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Article ; Online: Reply.

Takeda, Yoshiyu

2019 Volume 37, Issue 10, Page(s) 2110–2111

MeSH term(s)	Adrenocorticotropic Hormone ; Humans ; Hyperaldosteronism
Chemical Substances	Adrenocorticotropic Hormone (9002-60-2)
Language	English
Publishing date	2019-08-29
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	605532-1
ISSN	1473-5598 ; 0263-6352 ; 0952-1178
ISSN (online)	1473-5598
ISSN	0263-6352 ; 0952-1178
DOI	10.1097/HJH.0000000000002196
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1885: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 614: Show issues

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Article ; Online: Molecular and Epigenetic Control of Aldosterone Synthase, CYP11B2 and 11-Hydroxylase, CYP11B1.

Takeda, Yoshimichi / Demura, Masashi / Kometani, Mitsuhiro / Karashima, Shigehiro / Yoneda, Takashi / Takeda, Yoshiyu

International journal of molecular sciences

2023 Volume 24, Issue 6

Abstract: Aldosterone and cortisol serve important roles in the pathogenesis of cardiovascular diseases and metabolic disorders. Epigenetics is a mechanism to control enzyme expression by genes without changing the gene sequence. Steroid hormone synthase gene ... ...

Abstract	Aldosterone and cortisol serve important roles in the pathogenesis of cardiovascular diseases and metabolic disorders. Epigenetics is a mechanism to control enzyme expression by genes without changing the gene sequence. Steroid hormone synthase gene expression is regulated by transcription factors specific to each gene, and methylation has been reported to be involved in steroid hormone production and disease. Angiotensin II or potassium regulates the aldosterone synthase gene,
MeSH term(s)	Humans ; Cytochrome P-450 CYP11B2/genetics ; Cytochrome P-450 CYP11B2/metabolism ; Steroid 11-beta-Hydroxylase/genetics ; Steroid 11-beta-Hydroxylase/metabolism ; Aldosterone/metabolism ; Mixed Function Oxygenases/genetics ; Hydrocortisone/metabolism ; Angiotensin II/metabolism ; Adrenocortical Adenoma/genetics ; Adenoma/pathology ; Epigenesis, Genetic ; Transcription Factors/metabolism ; Potassium/metabolism ; DNA
Chemical Substances	Cytochrome P-450 CYP11B2 (EC 1.14.15.4) ; Steroid 11-beta-Hydroxylase (EC 1.14.15.4) ; Aldosterone (4964P6T9RB) ; Mixed Function Oxygenases (EC 1.-) ; Hydrocortisone (WI4X0X7BPJ) ; Angiotensin II (11128-99-7) ; Transcription Factors ; Potassium (RWP5GA015D) ; DNA (9007-49-2)
Language	English
Publishing date	2023-03-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24065782
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: DNA Methylation of the Angiotensinogen Gene,

Takeda, Yoshimichi / Demura, Masashi / Yoneda, Takashi / Takeda, Yoshiyu

International journal of molecular sciences

2021 Volume 22, Issue 9

Abstract: Angiotensinogen (AGT) and aldosterone play key roles in the regulation of blood pressure and are implicated in the pathogenesis of cardiovascular diseases. DNA methylation typically acts to repress gene transcription. The aldosterone synthase ... ...

Abstract	Angiotensinogen (AGT) and aldosterone play key roles in the regulation of blood pressure and are implicated in the pathogenesis of cardiovascular diseases. DNA methylation typically acts to repress gene transcription. The aldosterone synthase gene
MeSH term(s)	Aldosterone ; Angiotensin II ; Angiotensinogen/genetics ; Angiotensinogen/metabolism ; CCAAT-Enhancer-Binding Proteins/genetics ; CCAAT-Enhancer-Binding Proteins/metabolism ; Cardiovascular Diseases/genetics ; Cytochrome P-450 CYP11B2/genetics ; Cytochrome P-450 CYP11B2/metabolism ; DNA Methylation/genetics ; Epigenesis, Genetic/drug effects ; Gene Expression/genetics ; Gene Expression Regulation/genetics ; Humans ; Hypertension/genetics ; Promoter Regions, Genetic/drug effects ; Transcription Factors/metabolism
Chemical Substances	CCAAT-Enhancer-Binding Proteins ; Transcription Factors ; Angiotensinogen (11002-13-4) ; Angiotensin II (11128-99-7) ; Aldosterone (4964P6T9RB) ; Cytochrome P-450 CYP11B2 (EC 1.14.15.4)
Language	English
Publishing date	2021-04-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22094587
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Article ; Online: Molecular and Epigenetic Control of Aldosterone Synthase, CYP11B2 and 11-Hydroxylase, CYP11B1

Yoshimichi Takeda / Masashi Demura / Mitsuhiro Kometani / Shigehiro Karashima / Takashi Yoneda / Yoshiyu Takeda

International Journal of Molecular Sciences, Vol 24, Iss 5782, p

2023 Volume 5782

Abstract	Aldosterone and cortisol serve important roles in the pathogenesis of cardiovascular diseases and metabolic disorders. Epigenetics is a mechanism to control enzyme expression by genes without changing the gene sequence. Steroid hormone synthase gene expression is regulated by transcription factors specific to each gene, and methylation has been reported to be involved in steroid hormone production and disease. Angiotensin II or potassium regulates the aldosterone synthase gene, CYP11B2 . The adrenocorticotropic hormone controls the 11b-hydroxylase, CYP11B1 . DNA methylation negatively controls the CYP11B2 and CYP11B1 expression and dynamically changes the expression responsive to continuous stimulation of the promoter gene. Hypomethylation status of the CYP11B2 promoter region is seen in aldosterone-producing adenomas. Methylation of recognition sites of transcription factors, including cyclic AMP responsive element binding protein 1 or nerve growth factor-induced clone B, diminish their DNA-binding activity. A methyl-CpG-binding protein 2 cooperates directly with the methylated CpG dinucleotides of CYP11B2 . A low-salt diet, treatment with angiotensin II, and potassium increase the CYP11B2 mRNA levels and induce DNA hypomethylation in the adrenal gland. A close association between a low DNA methylation ratio and an increased CYP11B1 expression is seen in Cushing’s adenoma and aldosterone-producing adenoma with autonomous cortisol secretion. Epigenetic control of CYP11B2 or CYP11B1 plays an important role in autonomic aldosterone or cortisol synthesis.
Keywords	aldosterone ; cortisol ; methylation ; adrenal gland ; hormone-producing adenoma ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	570
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: DNA Methylation of the Angiotensinogen Gene, AGT and the Aldosterone Synthase Gene, CYP11B2 in Cardiovascular Diseases

Yoshimichi Takeda / Masashi Demura / Takashi Yoneda / Yoshiyu Takeda

International Journal of Molecular Sciences, Vol 22, Iss 4587, p

2021 Volume 4587

Abstract	Angiotensinogen (AGT) and aldosterone play key roles in the regulation of blood pressure and are implicated in the pathogenesis of cardiovascular diseases. DNA methylation typically acts to repress gene transcription. The aldosterone synthase gene CYP11B2 is regulated by angiotensin II and potassium. DNA methylation negatively regulates AGT and CYP11B2 expression and dynamically changes in response to continuous promoter stimulation of each gene. High salt intake and excess circulating aldosterone cause DNA demethylation around the CCAAT-enhancer-binding-protein (CEBP) sites of the CYP11B2 promoter region, thereby converting the phenotype of AGT expression from an inactive to an active state in visceral adipose tissue and heart. A close association exists between low DNA methylation at CEBP-binding sites and increased AGT expression in salt-sensitive hypertensive rats. Salt-dependent hypertension may be partially affected by increased cardiac AGT expression. CpG dinucleotides in the CYP11B2 promoter are hypomethylated in aldosterone-producing adenomas. Methylation of recognition sequences of transcription factors, including CREB1, NGFIB (NR4A1), and NURR1 (NR4A2) diminish their DNA-binding activity. The methylated CpG-binding protein MECP2 interacts directly with the methylated CYP11B2 promoter. Low salt intake and angiotensin II infusion lead to upregulation of CYP11B2 expression and DNA hypomethylation in the adrenal gland. Treatment with the angiotensin II type 1 receptor antagonist decreases CYP11B2 expression and leads to DNA hypermethylation. A close association between low DNA methylation and increased CYP11B2 expression are seen in the hearts of patients with hypertrophic cardiomyopathy. These results indicate that epigenetic regulation of both AGT and CYP11B2 contribute to the pathogenesis of cardiovascular diseases.
Keywords	angiotensinogen ; aldosterone ; methylation ; cardiovascular disease ; salt ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	570
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Adrenal Hemorrhaging in a Patient with Severe Obstructive Sleep Apnea Syndrome with Elevated Plasma ACTH Levels.

Sawamura, Toshitaka / Karashima, Shigehiro / Aono, Daisuke / Ohmori, Ai / Kometani, Mitsuhiro / Takeda, Yoshiyu / Yoneda, Takashi

Internal medicine (Tokyo, Japan)

2022 Volume 62, Issue 15, Page(s) 2205–2208

Abstract: Adrenal hemorrhaging (AH) is a rare condition characterized by bleeding into the suprarenal glands. A 62-year-old man with untreated obstructive sleep apnea syndrome (OSAS) was admitted to our hospital complaining of abdominal stiffness. He was diagnosed ...

Abstract	Adrenal hemorrhaging (AH) is a rare condition characterized by bleeding into the suprarenal glands. A 62-year-old man with untreated obstructive sleep apnea syndrome (OSAS) was admitted to our hospital complaining of abdominal stiffness. He was diagnosed with left-sided AH and underwent adrenalectomy. Pre- and post-surgery, elevated plasma adrenocorticotropic hormone (ACTH) levels were observed. However, Cushing's syndrome and adrenal insufficiency were negative, and nasal continuous positive airway pressure (CPAP) normalized the plasma ACTH levels. Elevated ACTH levels are reportedly present in patients with OSAS. ACTH may be associated with the development of AH through the change in blood supply and other mechanisms.
MeSH term(s)	Male ; Humans ; Middle Aged ; Cushing Syndrome/complications ; Cushing Syndrome/diagnosis ; Adrenal Glands/diagnostic imaging ; Adrenal Glands/surgery ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/therapy ; Adrenalectomy ; Adrenocorticotropic Hormone ; Hemorrhage/etiology ; Hydrocortisone
Chemical Substances	Adrenocorticotropic Hormone (9002-60-2) ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2022-12-14
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.0895-22
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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome Worsen after the Administration of Dulaglutide

Toshitaka Sawamura / Shigehiro Karashima / Ai Ohmori / Kei Sawada / Mitsuhiro Kometani / Yoshiyu Takeda / Takashi Yoneda

Medicina, Vol 58, Iss 289, p

2022 Volume 289

Abstract: Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome is characterized by symmetrical polyarthritis and limb pitting edema. Although the detailed mechanisms of this syndrome have not been clearly understood, some agents ... ...

Abstract	Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome is characterized by symmetrical polyarthritis and limb pitting edema. Although the detailed mechanisms of this syndrome have not been clearly understood, some agents including dipeptidyl peptidase-4 inhibitors have been reported to induce RS3PE syndrome. However, glucagon-like peptide-1 (GLP-1) analogues have not been reported to be associated with this syndrome. A 91-year-old woman was admitted to our hospital with complaints of severe polyarthritis and limb edema. She was diagnosed with RS3PE syndrome. Oral prednisolone improved her symptoms. However, her symptoms worsened after the administration of dulaglutide, with elevated serum inflammatory markers. Discontinuation of dulaglutide without additional treatment improved her symptoms and laboratory findings. This case might indicate the possibility of development and worsening of RS3PE syndrome caused after GLP-1 analogue.
Keywords	RS3PE syndrome ; GLP-1 analogue ; dulaglutide ; Medicine (General) ; R5-920
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Fulminant type 1 diabetes developed after influenza split vaccination.

Sawamura, Toshitaka / Karashima, Shigehiro / Ohmori, Ai / Sawada, Kei / Aono, Daisuke / Kometani, Mitsuhiro / Takeda, Yoshiyu / Yoneda, Takashi

Endocrinology, diabetes & metabolism case reports

2023 Volume 2023, Issue 2

Abstract: Summary: Fulminant type 1 diabetes (FT1D) is a subtype of diabetes characterized by rapid progression of β-cell destruction, hyperglycemia, and diabetic ketoacidosis (DKA). The pathogenesis of this disease remains unclear. However, viral infections, HLA ...

Abstract	Summary: Fulminant type 1 diabetes (FT1D) is a subtype of diabetes characterized by rapid progression of β-cell destruction, hyperglycemia, and diabetic ketoacidosis (DKA). The pathogenesis of this disease remains unclear. However, viral infections, HLA genes, and immune checkpoint inhibitor use were reportedly involved in this disease. A 51-year-old Japanese man with no chronic medical condition was admitted to our hospital with complaints of nausea and vomiting. Cough, sore throat, nasal discharge, and diarrhea were not noted. He had a medical history of at least two influenza infections. His vaccination history was notable for receiving an inactive split influenza vaccine 12 days prior to developing these symptoms. He was diagnosed with DKA associated with FT1D. His HLA class II genotypes were nonsusceptible to FT1D, and he had a negative history of immune checkpoint inhibitor use. The destruction of the pancreas by cytotoxic T cells is reported to be involved in FT1D. Inactive split influenza vaccines do not directly activate cytotoxic T cells. However, these could activate the redifferentiation of memory CD8-positive T cells into cytotoxic T cells and induce FT1D, as this patient had a history of influenza infections. Learning points: Influenza split vaccination could cause fulminant type 1 diabetes (FT1D). The mechanism of influenza split vaccine-induced FT1D might be through the redifferentiation of CD8-positive memory T cells into cytotoxic T cells.
Language	English
Publishing date	2023-05-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2785530-2
ISSN	2052-0573
ISSN	2052-0573
DOI	10.1530/EDM-22-0342
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Article: Using telemedicine to manage a patient with a hypertensive emergency due to pheochromocytoma.

Konishi, Seigo / Kometani, Mitsuhiro / Aiga, Ko / Aono, Daisuke / Nohara, Takahiro / Ikeda, Hiroko / Karashima, Shigehiro / Takeda, Yoshiyu / Yoneda, Takashi

Endocrinology, diabetes & metabolism case reports

2023 Volume 2023, Issue 3

Abstract: Summary: The COVID-19 pandemic has led to the emergence of telemedicine on a global scale. In endocrinology, telemedicine has mainly been used in relation to chronic diseases, including diabetes. Herein, we report the case of an 18-year-old woman with a ...

Abstract	Summary: The COVID-19 pandemic has led to the emergence of telemedicine on a global scale. In endocrinology, telemedicine has mainly been used in relation to chronic diseases, including diabetes. Herein, we report the case of an 18-year-old woman with a hypertensive emergency due to a pheochromocytoma who was quickly diagnosed and treated using telemedicine. The patient was referred to a cardiovascular hospital because of fatigue and sweating that did not improve with carvedilol. She had fluctuating blood pressure and tachycardia. Subsequently, since her thyroid function was normal, endocrine hypertension not due to thyroid dysfunction was suspected; a case consultation was made by phone to our clinic. Plain computed tomography (CT) was recommended owing to the high possibility of a pheochromocytoma; the CT scan showed an adrenal tumor with a 30 mm diameter. To assess her condition, endocrinologists, together with the attending doctor, interviewed her and her family directly using an online tool to obtain detailed information. We thus determined that she was at risk of a pheochromocytoma crisis. She was transferred to our hospital immediately for treatment, was diagnosed with pheochromocytoma, and underwent surgery. Telemedicine, especially involving doctor-to-patient with doctor consultations, can be effective in treating rare and emergent medical conditions such as pheochromocytoma crisis. Learning points: Telemedicine can be used for chronic diseases and emergency conditions. Online doctor-to-patient with doctor (D-to-P with D) consultations are useful when the expert opinion of a highly specialized physician present in a different geographical location is required. Telemedicine, especially D-to-P with D online consultations, can be effectively used for the diagnosis of rare and emergent medical conditions, such as pheochromocytoma crisis.
Language	English
Publishing date	2023-07-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2785530-2
ISSN	2052-0573
ISSN	2052-0573
DOI	10.1530/EDM-23-0033
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Article ; Online: Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome Worsen after the Administration of Dulaglutide.

Sawamura, Toshitaka / Karashima, Shigehiro / Ohmori, Ai / Sawada, Kei / Kometani, Mitsuhiro / Takeda, Yoshiyu / Yoneda, Takashi

Medicina (Kaunas, Lithuania)

2022 Volume 58, Issue 2

Abstract	Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome is characterized by symmetrical polyarthritis and limb pitting edema. Although the detailed mechanisms of this syndrome have not been clearly understood, some agents including dipeptidyl peptidase-4 inhibitors have been reported to induce RS3PE syndrome. However, glucagon-like peptide-1 (GLP-1) analogues have not been reported to be associated with this syndrome. A 91-year-old woman was admitted to our hospital with complaints of severe polyarthritis and limb edema. She was diagnosed with RS3PE syndrome. Oral prednisolone improved her symptoms. However, her symptoms worsened after the administration of dulaglutide, with elevated serum inflammatory markers. Discontinuation of dulaglutide without additional treatment improved her symptoms and laboratory findings. This case might indicate the possibility of development and worsening of RS3PE syndrome caused after GLP-1 analogue.
MeSH term(s)	Aged, 80 and over ; Edema/chemically induced ; Female ; Glucagon-Like Peptides/analogs & derivatives ; Humans ; Immunoglobulin Fc Fragments ; Recombinant Fusion Proteins ; Synovitis/chemically induced ; Synovitis/diagnosis ; Synovitis/drug therapy
Chemical Substances	Immunoglobulin Fc Fragments ; Recombinant Fusion Proteins ; Glucagon-Like Peptides (62340-29-8) ; dulaglutide (WTT295HSY5)
Language	English
Publishing date	2022-02-14
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina58020289
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 6270: Show issues

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