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Article ; Online: Targeting triple negative breast cancer stem cells using nanocarriers.

Dasari, Nagasen / Guntuku, Girija Sankar / Pindiprolu, Sai Kiran S S

Discover nano

2024 Volume 19, Issue 1, Page(s) 41

Abstract: Breast cancer is a complex and heterogeneous disease, encompassing various subtypes characterized by distinct molecular features, clinical behaviors, and treatment responses. Categorization of subtypes is based on the presence or absence of estrogen ... ...

Abstract	Breast cancer is a complex and heterogeneous disease, encompassing various subtypes characterized by distinct molecular features, clinical behaviors, and treatment responses. Categorization of subtypes is based on the presence or absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), leading to subtypes such as luminal A, luminal B, HER2-positive, and triple-negative breast cancer (TNBC). TNBC, comprising around 20% of all breast cancers, lacks expression of ER, PR, and HER2 receptors, rendering it unresponsive to targeted therapies and presenting significant challenges in treatment. TNBC is associated with aggressive behavior, high rates of recurrence, and resistance to chemotherapy. Tumor initiation, progression, and treatment resistance in TNBC are attributed to breast cancer stem cells (BCSCs), which possess self-renewal, differentiation, and tumorigenic potential. Surface markers, self-renewal pathways (Notch, Wnt, Hedgehog signaling), apoptotic protein (Bcl-2), angiogenesis inhibition (VEGF inhibitors), and immune modulation (cytokines, immune checkpoint inhibitors) are among the key targets discussed in this review. However, targeting the BCSC subpopulation in TNBC presents challenges, including off-target effects, low solubility, and bioavailability of anti-BCSC agents. Nanoparticle-based therapies offer a promising approach to target various molecular pathways and cellular processes implicated in survival of BSCS in TNBC. In this review, we explore various nanocarrier-based approaches for targeting BCSCs in TNBC, aiming to overcome these challenges and improve treatment outcomes for TNBC patients. These nanoparticle-based therapeutic strategies hold promise for addressing the therapeutic gap in TNBC treatment by delivering targeted therapies to BCSCs while minimizing systemic toxicity and enhancing treatment efficacy.
Language	English
Publishing date	2024-03-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	2731-9229
ISSN (online)	2731-9229
DOI	10.1186/s11671-024-03985-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Plausible mechanisms of Niclosamide as an antiviral agent against COVID-19.

Pindiprolu, Sai Kiran S S / Pindiprolu, Sai Harshini

Medical hypotheses

2020 Volume 140, Page(s) 109765

Abstract: Corona virus disease 2019 (COVID-19) pandemic caused 18 440 deaths world wide as of 25 March 2020 and posing a serious threat to public health. There is a need, therefore, for effective therapeutic strategies to cure this disease. However, high attrition ...

Abstract	Corona virus disease 2019 (COVID-19) pandemic caused 18 440 deaths world wide as of 25 March 2020 and posing a serious threat to public health. There is a need, therefore, for effective therapeutic strategies to cure this disease. However, high attrition rates, substantial costs and slow pace are the major limitations of novel drug discovery. Drug repurposing, by employing 'old' drugs to treat 'new' diseases is an attractive approach in drug discovery. Niclosamide (NIC) is an approved anti-helminthic drug with diverse antiviral mechanisms. In this work we hypothesize, the potential antiviral mechanisms of NIC against COVID-19.
Keywords	covid19
Language	English
Publishing date	2020-04-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	193145-3
ISSN	1532-2777 ; 0306-9877
ISSN (online)	1532-2777
ISSN	0306-9877
DOI	10.1016/j.mehy.2020.109765
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Article ; Online: Conquering chemoresistance in pancreatic cancer: Exploring novel drug therapies and delivery approaches amidst desmoplasia and hypoxia.

Chintamaneni, Pavan Kumar / Pindiprolu, Sai Kiran S S / Swain, Swati Swagatika / Karri, Veera Venkata Satyanarayana Reddy / Nesamony, Jerry / Chelliah, Selvam / Bhaskaran, Mahendran

Cancer letters

2024 Volume 588, Page(s) 216782

Abstract: Pancreatic cancer poses a significant challenge within the field of oncology due to its aggressive behaviour, limited treatment choices, and unfavourable outlook. With a mere 10% survival rate at the 5-year mark, finding effective interventions becomes ... ...

Abstract	Pancreatic cancer poses a significant challenge within the field of oncology due to its aggressive behaviour, limited treatment choices, and unfavourable outlook. With a mere 10% survival rate at the 5-year mark, finding effective interventions becomes even more pressing. The intricate relationship between desmoplasia and hypoxia in the tumor microenvironment further complicates matters by promoting resistance to chemotherapy and impeding treatment efficacy. The dense extracellular matrix and cancer-associated fibroblasts characteristic of desmoplasia create a physical and biochemical barrier that impedes drug penetration and fosters an immunosuppressive milieu. Concurrently, hypoxia nurtures aggressive tumor behaviour and resistance to conventional therapies. a comprehensive exploration of emerging medications and innovative drug delivery approaches. Notably, advancements in nanoparticle-based delivery systems, local drug delivery implants, and oxygen-carrying strategies are highlighted for their potential to enhance drug accessibility and therapeutic outcomes. The integration of these strategies with traditional chemotherapies and targeted agents reveals the potential for synergistic effects that amplify treatment responses. These emerging interventions can mitigate desmoplasia and hypoxia-induced barriers, leading to improved drug delivery, treatment efficacy, and patient outcomes in pancreatic cancer. This review article delves into the dynamic landscape of emerging anticancer medications and innovative drug delivery strategies poised to overcome the challenges imposed by desmoplasia and hypoxia in the treatment of pancreatic cancer.
MeSH term(s)	Humans ; Pharmaceutical Preparations ; Drug Resistance, Neoplasm ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/pathology ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Hypoxia ; Tumor Microenvironment ; Drug Delivery Systems
Chemical Substances	Pharmaceutical Preparations ; Antineoplastic Agents
Language	English
Publishing date	2024-03-06
Publishing country	Ireland
Document type	Review ; Journal Article
ZDB-ID	195674-7
ISSN	1872-7980 ; 0304-3835
ISSN (online)	1872-7980
ISSN	0304-3835
DOI	10.1016/j.canlet.2024.216782
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Article ; Online: Plausible mechanisms of Niclosamide as an antiviral agent against COVID-19

Pindiprolu, Sai Kiran S.S. / Pindiprolu, Sai Harshini

Medical Hypotheses

2020 Volume 140, Page(s) 109765

Keywords	General Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	193145-3
ISSN	1532-2777 ; 0306-9877
ISSN (online)	1532-2777
ISSN	0306-9877
DOI	10.1016/j.mehy.2020.109765
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: CD133 receptor mediated delivery of STAT3 inhibitor for simultaneous elimination of cancer cells and cancer stem cells in oral squamous cell carcinoma.

Pindiprolu, Sai Harshini / Pindiprolu, Sai Kiran S S

Medical hypotheses

2019 Volume 129, Page(s) 109241

Abstract: Oral Squamous Cell Carcinoma (OSCC) is one of the major causes of cancer related deaths worldwide. Presence of chemoresistant cancer stem cells is the major reason behind metastasis, tumor relapse and treatment resistance in OSCC. STAT 3 signalling plays ...

Abstract	Oral Squamous Cell Carcinoma (OSCC) is one of the major causes of cancer related deaths worldwide. Presence of chemoresistant cancer stem cells is the major reason behind metastasis, tumor relapse and treatment resistance in OSCC. STAT 3 signalling plays a key role in survival of cancer stem cells (CSC's), Epithelial Mesenchymal Transition (EMT) mediated metastasis in OSCC. CD 133 is the surface marker for identification of cancer stem cells. In the present study we hypothesise the selective targeting of CSC's using CD 133 mediated delivery of STAT 3 inhibitor, Niclosamide to specifically target CSC's and Non CSC's.
MeSH term(s)	AC133 Antigen/chemistry ; Apoptosis ; Carcinoma, Squamous Cell/drug therapy ; Drug Carriers ; Drug Delivery Systems ; Epithelial-Mesenchymal Transition ; Humans ; Models, Theoretical ; Mouth Neoplasms/drug therapy ; Neoplasm Recurrence, Local ; Neoplastic Stem Cells/drug effects ; Niclosamide/administration & dosage ; STAT3 Transcription Factor/antagonists & inhibitors ; Signal Transduction
Chemical Substances	AC133 Antigen ; Drug Carriers ; PROM1 protein, human ; STAT3 Transcription Factor ; STAT3 protein, human ; Niclosamide (8KK8CQ2K8G)
Language	English
Publishing date	2019-05-20
Publishing country	United States
Document type	Letter
ZDB-ID	193145-3
ISSN	1532-2777 ; 0306-9877
ISSN (online)	1532-2777
ISSN	0306-9877
DOI	10.1016/j.mehy.2019.109241
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Article ; Online: Phenylboronic acid modified lipid nanocarriers mediated co-delivery of immunocytokine TRAIL and gamma-secretase inhibitor to triple negative breast cancer cells and cancer stem cells.

Pindiprolu, Sai Kiran S S / Avasarala, Harani / Dinakaran, Sathis Kumar

Medical hypotheses

2021 Volume 157, Page(s) 110716

Abstract: Triple negative breast cancer (TNBC) is an aggressive form of breast cancer with high rates of tumor relapse and metastasis. The existing drugs for treatment of TNBC are unable to target the cells of origin (breast cancer stem cells) of TNBC. TNF-α ... ...

Abstract	Triple negative breast cancer (TNBC) is an aggressive form of breast cancer with high rates of tumor relapse and metastasis. The existing drugs for treatment of TNBC are unable to target the cells of origin (breast cancer stem cells) of TNBC. TNF-α related apoptosis inducing ligand (TRAIL) has propensity to target TNBC cells including cancer stem cells. However, resistance to TRAIL due to activation of anti-apoptotic mechanisms is a limitation for TRAIL based anticancer therapy for TNBC. In the present study we propose an hypothesis for effective targeting of triple negative breast cancer by overcoming TRAIL resistance.
MeSH term(s)	Amyloid Precursor Protein Secretases ; Apoptosis ; Boronic Acids ; Cell Line, Tumor ; Humans ; Lipids ; Neoplasm Recurrence, Local ; Neoplastic Stem Cells ; TNF-Related Apoptosis-Inducing Ligand ; Triple Negative Breast Neoplasms/drug therapy
Chemical Substances	Boronic Acids ; Lipids ; TNF-Related Apoptosis-Inducing Ligand ; Amyloid Precursor Protein Secretases (EC 3.4.-) ; benzeneboronic acid (L12H7B02G5)
Language	English
Publishing date	2021-10-20
Publishing country	United States
Document type	Letter
ZDB-ID	193145-3
ISSN	1532-2777 ; 0306-9877
ISSN (online)	1532-2777
ISSN	0306-9877
DOI	10.1016/j.mehy.2021.110716
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Article ; Online: Polysorbate-80 surface modified nano-stearylamine BQCA conjugate for the management of Alzheimer's disease.

Chintamaneni, Pavan Kumar / Krishnamurthy, Praveen Thaggikuppe / Pindiprolu, Sai Kiran S S

RSC advances

2021 Volume 11, Issue 10, Page(s) 5325–5334

Abstract: Acetylcholinesterase (AChE) inhibitors such as donepezil, galantamine and rivastigmine are used for the management of dementia in Alzheimer's Disease (AD). These drugs elevate endogenous acetylcholine (ACh) levels at the ... ...

Abstract	Acetylcholinesterase (AChE) inhibitors such as donepezil, galantamine and rivastigmine are used for the management of dementia in Alzheimer's Disease (AD). These drugs elevate endogenous acetylcholine (ACh) levels at the M
Language	English
Publishing date	2021-01-28
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d1ra00049g
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Plausible mechanisms of Niclosamide as an antiviral agent against COVID-19

Pindiprolu, Sai Kiran S S / Pindiprolu, Sai Harshini

Med Hypotheses

Abstract	Corona virus disease 2019 (COVID-19) pandemic caused 18 440 deaths world wide as of 25 March 2020 and posing a serious threat to public health. There is a need, therefore, for effective therapeutic strategies to cure this disease. However, high attrition rates, substantial costs and slow pace are the major limitations of novel drug discovery. Drug repurposing, by employing 'old' drugs to treat 'new' diseases is an attractive approach in drug discovery. Niclosamide (NIC) is an approved anti-helminthic drug with diverse antiviral mechanisms. In this work we hypothesize, the potential antiviral mechanisms of NIC against COVID-19.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #101994
Database	COVID19

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Article ; Online: Possible role of DPP4 inhibitors to promote hippocampal neurogenesis in Alzheimer's disease.

Chalichem, Nehru Sai Suresh / Sai Kiran, Pindiprolu S S / Basavan, Duraiswamy

Journal of drug targeting

2018 Volume 26, Issue 8, Page(s) 670–675

Abstract: As well-known to the scientific community, Alzheimer's disease (AD) is an irreversible neurodegenerative disease that ends up with impairment of memory and cognition. Patient quality of life can be enhanced by targeting neurogenesis as a therapeutic ... ...

Abstract	As well-known to the scientific community, Alzheimer's disease (AD) is an irreversible neurodegenerative disease that ends up with impairment of memory and cognition. Patient quality of life can be enhanced by targeting neurogenesis as a therapeutic paradigm. Preserving functional activity of SDF-1α and GLP-1 by DPPIV inhibition will enhance the homing of stem cells and modulate cell signalling pathways. The non-invasive approach presented in this article is a major advantage for managing AD, as regular/conventional stem-cell therapy necessarily relies on the application of regenerative stem cells exogenously. Using DPP-4 inhibitors to achieve the SDF-1α/CXCR4 axis stabilisation and augmenting GLP-1 levels, will enhance the homing/recruitment of brain resident and non-resident circulating stem cells/progenitor cells towards the sites of lesion to increase synaptic plasticity, a promising approach and also a novel one as well.
MeSH term(s)	Alzheimer Disease/pathology ; Dipeptidyl Peptidase 4/drug effects ; Hippocampus/drug effects ; Hippocampus/pathology ; Humans ; Neurogenesis/drug effects ; Protease Inhibitors/pharmacology
Chemical Substances	Protease Inhibitors ; DPP4 protein, human (EC 3.4.14.5) ; Dipeptidyl Peptidase 4 (EC 3.4.14.5)
Language	English
Publishing date	2018-03-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1187110-6
ISSN	1029-2330 ; 1061-186X
ISSN (online)	1029-2330
ISSN	1061-186X
DOI	10.1080/1061186X.2018.1433682
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Article ; Online: HER2 targeted biological macromolecule modified liposomes for improved efficacy of capecitabine in breast cancer.

Singh, Mantosh Kumar / Pindiprolu, Sai Kiran S S / Sanapalli, Bharat Kumar Reddy / Yele, Vidyasrilekha / Ganesh, G N K

International journal of biological macromolecules

2020 Volume 150, Page(s) 631–636

Abstract: The present research reports the beneficial effects of surface modified chitosan and tumor-homing peptide conjugated liposomes of capecitabine (CAP) for treating breast cancer. Liposomal formulation of CAP was prepared by film hydration method using ... ...

Abstract	The present research reports the beneficial effects of surface modified chitosan and tumor-homing peptide conjugated liposomes of capecitabine (CAP) for treating breast cancer. Liposomal formulation of CAP was prepared by film hydration method using cholesterol-THP conjugate (CTHP-CAP-LPs) to achieve active targeting through HER2 receptors. CTHP-CAP-LPs significantly improved the specificity and efficacy of CAP by improving cell uptake, cytotoxicity and tumor regression in tumor bearing mice. CTHP-CAP-LPs, therefore, is a promising approach to improve the anticancer effects of CAP.
MeSH term(s)	Antimetabolites, Antineoplastic/chemistry ; Antimetabolites, Antineoplastic/pharmacology ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Capecitabine/chemistry ; Capecitabine/pharmacology ; Cell Line, Tumor ; Chitosan/chemistry ; Chitosan/pharmacology ; Female ; Humans ; Liposomes ; Peptides/chemistry ; Peptides/pharmacology ; Receptor, ErbB-2/agonists ; Receptor, ErbB-2/metabolism
Chemical Substances	Antimetabolites, Antineoplastic ; Liposomes ; Peptides ; Capecitabine (6804DJ8Z9U) ; Chitosan (9012-76-4) ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1)
Language	English
Publishing date	2020-02-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2020.02.131
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