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  1. Article ; Online: Employing non-canonical amino acids towards the immobilization of a hyperthermophilic enzyme to increase protein stability.

    Switzer, Hannah J / Howard, Christina A / Halonski, John F / Peairs, Emily M / Smith, Nolan / Zamecnik, Maddy P / Verma, Sanjana / Young, Douglas D

    RSC advances

    2023  Volume 13, Issue 13, Page(s) 8496–8501

    Abstract: A carboxylesterase derived ... ...

    Abstract A carboxylesterase derived from
    Language English
    Publishing date 2023-03-14
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra00392b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Implementation of rapid genomic sequencing in safety-net neonatal intensive care units: protocol for the VIrtual GenOme CenteR (VIGOR) proof-of-concept study.

    D'Gama, Alissa M / Hills, Sonia / Douglas, Jessica / Young, Vanessa / Genetti, Casie A / Wojcik, Monica H / Feldman, Henry A / Yu, Timothy W / G Parker, Margaret / Agrawal, Pankaj B

    BMJ open

    2024  Volume 14, Issue 2, Page(s) e080529

    Abstract: Introduction: Rapid genomic sequencing (rGS) in critically ill infants with suspected genetic disorders has high diagnostic and clinical utility. However, rGS has primarily been available at large referral centres with the resources and expertise to ... ...

    Abstract Introduction: Rapid genomic sequencing (rGS) in critically ill infants with suspected genetic disorders has high diagnostic and clinical utility. However, rGS has primarily been available at large referral centres with the resources and expertise to offer state-of-the-art genomic care. Critically ill infants from racial and ethnic minority and/or low-income populations disproportionately receive care in safety-net and/or community settings lacking access to state-of-the-art genomic care, contributing to unacceptable health equity gaps. VIrtual GenOme CenteR is a 'proof-of-concept' implementation science study of an innovative delivery model for genomic care in safety-net neonatal intensive care units (NICUs).
    Methods and analysis: We developed a virtual genome centre at a referral centre to remotely support safety-net NICU sites predominantly serving racial and ethnic minority and/or low-income populations and have limited to no access to rGS. Neonatal providers at each site receive basic education about genomic medicine from the study team and identify eligible infants. The study team enrols eligible infants (goal n of 250) and their parents and follows families for 12 months. Enrolled infants receive rGS, the study team creates clinical interpretive reports to guide neonatal providers on interpreting results, and neonatal providers return results to families. Data is collected via (1) medical record abstraction, (2) surveys, interviews and focus groups with neonatal providers and (3) surveys and interviews with families. We aim to examine comprehensive implementation outcomes based on the Proctor Implementation Framework using a mixed methods approach.
    Ethics and dissemination: This study is approved by the institutional review board of Boston Children's Hospital (IRB-P00040496) and participating sites. Participating families are required to provide electronic written informed consent and neonatal provider consent is implied through the completion of surveys. The results will be disseminated via peer-reviewed publications and data will be made accessible per National Institutes of Health (NIH) policies.
    Trial registration number: NCT05205356/clinicaltrials.gov.
    MeSH term(s) Infant, Newborn ; Infant ; Child ; Humans ; Intensive Care Units, Neonatal ; Ethnicity ; Critical Illness ; Minority Groups ; Genomics
    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-080529
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  3. Article ; Online: Playing with the Molecules of Life.

    Young, Douglas D / Schultz, Peter G

    ACS chemical biology

    2018  Volume 13, Issue 4, Page(s) 854–870

    Abstract: Our understanding of the complex molecular processes of living organisms at the molecular level is growing exponentially. This knowledge, together with a powerful arsenal of tools for manipulating the structures of macromolecules, is allowing chemists to ...

    Abstract Our understanding of the complex molecular processes of living organisms at the molecular level is growing exponentially. This knowledge, together with a powerful arsenal of tools for manipulating the structures of macromolecules, is allowing chemists to to harness and reprogram the cellular machinery in ways previously unimaged. Here we review one example in which the genetic code itself has been expanded with new building blocks that allow us to probe and manipulate the structures and functions of proteins with unprecedented precision.
    MeSH term(s) Directed Molecular Evolution ; Genetic Code/genetics ; Protein Engineering/methods ; Proteins/genetics ; Proteins/therapeutic use
    Chemical Substances Proteins
    Language English
    Publishing date 2018-03-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ISSN 1554-8937
    ISSN (online) 1554-8937
    DOI 10.1021/acschembio.7b00974
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Tracing metabolic flux through time and space with isotope labeling experiments

    Allen, Douglas K / Young, Jamey D

    Current opinion in biotechnology. 2020 Aug., v. 64

    2020  

    Abstract: Metabolism is dynamic and must function in context-specific ways to adjust to changes in the surrounding cellular and ecological environment. When isotopic tracers are used, metabolite flow (i.e. metabolic flux) can be quantified through biochemical ... ...

    Abstract Metabolism is dynamic and must function in context-specific ways to adjust to changes in the surrounding cellular and ecological environment. When isotopic tracers are used, metabolite flow (i.e. metabolic flux) can be quantified through biochemical networks to assess metabolic pathway operation. The cellular activities considered across multiple tissues and organs result in the observed phenotype and can be analyzed to discover emergent, whole-system properties of biology and elucidate misconceptions about network operation. However, temporal and spatial challenges remain significant hurdles and require novel approaches and creative solutions. We survey current investigations in higher plant and animal systems focused on dynamic isotope labeling experiments, spatially resolved measurement strategies, and observations from re-analysis of our own studies that suggest prospects for future work. Related discoveries will be necessary to push the frontier of our understanding of metabolism to suggest novel solutions to cure disease and feed a growing future world population.
    Keywords biochemical pathways ; isotope labeling ; metabolism ; metabolites ; phenotype ; surveys
    Language English
    Dates of publication 2020-08
    Size p. 92-100.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1052045-4
    ISSN 1879-0429 ; 0958-1669
    ISSN (online) 1879-0429
    ISSN 0958-1669
    DOI 10.1016/j.copbio.2019.11.003
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3071: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: In silico

    Algarni, Suad / Han, Jing / Gudeta, Dereje D / Khajanchi, Bijay K / Ricke, Steven C / Kwon, Young Min / Rhoads, Douglas D / Foley, Steven L

    Frontiers in microbiology

    2023  Volume 13, Page(s) 1095128

    Abstract: Introduction: The antimicrobial resistance (AMR) mobilome plays a key role in the dissemination of resistance genes encoded by mobile genetics elements (MGEs) including plasmids, transposons (Tns), and insertion sequences (ISs). These MGEs contribute to ...

    Abstract Introduction: The antimicrobial resistance (AMR) mobilome plays a key role in the dissemination of resistance genes encoded by mobile genetics elements (MGEs) including plasmids, transposons (Tns), and insertion sequences (ISs). These MGEs contribute to the dissemination of multidrug resistance (MDR) in enteric bacterial pathogens which have been considered as a global public health risk.
    Methods: To further understand the diversity and distribution of AMR genes and MGEs across different plasmid types, we utilized multiple sequence-based computational approaches to evaluate AMR-associated plasmid genetics. A collection of 1,309 complete plasmid sequences from Gammaproteobacterial species, including 100 plasmids from each of the following 14 incompatibility (Inc) types: A/C, BO, FIA, FIB, FIC, FIIA, HI1, HI2, I1, K, M, N, P except W, where only 9 sequences were available, was extracted from the National Center for Biotechnology Information (NCBI) GenBank database using BLAST tools. The extracted FASTA files were analyzed using the AMRFinderPlus web-based tools to detect antimicrobial, disinfectant, biocide, and heavy metal resistance genes and ISFinder to identify IS/Tn MGEs within the plasmid sequences.
    Results and discussion: In silico
    Language English
    Publishing date 2023-01-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.1095128
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  6. Article ; Online: Recommendations on the Use of Multiple Labels in Human Mass Balance Studies.

    Cuyckens, Filip / Hvenegaard, Mette G / Cassidy, Kenneth C / Spracklin, Douglas K / James, Alexander D / Pedersen, Mette L / Scarfe, Graeme / Wagner, David S / Georgi, Katrin / Schulz, Simone I / Schieferstein, Hanno / Bjornsdottir, Inga / Romeo, Andrea A / Da Violante, Georges / Blech, Stefan / Moliner, Patricia / Young, Graeme C

    Drug metabolism and disposition: the biological fate of chemicals

    2024  Volume 52, Issue 3, Page(s) 153–158

    Abstract: The administration of radiolabeled drug candidates is considered the gold standard in absorption, distribution, metabolism, and excretion studies for small-molecule drugs since it allows facile and accurate quantification of parent drug, metabolites, and ...

    Abstract The administration of radiolabeled drug candidates is considered the gold standard in absorption, distribution, metabolism, and excretion studies for small-molecule drugs since it allows facile and accurate quantification of parent drug, metabolites, and total drug-related material independent of the compound structure. The choice of the position of the radiolabel, typically
    MeSH term(s) Humans ; Pharmaceutical Preparations/metabolism ; Metabolic Clearance Rate ; Biotransformation
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 186795-7
    ISSN 1521-009X ; 0090-9556
    ISSN (online) 1521-009X
    ISSN 0090-9556
    DOI 10.1124/dmd.123.001429
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1014: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Pick-and-eat space crop production flight testing on the International Space Station

    Jess M. Bunchek / Mary E. Hummerick / LaShelle E. Spencer / Matthew W. Romeyn / Millennia Young / Robert C. Morrow / Cary A. Mitchell / Grace L. Douglas / Raymond M. Wheeler / Gioia D. Massa

    Journal of Plant Interactions, Vol 19, Iss

    2024  Volume 1

    Abstract: ABSTRACTFresh, nutritious, palatable produce for crew consumption on long-duration spaceflight missions may provide health-promoting, bioavailable nutrients and enhance the dietary experience. VEG-04A and VEG-04B explored growing leafy greens on the ... ...

    Abstract ABSTRACTFresh, nutritious, palatable produce for crew consumption on long-duration spaceflight missions may provide health-promoting, bioavailable nutrients and enhance the dietary experience. VEG-04A and VEG-04B explored growing leafy greens on the International Space Station using the Veggie Vegetable Production System. Two flight tests with ground controls were conducted in 2019 growing mizuna mustard, where Veggie chambers were set to different red-to-blue-to-green light formulations. Light quality affects plant growth, nutrition, microbiology, and organoleptic characteristics on Earth, and we examined how these vary in microgravity and under different harvest scenarios. Astronauts harvested and weighed mizuna and completed organoleptic evaluations. Flight samples were returned to Earth for nutritional quality and microbial food safety analyses. Yield and chemistry differed between ground and flight samples and light treatments, and bacterial and fungal counts were lower in ground than in flight samples. This research helps increase our understanding of the requirements for growing high-quality crops in spaceflight.
    Keywords Food safety ; International Space Station ; nutrition ; plant growth ; space-crop production ; Veggie ; Plant culture ; SB1-1110 ; Plant ecology ; QK900-989
    Subject code 580
    Language English
    Publishing date 2024-12-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Immersive Cooling in the Prehospital Setting for Heat Stroke: A Case Report.

    Young, Douglas / Everitt, Bryan / Fine, Brandon / Miramontes, David

    Prehospital emergency care

    2023  Volume 27, Issue 6, Page(s) 838–840

    Abstract: Non-exertional heat stroke is defined as exposure to high outdoor temperatures, core body temperature >40 °C, and alteration of mentation. Early identification and treatment are imperative to reduce morbidity and mortality in these patients. Cold water ... ...

    Abstract Non-exertional heat stroke is defined as exposure to high outdoor temperatures, core body temperature >40 °C, and alteration of mentation. Early identification and treatment are imperative to reduce morbidity and mortality in these patients. Cold water immersion therapy is the most efficient and efficacious modality in treating heat stroke, yet it is rarely initiated in the prehospital setting. We outline a case of an 82-year-old man found unconscious outside during a regional heat wave with a temperature >107 °F. He was treated with cold water immersion using a body bag in the back of the ambulance and cooled to 104.1 °F during transport. During the 9-minute transport, the patient regained consciousness, followed basic commands, and answered basic questions. This case highlights the novel use of body bag cold water immersion as early initiation of treatment for heat stroke patients.
    MeSH term(s) Male ; Humans ; Aged, 80 and over ; Exercise ; Emergency Medical Services ; Heat Stroke/therapy ; Cold Temperature ; Body Temperature ; Water ; Immersion
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2023-04-27
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1461751-1
    ISSN 1545-0066 ; 1090-3127
    ISSN (online) 1545-0066
    ISSN 1090-3127
    DOI 10.1080/10903127.2023.2201515
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4762: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Book ; Online: High Accuracy and Low Regret for User-Cold-Start Using Latent Bandits

    Young, David / Leith, Douglas

    2023  

    Abstract: We develop a novel latent-bandit algorithm for tackling the cold-start problem for new users joining a recommender system. This new algorithm significantly outperforms the state of the art, simultaneously achieving both higher accuracy and lower regret. ; ...

    Abstract We develop a novel latent-bandit algorithm for tackling the cold-start problem for new users joining a recommender system. This new algorithm significantly outperforms the state of the art, simultaneously achieving both higher accuracy and lower regret.

    Comment: 7 pages, 7 figures, Esann 2022 conference
    Keywords Computer Science - Information Retrieval ; Computer Science - Machine Learning
    Publishing date 2023-05-12
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Modeling and multiobjective optimization of indoor airborne disease transmission risk and associated energy consumption for building HVAC systems.

    Risbeck, Michael J / Bazant, Martin Z / Jiang, Zhanhong / Lee, Young M / Drees, Kirk H / Douglas, Jonathan D

    Energy and buildings

    2021  Volume 253, Page(s) 111497

    Abstract: The COVID-19 pandemic has renewed interest in assessing how the operation of HVAC systems influences the risk of airborne disease transmission in buildings. Various processes, such as ventilation and filtration, have been shown to reduce the probability ... ...

    Abstract The COVID-19 pandemic has renewed interest in assessing how the operation of HVAC systems influences the risk of airborne disease transmission in buildings. Various processes, such as ventilation and filtration, have been shown to reduce the probability of disease spread by removing or deactivating exhaled aerosols that potentially contain infectious material. However, such qualitative recommendations fail to specify
    Language English
    Publishing date 2021-09-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1502295-x
    ISSN 0378-7788
    ISSN 0378-7788
    DOI 10.1016/j.enbuild.2021.111497
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