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  1. Article ; Online: Potential role of platelets in COVID-19: Implications for thrombosis.

    Koupenova, Milka

    Research and practice in thrombosis and haemostasis

    2020  Volume 4, Issue 5, Page(s) 737–740

    Abstract: For the past 150 years, platelets have been recognized as the major blood component that mediates hemostasis and thrombosis. In more recent years, however, we have come to appreciate that platelets also perform profound immune functions during infection ... ...

    Abstract For the past 150 years, platelets have been recognized as the major blood component that mediates hemostasis and thrombosis. In more recent years, however, we have come to appreciate that platelets also perform profound immune functions during infection with various pathogens. We now recognize that platelets can also mediate a response to various RNA viruses such as influenza and that many viral infections, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can affect platelet count. Thrombocytopenia and increased coagulation have been independently associated with increased mortality. This article provides a perspective on the potential roles of platelets during coronavirus disease 2019.
    Keywords covid19
    Language English
    Publishing date 2020-06-21
    Publishing country United States
    Document type Journal Article
    ISSN 2475-0379
    ISSN (online) 2475-0379
    DOI 10.1002/rth2.12397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Potential role of platelets in COVID‐19

    Milka Koupenova

    Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 5, Pp 737-

    Implications for thrombosis

    2020  Volume 740

    Abstract: Abstract For the past 150 years, platelets have been recognized as the major blood component that mediates hemostasis and thrombosis. In more recent years, however, we have come to appreciate that platelets also perform profound immune functions during ... ...

    Abstract Abstract For the past 150 years, platelets have been recognized as the major blood component that mediates hemostasis and thrombosis. In more recent years, however, we have come to appreciate that platelets also perform profound immune functions during infection with various pathogens. We now recognize that platelets can also mediate a response to various RNA viruses such as influenza and that many viral infections, including severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), can affect platelet count. Thrombocytopenia and increased coagulation have been independently associated with increased mortality. This article provides a perspective on the potential roles of platelets during coronavirus disease 2019.
    Keywords COVID‐19 ; immunity ; platelets ; SARS‐CoV‐2 ; thrombosis ; Diseases of the blood and blood-forming organs ; RC633-647.5 ; covid19
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: COVID-19 and the Cardiovascular System:

    Koupenova, Milka / Chung, Mina K / Bristow, Michael R

    Circulation research

    2023  Volume 132, Issue 10, Page(s) 1255–1258

    MeSH term(s) Humans ; COVID-19 ; Cardiovascular System
    Language English
    Publishing date 2023-05-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.123.322935
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Potential role of platelets in COVID‐19

    Koupenova, Milka

    Research and Practice in Thrombosis and Haemostasis

    Implications for thrombosis

    2020  Volume 4, Issue 5, Page(s) 737–740

    Keywords covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ISSN 2475-0379
    DOI 10.1002/rth2.12397
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article: Potential role of platelets in COVID-19: Implications for thrombosis

    Koupenova, Milka

    Res. Pract. Thromb. Haemost.

    Abstract: For the past 150 years, platelets have been recognized as the major blood component that mediates hemostasis and thrombosis. In more recent years, however, we have come to appreciate that platelets also perform profound immune functions during infection ... ...

    Abstract For the past 150 years, platelets have been recognized as the major blood component that mediates hemostasis and thrombosis. In more recent years, however, we have come to appreciate that platelets also perform profound immune functions during infection with various pathogens. We now recognize that platelets can also mediate a response to various RNA viruses such as influenza and that many viral infections, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can affect platelet count. Thrombocytopenia and increased coagulation have been independently associated with increased mortality. This article provides a perspective on the potential roles of platelets during coronavirus disease 2019.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #436594
    Database COVID19

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  6. Book ; Online: Potential Role of Platelets in COVID‐19

    Koupenova, Milka

    COVID-19 Publications by UMMS Authors

    Implications for Thrombosis

    2020  

    Abstract: For the past 150 years, platelets have been recognized as the major blood component that mediates hemostasis and thrombosis. In more recent years, however, we have come to appreciate that platelets also perform profound immune functions during infection ... ...

    Abstract For the past 150 years, platelets have been recognized as the major blood component that mediates hemostasis and thrombosis. In more recent years, however, we have come to appreciate that platelets also perform profound immune functions during infection with various pathogens. We now recognize that platelets can also mediate a response to various RNA viruses such as influenza and that many viral infections, including the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), can affect platelet count. Thrombocytopenia and increased coagulation have been independently associated with increased mortality. This article provides a perspective on the potential roles of platelets during COVID‐19.
    Keywords platelets ; COVID-19 ; SARS-CoV-2 ; immunity ; thrombosis ; Cardiology ; Cardiovascular Diseases ; Fluids and Secretions ; Immunology and Infectious Disease ; Infectious Disease ; Virus Diseases ; covid19
    Publishing date 2020-05-29T07:00:00Z
    Publisher eScholarship@UMMS
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article ; Online: Platelets and SARS-CoV-2 During COVID-19: Immunity, Thrombosis, and Beyond.

    Sciaudone, Anthony / Corkrey, Heather / Humphries, Fiachra / Koupenova, Milka

    Circulation research

    2023  Volume 132, Issue 10, Page(s) 1272–1289

    Abstract: COVID-19 is characterized by dysregulated thrombosis and coagulation that can increase mortality in patients. Platelets are fast responders to pathogen presence, alerting the surrounding immune cells and contributing to thrombosis and intravascular ... ...

    Abstract COVID-19 is characterized by dysregulated thrombosis and coagulation that can increase mortality in patients. Platelets are fast responders to pathogen presence, alerting the surrounding immune cells and contributing to thrombosis and intravascular coagulation. The SARS-CoV-2 genome has been found in platelets from patients with COVID-19, and its coverage varies according to the method of detection, suggesting direct interaction of the virus with these cells. Antibodies against Spike and Nucleocapsid have confirmed this platelet-viral interaction. This review discusses the immune, prothrombotic, and procoagulant characteristics of platelets observed in patients with COVID-19. We outline the direct and indirect interaction of platelets with SARS-CoV-2, the contribution of the virus to programmed cell death pathway activation in platelets and the consequent extracellular vesicle release. We discuss platelet activation and immunothrombosis in patients with COVID-19, the effect of Spike on platelets, and possible activation of platelets by classical platelet activation triggers as well as contribution of platelets to complement activation. As COVID-19-mediated thrombosis and coagulation are still not well understood in vivo, we discuss available murine models and mouse adaptable strains.
    MeSH term(s) Mice ; Animals ; COVID-19/metabolism ; SARS-CoV-2 ; Blood Platelets/metabolism ; Thrombosis ; Platelet Activation
    Language English
    Publishing date 2023-05-11
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.122.321930
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Platelets and Immunity: Going Viral.

    Koupenova, Milka / Freedman, Jane E

    Arteriosclerosis, thrombosis, and vascular biology

    2020  Volume 40, Issue 7, Page(s) 1605–1607

    MeSH term(s) Blood Platelets ; Endocytosis ; Platelet Activation ; Toll-Like Receptors ; Virion
    Chemical Substances Toll-Like Receptors
    Keywords covid19
    Language English
    Publishing date 2020-06-24
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.120.314620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Platelets and COVID-19: Inflammation, Hyperactivation and Additional Questions.

    Koupenova, Milka / Freedman, Jane E

    Circulation research

    2020  Volume 127, Issue 11, Page(s) 1419–1421

    MeSH term(s) Betacoronavirus ; Blood Platelets ; COVID-19 ; Coronavirus Infections ; Humans ; Inflammation ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-11-05
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.120.318218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Platelet and Megakaryocyte Roles in Innate and Adaptive Immunity.

    Koupenova, Milka / Livada, Alison C / Morrell, Craig N

    Circulation research

    2022  Volume 130, Issue 2, Page(s) 288–308

    Abstract: Classically, platelets have been described as the cellular blood component that mediates hemostasis and thrombosis. This important platelet function has received significant research attention for >150 years. The immune cell functions of platelets are ... ...

    Abstract Classically, platelets have been described as the cellular blood component that mediates hemostasis and thrombosis. This important platelet function has received significant research attention for >150 years. The immune cell functions of platelets are much less appreciated. Platelets interact with and activate cells of all branches of immunity in response to pathogen exposures and infection, as well as in response to sterile tissue injury. In this review, we focus on innate immune mechanisms of platelet activation, platelet interactions with innate immune cells, as well as the intersection of platelets and adaptive immunity. The immune potential of platelets is dependent in part on their megakaryocyte precursor providing them with the molecular composition to be first responders and immune sentinels in initiating and orchestrating coordinated pathogen immune responses. There is emerging evidence that extramedullary megakaryocytes may be immune differentiated compared with bone marrow megakaryocytes, but the physiological relevance of immunophenotypic differences are just beginning to be explored. These concepts are also discussed in this review. The immune functions of the megakaryocyte/platelet lineage have likely evolved to coordinate the need to repair a vascular breach with the simultaneous need to induce an immune response that may limit pathogen invasion once the blood is exposed to an external environment.
    MeSH term(s) Adaptive Immunity ; Animals ; Blood Platelets/immunology ; Humans ; Immunity, Innate ; Megakaryocytes/immunology
    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.121.319821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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