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Article ; Online: Dietary Antiplatelets: A New Perspective on the Health Benefits of the Water-Soluble Tomato Concentrate Fruitflow

O'Kennedy, Niamh / Duss, Ruedi / Duttaroy, Asim K

2021 Volume 13, Issue 7

Abstract: Our understanding of platelet functionality has undergone a sea change in the last decade. No longer are platelets viewed simply as regulators of haemostasis; they are now acknowledged to be pivotal in coordinating the inflammatory and immune responses. ... ...

Abstract	Our understanding of platelet functionality has undergone a sea change in the last decade. No longer are platelets viewed simply as regulators of haemostasis; they are now acknowledged to be pivotal in coordinating the inflammatory and immune responses. This expanded role for platelets brings new opportunities for controlling a range of health conditions, targeting platelet activation and their interactions with other vascular cells. Antiplatelet drugs may be of wider utility than ever expected but often cause platelet suppression too strong to be used out of clinical settings. Dietary antiplatelets represent a nutritional approach that can be efficacious while safe for general use. In this review, we discuss potential new uses for dietary antiplatelets outside the field of cardiovascular health, with specific reference to the water-soluble tomato extract Fruitflow
MeSH term(s)	Blood Platelets/drug effects ; Diet/methods ; Humans ; Immunity/drug effects ; Inflammation ; Lycopersicon esculentum ; Plant Extracts/pharmacology ; Platelet Activation/drug effects ; Platelet Aggregation Inhibitors/pharmacology
Chemical Substances	Plant Extracts ; Platelet Aggregation Inhibitors
Language	English
Publishing date	2021-06-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13072184
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Platelet hyperactivity in COVID-19: Can the tomato extract Fruitflow® be used as an antiplatelet regime?

O'Kennedy, Niamh / Duttaroy, Asim K

Medical hypotheses

2021 Volume 147, Page(s) 110480

Abstract: The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by the SARS-CoV-2 virus is now considered a global public health threat. The primary focus has been on reducing the viral spread and treating respiratory symptoms; as time goes on, the ... ...

Abstract	The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by the SARS-CoV-2 virus is now considered a global public health threat. The primary focus has been on reducing the viral spread and treating respiratory symptoms; as time goes on, the impact of COVID-19 on neurological and haemostatic systems becomes more evident. The clinical data suggest that platelet hyperactivity plays a role in the pathology of COVID-19 from its onset and that platelets may serve critical functions during COVID-19 progression. Hyperactivation of blood platelets and the coagulation system are emerging as important drivers of inflammation and may be linked to the severity of the 'cytokine storm' induced in severe cases of COVID-19, in which disseminated intravascular coagulation, and platelet hyperactivity are associated with poor prognosis and increased risk of mortality. We propose that targeting platelet hyperactivity in the early stages of COVID-19 infection may reduce the immunothrombotic complications of COVID-19 and subdue the systemic inflammatory response. Lowering baseline platelet activity may be of particular importance for higher-risk groups. As an alternative to antiplatelet drugs, an inappropriate intervention in public health, we propose that the dietary antiplatelet agent Fruitflow®, derived from tomatoes, may be considered a suitable therapy. Fruitflow® contains antiplatelet and anti-inflammatory compounds that target the mechanisms of platelet activation specific to COVID-19 and can be considered a safe and natural antiplatelet regime.
MeSH term(s)	Anti-Inflammatory Agents ; Blood Coagulation ; Blood Platelets/cytology ; Blood Pressure ; COVID-19/blood ; COVID-19/complications ; Disease Progression ; Humans ; Immunoglobulin G ; Inflammation/pathology ; Lycopersicon esculentum ; Models, Theoretical ; Plant Extracts/pharmacology ; Platelet Activation ; Platelet Aggregation Inhibitors/pharmacology ; Prognosis ; Thrombosis
Chemical Substances	Anti-Inflammatory Agents ; Immunoglobulin G ; Plant Extracts ; Platelet Aggregation Inhibitors
Language	English
Publishing date	2021-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	193145-3
ISSN	1532-2777 ; 0306-9877
ISSN (online)	1532-2777
ISSN	0306-9877
DOI	10.1016/j.mehy.2020.110480
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Article: Dietary Antiplatelets: A New Perspective on the Health Benefits of the Water-Soluble Tomato Concentrate Fruitflow®

O’Kennedy, Niamh / Duss, Ruedi / Duttaroy, Asim K

Nutrients. 2021 June 25, v. 13, no. 7

2021

Abstract	Our understanding of platelet functionality has undergone a sea change in the last decade. No longer are platelets viewed simply as regulators of haemostasis; they are now acknowledged to be pivotal in coordinating the inflammatory and immune responses. This expanded role for platelets brings new opportunities for controlling a range of health conditions, targeting platelet activation and their interactions with other vascular cells. Antiplatelet drugs may be of wider utility than ever expected but often cause platelet suppression too strong to be used out of clinical settings. Dietary antiplatelets represent a nutritional approach that can be efficacious while safe for general use. In this review, we discuss potential new uses for dietary antiplatelets outside the field of cardiovascular health, with specific reference to the water-soluble tomato extract Fruitflow®. Its uses in different aspects of inflammation and immune function are discussed, highlighting exercise-induced inflammation, mediating the effects of air pollution, and controlling thrombotic aspects of the immune response. Potential future developments in women’s health, erectile dysfunction, and the allergic response indicate how broad the utility of dietary antiplatelets can be.
Keywords	air pollution ; exercise ; immune response ; inflammation ; platelet activation ; tomato paste ; tomatoes ; water solubility
Language	English
Dates of publication	2021-0625
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13072184
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Evaluation of the equivalence of different intakes of Fruitflow in affecting platelet aggregation and thrombin generation capacity in a randomized, double-blinded pilot study in male subjects.

Das, Ranjit K / Datta, Tanushree / Biswas, Dipankar / Duss, Ruedi / O'Kennedy, Niamh / Duttaroy, Asim K

BMC nutrition

2021 Volume 7, Issue 1, Page(s) 80

Abstract: Background: The water-soluble tomato extract, Fruitflow® is a dietary antiplatelet which can be used to lower platelet aggregability in primary preventative settings. We carried out a pilot study to investigate the range of intakes linked to efficacy ... ...

Abstract	Background: The water-soluble tomato extract, Fruitflow® is a dietary antiplatelet which can be used to lower platelet aggregability in primary preventative settings. We carried out a pilot study to investigate the range of intakes linked to efficacy and to make an initial assessment of variability in response to Fruitflow®. Methods: Platelet response to adenosine diphosphate (ADP) agonist and thrombin generation capacity were monitored at baseline and 24 h after consuming 0, 30, 75, 150 or 300 mg of Fruitflow® in a randomized, double-blinded crossover study in male subjects 30-65 years of age (N = 12). Results were evaluated for equivalence to the standard 150 mg dose. Results: Results showed that the changes from baseline aggregation and thrombin generation observed after the 75 mg, 150 mg, and 300 mg supplements were equivalent. Aggregation was reduced from baseline by - 12.9 ± 17.7%, - 12.0 ± 13.9% and - 17.7 ± 15.7% respectively, while thrombin generation capacity fell by - 8.6 ± 4.1%, - 9.2 ± 3.1% and - 11.3 ± 2.3% respectively. Effects observed for 0 mg and 30 mg supplements were non-equivalent to 150 mg and not different from baseline (aggregation changed by 3.0 ± 5.0% and - 0.7 ± 10.2% respectively, while thrombin generation changed by 0.8 ± 3.0% and 0.8 ± 3.1% respectively). Conclusions: The data suggest that the efficacious range for Fruitflow® lies between 75 mg and 300 mg, depending on the individual. It may be pertinent to personalize the daily intake of Fruitflow® depending on individual platelet response. Trial registration: ISRCTN53447583 , 24/02/2021.
Language	English
Publishing date	2021-12-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2809847-X
ISSN	2055-0928 ; 2055-0928
ISSN (online)	2055-0928
ISSN	2055-0928
DOI	10.1186/s40795-021-00485-5
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Article ; Online: Fruitflow

O'Kennedy, Niamh / Raederstorff, Daniel / Duttaroy, Asim K

European journal of nutrition

2017 Volume 56, Issue 2, Page(s) 461–482

Abstract: Hyperactive platelets, in addition to their roles in thrombosis, are also important mediators of atherogenesis. Antiplatelet drugs are not suitable for use where risk of a cardiovascular event is relatively low. It is therefore important to find ... ...

Abstract	Hyperactive platelets, in addition to their roles in thrombosis, are also important mediators of atherogenesis. Antiplatelet drugs are not suitable for use where risk of a cardiovascular event is relatively low. It is therefore important to find alternative safe antiplatelet inhibitors for the vulnerable population who has hyperactive platelets in order to reduce the risk of cardiovascular disease. Potent antiplatelet factors were identified in water-soluble tomato extract (Fruitflow
MeSH term(s)	Angiotensin-Converting Enzyme Inhibitors ; Anti-Inflammatory Agents ; Atherosclerosis/epidemiology ; Atherosclerosis/prevention & control ; Blood Platelets/physiology ; Cardiotonic Agents ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/prevention & control ; Europe ; Food Safety ; Functional Food ; Humans ; Lycopersicon esculentum/chemistry ; Plant Extracts/administration & dosage ; Platelet Aggregation/drug effects ; Platelet Aggregation Inhibitors
Chemical Substances	Angiotensin-Converting Enzyme Inhibitors ; Anti-Inflammatory Agents ; Cardiotonic Agents ; Plant Extracts ; Platelet Aggregation Inhibitors
Language	English
Publishing date	2017-03
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1466536-0
ISSN	1436-6215 ; 1436-6207
ISSN (online)	1436-6215
ISSN	1436-6207
DOI	10.1007/s00394-016-1265-2
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Article: Precision Medicine and Novel Therapeutic Strategies in Detection and Treatment of Cancer: Highlights from the 58th IACR Annual Conference.

Kennedy, Sean P / Treacy, Oliver / Allott, Emma H / Eustace, Alex J / Lynam-Lennon, Niamh / Buckley, Niamh / Robson, Tracy

Cancers

2022 Volume 14, Issue 24

Abstract: Innovation in both detection and treatment of cancer is necessary for the constant improvement in therapeutic strategies, especially in patients with novel or resistant variants of cancer. Cancer mortality rates have declined by almost 30% since 1991, ... ...

Abstract	Innovation in both detection and treatment of cancer is necessary for the constant improvement in therapeutic strategies, especially in patients with novel or resistant variants of cancer. Cancer mortality rates have declined by almost 30% since 1991, however, depending on the cancer type, acquired resistance can occur to varying degrees. To combat this, researchers are looking towards advancing our understanding of cancer biology, in order to inform early detection, and guide novel therapeutic approaches. Through combination of these approaches, it is believed that a more complete and thorough intervention on cancer can be achieved. Here, we will discuss the advances and approaches in both detection and treatment of cancer, presented at the 58th Irish Association for Cancer Research (IACR) annual conference.
Language	English
Publishing date	2022-12-16
Publishing country	Switzerland
Document type	Congress
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14246213
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Article ; Online: A cross-sectional follow-up study of physical activity in adults with moderate and severe haemophilia.

Kennedy, Megan / Roche, Sheila / McGowan, Mark / Larkin, Niamh / O'Connell, Niamh M / O'Mahony, Brian / Lavin, Michelle / O'Donnell, James S / Turecek, Peter L / Gormley, John

Haemophilia : the official journal of the World Federation of Hemophilia

2023 Volume 29, Issue 3, Page(s) 892–899

Abstract: Aim: To conduct a cross-sectional follow-up assessment of physical activity (PA) in people with moderate and severe haemophilia (PwMSH) from the Irish Personalised Approach to the Treatment of Haemophilia (iPATH) study.: Methods: Between June- ... ...

Abstract	Aim: To conduct a cross-sectional follow-up assessment of physical activity (PA) in people with moderate and severe haemophilia (PwMSH) from the Irish Personalised Approach to the Treatment of Haemophilia (iPATH) study. Methods: Between June-December 2021, participants' PA was measured over one week using accelerometery, and was compared with their previously measured data from the original iPATH assessment. Self-awareness of PA and the impact of the Covid-19 pandemic on PA, pain, mobility and function were retrospectively examined using a survey. Results: Of 30 participants who returned surveys [n = 19, severe (FVIII, <.01 IU/mL); n = 4, moderate (FVIII, .01-.05 IU/mL); n = 7, severe (FIX, <.01 IU/mL); age: 47 (36, 55) years], 28 completed accelerometery (follow-up time: 3 years). There were no significant differences in accelerometer PA (all p > .05), but achievement of World Health Organisation guidelines increased (67.9%-75.0%; p = .646). Increased self-awareness of PA was reported by 76.7%, and 66.7% reported desires to become more physically active. Compared to normal, most reported either no differences or lower levels of PA during lockdown restrictions. Self-reported PA increased for most when restrictions eased from April 2021 onwards. Beyond the pandemic, concerns included pain and access to exercise resources. Conclusion: Self-reported PA throughout the pandemic was variable, whilst there were no significant differences in objectively measured PA between assessment periods, despite reports of increased self-awareness and desires to be physically active at follow-up. Further qualitative research is needed to design personalised PA and health interventions, capturing perspectives of patients, their families, and multi-disciplinary haemophilia healthcare providers.
MeSH term(s)	Humans ; Adult ; Middle Aged ; Follow-Up Studies ; Hemophilia A/epidemiology ; Hemophilia A/therapy ; Cross-Sectional Studies ; Pandemics ; Retrospective Studies ; COVID-19/epidemiology ; Communicable Disease Control ; Exercise
Language	English
Publishing date	2023-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1229713-6
ISSN	1365-2516 ; 1351-8216 ; 1355-0691
ISSN (online)	1365-2516
ISSN	1351-8216 ; 1355-0691
DOI	10.1111/hae.14775
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Zs.A 4249: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 450: Show issues

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Article: Soluble Non-Starch Polysaccharides From Plantain (

Simpson, Hannah L / Roberts, Carol L / Thompson, Louise M / Leiper, Cameron R / Gittens, Nehana / Trotter, Ellie / Duckworth, Carrie A / Papoutsopoulou, Stamatia / Miyajima, Fabio / Roberts, Paul / O'Kennedy, Niamh / Rhodes, Jonathan M / Campbell, Barry J

Frontiers in pharmacology

2021 Volume 12, Page(s) 766293

Abstract: Clostridioides ... ...

Abstract	Clostridioides difficile
Language	English
Publishing date	2021-12-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.766293
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Nanobiotechnologies for the detection and reduction of pathogens.

Gilmartin, Niamh / O'Kennedy, Richard

Enzyme and microbial technology

2012 Volume 50, Issue 2, Page(s) 87–95

Abstract: Advances in the manipulation of nanomaterials has permitted the development of nanobiotechnology with enhanced sensitivities and improved response times. Low levels of infection of the major pathogens require the need for sensitive detection platforms ... ...

Abstract	Advances in the manipulation of nanomaterials has permitted the development of nanobiotechnology with enhanced sensitivities and improved response times. Low levels of infection of the major pathogens require the need for sensitive detection platforms and the properties of nanomaterials make them suitable for the development of assays with enhanced sensitivity, improved response time and increased portability. Nanobiotechnologies focusing on the key requirements of signal amplification and pre-concentration for the development of sensitive assays for food-borne pathogen detection in food matrices will be described and evaluated. The potential that exists for the use of nanomaterials as antimicrobial agents will also be examined.
MeSH term(s)	Bacteria/isolation & purification ; Biosensing Techniques/methods ; Biotechnology/methods ; Biotechnology/trends ; Food Contamination/analysis ; Food Microbiology ; Humans ; Nanostructures ; Nanotechnology/methods ; Nanotechnology/trends
Language	English
Publishing date	2012-02-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	423729-8
ISSN	1879-0909 ; 0141-0229
ISSN (online)	1879-0909
ISSN	0141-0229
DOI	10.1016/j.enzmictec.2011.11.005
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Article ; Online: Evaluation of the equivalence of different intakes of Fruitflow in affecting platelet aggregation and thrombin generation capacity in a randomized, double-blinded pilot study in male subjects

Ranjit K. Das / Tanushree Datta / Dipankar Biswas / Ruedi Duss / Niamh O’Kennedy / Asim K. Duttaroy

BMC Nutrition, Vol 7, Iss 1, Pp 1-

2021 Volume 9

Abstract: Abstract Background The water-soluble tomato extract, Fruitflow® is a dietary antiplatelet which can be used to lower platelet aggregability in primary preventative settings. We carried out a pilot study to investigate the range of intakes linked to ... ...

Abstract	Abstract Background The water-soluble tomato extract, Fruitflow® is a dietary antiplatelet which can be used to lower platelet aggregability in primary preventative settings. We carried out a pilot study to investigate the range of intakes linked to efficacy and to make an initial assessment of variability in response to Fruitflow®. Methods Platelet response to adenosine diphosphate (ADP) agonist and thrombin generation capacity were monitored at baseline and 24 h after consuming 0, 30, 75, 150 or 300 mg of Fruitflow® in a randomized, double-blinded crossover study in male subjects 30–65 years of age (N = 12). Results were evaluated for equivalence to the standard 150 mg dose. Results Results showed that the changes from baseline aggregation and thrombin generation observed after the 75 mg, 150 mg, and 300 mg supplements were equivalent. Aggregation was reduced from baseline by − 12.9 ± 17.7%, − 12.0 ± 13.9% and − 17.7 ± 15.7% respectively, while thrombin generation capacity fell by − 8.6 ± 4.1%, − 9.2 ± 3.1% and − 11.3 ± 2.3% respectively. Effects observed for 0 mg and 30 mg supplements were non-equivalent to 150 mg and not different from baseline (aggregation changed by 3.0 ± 5.0% and − 0.7 ± 10.2% respectively, while thrombin generation changed by 0.8 ± 3.0% and 0.8 ± 3.1% respectively). Conclusions The data suggest that the efficacious range for Fruitflow® lies between 75 mg and 300 mg, depending on the individual. It may be pertinent to personalize the daily intake of Fruitflow® depending on individual platelet response. Trial registration ISRCTN53447583 , 24/02/2021.
Keywords	Fruitflow ; Water-soluble tomato extract ; Platelet aggregation ; Thrombin generation capacity ; Equivalence ; Integrative medicine ; Nutrition. Foods and food supply ; TX341-641 ; Food processing and manufacture ; TP368-456 ; Medicine (General) ; R5-920
Subject code	001
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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