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  1. Article ; Online: Redox stress in COVID-19: Implications for hematologic disorders.

    Yang, Moua

    Best practice & research. Clinical haematology

    2022  Volume 35, Issue 3, Page(s) 101373

    Abstract: COVID-19 is the respiratory illness caused by the beta coronavirus SARS-CoV-2. COVID-19 is complicated by an increased risk for adverse thrombotic events that promote organ failure and death. While the mechanism of action for SARS-CoV-2 is still being ... ...

    Abstract COVID-19 is the respiratory illness caused by the beta coronavirus SARS-CoV-2. COVID-19 is complicated by an increased risk for adverse thrombotic events that promote organ failure and death. While the mechanism of action for SARS-CoV-2 is still being understood, how SARS-CoV-2 infection impacts the redox environment in hematologic conditions is unclear. In this review, the redox mechanisms contributing to SARS-CoV-2 infection, coagulopathy and inflammation are briefly discussed. Specifically, sources of oxidant generation by hematopoietic and non-hematopoietic cells are identified with special emphasis on leukocytes, platelets, red cells, and endothelial cells. Furthermore, reactive cysteines in SARS-CoV-2 are also discussed with respect to oxidative cysteine modification and current therapeutic implications. Lastly, sickle cell disease will be discussed as a hematologic disorder with a pre-existing prothrombotic redox condition that complicates treatment strategies for COVID-19. An understanding of the redox mechanism may identify potential targets for COVID-19-mediated thrombosis in hematologic disorders.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Endothelial Cells ; Inflammation
    Language English
    Publishing date 2022-08-13
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2048027-1
    ISSN 1532-1924 ; 1521-6926
    ISSN (online) 1532-1924
    ISSN 1521-6926
    DOI 10.1016/j.beha.2022.101373
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Se 1029: Show issues Location:
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  2. Article: Targeting Cysteine Oxidation in Thrombotic Disorders.

    Yang, Moua / Silverstein, Roy L

    Antioxidants (Basel, Switzerland)

    2024  Volume 13, Issue 1

    Abstract: Oxidative stress increases the risk for clinically significant thrombotic events, yet the mechanisms by which oxidants become prothrombotic are unclear. In this review, we provide an overview of cysteine reactivity and oxidation. We then highlight recent ...

    Abstract Oxidative stress increases the risk for clinically significant thrombotic events, yet the mechanisms by which oxidants become prothrombotic are unclear. In this review, we provide an overview of cysteine reactivity and oxidation. We then highlight recent findings on cysteine oxidation events in oxidative stress-related thrombosis. Special emphasis is on the signaling pathway induced by a platelet membrane protein, CD36, in dyslipidemia, and by protein disulfide isomerase (PDI), a member of the thiol oxidoreductase family of proteins. Antioxidative and chemical biology approaches to target cysteine are discussed. Lastly, the knowledge gaps in the field are highlighted as they relate to understanding how oxidative cysteine modification might be targeted to limit thrombosis.
    Language English
    Publishing date 2024-01-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox13010083
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  3. Article ; Online: Protocol to identify flavonoid antagonists of the SARS-CoV-2 main protease.

    Yang, Moua / Lin, Lin / Flaumenhaft, Robert

    STAR protocols

    2024  Volume 5, Issue 2, Page(s) 102990

    Abstract: Flavonoids are naturally occurring metabolites of plants that can inhibit the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro), which is required for viral replication. Here, we present a protocol to identify flavonoid ... ...

    Abstract Flavonoids are naturally occurring metabolites of plants that can inhibit the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro), which is required for viral replication. Here, we present a protocol to identify flavonoid antagonists of the SARS-CoV-2 Mpro. We describe steps for the expression and purification of Mpro and a kinetic enzymatic assay for Mpro activity using a dequenching fluorescence resonance energy transfer peptide substrate. We then detail procedures for using this enzymatic assay to test flavonoid antagonism and reversible inhibition. For complete details on the use and execution of this protocol, please refer to Lin et al.
    Language English
    Publishing date 2024-04-06
    Publishing country United States
    Document type Journal Article
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2024.102990
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  4. Article ; Online: Cysteine and methionine oxidation in thrombotic disorders.

    Yang, Moua / Smith, Brian C

    Current opinion in chemical biology

    2023  Volume 76, Page(s) 102350

    Abstract: Thrombosis is the leading cause of death in many diseased conditions. Oxidative stress is characteristic of these conditions. Yet, the mechanisms through which oxidants become prothrombotic are unclear. Recent evidence suggests protein cysteine and ... ...

    Abstract Thrombosis is the leading cause of death in many diseased conditions. Oxidative stress is characteristic of these conditions. Yet, the mechanisms through which oxidants become prothrombotic are unclear. Recent evidence suggests protein cysteine and methionine oxidation as prothrombotic regulators. These oxidative post-translational modifications occur on proteins that participate in the thrombotic process, including Src family kinases, protein disulfide isomerase, β2 glycoprotein I, von Willebrand factor, and fibrinogen. New chemical tools to identify oxidized cysteine and methionine proteins in thrombosis and hemostasis, including carbon nucleophiles for cysteine sulfenylation and oxaziridines for methionine, are critical to understanding why clots occur during oxidative stress. These mechanisms will identify alternative or novel therapeutic approaches to treat thrombotic disorders in diseased conditions.
    MeSH term(s) Humans ; Methionine/metabolism ; Cysteine/metabolism ; Oxidation-Reduction ; Proteins/metabolism ; Racemethionine/metabolism ; Thrombosis
    Chemical Substances Methionine (AE28F7PNPL) ; Cysteine (K848JZ4886) ; Proteins ; Racemethionine (73JWT2K6T3)
    Language English
    Publishing date 2023-06-16
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1439176-4
    ISSN 1879-0402 ; 1367-5931
    ISSN (online) 1879-0402
    ISSN 1367-5931
    DOI 10.1016/j.cbpa.2023.102350
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    Zs.A 4986: Show issues Location:
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  5. Article ; Online: Oxidative Cysteine Modification of Thiol Isomerases in Thrombotic Disease: A Hypothesis.

    Yang, Moua / Flaumenhaft, Robert

    Antioxidants & redox signaling

    2021  Volume 35, Issue 13, Page(s) 1134–1155

    Abstract: Significance: ...

    Abstract Significance:
    MeSH term(s) Animals ; Cysteine/metabolism ; Humans ; Isomerases/metabolism ; Oxidation-Reduction ; Oxidative Stress ; Sulfhydryl Compounds/metabolism ; Thrombosis/metabolism
    Chemical Substances Sulfhydryl Compounds ; Isomerases (EC 5.-) ; Cysteine (K848JZ4886)
    Language English
    Publishing date 2021-09-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1483836-9
    ISSN 1557-7716 ; 1523-0864
    ISSN (online) 1557-7716
    ISSN 1523-0864
    DOI 10.1089/ars.2021.0108
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    Zs.A 5488: Show issues Location:
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  6. Article ; Online: Treatment of the Connective Tissue Disease-Related Interstitial Lung Diseases: A Narrative Review.

    Gao, Yang / Moua, Teng

    Mayo Clinic proceedings

    2020  Volume 95, Issue 3, Page(s) 554–573

    Abstract: Interstitial lung disease (ILD) is a frequent complication of patients with connective tissue disease (CTD) and significantly affects morbidity and mortality. Disease course may vary from stable or mildly progressive to more severe, with rapid loss of ... ...

    Abstract Interstitial lung disease (ILD) is a frequent complication of patients with connective tissue disease (CTD) and significantly affects morbidity and mortality. Disease course may vary from stable or mildly progressive to more severe, with rapid loss of lung function. We conducted a search of PubMed (National Library of Medicine) and the Web of Science Core Collection using the key words lung, pulmonary, pneumonia, pneumonitis, and alveolar and subtypes of CTD. All clinical studies from January 1, 1980, through September 1, 2018, were reviewed for descriptions of specific therapies and their efficacy or safety and were categorized as controlled interventional trials, observational prospective or retrospective cohort studies, case series (>5 patients), and case reports (<5 patients). Low-quality reports (<5 patients) before 2000, reviews, editorials, popular science papers, and letters to the editor without complete descriptions of the therapies used or their outcomes were excluded. Directed therapy for CTD-ILD is dominated by empirical use of immunosuppressive agents, with the decision to treat, treatment choice, and treatment duration limited to cases and cohort observations. Only a few higher-level controlled studies were available specifically in scleroderma-related ILD. We summarize herein for the clinician the published treatment scope and experience, highlighted clinical response, and common adverse reactions for the management of CTD-ILD.
    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Biological Products/therapeutic use ; Connective Tissue Diseases/complications ; Connective Tissue Diseases/therapy ; Disease Progression ; Hematopoietic Stem Cell Transplantation ; Humans ; Immunosuppressive Agents/therapeutic use ; Lung Diseases, Interstitial/etiology ; Lung Diseases, Interstitial/therapy ; Prognosis
    Chemical Substances Adrenal Cortex Hormones ; Biological Products ; Immunosuppressive Agents
    Language English
    Publishing date 2020-03-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2019.07.007
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  7. Article: Stories from Hmong in STEMM.

    Vue, Zer / Yang, Moua / Yang, Shany E / Vangay, Pajau / Vue, Tou Yia / Vang, Kieng Bao / Yang, Kao Lee

    Trends in genetics : TIG

    2023  Volume 39, Issue 8, Page(s) 587–592

    Language English
    Publishing date 2023-05-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 619240-3
    ISSN 1362-4555 ; 0168-9525 ; 0168-9479
    ISSN (online) 1362-4555
    ISSN 0168-9525 ; 0168-9479
    DOI 10.1016/j.tig.2023.04.007
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    Zs.A 2272: Show issues Location:
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  8. Article: Platelet reactivity in dyslipidemia: atherothrombotic signaling and therapeutic implications.

    Yang, Moua / Kholmukhamedov, Andaleb

    Reviews in cardiovascular medicine

    2021  Volume 22, Issue 1, Page(s) 67–81

    Abstract: The risks for adverse thrombotic events, including myocardial infarction, stroke, and deep vein thrombosis, are markedly increased in dyslipidemia and other metabolic disorders and are the major cause of death worldwide. Recent evidence points out that ... ...

    Abstract The risks for adverse thrombotic events, including myocardial infarction, stroke, and deep vein thrombosis, are markedly increased in dyslipidemia and other metabolic disorders and are the major cause of death worldwide. Recent evidence points out that increased thrombotic risk in dyslipidemia is mediated by platelets circulating in a pre-activated state. The mechanisms of platelet reactivity in this setting are multifaceted including platelet activation by classic agonist receptor signaling as well as platelet sensitization by pattern recognition receptors. Elevated platelet counts in dyslipidemia due to dysregulation in hematopoiesis also contribute to the overall thrombotic phenotype. Despite recent advancements in antiplatelet and anticoagulation therapies, recurrences of adverse thrombotic events remain to be a large clinical burden. In the light of new knowledge, understanding mechanisms that drive pathologic thrombosis in dyslipidemia, the antithrombotic approach shall be revisited. Here, we discuss potential therapeutic avenues based on the overview of platelet signaling mechanisms that contribute to a prothrombotic phenotype in dyslipidemia.
    MeSH term(s) Blood Platelets ; Dyslipidemias/diagnosis ; Dyslipidemias/drug therapy ; Humans ; Platelet Activation ; Platelet Aggregation Inhibitors/adverse effects ; Signal Transduction ; Thrombosis/drug therapy
    Chemical Substances Platelet Aggregation Inhibitors
    Language English
    Publishing date 2021-04-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2108910-3
    ISSN 1530-6550
    ISSN 1530-6550
    DOI 10.31083/j.rcm.2021.01.256
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    Zs.A 6410: Show issues Location:
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  9. Article ; Online: Role of Angiopoietin-Tie axis in vascular and lymphatic systems and therapeutic interventions.

    Wang, Rui / Yang, Moua / Jiang, Longguang / Huang, Mingdong

    Pharmacological research

    2022  Volume 182, Page(s) 106331

    Abstract: The Angiopoietin (Ang)-Tyrosine kinase with immunoglobulin-like and EGF-like domains (Tie) axis is an endothelial cell-specific ligand-receptor signaling pathway necessary for vascular and lymphatic development. The Ang-Tie axis is involved in regulating ...

    Abstract The Angiopoietin (Ang)-Tyrosine kinase with immunoglobulin-like and EGF-like domains (Tie) axis is an endothelial cell-specific ligand-receptor signaling pathway necessary for vascular and lymphatic development. The Ang-Tie axis is involved in regulating angiogenesis, vascular remodeling, vascular permeability, and inflammation to maintain vascular quiescence. Disruptions in the Ang-Tie axis are involved in many vascular and lymphatic diseases and play an important role in physiological and pathological vascular processes. Given recent advances in the Ang-Tie axis in the vascular and lymphatic systems, this review focuses on the multiple functions of the Ang-Tie axis in inflammation-induced vascular permeability, vascular remodeling, atherosclerosis, ocular angiogenesis, tumor angiogenesis, and metastasis. A summary of relevant therapeutic approaches to the Ang-Tie axis, including therapeutic antibodies, recombinant proteins and small molecule drugs are also discussed. The purpose of this review is to provide new hypotheses and identify potential therapeutic strategies based on the Ang-Tie signaling axis for the treatment of vascular and lymphatic-related diseases.
    MeSH term(s) Angiopoietin-1 ; Angiopoietins/metabolism ; Humans ; Inflammation ; Lymphatic System/metabolism ; Neovascularization, Pathologic ; Receptor, TIE-2/metabolism
    Chemical Substances Angiopoietin-1 ; Angiopoietins ; Receptor, TIE-2 (EC 2.7.10.1)
    Language English
    Publishing date 2022-06-27
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2022.106331
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    Zs.A 721: Show issues Location:
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  10. Article ; Online: Regulation of pro-σ

    Sun, Gaohui / Yang, Moua / Jiang, Longguang / Huang, Mingdong

    Environmental microbiology

    2021  Volume 23, Issue 5, Page(s) 2366–2373

    Abstract: The Gram-positive bacterium Bacillus subtilis initiates the sporulation process under conditions of nutrient limitation. Here, we review related work in this field, focusing on the protein processing of the pro- ... ...

    Abstract The Gram-positive bacterium Bacillus subtilis initiates the sporulation process under conditions of nutrient limitation. Here, we review related work in this field, focusing on the protein processing of the pro-σ
    MeSH term(s) Bacillus subtilis/genetics ; Bacillus subtilis/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Gene Expression Regulation, Bacterial ; Sigma Factor/metabolism ; Spores, Bacterial/metabolism
    Chemical Substances Bacterial Proteins ; Sigma Factor
    Language English
    Publishing date 2021-02-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2020213-1
    ISSN 1462-2920 ; 1462-2912
    ISSN (online) 1462-2920
    ISSN 1462-2912
    DOI 10.1111/1462-2920.15415
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