-3449
    ISSN 0921-3449
    DOI 10.1016/j.resconrec.2020.104948
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  5. Article ; Online: Preoperative IL-8 levels as prognostic indicators of overall survival: an extended follow-up in a prospective cohort with colorectal liver metastases.

    Pecqueux, Mathieu / Brückner, Frederik / Oehme, Florian / Hempel, Sebastian / Baenke, Franziska / Riediger, Carina / Distler, Marius / Weitz, Jürgen / Kahlert, Christoph

    BMC cancer

    2024  Volume 24, Issue 1, Page(s) 90

    Abstract: Introduction: CRC with liver metastases is a major contributor to cancer-related mortality. Despite advancements in liver resection techniques, patient survival remains a concern due to high recurrence rates. This study seeks to uncover prognostic ... ...

    Abstract Introduction: CRC with liver metastases is a major contributor to cancer-related mortality. Despite advancements in liver resection techniques, patient survival remains a concern due to high recurrence rates. This study seeks to uncover prognostic biomarkers that predict overall survival in patients undergoing curative hepatic resection for CRC liver metastases.
    Methods: Prospectively collected serum samples from a cohort of 49 patients who received curative hepatic resection for CRC liver metastases were studied. The patients are part of a cohort, previously analyzed for perioperative complications (see methods). Various preoperative serum markers, clinical characteristics, and factors were analyzed. Univariate and multivariate Cox regression analyses were conducted to determine associations between these variables and disease-free survival as well as overall survival.
    Results: For disease-free survival, univariate analysis highlighted the correlation between poor outcomes and advanced primary tumor stage, high ASA score, and synchronous liver metastases. Multivariate analysis identified nodal-positive primary tumors and synchronous metastases as independent risk factors for disease-free survival. Regarding overall survival, univariate analysis demonstrated significant links between poor survival and high preoperative IL-8 levels, elevated neutrophil-lymphocyte ratio (NLR), and presence of metastases in other organs. Multivariate analysis confirmed preoperative IL-8 and having three or more liver metastases as independent risk factors for overall survival. The impact of IL-8 on survival was particularly noteworthy, surpassing the influence of established clinical factors.
    Conclusion: This study establishes preoperative IL-8 levels as a potential prognostic biomarker for overall survival in patients undergoing curative liver resection for CRC liver metastases. This study underscores the importance of incorporating IL-8 and other biomarkers into clinical decision-making, facilitating improved patient stratification and tailored treatment approaches. Further research and validation studies are needed to solidify the clinical utility of IL-8 as a prognostic marker.
    MeSH term(s) Humans ; Biomarkers ; Colorectal Neoplasms/pathology ; Follow-Up Studies ; Hepatectomy ; Interleukin-8 ; Liver Neoplasms/secondary ; Prognosis ; Prospective Studies ; Retrospective Studies
    Chemical Substances Biomarkers ; Interleukin-8 ; CXCL8 protein, human
    Language English
    Publishing date 2024-01-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041352-X
    ISSN 1471-2407 ; 1471-2407
    ISSN (online) 1471-2407
    ISSN 1471-2407
    DOI 10.1186/s12885-023-11787-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The true cost of solving the plastic waste challenge in developing countries: The case of Ghana

    Bening, Catharina R. / Kahlert, Sebastian / Asiedu, Edward

    Journal of cleaner production. 2022 Jan. 01, v. 330

    2022  

    Abstract: Mismanaged plastic waste is a major environmental concern, especially in countries of the Global South. Municipal solid waste management can not only alleviate environmental problems but also create jobs and promote local economic growth. However, ... ...

    Abstract Mismanaged plastic waste is a major environmental concern, especially in countries of the Global South. Municipal solid waste management can not only alleviate environmental problems but also create jobs and promote local economic growth. However, providing appropriate waste management services is costly. The question is to what extent waste management policies that have proven to be successful in other geographies can help solve the challenge in developing countries. Specifically, the economics and financial flows along the value chain need to be known. In this paper, we shed light on these questions by presenting a novel, model-based method to elicit and assess the cost structure of the recycling sector in developing countries. We exemplify our method with plastics waste management in the Greater Accra Region of Ghana—an area particularly challenged by plastic waste. For this purpose, we surveyed over 80 participants of the waste management value chain and combined the data with insights from expert interviews and workshops. Based on this data, we built a bottom-up model with 67 parameters, reflecting all cost positions in the waste management value chain. We found that street waste pickers are the poorest and most vulnerable, earning only a fraction of the already low minimum wage. Middlemen and aggregators, while often being criticized for their earnings, also provide social-security-like services to waste pickers. In addition, formal and informal recyclers differ not only in earnings and size but also in recyclate quality where the informal sector provides higher quality.
    Keywords models ; municipal solid waste ; supply chain ; Ghana
    Language English
    Dates of publication 2022-0101
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 0959-6526
    DOI 10.1016/j.jclepro.2021.129649
    Database NAL-Catalogue (AGRICOLA)

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  8. Thesis ; Book: In-Game Advertising in digitalen Sportspielen

    Kahlert, Sebastian

    über den Einfluss von Immersion und Flow auf die Wahrnehmung von digitalen Werbeträgern

    2014  

    Author's details von Sebastian Kahlert
    Size III, 63 Blatt: Illustrationen, graphische Darstellungen
    Document type Thesis ; Book
    Thesis / German Habilitation thesis Köln, deutsche Sporthochschule, Masterarbeit, 2014
    HBZ-ID HT018524391
    Database Central Library of Sport Science of the German Sport University Cologne

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  9. Article ; Online: RAB27B expression in pancreatic cancer is predictive of poor survival but good response to chemotherapy.

    Pecqueux, Mathieu / Wende, Beate / Sommer, Ulrich / Baenke, Franziska / Oehme, Florian / Hempel, Sebastian / Aust, Daniela / Distler, Marius / Weitz, Jürgen / Kahlert, Christoph

    Cancer biomarkers : section A of Disease markers

    2023  Volume 37, Issue 4, Page(s) 207–215

    Abstract: Background: Pancreatic cancer is the 4th leading cause of cancer-related death with poor survival even after curative resection. RAB27A and RAB27B are key players in the exosome pathway where they play important roles in exosome secretion. Evidence ... ...

    Abstract Background: Pancreatic cancer is the 4th leading cause of cancer-related death with poor survival even after curative resection. RAB27A and RAB27B are key players in the exosome pathway where they play important roles in exosome secretion. Evidence suggests that RAB27A and RAB27B expression not only leads to tumor proliferation and invasion, but also plays an important role in antigen transfer necessary for anticancer immunity.
    Objective: In this study, we analyze the expression of RAB27A and RAB27B in patients after pancreatic cancer surgery with or without adjuvant chemotherapy and its influence on overall survival.
    Methods: We analyzed a total of 167 patients with pancreatic cancer for their RAB27A and RAB27B expression. We dichotomized the patients along the median and compared survival in patients with high and low RAB27A and RAB27B expression with or without adjuvant chemotherapy treatment.
    Results: We found a significant improvement in overall survival in patients with a negative resection margin (p= 0.037) and in patients who received adjuvant chemotherapy (p= 0.039). The survival benefit after chemotherapy was dependent on RAB27B expression status: only the subgroup of patients with high RAB27B expression benefited from adjuvant chemotherapy (p= 0.006), but not the subgroup with low RAB27B expression (p= 0.59). Patients with high RAB27B expression who did not receive adjuvant chemotherapy showed a trend towards worse survival compared to the other subgroups. This difference was abolished after treatment with adjuvant chemotherapy.
    Conclusion: These results suggest that RAB27B expression in pancreatic cancer might identify a subgroup of patients with poor survival who might respond well to adjuvant chemotherapy. If resectable, these patients could be considered for neoadjuvant chemotherapy to minimize the risk of not receiving adjuvant chemotherapy. Further prospective studies are needed to confirm these findings.
    MeSH term(s) Humans ; rab GTP-Binding Proteins/genetics ; rab GTP-Binding Proteins/metabolism ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism ; Chemotherapy, Adjuvant ; Pancreas/pathology ; Pancreatic Neoplasms
    Chemical Substances rab GTP-Binding Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2023-05-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2203517-5
    ISSN 1875-8592 ; 1574-0153 ; 1875-8592
    ISSN (online) 1875-8592 ; 1574-0153
    ISSN 1875-8592
    DOI 10.3233/CBM-220460
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Preoperative anaemia in distal pancreatectomy: a propensity-score matched analysis.

    Radulova-Mauersberger, Olga / von Bechtolsheim, Felix / Teske, Christian / Hempel, Sebastian / Kroesen, Louisa / Pecqueux, Mathieu / Kahlert, Christoph / Weitz, Jürgen / Distler, Marius / Oehme, Florian

    Langenbeck's archives of surgery

    2024  Volume 409, Issue 1, Page(s) 119

    Abstract: Background: Preoperative anaemia is a prevalent morbidity predictor that adversely affects short- and long-term outcomes of patients undergoing surgery. This analysis aimed to investigate preoperative anaemia and its detrimental effects on patients ... ...

    Abstract Background: Preoperative anaemia is a prevalent morbidity predictor that adversely affects short- and long-term outcomes of patients undergoing surgery. This analysis aimed to investigate preoperative anaemia and its detrimental effects on patients after distal pancreatectomy.
    Material and methods: The present study was a propensity-score match analysis of 286 consecutive patients undergoing distal pancreatectomy. Patients were screened for preoperative anaemia and classified according to WHO recommendations. The primary outcome measure was overall morbidity. The secondary endpoints were in-hospital mortality and rehospitalization.
    Results: The preoperative anaemia rate before matching was 34.3% (98 patients), and after matching a total of 127 patients (non-anaemic 42 vs. anaemic 85) were included. Anaemic patients had significantly more postoperative major complications (54.1% vs. 23.8%; p < 0.01), a higher comprehensive complication index (26.2 vs. 4.3; p < 0.01), and higher in-hospital mortality rate (14.1% vs. 2.4%; p = 0.04). Multivariate regression analysis confirmed these findings and identified preoperative anaemia as a strong independent risk factor for postoperative major morbidity (OR 4.047; 95% CI: 1.587-10.320; p < 0.01).
    Conclusion: The current propensity-score matched analysis strongly considered preoperative anaemia as a risk factor for major complications following distal pancreatectomy. Therefore, an intense preoperative anaemia workup should be increasingly prioritised.
    MeSH term(s) Humans ; Pancreatectomy/adverse effects ; Anemia/complications ; Anemia/epidemiology ; Hospital Mortality ; Multivariate Analysis ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology
    Language English
    Publishing date 2024-04-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1423681-3
    ISSN 1435-2451 ; 1435-2443
    ISSN (online) 1435-2451
    ISSN 1435-2443
    DOI 10.1007/s00423-024-03300-4
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