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  1. Article ; Online: Platelet Dysregulation in the Pathobiology of COVID-19.

    Mellema, Rebecca A / Crandell, Jacob / Petrey, Aaron C

    Hamostaseologie

    2021  Volume 42, Issue 4, Page(s) 221–228

    Abstract: Coronavirus disease 2019 (COVID-19) encompasses a broad spectrum of clinical manifestations caused by infection with severe acute respiratory syndrome coronavirus 2.Patients with severe disease present with hyperinflammation which can affect multiple ... ...

    Abstract Coronavirus disease 2019 (COVID-19) encompasses a broad spectrum of clinical manifestations caused by infection with severe acute respiratory syndrome coronavirus 2.Patients with severe disease present with hyperinflammation which can affect multiple organs which often include observations of microvascular and macrovascular thrombi. COVID-19 is increasingly recognized as a thromboinflammatory disease where alterations of both coagulation and platelets are closely linked to mortality and clinical outcomes. Although platelets are most well known as central mediators of hemostasis, they possess chemotactic molecules, cytokines, and adhesion molecules that are now appreciated as playing an important role in the regulation of immune response. This review summarizes the current knowledge of platelet alterations observed in the context of COVID-19 and their impact upon disease pathobiology.
    MeSH term(s) Blood Platelets ; COVID-19 ; Hemostasis ; Humans ; SARS-CoV-2 ; Thrombosis
    Language English
    Publishing date 2021-12-08
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/a-1646-3392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1631: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Hyaluronan and Its Receptors as Regulatory Molecules of the Endothelial Interface.

    Queisser, Kimberly A / Mellema, Rebecca A / Petrey, Aaron C

    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

    2020  Volume 69, Issue 1, Page(s) 25–34

    Abstract: On the surface of endothelial cells (ECs) lies the glycocalyx, a barrier of polysaccharides that isolates the ECs from the blood. The role of the glycocalyx is dynamic and complex, thanks to not only its structure, but its vast number of components, one ... ...

    Abstract On the surface of endothelial cells (ECs) lies the glycocalyx, a barrier of polysaccharides that isolates the ECs from the blood. The role of the glycocalyx is dynamic and complex, thanks to not only its structure, but its vast number of components, one being hyaluronan (HA). HA is a critical component of the glycocalyx, having been found to have a wide variety of functions depending on its molecular weight, its modification, and receptor-ligand interactions. As HA and viscous blood are in constant contact, HA can transmit mechanosensory information directly to the cytoskeleton of the ECs. The degradation and synthesis of HA directly alters the permeability of the EC barrier; HA modulation not only alters the physical barrier but also can signal the initiation of other pathways. EC proliferation and angiogenesis are in part regulated by HA fragmentation, HA-dependent receptor binding, and downstream signals. The interaction between the CD44 receptor and HA is a driving force behind leukocyte recruitment, but each class of leukocyte still interacts with HA in unique ways during inflammation. HA regulates a diverse repertoire of EC functions.
    MeSH term(s) Animals ; Endothelial Cells/metabolism ; Glycocalyx/metabolism ; Humans ; Hyaluronan Receptors/metabolism ; Hyaluronic Acid/metabolism ; Inflammation/metabolism ; Neovascularization, Physiologic
    Chemical Substances Hyaluronan Receptors ; Hyaluronic Acid (9004-61-9)
    Language English
    Publishing date 2020-09-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 218208-7
    ISSN 1551-5044 ; 0022-1554
    ISSN (online) 1551-5044
    ISSN 0022-1554
    DOI 10.1369/0022155420954296
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Platelet Dysregulation in the Pathobiology of COVID-19

    Mellema, Rebecca A. / Crandell, Jacob / Petrey, Aaron C.

    Hämostaseologie

    2021  Volume 42, Issue 04, Page(s) 221–228

    Abstract: Coronavirus disease 2019 (COVID-19) encompasses a broad spectrum of clinical manifestations caused by infection with severe acute respiratory syndrome coronavirus 2. Patients with severe disease present with hyperinflammation which can affect multiple ... ...

    Abstract Coronavirus disease 2019 (COVID-19) encompasses a broad spectrum of clinical manifestations caused by infection with severe acute respiratory syndrome coronavirus 2. Patients with severe disease present with hyperinflammation which can affect multiple organs which often include observations of microvascular and macrovascular thrombi. COVID-19 is increasingly recognized as a thromboinflammatory disease where alterations of both coagulation and platelets are closely linked to mortality and clinical outcomes. Although platelets are most well known as central mediators of hemostasis, they possess chemotactic molecules, cytokines, and adhesion molecules that are now appreciated as playing an important role in the regulation of immune response. This review summarizes the current knowledge of platelet alterations observed in the context of COVID-19 and their impact upon disease pathobiology.
    Keywords platelets ; COVID-19 ; SARS-CoV-2 ; immunothrombosis
    Language English
    Publishing date 2021-12-08
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/a-1646-3392
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1631: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: COVID-19 generates hyaluronan fragments that directly induce endothelial barrier dysfunction.

    Queisser, Kimberly A / Mellema, Rebecca A / Middleton, Elizabeth A / Portier, Irina / Manne, Bhanu Kanth / Denorme, Frederik / Beswick, Ellen J / Rondina, Matthew T / Campbell, Robert A / Petrey, Aaron C

    JCI insight

    2021  Volume 6, Issue 17

    Abstract: Vascular injury has emerged as a complication contributing to morbidity in coronavirus disease 2019 (COVID-19). The glycosaminoglycan hyaluronan (HA) is a major component of the glycocalyx, a protective layer of glycoconjugates that lines the vascular ... ...

    Abstract Vascular injury has emerged as a complication contributing to morbidity in coronavirus disease 2019 (COVID-19). The glycosaminoglycan hyaluronan (HA) is a major component of the glycocalyx, a protective layer of glycoconjugates that lines the vascular lumen and regulates key endothelial cell functions. During critical illness, as in the case of sepsis, enzymes degrade the glycocalyx, releasing fragments with pathologic activities into circulation and thereby exacerbating disease. Here, we analyzed levels of circulating glycosaminoglycans in 46 patients with COVID-19 ranging from moderate to severe clinical severity and measured activities of corresponding degradative enzymes. This report provides evidence that the glycocalyx becomes significantly damaged in patients with COVID-19 and corresponds with severity of disease. Circulating HA fragments and hyaluronidase, 2 signatures of glycocalyx injury, strongly associate with sequential organ failure assessment scores and with increased inflammatory cytokine levels in patients with COVID-19. Pulmonary microvascular endothelial cells exposed to COVID-19 milieu show dysregulated HA biosynthesis and degradation, leading to production of pathological HA fragments that are released into circulation. Finally, we show that HA fragments present at high levels in COVID-19 patient plasma can directly induce endothelial barrier dysfunction in a ROCK- and CD44-dependent manner, indicating a role for HA in the vascular pathology of COVID-19.
    MeSH term(s) Aged ; COVID-19/blood ; COVID-19/metabolism ; COVID-19/pathology ; Cytokines/blood ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/pathology ; Female ; Glycocalyx/metabolism ; Glycocalyx/pathology ; Humans ; Hyaluronan Receptors/metabolism ; Hyaluronic Acid/blood ; Hyaluronic Acid/metabolism ; Hyaluronoglucosaminidase/blood ; Hyaluronoglucosaminidase/metabolism ; Male ; Middle Aged ; rho-Associated Kinases/metabolism
    Chemical Substances Cytokines ; Hyaluronan Receptors ; Hyaluronic Acid (9004-61-9) ; rho-Associated Kinases (EC 2.7.11.1) ; Hyaluronoglucosaminidase (EC 3.2.1.35)
    Language English
    Publishing date 2021-09-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.147472
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: COVID-19 generates hyaluronan fragments that directly induce endothelial barrier dysfunction

    Kimberly A. Queisser / Rebecca A. Mellema / Elizabeth A. Middleton / Irina Portier / Bhanu Kanth Manne / Frederik Denorme / Ellen J. Beswick / Matthew T. Rondina / Robert A. Campbell / Aaron C. Petrey

    JCI Insight, Vol 6, Iss

    2021  Volume 17

    Abstract: Vascular injury has emerged as a complication contributing to morbidity in coronavirus disease 2019 (COVID-19). The glycosaminoglycan hyaluronan (HA) is a major component of the glycocalyx, a protective layer of glycoconjugates that lines the vascular ... ...

    Abstract Vascular injury has emerged as a complication contributing to morbidity in coronavirus disease 2019 (COVID-19). The glycosaminoglycan hyaluronan (HA) is a major component of the glycocalyx, a protective layer of glycoconjugates that lines the vascular lumen and regulates key endothelial cell functions. During critical illness, as in the case of sepsis, enzymes degrade the glycocalyx, releasing fragments with pathologic activities into circulation and thereby exacerbating disease. Here, we analyzed levels of circulating glycosaminoglycans in 46 patients with COVID-19 ranging from moderate to severe clinical severity and measured activities of corresponding degradative enzymes. This report provides evidence that the glycocalyx becomes significantly damaged in patients with COVID-19 and corresponds with severity of disease. Circulating HA fragments and hyaluronidase, 2 signatures of glycocalyx injury, strongly associate with sequential organ failure assessment scores and with increased inflammatory cytokine levels in patients with COVID-19. Pulmonary microvascular endothelial cells exposed to COVID-19 milieu show dysregulated HA biosynthesis and degradation, leading to production of pathological HA fragments that are released into circulation. Finally, we show that HA fragments present at high levels in COVID-19 patient plasma can directly induce endothelial barrier dysfunction in a ROCK- and CD44-dependent manner, indicating a role for HA in the vascular pathology of COVID-19.
    Keywords COVID-19 ; Vascular biology ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher American Society for Clinical investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article: Osteogenic sarcoma of the sacral spine: an interdisciplinary team challenge.

    King, Nancy / Berkhof, Rebecca / Mellema, Heather / Reichel, Jammie / Joseph, Tommi / Keenan, Kim / Parker, Jenny / Delgado, Karina

    Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses

    2005  Volume 22, Issue 4, Page(s) 194–202

    Abstract: A child with osteogenic sarcoma of the sacral spine has complex nursing and interdisciplinary team needs. The course of one patient is discussed, both from the patient and family's perspective and that of her inter-disciplinary care team. The need for a ... ...

    Abstract A child with osteogenic sarcoma of the sacral spine has complex nursing and interdisciplinary team needs. The course of one patient is discussed, both from the patient and family's perspective and that of her inter-disciplinary care team. The need for a coordinated, holistic approach to care that involves advance planning, continual reassessment of goals, and clear communication among the team members and consulting services is clearly demonstrated.
    MeSH term(s) Child ; Female ; Humans ; Oncology Nursing ; Osteosarcoma/diagnosis ; Osteosarcoma/nursing ; Osteosarcoma/physiopathology ; Patient Care Team ; Patient-Centered Care ; Sacrococcygeal Region ; Sacrum/pathology ; Spinal Diseases/diagnosis ; Spinal Diseases/nursing ; Spinal Diseases/physiopathology
    Language English
    Publishing date 2005-07
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1038107-7
    ISSN 1043-4542
    ISSN 1043-4542
    DOI 10.1177/1043454204273890
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2843: Show issues Location:
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