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  1. Artikel ; Online: Small GTPase Rab5 participates in chromosome congression and regulates localization of the centromere-associated protein CENP-F to kinetochores.

    Serio, Gaetana / Margaria, Valentina / Jensen, Sanne / Oldani, Amanda / Bartek, Jiri / Bussolino, Federico / Lanzetti, Letizia

    Proceedings of the National Academy of Sciences of the United States of America

    2011  Band 108, Heft 42, Seite(n) 17337–17342

    Abstract: ... reduction in the localization of the centromere-associated protein CENP-F to kinetochores. CENP-F is ... interactions. We found that Rab5 forms a complex with a subset of CENP-F in mitotic cells and regulates ... the kinetics of release of CENP-F from the nuclear envelope and its accumulation on kinetochores. Simultaneous ...

    Abstract Rab5 is a small GTPase known to regulate vesicular trafficking during interphase. Here, we show that Rab5 also plays an unexpected role during mitotic progression. RNAi-mediated silencing of Rab5 caused defects in chromosome congression and extensive prometaphase delay, and it correlated with a severe reduction in the localization of the centromere-associated protein CENP-F to kinetochores. CENP-F is a component of the nuclear matrix required for chromosome congression that, at mitotic entry, localizes to the nuclear envelope and assembles on kinetochores, contributing to the establishment of kinetochore microtubule interactions. We found that Rab5 forms a complex with a subset of CENP-F in mitotic cells and regulates the kinetics of release of CENP-F from the nuclear envelope and its accumulation on kinetochores. Simultaneous depletion of both Rab5 and CENP-F recapitulated the mitotic defects caused by silencing of either Rab5 or CENP-F alone, indicating epistatic roles for these two proteins in the pathway that orchestrates chromosome congression. These results reveal the involvement of Rab5 in the proper execution of mitotic programs whose deregulation can undermine chromosomal stability.
    Mesh-Begriff(e) Cell Line ; Chromosomal Proteins, Non-Histone/antagonists & inhibitors ; Chromosomal Proteins, Non-Histone/genetics ; Chromosomal Proteins, Non-Histone/metabolism ; Chromosome Segregation/physiology ; Chromosomes, Human/metabolism ; Humans ; Kinetochores/metabolism ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Microfilament Proteins/antagonists & inhibitors ; Microfilament Proteins/genetics ; Microfilament Proteins/metabolism ; Microscopy, Confocal ; Microtubules/metabolism ; Mitosis/physiology ; Multiprotein Complexes/metabolism ; RNA Interference ; RNA, Small Interfering/genetics ; rab5 GTP-Binding Proteins/antagonists & inhibitors ; rab5 GTP-Binding Proteins/genetics ; rab5 GTP-Binding Proteins/metabolism
    Chemische Substanzen Chromosomal Proteins, Non-Histone ; Luminescent Proteins ; Microfilament Proteins ; Multiprotein Complexes ; RNA, Small Interfering ; centromere protein F ; rab5 GTP-Binding Proteins (EC 3.6.5.2)
    Sprache Englisch
    Erscheinungsdatum 2011-10-10
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1103516108
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Konferenzbeitrag: Small GTPase Rab5 participates in chromosome congression and regulates localization of the centromere-associated protein CENP-F to kinetochores

    Serio, Gaetana / Margaria, Valentina / Jensen, Sanne / Oldani, Amanda / Bartek, Jiri / Bussolino, Federico / Lanzetti, Letizia

    Proceedings of the National Academy of Sciences of the United States of America. 2011 Oct. 18, v. 108, no. 42

    2011  

    Abstract: ... reduction in the localization of the centromere-associated protein CENP-F to kinetochores. CENP-F is ... interactions. We found that Rab5 forms a complex with a subset of CENP-F in mitotic cells and regulates ... the kinetics of release of CENP-F from the nuclear envelope and its accumulation on kinetochores. Simultaneous ...

    Abstract Rab5 is a small GTPase known to regulate vesicular trafficking during interphase. Here, we show that Rab5 also plays an unexpected role during mitotic progression. RNAi-mediated silencing of Rab5 caused defects in chromosome congression and extensive prometaphase delay, and it correlated with a severe reduction in the localization of the centromere-associated protein CENP-F to kinetochores. CENP-F is a component of the nuclear matrix required for chromosome congression that, at mitotic entry, localizes to the nuclear envelope and assembles on kinetochores, contributing to the establishment of kinetochore microtubule interactions. We found that Rab5 forms a complex with a subset of CENP-F in mitotic cells and regulates the kinetics of release of CENP-F from the nuclear envelope and its accumulation on kinetochores. Simultaneous depletion of both Rab5 and CENP-F recapitulated the mitotic defects caused by silencing of either Rab5 or CENP-F alone, indicating epistatic roles for these two proteins in the pathway that orchestrates chromosome congression. These results reveal the involvement of Rab5 in the proper execution of mitotic programs whose deregulation can undermine chromosomal stability.
    Schlagwörter guanosinetriphosphatase ; kinetochores ; nuclear matrix ; nuclear membrane
    Sprache Englisch
    Erscheinungsverlauf 2011-1018
    Umfang p. 17337-17342.
    Erscheinungsort National Academy of Sciences
    Dokumenttyp Artikel ; Konferenzbeitrag
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    Datenquelle NAL Katalog (AGRICOLA)

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  3. Artikel ; Online: RNA aptamer-mediated gene therapy of prostate cancer: lessons from the past and future directions.

    Arese, Marco / Mahmoudian, Mohammad / Bussolino, Federico

    Expert opinion on drug delivery

    2023  Band 20, Heft 11, Seite(n) 1609–1621

    Abstract: Introduction: Prostate cancer (PCa) is one of the most prevalent cancers in the world, and the fifth cause of death from cancer in men. Among the non-surgical treatments for PCa, gene therapy strategies are in the early stages of development and recent ... ...

    Abstract Introduction: Prostate cancer (PCa) is one of the most prevalent cancers in the world, and the fifth cause of death from cancer in men. Among the non-surgical treatments for PCa, gene therapy strategies are in the early stages of development and recent clinical trials have provided new insights suggesting promising future.
    Areas covered: Recently, the creation of targeted gene delivery systems, based on specific PCa cell surface markers, has been viewed as a viable therapeutic approach. Prostate-specific membrane antigen (PSMA) is vastly expressed in nearly all prostate malignancies, and the intensity of expression increases with tumor aggressiveness, androgen independence, and metastasis. RNA aptamers are short and single-stranded oligonucleotides, which selectively bind to a specific ligand on the surface of the cells, which makes them fascinating small molecules for target delivery of therapeutics. PSMA-selective RNA aptamers represent great potential for developing targeted-gene delivery tools for PCa.
    Expert opinion: This review provides a thorough horizon for the researchers interested in developing targeted gene delivery systems for PCa via PSMA RNA aptamers. In addition, we provided general information about different prospects of RNA aptamers including discovery approaches, stability, safety, and pharmacokinetics.
    Mesh-Begriff(e) Male ; Humans ; Aptamers, Nucleotide/genetics ; Prostatic Neoplasms/therapy ; Prostatic Neoplasms/drug therapy ; Genetic Therapy
    Chemische Substanzen Aptamers, Nucleotide
    Sprache Englisch
    Erscheinungsdatum 2023-12-20
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2167286-6
    ISSN 1744-7593 ; 1742-5247
    ISSN (online) 1744-7593
    ISSN 1742-5247
    DOI 10.1080/17425247.2023.2292691
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: E15.5 Mouse Embryo Micro-CT Using a Bruker Skyscan 1172 Micro-CT.

    Astanina, Elena / Petrillo, Sara / Genova, Tullio / Mussano, Federico / Bussolino, Federico

    Bio-protocol

    2023  Band 13, Heft 9, Seite(n) e4662

    Abstract: X-ray computed microtomography (µCT) is a powerful tool to reveal the 3D structure of tissues and organs. Compared with the traditional sectioning, staining, and microscopy image acquisition, it allows a better understanding of the morphology and a ... ...

    Abstract X-ray computed microtomography (µCT) is a powerful tool to reveal the 3D structure of tissues and organs. Compared with the traditional sectioning, staining, and microscopy image acquisition, it allows a better understanding of the morphology and a precise morphometric analysis. Here, we describe a method for 3D visualization and morphometric analysis by µCT scanning of the embryonic heart of iodine-stained E15.5 mouse embryos.
    Sprache Englisch
    Erscheinungsdatum 2023-05-05
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.4662
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: The tissue-specific transcriptional landscape underlines the involvement of endothelial cells in health and disease.

    Parab, Sushant / Setten, Elisa / Astanina, Elena / Bussolino, Federico / Doronzo, Gabriella

    Pharmacology & therapeutics

    2023  Band 246, Seite(n) 108418

    Abstract: Endothelial cells (ECs) that line vascular and lymphatic vessels are being increasingly recognized as important to organ function in health and disease. ECs participate not only in the trafficking of gases, metabolites, and cells between the bloodstream ... ...

    Abstract Endothelial cells (ECs) that line vascular and lymphatic vessels are being increasingly recognized as important to organ function in health and disease. ECs participate not only in the trafficking of gases, metabolites, and cells between the bloodstream and tissues but also in the angiocrine-based induction of heterogeneous parenchymal cells, which are unique to their specific tissue functions. The molecular mechanisms regulating EC heterogeneity between and within different tissues are modeled during embryogenesis and become fully established in adults. Any changes in adult tissue homeostasis induced by aging, stress conditions, and various noxae may reshape EC heterogeneity and induce specific transcriptional features that condition a functional phenotype. Heterogeneity is sustained via specific genetic programs organized through the combinatory effects of a discrete number of transcription factors (TFs) that, at the single tissue-level, constitute dynamic networks that are post-transcriptionally and epigenetically regulated. This review is focused on outlining the TF-based networks involved in EC specialization and physiological and pathological stressors thought to modify their architecture.
    Mesh-Begriff(e) Endothelial Cells/metabolism ; Transcription Factors/metabolism
    Chemische Substanzen Transcription Factors
    Sprache Englisch
    Erscheinungsdatum 2023-04-22
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 194735-7
    ISSN 1879-016X ; 0163-7258
    ISSN (online) 1879-016X
    ISSN 0163-7258
    DOI 10.1016/j.pharmthera.2023.108418
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: An Overview of the Molecular Cues and Their Intracellular Signaling Shared by Cancer and the Nervous System: From Neurotransmitters to Synaptic Proteins, Anatomy of an All-Inclusive Cooperation.

    Arese, Marco / Bussolino, Federico / Pergolizzi, Margherita / Bizzozero, Laura

    International journal of molecular sciences

    2022  Band 23, Heft 23

    Abstract: We propose an overview of the molecular cues and their intracellular signaling involved in the crosstalk between cancer and the nervous system. While "cancer neuroscience" as a field is still in its infancy, the relation between cancer and the nervous ... ...

    Abstract We propose an overview of the molecular cues and their intracellular signaling involved in the crosstalk between cancer and the nervous system. While "cancer neuroscience" as a field is still in its infancy, the relation between cancer and the nervous system has been known for a long time, and a huge body of experimental data provides evidence that tumor-nervous system connections are widespread. They encompass different mechanisms at different tumor progression steps, are multifaceted, and display some intriguing analogies with the nervous system's physiological processes. Overall, we can say that many of the paradigmatic "hallmarks of cancer" depicted by Weinberg and Hanahan are affected by the nervous system in a variety of manners.
    Sprache Englisch
    Erscheinungsdatum 2022-11-24
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232314695
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Transcription factor EB controls both motogenic and mitogenic cell activities.

    Astanina, Elena / Bussolino, Federico / Doronzo, Gabriella

    FEBS letters

    2022  Band 596, Heft 16, Seite(n) 1973–1980

    Abstract: Transcription factor EB (TFEB) belongs to the microphthalmia family of bHLH-leucine zipper transcription factors and was first identified as an oncogene in a subset of renal cell carcinomas. In addition to exhibiting oncogenic activity, TFEB coordinates ... ...

    Abstract Transcription factor EB (TFEB) belongs to the microphthalmia family of bHLH-leucine zipper transcription factors and was first identified as an oncogene in a subset of renal cell carcinomas. In addition to exhibiting oncogenic activity, TFEB coordinates genetic programs connected with the cellular response to stress conditions, including roles in lysosome biogenesis, autophagy, and modulation of metabolism. As is the case for other transcription factors, the activities of TFEB are not limited to a specific cellular condition such as the response to stress, and recent findings indicate that TFEB has more widespread functions. Here, we review the emerging roles of TFEB in regulating cellular proliferation and motility. The well-established and emerging roles of TFEB suggest that this protein serves as a hub of signaling networks involved in many non-communicable diseases, such as cancer, ischaemic diseases and immune disorders, drug resistance mechanisms, and tissue generation.
    Mesh-Begriff(e) Autophagy ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/metabolism ; Cell Cycle Checkpoints ; Humans ; Lysosomes ; Neoplasms ; Transcription Factors
    Chemische Substanzen Basic Helix-Loop-Helix Leucine Zipper Transcription Factors ; TFEB protein, human ; Transcription Factors
    Sprache Englisch
    Erscheinungsdatum 2022-07-13
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 212746-5
    ISSN 1873-3468 ; 0014-5793
    ISSN (online) 1873-3468
    ISSN 0014-5793
    DOI 10.1002/1873-3468.14442
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Long Non-Coding RNA LINC02802 Regulates In Vitro Sprouting Angiogenesis by Sponging microRNA-486-5p.

    Rosano, Stefania / Parab, Sushant / Noghero, Alessio / Corà, Davide / Bussolino, Federico

    International journal of molecular sciences

    2022  Band 23, Heft 3

    Abstract: In the last several years, accumulating evidence indicates that noncoding RNAs, especially long-noncoding RNAs (lncRNAs) and microRNAs, play essential roles in regulating angiogenesis. However, the contribution of lncRNA-mediated competing-endogenous RNA ...

    Abstract In the last several years, accumulating evidence indicates that noncoding RNAs, especially long-noncoding RNAs (lncRNAs) and microRNAs, play essential roles in regulating angiogenesis. However, the contribution of lncRNA-mediated competing-endogenous RNA (ceRNA) activity in the control of capillary sprouting from the pre-existing ones has not been described so far. Here, by exploiting the transcriptomic profile of VEGF-A-activated endothelial cells in a consolidate three-dimensional culture system, we identified a list of lncRNAs whose expression was modified during the sprouting process. By crossing the lncRNAs with a higher expression level and the highest fold change value between unstimulated and VEGF-A-stimulated endothelial cells, we identified the unknown LINC02802 as the best candidate to take part in sprouting regulation. LINC02802 was upregulated after VEGF-A stimulation and its knockdown resulted in a significant reduction in sprouting activity. Mechanistically, we demonstrated that LINC02802 acts as a ceRNA in the post-transcriptional regulation of Mastermind-like-3 (MAML3) gene expression through a competitive binding with miR-486-5p. Taken together, these results suggest that LINC02802 plays a critical role in preventing the miR-486-5p anti-angiogenic effect and that this inhibitory effect results from the reduction in MAML3 expression.
    Mesh-Begriff(e) Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neovascularization, Physiologic ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Up-Regulation ; Vascular Endothelial Growth Factor A/biosynthesis ; Vascular Endothelial Growth Factor A/genetics
    Chemische Substanzen MIRN486 microRNA, human ; MicroRNAs ; RNA, Long Noncoding ; VEGFA protein, human ; Vascular Endothelial Growth Factor A
    Sprache Englisch
    Erscheinungsdatum 2022-01-31
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23031653
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: The Oncogene Transcription Factor EB Regulates Vascular Functions.

    Doronzo, Gabriella / Astanina, Elena / Bussolino, Federico

    Frontiers in physiology

    2021  Band 12, Seite(n) 640061

    Abstract: Transcription factor EB (TFEB) represents an emerging player in vascular biology. It belongs to the bHLH-leucine zipper transcription factor microphthalmia family, which includes microphthalmia-associated transcription factor, transcription factor E3 and ...

    Abstract Transcription factor EB (TFEB) represents an emerging player in vascular biology. It belongs to the bHLH-leucine zipper transcription factor microphthalmia family, which includes microphthalmia-associated transcription factor, transcription factor E3 and transcription factor EC, and is known to be deregulated in cancer. The canonical transcriptional pathway orchestrated by TFEB adapts cells to stress in all kinds of tissues by supporting lysosomal and autophagosome biogenesis. However, emerging findings highlight that TFEB activates other genetic programs involved in cell proliferation, metabolism, inflammation and immunity. Here, we first summarize the general principles and mechanisms by which TFEB activates its transcriptional program. Then, we analyze the current knowledge of TFEB in the vascular system, placing particular emphasis on its regulatory role in angiogenesis and on the involvement of the vascular unit in inflammation and atherosclerosis.
    Sprache Englisch
    Erscheinungsdatum 2021-04-12
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.640061
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: TFEB Signalling-Related MicroRNAs and Autophagy.

    Corà, Davide / Bussolino, Federico / Doronzo, Gabriella

    Biomolecules

    2021  Band 11, Heft 7

    Abstract: The oncogenic Transcription Factor EB (TFEB), a member of MITF-TFE family, is known to be the most important regulator of the transcription of genes responsible for the control of lysosomal biogenesis and functions, autophagy, and vesicles flux. TFEB ... ...

    Abstract The oncogenic Transcription Factor EB (TFEB), a member of MITF-TFE family, is known to be the most important regulator of the transcription of genes responsible for the control of lysosomal biogenesis and functions, autophagy, and vesicles flux. TFEB activation occurs in response to stress factors such as nutrient and growth factor deficiency, hypoxia, lysosomal stress, and mitochondrial damage. To reach the final functional status, TFEB is regulated in multimodal ways, including transcriptional rate, post-transcriptional regulation, and post-translational modifications. Post-transcriptional regulation is in part mediated by miRNAs. miRNAs have been linked to many cellular processes involved both in physiology and pathology, such as cell migration, proliferation, differentiation, and apoptosis. miRNAs also play a significant role in autophagy, which exerts a crucial role in cell behaviour during stress or survival responses. In particular, several miRNAs directly recognise TFEB transcript or indirectly regulate its function by targeting accessory molecules or enzymes involved in its post-translational modifications. Moreover, the transcriptional programs triggered by TFEB may be influenced by the miRNA-mediated regulation of TFEB targets. Finally, recent important studies indicate that the transcription of many miRNAs is regulated by TFEB itself. In this review, we describe the interplay between miRNAs with TFEB and focus on how these types of crosstalk affect TFEB activation and cellular functions.
    Mesh-Begriff(e) Apoptosis ; Autophagy ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/metabolism ; Cell Differentiation ; Cell Movement ; Gene Expression Regulation ; Humans ; MicroRNAs/metabolism ; Signal Transduction
    Chemische Substanzen Basic Helix-Loop-Helix Leucine Zipper Transcription Factors ; MicroRNAs ; TFEB protein, human
    Sprache Englisch
    Erscheinungsdatum 2021-07-04
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom11070985
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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