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Article ; Online: Genistein prevents the production of hypospadias induced by Di-(2-ethylhexyl) phthalate through androgen signaling and antioxidant response in rats.

Shi, Bowen / He, Enyang / Chang, Kaili / Xu, Guodong / Meng, Qingya / Xu, Haihua / Chen, Ziying / Wang, Xiaojia / Jia, Miao / Sun, Wenjing / Zhao, Wei / Zhao, Hailan / Dong, Liang / Cui, Hualei

Journal of hazardous materials

2024 Volume 466, Page(s) 133537

Abstract: ... effect of genistein (GEN) were investigated through in vivo models prepared by Di-(2-ethylhexyl ...

Abstract	Environmental estrogen exposure has increased dramatically over the past 50 years. In particular, prenatal exposure to estrogen causes many congenital diseases, among which reproductive system development disorders are extremely serious. In this study, the molecular mechanism of hypospadias and the therapeutic effect of genistein (GEN) were investigated through in vivo models prepared by Di-(2-ethylhexyl) phthalate (DEHP) exposure between 12 and 19 days of gestation. With increased DEHP concentrations, the incidence of hypospadias increased gradually. DEHP inhibited the key enzymes involved in steroid synthesis, resulting in decreasing testosterone synthesis. At the same time, DEHP increased reactive oxygen species (ROS) and produced inflammatory factors via NADPH oxidase-1 (NOX1) and NADPH oxidase-4 (NOX4) pathways. It also inhibited Steroid 5 α Reductase 2 (Srd5α2) and decreased dihydrotestosterone (DHT) synthesis. Additionally, DEHP inhibited the androgen receptor (AR), resulting in reduced DHT binding to the AR that ultimately retarded the development of the external reproductive system. GEN, a phytoestrogen, competes with DEHP for binding to estrogen receptor β (ERβ). This competition, along with GEN's antiestrogen and antioxidant properties, could potentially reverse impairments. The findings of this study provide valuable insights into the role of phytoestrogens in alleviating environmental estrogen-induced congenital diseases.
MeSH term(s)	Pregnancy ; Male ; Humans ; Female ; Rats ; Animals ; Genistein/pharmacology ; Antioxidants/pharmacology ; Androgens ; Diethylhexyl Phthalate/toxicity ; Hypospadias/chemically induced ; Hypospadias/prevention & control ; Estrogens ; NADPH Oxidases ; Phthalic Acids
Chemical Substances	phthalic acid (6O7F7IX66E) ; Genistein (DH2M523P0H) ; Antioxidants ; Androgens ; Diethylhexyl Phthalate (C42K0PH13C) ; Estrogens ; NADPH Oxidases (EC 1.6.3.-) ; Phthalic Acids
Language	English
Publishing date	2024-01-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2024.133537
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: H-NS Represses Biofilm Formation and c-di-GMP Synthesis in

Xue, Xing Fan / Zhnag, Miao Miao / Sun, Jun Fang / Li, Xue / Wu, Qi Min / Yin, Zhe / Yang, Wen Hui / Ni, Bin / Hu, Ling Fei / Zhou, Dong Sheng / Lu, Ren Fei / Zhang, Yi Quan

Biomedical and environmental sciences : BES

2022 Volume 35, Issue 9, Page(s) 821–829

Abstract: ... structuring protein (H-NS) on biofilm formation and cyclic diguanylate (c-di-GMP) synthesis in : Methods ... of c-di-GMP, quantitative real-time polymerase chain reaction, LacZ fusion, and ...

Abstract	Objective: This study aimed to investigate the regulation of histone-like nucleoid structuring protein (H-NS) on biofilm formation and cyclic diguanylate (c-di-GMP) synthesis in Methods: Regulatory mechanisms were analyzed by the combined utilization of crystal violet staining, quantification of c-di-GMP, quantitative real-time polymerase chain reaction, LacZ fusion, and electrophoretic-mobility shift assay. Results: The deletion of Conclusion: One of the mechanisms by which H-NS represses the biofilm formation by
MeSH term(s)	Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Biofilms ; Cyclic GMP/analogs & derivatives ; Gene Expression Regulation, Bacterial ; Gentian Violet ; Histones/genetics ; Histones/metabolism ; Vibrio parahaemolyticus/genetics
Chemical Substances	Bacterial Proteins ; Histones ; bis(3',5')-cyclic diguanylic acid (61093-23-0) ; Cyclic GMP (H2D2X058MU) ; Gentian Violet (J4Z741D6O5)
Language	English
Publishing date	2022-10-03
Publishing country	China
Document type	Journal Article
ZDB-ID	645083-0
ISSN	2214-0190 ; 0895-3988
ISSN (online)	2214-0190
ISSN	0895-3988
DOI	10.3967/bes2022.106
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Zs.A 2459: Show issues

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Article ; Online: Di-(2-ethylhexyl) phthalate (DEHP) promoted hepatic lipid accumulation by activating Notch signaling pathway.

Zhang, Yuezhu / Qian, Honghao / Wang, Jia / Zhu, Ying / Miao, Xiaohan / Li, Xu / Yin, Jianli / Zhang, Ruxuan / Ye, Jiaming / Huo, Chuanyi / Zhao, Weisen / Ye, Lin

Environmental toxicology

2023 Volume 38, Issue 7, Page(s) 1628–1640

Abstract: Di-(2-ethylhexyl) phthalate (DEHP) and mono-2-ethylhexyl phthalate (MEHP) can induce hepatic ...

Abstract	Di-(2-ethylhexyl) phthalate (DEHP) and mono-2-ethylhexyl phthalate (MEHP) can induce hepatic lipid metabolism disorders, while the molecular mechanism still remain unknown. We aim to explore the underlying mechanism of Notch signaling pathway on hepatic lipid accumulation induced by DEHP/MEHP. A total of 40 male wistar rats were exposed to DEHP (0, 5, 50, and 500 mg/kg/d) for 8 weeks, BRL-3A hepatocytes were exposed to MEHP (0, 10, 50, 100, and 200 μM) for 24 h. About 50 μM DAPT and 100 μg/mL Aspirin were used to inhibit Notch pathway and prevent inflammation, respectively. Real-Time PCR was performed to detect the mRNA expression, western blot and immunofluorescence were used to detect the protein expression. Lipids and inflammatory factors levels were determined by commercial kits. The results showed that DEHP/MEHP promoted the expression of Notch pathway molecules and lipids accumulation in rat livers/BRL-3A cells. The up-regulated Notch receptors were correlated with the TG levels in the rat liver. MEHP increased the levels of IL-8 and IL-1β. The lipids levels were reduced after anti-inflammation. The inhibition of Notch pathway reversed the elevation of inflammation and lipid accumulation caused by MEHP. In conclusion, this study demonstrated that DEHP/MEHP led to lipid accumulation in hepatocytes by up-regulating Notch pathway and the inflammation might play a key role in the process.
MeSH term(s)	Rats ; Animals ; Male ; Diethylhexyl Phthalate/metabolism ; Liver/metabolism ; Rats, Wistar ; Signal Transduction ; Inflammation ; Lipids
Chemical Substances	phthalic acid (6O7F7IX66E) ; mono-(2-ethylhexyl)phthalate (FU2EWB60RT) ; Diethylhexyl Phthalate (C42K0PH13C) ; Lipids
Language	English
Publishing date	2023-03-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	1463449-1
ISSN	1522-7278 ; 1520-4081
ISSN (online)	1522-7278
ISSN	1520-4081
DOI	10.1002/tox.23792
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Zs.A 2676: Show issues

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Article: [Dao-di herbs pharmacology and new ideas of Dao-di herbs standard construction].

Zhao, Jun-Ning / Hua, Hua / Dai, Ying / Fang, Qing-Mao / Li, Qing-Miao / Jiang, Shun-Yuan / Xie, Chun-Guang / Yang, Si-Jin / Yan, Liang-Chun / Tan, Peng / Yang, An-Dong / Wang, Shu

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2020 Volume 45, Issue 4, Page(s) 709–714

Abstract: ... di herbs pharmacology studies the nature, performance, interaction with the body and its clinical ... application.It is a bridge between the basic research and clinical application of Dao-di herbs ... It can objectively describe the law of efficacy of Dao-di herbs, scientifically explain the mechanism of efficacy ...

Abstract	Guided by the basic theory of traditional Chinese medicine and using modern scientific methods, Dao-di herbs pharmacology studies the nature, performance, interaction with the body and its clinical application.It is a bridge between the basic research and clinical application of Dao-di herbs. It can objectively describe the law of efficacy of Dao-di herbs, scientifically explain the mechanism of efficacy of Dao-di herbs, explore and establish the standards and methods of Dao-di herbs based on biological effect and clinical efficacy, and provide scientific basis for the special properties, pharmacology and clinical value of Dao-di herbs.Furthermore, we put forward a new idea of building the standard of Dao-di herbs based on the curative effect rather than the origin.The Dao-di herbs standard should come from the systematic research of traditional Dao-di herbs producing areas and form a new characteristic system, through the extraction of environmental, genetic, character, chemical, pharmacological and other characteristics.This standard originates from the tradition, but it is higher than the tradition. It may not have the origin meaning of strict administrative division, but it can better reflect the pharmacological characteristics and excellent clinical value of Dao-di herbs.
MeSH term(s)	China ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/standards ; Medicine, Chinese Traditional ; Plants, Medicinal/chemistry
Chemical Substances	Drugs, Chinese Herbal
Language	Chinese
Publishing date	2020-03-31
Publishing country	China
Document type	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20191226.101
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Zs.A 3056: Show issues

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Article ; Online: Apigenin ameliorates di(2-ethylhexyl) phthalate-induced ferroptosis: The activation of glutathione peroxidase 4 and suppression of iron intake.

Han, Dongxu / Yao, Yujie / Chen, Lu / Miao, Zhiying / Xu, Shiwen

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2022 Volume 164, Page(s) 113089

Abstract: Di(2-ethylhexyl) phthalate (DEHP) is a widely artificial persistent organic pollutant ...

Abstract	Di(2-ethylhexyl) phthalate (DEHP) is a widely artificial persistent organic pollutant, the contamination of which infiltrates daily human life from many aspects, imperceptibly causing damage to multiple organs in the body, including the liver. Apigenin (APG) is widely distributed in vegetables and fruits and can relieve or prevent the injuries caused by exogenous chemicals through various pharmacological effects, such as antioxidant effects. To investigate the mechanism of DEHP-induced liver injury and the antagonistic effects of APG, we treated AML12 cells with 1 mM DEHP and/or APG. Ultrastructural morphology analysis indicated that DEHP induced typical ferroptosis-like damage. In addition, we found that DEHP exposure induced ferroptosis by enhancing reactive oxygen species (ROS) levels, disrupting iron homeostasis and lipid peroxidation, and regulating the expression of ferroptosis-related genes. Notably, supplementation with APG significantly inhibited these abnormal changes, and molecular docking further showed evidence of the activating effects of APG ligand on glutathione peroxidase 4 (GPX4). These results demonstrated that the protective effects of APG on DEHP-induced ferroptosis were achieved by activating GPX4 and suppressing intracellular iron accumulation. This information not only adds to DEHP toxicological data but also provides a basis for the practical application of APG.
MeSH term(s)	Apigenin/pharmacology ; Diethylhexyl Phthalate/toxicity ; Ferroptosis ; Glutathione Peroxidase ; Humans ; Iron ; Molecular Docking Simulation ; Phospholipid Hydroperoxide Glutathione Peroxidase ; Phthalic Acids
Chemical Substances	Phthalic Acids ; phthalic acid (6O7F7IX66E) ; Apigenin (7V515PI7F6) ; Diethylhexyl Phthalate (C42K0PH13C) ; Iron (E1UOL152H7) ; Phospholipid Hydroperoxide Glutathione Peroxidase (EC 1.11.1.12) ; Glutathione Peroxidase (EC 1.11.1.9)
Language	English
Publishing date	2022-04-30
Publishing country	England
Document type	Journal Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2022.113089
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Zs.A 529: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Role of ROS/JAK2/STAT3 signaling pathway in di-n-butyl phthalate-induced testosterone synthesis inhibition and antagonism of lycopene.

Wang, Qi / Wu, Xia / Zhang, Jian / Song, Miao / Du, Jiayu / Cui, Yilong / Li, Yanfei

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2023 Volume 175, Page(s) 113741

Abstract: Di-n-butyl phthalate (DBP) causes adverse effects on male reproduction, especially testosterone ...

Abstract	Di-n-butyl phthalate (DBP) causes adverse effects on male reproduction, especially testosterone synthesis inhibition. However, the specific mechanism of DBP-induced testosterone synthesis inhibition and its effective intervention measures of prevention and treatment are scarce presently. Lycopene (LYC) plays beneficial roles in male infertility because of its antioxidant activity. Nevertheless, it is unclear whether LYC could prevent DBP-induced male reproductive toxicity. By in vitro and in vivo investigations, this study demonstrated that DBP activated ROS/JAK2/STAT3 signaling pathway, promoted mitophagy and apoptosis, which in turn inhibited testosterone synthesis. Additionally, another major finding was that LYC supplement could reverse the above change, presenting as the restraint of ROS/JAK2/STAT3 signaling pathway, reduction of mitophagy and apoptosis, and improvement of testosterone synthesis. Our study facilitates deeper understandings of the mechanism in DBP-induced testosterone synthesis inhibition, and identifies LYC as the effective prevention and control strategies for DBP poisoning.
MeSH term(s)	Male ; Humans ; Dibutyl Phthalate/toxicity ; Dibutyl Phthalate/metabolism ; Testis ; Lycopene/pharmacology ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Testosterone/metabolism
Chemical Substances	Dibutyl Phthalate (2286E5R2KE) ; Lycopene (SB0N2N0WV6) ; Reactive Oxygen Species ; Testosterone (3XMK78S47O)
Language	English
Publishing date	2023-03-21
Publishing country	England
Document type	Journal Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2023.113741
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Article ; Online: Retraction Note: Chinese medicine Di-Huang-Yi-Zhi protects PC12 cells from H

Zhang, Li-Min / Zhen, Rong-Rong / Gu, Chao / Zhang, Tian-Li / Li, Yue / Jin, Miao / Hu, Bing / An, Hong-Mei

BMC complementary medicine and therapies

2022 Volume 22, Issue 1, Page(s) 183

Language	English
Publishing date	2022-07-08
Publishing country	England
Document type	Journal Article ; Retraction of Publication
ISSN	2662-7671
ISSN (online)	2662-7671
DOI	10.1186/s12906-022-03665-3
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Article ; Online: Chinese medicine Di-Huang-Yi-Zhi protects PC12 cells from H

Zhang, Li-Min / Zhen, Rong-Rong / Gu, Chao / Zhang, Tian-Li / Li, Yue / Jin, Miao / Hu, Bing / An, Hong-Mei

publication RETRACTED

BMC complementary medicine and therapies

2020 Volume 20, Issue 1, Page(s) 54

Abstract: ... Di-Huang-Yi-Zhi (DHYZ) is a Chinese medicine used for the treatment of AD, but its mechanism remains ...

Abstract	Background: Oxidative stress mediates the nerve injury during the pathogenesis of Alzheimer's disease (AD). Protecting against oxidative stress damage is an important strategy to prevent and treat AD. Di-Huang-Yi-Zhi (DHYZ) is a Chinese medicine used for the treatment of AD, but its mechanism remains unknown. This study is aimed to investigate the effect of DHYZ on H Methods: PC12 cells were treated with H Results: The results showed that DHYZ antagonized H Conclusions: The present study suggested that DHYZ protected PC12 cells from H
MeSH term(s)	Animals ; Apoptosis/drug effects ; Drugs, Chinese Herbal/pharmacology ; Hydrogen Peroxide ; MAP Kinase Signaling System/drug effects ; Oxidative Stress/drug effects ; PC12 Cells ; Rats ; p38 Mitogen-Activated Protein Kinases/metabolism
Chemical Substances	Drugs, Chinese Herbal ; di-huang-yi-zhi ; Hydrogen Peroxide (BBX060AN9V) ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24)
Language	English
Publishing date	2020-02-14
Publishing country	England
Document type	Journal Article ; Retracted Publication
ISSN	2662-7671
ISSN (online)	2662-7671
DOI	10.1186/s12906-020-2834-8
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Article ; Online: Di‐(2‐ethylhexyl) phthalate (DEHP) promoted hepatic lipid accumulation by activating Notch signaling pathway

Zhang, Yuezhu / Qian, Honghao / Wang, Jia / Zhu, Ying / Miao, Xiaohan / Li, Xu / Yin, Jianli / Zhang, Ruxuan / Ye, Jiaming / Huo, Chuanyi / Zhao, Weisen / Ye, Lin

Environmental Toxicology. 2023 July, v. 38, no. 7 p.1628-1640

2023

Abstract: Di‐(2‐ethylhexyl) phthalate (DEHP) and mono‐2‐ethylhexyl phthalate (MEHP) can induce hepatic ...

Abstract	Di‐(2‐ethylhexyl) phthalate (DEHP) and mono‐2‐ethylhexyl phthalate (MEHP) can induce hepatic lipid metabolism disorders, while the molecular mechanism still remain unknown. We aim to explore the underlying mechanism of Notch signaling pathway on hepatic lipid accumulation induced by DEHP/MEHP. A total of 40 male wistar rats were exposed to DEHP (0, 5, 50, and 500 mg/kg/d) for 8 weeks, BRL‐3A hepatocytes were exposed to MEHP (0, 10, 50, 100, and 200 μM) for 24 h. About 50 μM DAPT and 100 μg/mL Aspirin were used to inhibit Notch pathway and prevent inflammation, respectively. Real‐Time PCR was performed to detect the mRNA expression, western blot and immunofluorescence were used to detect the protein expression. Lipids and inflammatory factors levels were determined by commercial kits. The results showed that DEHP/MEHP promoted the expression of Notch pathway molecules and lipids accumulation in rat livers/BRL‐3A cells. The up‐regulated Notch receptors were correlated with the TG levels in the rat liver. MEHP increased the levels of IL‐8 and IL‐1β. The lipids levels were reduced after anti‐inflammation. The inhibition of Notch pathway reversed the elevation of inflammation and lipid accumulation caused by MEHP. In conclusion, this study demonstrated that DEHP/MEHP led to lipid accumulation in hepatocytes by up‐regulating Notch pathway and the inflammation might play a key role in the process.
Keywords	Western blotting ; aspirin ; ecotoxicology ; fluorescent antibody technique ; gene expression ; hepatocytes ; inflammation ; interleukin-8 ; lipid metabolism ; lipids ; liver ; phthalates ; protein synthesis ; quantitative polymerase chain reaction ; rats
Language	English
Dates of publication	2023-07
Size	p. 1628-1640.
Publishing place	John Wiley & Sons, Inc.
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	1463449-1
ISSN	1522-7278 ; 1520-4081
ISSN (online)	1522-7278
ISSN	1520-4081
DOI	10.1002/tox.23792
Database	NAL-Catalogue (AGRICOLA)

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Z 4957: Show issues

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Article ; Online: Novel insights into di‑(2‑ethylhexyl)phthalate activation: Implications for the hypothalamus‑pituitary‑thyroid axis.

Wu, Haoyu / Zhang, Wanying / Zhang, Yunbo / Kang, Zhen / Miao, Xinxiunan / Na, Xiaolin

Molecular medicine reports

2021 Volume 23, Issue 4

Abstract: Di (2‑ethylhexyl) phthalate (DEHP), an environmental pollutant, is widely used as a plasticizer and ...

Abstract	Di (2‑ethylhexyl) phthalate (DEHP), an environmental pollutant, is widely used as a plasticizer and causes serious pollution in the ecological environment. As previously reported, exposure to DEHP may cause thyroid dysfunction of the hypothalamic‑pituitary‑thyroid (HPT) axis. However, the underlying role of DEHP remains to be elucidated. The present study performed intragastrical administration of DEHP (150, 300 and 600 mg/kg) once a day for 90 consecutive days. DEHP‑stimulated oxidative stress increased the thyroid follicular cavity diameter and caused thyrocyte oedema. Furthermore, DEHP exposure altered mRNA and protein levels. Thus, DEHP may perturb TH homeostasis by affecting biosynthesis, biotransformation, bio‑transportation, receptor levels and metabolism through disruption of the HPT axis and activation of the thyroid‑stimulating hormone (TSH)/TSH receptor signaling pathway. These results identified the formerly unappreciated endocrine‑disrupting activities of phthalates and the molecular mechanisms of DEHP‑induced thyrotoxicity.
MeSH term(s)	Animals ; Diethylhexyl Phthalate/toxicity ; Environmental Pollutants/toxicity ; Gene Expression Regulation/drug effects ; Homeostasis/drug effects ; Hypothalamo-Hypophyseal System/drug effects ; Hypothalamo-Hypophyseal System/growth & development ; Hypothalamo-Hypophyseal System/metabolism ; Male ; Organ Size/drug effects ; Oxidative Stress/drug effects ; Plasticizers/toxicity ; Rats, Wistar ; Receptors, Thyrotropin/genetics ; Receptors, Thyrotropin/metabolism ; Receptors, Thyrotropin-Releasing Hormone/genetics ; Receptors, Thyrotropin-Releasing Hormone/metabolism ; Signal Transduction/drug effects ; Thyroid Gland/drug effects ; Thyroid Gland/growth & development ; Thyroid Gland/metabolism ; Thyroid Hormones/blood ; Thyroid Hormones/metabolism ; Thyroid Nuclear Factor 1/genetics ; Thyroid Nuclear Factor 1/metabolism ; Thyrotropin, beta Subunit/genetics ; Thyrotropin, beta Subunit/metabolism ; Rats
Chemical Substances	Environmental Pollutants ; Plasticizers ; Receptors, Thyrotropin ; Receptors, Thyrotropin-Releasing Hormone ; Thyroid Hormones ; Thyroid Nuclear Factor 1 ; Thyrotropin, beta Subunit ; Diethylhexyl Phthalate (C42K0PH13C)
Language	English
Publishing date	2021-03-02
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2469505-1
ISSN	1791-3004 ; 1791-2997
ISSN (online)	1791-3004
ISSN	1791-2997
DOI	10.3892/mmr.2021.11930
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