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  1. Article ; Online: Plausible role of combination of Chlorpromazine hydrochloride and Teicoplanin against COVID-19.

    Sathyamoorthy, NandhaKumar / Chintamaneni, Pavan Kumar / Chinni, Santhivardhan

    Medical hypotheses

    2020  Volume 144, Page(s) 110011

    MeSH term(s) Chlorpromazine/administration & dosage ; Drug Synergism ; Humans ; Hydrogen-Ion Concentration ; Inhibitory Concentration 50 ; Models, Theoretical ; Teicoplanin/administration & dosage ; COVID-19 Drug Treatment
    Chemical Substances Teicoplanin (61036-62-2) ; Chlorpromazine (U42B7VYA4P)
    Keywords covid19
    Language English
    Publishing date 2020-06-20
    Publishing country United States
    Document type Letter
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.110011
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    Zs.A 1132: Show issues Location:
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  2. Article: Plausible role of combination of Chlorpromazine hydrochloride and Teicoplanin against COVID-19

    Sathyamoorthy, NandhaKumar / Chintamaneni, Pavan Kumar / Chinni, Santhivardhan

    Med Hypotheses

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #608983
    Database COVID19

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  3. Article ; Online: Plausible role of combination of Chlorpromazine hydrochloride and Teicoplanin against COVID-19

    Sathyamoorthy, NandhaKumar / Chintamaneni, Pavan Kumar / Chinni, Santhivardhan

    Medical Hypotheses

    2020  Volume 144, Page(s) 110011

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.110011
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Shielding Therapeutic Drug Carriers from the Mononuclear Phagocyte System: A Review.

    Sathyamoorthy, Nandhakumar / Dhanaraju, Magharla Dasaratha

    Critical reviews in therapeutic drug carrier systems

    2016  Volume 33, Issue 6, Page(s) 489–567

    Abstract: The mononuclear phagocyte system (MPS) defends the body against the invasion of microorganisms by phagocytosis. In the presence of opsonins, the invading matter is readily recognized by phagocytes because of the interaction between receptors on the ... ...

    Abstract The mononuclear phagocyte system (MPS) defends the body against the invasion of microorganisms by phagocytosis. In the presence of opsonins, the invading matter is readily recognized by phagocytes because of the interaction between receptors on the phagocytic cell surfaces and the modified conformation of opsonins. The particulate carriers, which are otherwise capable of optimizing drug delivery, are subjected to opsonization and phagocytosis by the MPS immediately following intravenous administration. These drug carriers should remain in the bloodstream in order to spatially locate the drug to the target site and temporally control the drug's release from there on; however, they are devastated by opsonization by serum proteins. Therefore, to restrict opsonization, which is critical for recognition of particulate carriers by the MPS, stealth devices have been developed by engineering the carriers' surface characteristics. Physicochemical properties that influence protein immunogenicity include particle size, surface charge, and surface hydrophobicity. Steric stabilization using polyethylene glycol (PEG) and polyethylene oxide (PEO) chains attached to the particle surface is principally effective in preventing the adsorption of serum opsonins. This article reviews the literature on the MPS and its development and functions, as well as approaches for designing long-circulating carrier particles. It also comprehensively reviews parameters affecting the steric characteristics of drug carriers, such as particle size, shape, surface charge, and surface affinity, including PEGylation of carriers.
    MeSH term(s) Drug Carriers/chemistry ; Humans ; Hydrophobic and Hydrophilic Interactions ; Opsonin Proteins/blood ; Opsonin Proteins/chemistry ; Opsonin Proteins/immunology ; Particle Size ; Phagocytes/immunology ; Phagocytosis ; Polyethylene Glycols/chemistry ; Static Electricity ; Surface Properties
    Chemical Substances Drug Carriers ; Opsonin Proteins ; Polyethylene Glycols (30IQX730WE)
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2012632-3
    ISSN 2162-660X ; 0743-4863
    ISSN (online) 2162-660X
    ISSN 0743-4863
    DOI 10.1615/CritRevTherDrugCarrierSyst.2016012303
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2124: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article ; Online: Effect of surface modification on the In vitro protein adsorption and cell cytotoxicity of vinorelbine nanoparticles

    Nandhakumar Sathyamoorthy / Dhanaraju Dasaratha Magharla / Sundar Devendaran Vankayalu

    Journal of Pharmacy and Bioallied Sciences, Vol 9, Iss 2, Pp 135-

    2017  Volume 143

    Abstract: Context: Nanocarriers possessing long-circulating abilities could take advantage of the pathophysiology of tumor vasculature to achieve spatial placement. To attain such qualities, the drug carriers should possess suitable physicochemical properties such ...

    Abstract Context: Nanocarriers possessing long-circulating abilities could take advantage of the pathophysiology of tumor vasculature to achieve spatial placement. To attain such qualities, the drug carriers should possess suitable physicochemical properties such as size and surface hydrophilicity. Aim: The aim of this study was to prepare poly(ε-caprolactone) nanoparticles (NPs) loaded with vinorelbine bitartrate (VB) and to modify its steric properties using polyethylene glycol and poloxamer. Furthermore, the influence of surface modification of NPs on their physicochemical and cell interactive properties was evaluated. Materials and Methods: NPs were prepared by double emulsion solvent extraction–evaporation technique. The prepared NPs were evaluated for their physicochemical properties, in vitro protein adsorption and cell cytotoxicity. Results and Discussion: The NPs were <250 nm with an entrapment efficiency ranging between 40% and 52%. The zeta potential of the NPs varied from −7.52 mV to −1.27 mV depending on the surface modification. The in vitro release studies exhibited a biphasic pattern with an initial burst release followed by controlled release of the drug over 72 h. The protein adsorption studies revealed that the ability to resist protein adsorption was influenced by the concentration of surface-modifying agents and the amount of proteins available for interaction. The surface-modified NPs produced cell cytotoxicity comparable to free VB at higher concentrations owing to sustained release of the drug into the cellular environment. Conclusion: The results emphasize that surface modification of nanocarriers is an essential and effective tool to dodge opsonization and phagocytosis in the physiological milieu.
    Keywords Cell cytotoxicity ; nanoparticles ; protein adsorption ; surface modification ; vinorelbine ; Pharmacy and materia medica ; RS1-441 ; Analytical chemistry ; QD71-142
    Subject code 500
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Optimization of paclitaxel loaded poly (ε-caprolactone) nanoparticles using Box Behnken design

    Nandhakumar Sathyamoorthy / Dhanaraju Magharla / Pavankumar Chintamaneni / Sundar Vankayalu

    Beni-Suef University Journal of Basic and Applied Sciences, Vol 6, Iss 4, Pp 362-

    2017  Volume 373

    Abstract: Optimization is a critical process in the development of nanoparticles to apprehend the formulation variables and quality attributes. The purpose of this study was to evaluate the influence of formulation variables viz., drug/polymer ratio (A), ... ...

    Abstract Optimization is a critical process in the development of nanoparticles to apprehend the formulation variables and quality attributes. The purpose of this study was to evaluate the influence of formulation variables viz., drug/polymer ratio (A), surfactant concentration (B) and ratio of volume of internal to external phase (C) on the dependent variables (particle size, % EE and zeta potential) of paclitaxel loaded poly (ε-caprolactone) nanoparticles using Box-Behnken design. The nanoparticles were fabricated using emulsion-solvent evaporation technique. The generated polynomial equations, contour plots and response surface plots of the design space were used to analyze the relationship between independent variables and the observed response. An optimal batch was formulated with selected variables (A: +1 level, B: 0 level, C: â1 level) and the prepared nanoparticles were found to have particle size 215.6 µm, zeta potential â7.52 mV and % drug entrapment 86.78%. The observed responses are in close agreement with the predicted values. NPs were spherical with a smooth surface as revealed by morphological studies and the drug-polymer compatibility was established using FTIR and thermal analysis. The drug was released from the NPs in a biphasic pattern with an initial burst release (32.1 %) followed by sustained release (53 %) at the end of 5 d. The in vitro cell cytotoxicity studies on MCF-7 cells showed that the NPs held superior tumor inhibition ability. The results encourage the application of Box-Behnken design for the optimization of critical variables and fabrication of nanoparticles with desirable properties for drug delivery. Keywords: Nanoparticles, Poly (ε-caprolactone), Box-Behnken design, Optimization, Characterization
    Keywords Medicine (General) ; R5-920 ; Science ; Q
    Subject code 620
    Language English
    Publishing date 2017-12-01T00:00:00Z
    Publisher SpringerOpen
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Effect of Surface Modification on the

    Sathyamoorthy, Nandhakumar / Magharla, Dhanaraju Dasaratha / Vankayalu, Sundar Devendaran

    Journal of pharmacy & bioallied sciences

    2016  Volume 9, Issue 2, Page(s) 135–143

    Abstract: Context: Nanocarriers possessing long-circulating abilities could take advantage of the pathophysiology of tumor vasculature to achieve spatial placement. To attain such qualities, the drug carriers should possess suitable physicochemical properties ... ...

    Abstract Context: Nanocarriers possessing long-circulating abilities could take advantage of the pathophysiology of tumor vasculature to achieve spatial placement. To attain such qualities, the drug carriers should possess suitable physicochemical properties such as size and surface hydrophilicity.
    Aim: The aim of this study was to prepare poly(ε-caprolactone) nanoparticles (NPs) loaded with vinorelbine bitartrate (VB) and to modify its steric properties using polyethylene glycol and poloxamer. Furthermore, the influence of surface modification of NPs on their physicochemical and cell interactive properties was evaluated.
    Materials and methods: NPs were prepared by double emulsion solvent extraction-evaporation technique. The prepared NPs were evaluated for their physicochemical properties,
    Results and discussion: The NPs were <250 nm with an entrapment efficiency ranging between 40% and 52%. The zeta potential of the NPs varied from -7.52 mV to -1.27 mV depending on the surface modification. The
    Conclusion: The results emphasize that surface modification of nanocarriers is an essential and effective tool to dodge opsonization and phagocytosis in the physiological milieu.
    Language English
    Publishing date 2016-03-28
    Publishing country India
    Document type Journal Article
    ZDB-ID 2573569-X
    ISSN 0975-7406 ; 0976-4879
    ISSN (online) 0975-7406
    ISSN 0976-4879
    DOI 10.4103/jpbs.JPBS_258_16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Influence of surface charge on the in vitro protein adsorption and cell cytotoxicity of paclitaxel loaded poly(ε-caprolactone) nanoparticles

    Nandhakumar, Sathyamoorthy / Dhanaraju, Magharla Dasaratha / Sundar, Vankayalu Devendran / Heera, Battu

    Bulletin of Faculty of Pharmacy, Cairo University. 2017,

    2017  

    Abstract: The biokinetic fate of polymeric nanoparticles in the physiological milieu is strongly influenced by its properties such as size, surface charge and surface affinity. The electrostatic properties of the polymeric nanoparticles and, thereby, the reliant ... ...

    Abstract The biokinetic fate of polymeric nanoparticles in the physiological milieu is strongly influenced by its properties such as size, surface charge and surface affinity. The electrostatic properties of the polymeric nanoparticles and, thereby, the reliant properties such as cellular interactions, reactivity and toxicity, can be tailored by modulating the surface charge. Therefore, the present study aimed at studying the influence of surface charge on the physicochemical properties, in vitro protein adsorption and cell cytotoxicity of poly(ε-caprolactone) (PCL) nanoparticles (NPs). Paclitaxel loaded PCL nanoparticles were obtained by emulsion solvent evaporation extraction technique and differently charged using ionic surfactants. The NPs were characterized for size, zeta potential, morphology, entrapment and release. In vitro protein adsorption and cytotoxicity of NPs with different surface charge was investigated. The prepared NPs were rounded with a smooth surface and had a particle size less than 250nm with narrow distribution and high entrapment efficiency (>80%). The zeta potential of the particles varied between −22mV and +16mV depending on its composition. The in vitro protein adsorption studies revealed that positively charged NPs adsorbed more proteins than other formulations. The cytotoxicity studies on MCF-7 cells exhibited that positively charged NPs engender the highest cell inhibition due to preferential uptake based on electrostatic interactions with cell membranes. The results suggest that surface charge could be undeniably significant in determining the protein adsorption and cellular interactions and must be intently considered during the design of colloidal particles to impart better performance in the physiological system.
    Keywords Poly(ε-caprolactone) ; Nanoparticles ; Surface charge ; Protein adsorption ; Cytotoxicity
    Language English
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 2638130-8
    ISSN 1110-0931
    ISSN 1110-0931
    DOI 10.1016/j.bfopcu.2017.06.003
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: FABRICATION AND CHARACTERIZATION OF ETOPOSIDE LOADED MAGNETIC POLYMERIC MICROPARTICLES

    Vankayalu Devendiran Sundar / Magharla Dasaratha Dhanaraju / Nandhakumar Sathyamoorthy

    International Journal of Drug Delivery, Vol 6, Iss 1, Pp 24-

    2014  Volume 35

    Abstract: The purpose of this study is to develop a targeted drug carrier system. Magnetic poly (ε-caprolactone) (PCL) microspheres were prepared using classical oil-in-water solvent evaporation method by loading magnetite nanoparticles and anticancer drug ... ...

    Abstract The purpose of this study is to develop a targeted drug carrier system. Magnetic poly (ε-caprolactone) (PCL) microspheres were prepared using classical oil-in-water solvent evaporation method by loading magnetite nanoparticles and anticancer drug etoposide. The prepared magnetic microspheres were smooth, free flowing, individual and homogenous in nature. Fourier transformed infrared spectroscopy studies revealed the absence of any potential incompatibility of drug with other excipients. DSC studies were conducted to study the state of etoposide in the formulation. Further the magnetic microspheres were characterized for entrapment efficiency, drug loading, invitro release studies and subjected to particle size analysis and scanning electron microscopy. The magnetite nanoparticles were well dispersed in polymer matrix, which are responsible for magnetic response. The magnetic property of the prepared microspheres was measured by using vibrating sample magnetometer. The amount of magnetite in the formulation was estimated quantitatively by atomic absorption spectroscopy which was about 31.5%. The experimental results proved that the magnetic microspheres exhibited superparamagnetic behavior and the saturation magnetization was 7.26 emu/g. The optimized formulations exhibited a narrow size distribution which were below 10 μm and are evident from SEM analysis. Formulation batches prepared with drug/polymer ratio 1:10 showed a maximum encapsulation efficiency and the invitro release profile in phosphate buffer (pH 7.4) solution showed an extended release of etoposide up to 76.25% at the end of 21 day. Histopathological studies proved that the etoposide loaded magnetic microspheres were nontoxic and safe.
    Keywords poly (ε-caprolactone) ; solvent evaporation ; superparamagnetic ; saturation magnetization ; Pharmacy and materia medica ; RS1-441 ; Medicine ; R
    Subject code 500
    Language English
    Publishing date 2014-03-01T00:00:00Z
    Publisher Advanced Research Journals
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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