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Article ; Online: Progress in the evaluation of modified vaccinia Ankara vaccine against mpox.

Mazzotta, Valentina / Matusali, Giulia / Oliva, Alessandra / Maggi, Fabrizio / Antinori, Andrea

2023 Volume 23, Issue 11, Page(s) 1214–1215

MeSH term(s)	Humans ; Vaccinia/prevention & control ; Mpox (monkeypox) ; Vaccinia virus ; Viral Vaccines
Chemical Substances	Viral Vaccines
Language	English
Publishing date	2023-07-17
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2061641-7
ISSN	1474-4457 ; 1473-3099
ISSN (online)	1474-4457
ISSN	1473-3099
DOI	10.1016/S1473-3099(23)00369-9
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Zs.A 5743: Show issues

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Article ; Online: Biomimetic nanoplasmonic sensor for rapid evaluation of neutralizing SARS-CoV-2 monoclonal antibodies as antiviral therapy.

Batool, Razia / Soler, Maria / Colavita, Francesca / Fabeni, Lavinia / Matusali, Giulia / Lechuga, Laura M

Biosensors & bioelectronics

2023 Volume 226, Page(s) 115137

Abstract: Monoclonal antibody (mAb) therapy is one of the most promising immunotherapies that have shown the potential to prevent or neutralize the effects of COVID-19 in patients at very early stages, with a few formulations recently approved by the European and ... ...

Abstract	Monoclonal antibody (mAb) therapy is one of the most promising immunotherapies that have shown the potential to prevent or neutralize the effects of COVID-19 in patients at very early stages, with a few formulations recently approved by the European and American medicine agencies. However, a main bottleneck for their general implementation resides in the time-consuming, laborious, and highly-specialized techniques employed for the manufacturing and assessing of these therapies, excessively increasing their prices and delaying their administration to the patients. We propose a biomimetic nanoplasmonic biosensor as a novel analytical technique for the screening and evaluation of COVID-19 mAb therapies in a simpler, faster, and reliable manner. By creating an artificial cell membrane on the plasmonic sensor surface, our label-free sensing approach enables real-time monitoring of virus-cell interactions as well as direct analysis of antibody blocking effects in only 15 min assay time. We have achieved detection limits in the 10
MeSH term(s)	Humans ; Biomimetics ; SARS-CoV-2 ; Biosensing Techniques ; COVID-19 ; Antibodies, Viral ; Antiviral Agents
Chemical Substances	Antibodies, Viral ; Antiviral Agents
Language	English
Publishing date	2023-02-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2023.115137
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Zs.A 2275: Show issues

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Article ; Online: Asymptomatic Mpox Virus Infection in Subjects Presenting for MVA-BN Vaccine.

Matusali, Giulia / Mazzotta, Valentina / Piselli, Pierluca / Bettini, Aurora / Colavita, Francesca / Coen, Sabrina / Vaia, Francesco / Girardi, Enrico / Antinori, Andrea / Maggi, Fabrizio

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2023 Volume 77, Issue 10, Page(s) 1483–1484

MeSH term(s)	Humans ; Monkeypox virus/immunology ; Mpox (monkeypox) ; Smallpox Vaccine/immunology ; Vaccinia virus/immunology ; Antibodies, Neutralizing
Chemical Substances	smallpox and monkeypox vaccine modified vaccinia ankara-bavarian nordic (TU8J357395) ; Smallpox Vaccine ; Antibodies, Neutralizing
Language	English
Publishing date	2023-07-03
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciad414
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Zs.A 1505: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 480: Show issues

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Article ; Online: TTV and other anelloviruses: The astonishingly wide spread of a viral infection.

Spezia, Pietro Giorgio / Focosi, Daniele / Baj, Andreina / Novazzi, Federica / Ferrante, Francesca Drago / Carletti, Fabrizio / Minosse, Claudia / Matusali, Giulia / Maggi, Fabrizio

Aspects of molecular medicine

2023 Volume 1, Page(s) None

Abstract: The broad family of viruses known as anelloviruses (AV) infects both humans and numerous animal species. They have a tiny, covalently closed single-stranded DNA genome and the astonishing capacity to infect a very high percentage of healthy and ill ... ...

Abstract	The broad family of viruses known as anelloviruses (AV) infects both humans and numerous animal species. They have a tiny, covalently closed single-stranded DNA genome and the astonishing capacity to infect a very high percentage of healthy and ill people with chronic infections that could last a lifetime. AV, and particularly the prototype Torquetenovirus, have established a successful interaction with the host's immune system and the rate at which they replicate is a gauge to measure overall immune function, even though many aspects of their life cycle and pathogenesis are still poorly understood.
Language	English
Publishing date	2023-02-16
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2949-6888
ISSN (online)	2949-6888
DOI	10.1016/j.amolm.2023.100006
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Article ; Online: Poor durability of the neutralizing response against XBB sublineages after a bivalent mRNA COVID-19 booster dose in persons with HIV.

Matusali, Giulia / Vergori, Alessandra / Cimini, Eleonora / Mariotti, Davide / Mazzotta, Valentina / Lepri, Alessandro Cozzi / Colavita, Francesca / Gagliardini, Roberta / Notari, Stefania / Meschi, Silvia / Fusto, Marisa / Tartaglia, Eleonora / Girardi, Enrico / Maggi, Fabrizio / Antinori, Andrea

Journal of medical virology

2024 Volume 96, Issue 4, Page(s) e29598

Abstract: We estimated the dynamics of the neutralizing response against XBB sublineages and T cell response in persons with HIV (PWH) with previous AIDS and/or CD4 < 200/ ... ...

Abstract	We estimated the dynamics of the neutralizing response against XBB sublineages and T cell response in persons with HIV (PWH) with previous AIDS and/or CD4 < 200/mm
MeSH term(s)	Humans ; COVID-19/prevention & control ; Immunization Programs ; RNA, Messenger ; Seasons ; mRNA Vaccines ; HIV Infections ; Antibodies, Neutralizing ; Antibodies, Viral
Chemical Substances	RNA, Messenger ; mRNA Vaccines ; Antibodies, Neutralizing ; Antibodies, Viral
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.29598
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Zs.A 1320: Show issues

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Article ; Online: SARS-CoV-2 Infection of Airway Epithelium Triggers Pulmonary Endothelial Cell Activation and Senescence Associated with Type I IFN Production.

Bordoni, Veronica / Mariotti, Davide / Matusali, Giulia / Colavita, Francesca / Cimini, Eleonora / Ippolito, Giuseppe / Agrati, Chiara

Cells

2022 Volume 11, Issue 18

Abstract: Airway epithelial cells represent the main target of SARS-CoV-2 replication but several pieces of evidence suggest that endothelial cells (ECs), lining pulmonary blood vessels, are key players in lung injury in COVID-19 patients. Although in vivo ... ...

Abstract	Airway epithelial cells represent the main target of SARS-CoV-2 replication but several pieces of evidence suggest that endothelial cells (ECs), lining pulmonary blood vessels, are key players in lung injury in COVID-19 patients. Although in vivo evidence of SARS-CoV-2 affecting the vascular endothelium exists, in vitro data are limited. In the present study, we set up an organotypic model to dissect the crosstalk between airway epithelium and pulmonary endothelial cells during SARS-CoV-2 infection. We showed that SARS-CoV-2 infected airway epithelium triggers the induction of endothelial adhesion molecules in ECs, suggesting a bystander effect of dangerous soluble signals from the infected epithelium. The endothelial activation was correlated with inflammatory cytokines (IL-1β, IL-6, IL-8) and with the viral replication in the airway epithelium. Interestingly, SARS-CoV-2 infection determined a modulation of endothelial p21, which could be partially reversed by inhibiting IFN-β production from ECs when co-cultured with HAE. Altogether, we demonstrated that SARS-CoV-2 infected epithelium triggers activation/senescence processes in ECs involving type I IFN-β production, suggesting possible antiviral/damage mechanisms occurring in the endothelium.
MeSH term(s)	COVID-19/immunology ; Cellular Senescence ; Endothelial Cells/immunology ; Epithelium ; Humans ; Interferon Type I/immunology ; Interleukin-6 ; Interleukin-8 ; Lung ; SARS-CoV-2
Chemical Substances	Interferon Type I ; Interleukin-6 ; Interleukin-8
Language	English
Publishing date	2022-09-17
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11182912
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Article: B-cell-depleted patients with persistent SARS-CoV-2 infection: combination therapy or monotherapy? A real-world experience.

D'Abramo, Alessandra / Vita, Serena / Beccacece, Alessia / Navarra, Assunta / Pisapia, Raffaella / Fusco, Francesco Maria / Matusali, Giulia / Girardi, Enrico / Maggi, Fabrizio / Goletti, Delia / Nicastri, Emanuele

Frontiers in medicine

2024 Volume 11, Page(s) 1344267

Abstract: Objectives: The aim of the study was to describe a cohort of B-cell-depleted immunocompromised (IC) patients with prolonged or relapsing COVID-19 treated with monotherapy or combination therapy.: Methods: This is a multicenter observational ... ...

Abstract	Objectives: The aim of the study was to describe a cohort of B-cell-depleted immunocompromised (IC) patients with prolonged or relapsing COVID-19 treated with monotherapy or combination therapy. Methods: This is a multicenter observational retrospective study conducted on IC patients consecutively hospitalized with a prolonged or relapsing SARS-CoV-2 infection from November 2020 to January 2023. IC COVID-19 subjects were stratified according to the monotherapy or combination anti-SARS-CoV-2 therapy received. Results: Eighty-eight patients were enrolled, 19 under monotherapy and 69 under combination therapy. The study population had a history of immunosuppression (median of 2 B-cells/mm Conclusion: In IC persistent COVID-19 patients, it is essential to explore new therapeutic strategies such as combination multi-target therapy (antiviral or double antiviral plus antibody-based therapies) to avoid persistent viral shedding and/or severe SARS-CoV-2 infection.
Language	English
Publishing date	2024-02-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2024.1344267
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Article: SARS-CoV-2 Variants Identification: Overview of Molecular Existing Methods.

Berno, Giulia / Fabeni, Lavinia / Matusali, Giulia / Gruber, Cesare Ernesto Maria / Rueca, Martina / Giombini, Emanuela / Garbuglia, Anna Rosa

Pathogens (Basel, Switzerland)

2022 Volume 11, Issue 9

Abstract: Since the beginning of COVID-19 pandemic the Real Time sharing of genome sequences of circulating virus supported the diagnostics and surveillance of SARS-CoV-2 and its transmission dynamics. SARS-CoV-2 straightaway showed its tendency to mutate and ... ...

Abstract	Since the beginning of COVID-19 pandemic the Real Time sharing of genome sequences of circulating virus supported the diagnostics and surveillance of SARS-CoV-2 and its transmission dynamics. SARS-CoV-2 straightaway showed its tendency to mutate and adapt to the host, culminating in the emergence of variants; so it immediately became of crucial importance to be able to detect them quickly but also to be able to monitor in depth the changes on the whole genome to early identify the new possibly emerging variants. In this scenario, this manuscript aims to provide an overview of the existing methods for the identification of SARS-CoV-2 variants (from rapid method based on identification of one or more specific mutations to Whole Genome sequencing approach-WGS), taking into account limitations, advantages and applications of them in the field of diagnosis and surveillance of SARS-CoV-2.
Language	English
Publishing date	2022-09-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens11091058
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Article ; Online: Development and validation of a nanoplate-based digital PCR assay for absolute MPXV quantification.

Specchiarello, Eliana / Carletti, Fabrizio / Matusali, Giulia / Abbate, Isabella / Rozera, Gabriella / Minosse, Claudia / Petrivelli, Elisabetta / Ferraioli, Valeria / Sciamanna, Roberta / Maggi, Fabrizio

Journal of virological methods

2023 Volume 321, Page(s) 114802

Abstract: Quantification of mpox virus (MPXV) across different human body anatomical sites can provide insights about the most likely transmission routes, so methods able to release absolute and exact quantitative values of MPXV DNA are crucial. Here, we optimized ...

Abstract	Quantification of mpox virus (MPXV) across different human body anatomical sites can provide insights about the most likely transmission routes, so methods able to release absolute and exact quantitative values of MPXV DNA are crucial. Here, we optimized a new QIAcuity digital PCR (dPCR) protocol for the detection and quantification of MPXV DNA in clinical samples and assessed the performance of the assay by comparing the results obtained in 144 biological samples with those resulting from the use of an in-house real-time PCR (qPCR). Overall, the concordance between the two assays was 95%, with samples identified concordantly as MPXV DNA positive and having a mean number of copies per μl of 1708 (95% CI: 107-2830 copies/μl). The remaining samples gave discordant results, with 5 out of 7 detected with the QIAcuity dPCR assay but not with the in-house qPCR. MPXV DNA levels measured by QIAcuity dPCR were strongly correlated with the Ct values detected by in-house qPCR and with those detected by another dPCR assay previously developed in our laboratories. The QIAcuity dPCR assay may be a robust and easy-to-perform method for MPXV DNA quantification in several biological samples.
MeSH term(s)	Humans ; Biological Assay ; DNA, Viral/genetics ; Laboratories ; Real-Time Polymerase Chain Reaction ; Mpox (monkeypox)/diagnosis ; Monkeypox virus/isolation & purification
Chemical Substances	DNA, Viral
Language	English
Publishing date	2023-08-24
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	8013-5
ISSN	1879-0984 ; 0166-0934
ISSN (online)	1879-0984
ISSN	0166-0934
DOI	10.1016/j.jviromet.2023.114802
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Zs.A 1565: Show issues

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Article ; Online: Biomimetic nanoplasmonic sensor for rapid evaluation of neutralizing SARS-CoV-2 monoclonal antibodies as antiviral therapy

Batool, Razia / Soler, Maria / Colavita, Francesca / Fabeni, Lavinia / Matusali, Giulia / Lechuga, Laura M.

Biosensors and Bioelectronics. 2023 Feb. 08, p.115137-

2023 , Page(s) 115137–

Abstract	Monoclonal antibody (mAb) therapy is one of the most promising immunotherapies that have shown the potential to prevent or neutralize the effects of COVID-19 in patients at very early stages, with a few formulations recently approved by the European and American medicine agencies. However, a main bottleneck for their general implementation resides in the time-consuming, laborious, and highly-specialized techniques employed for the manufacturing and assessing of these therapies, excessively increasing their prices and delaying their administration to the patients. We propose a biomimetic nanoplasmonic biosensor as a novel analytical technique for the screening and evaluation of COVID-19 mAb therapies in a simpler, faster, and reliable manner. By creating an artificial cell membrane on the plasmonic sensor surface, our label-free sensing approach enables real-time monitoring of virus-cell interactions as well as direct analysis of antibody blocking effects in only 15 minutes assay time. We have achieved detection limits in the 10² TCID50/mL range for the study of SARS-CoV-2 viruses, which allows to perform neutralization assays by only employing a low-volume sample with common viral loads. We have demonstrated the accuracy of the biosensor for the evaluation of two different neutralizing antibodies targeting both Delta and Omicron variants of SARS-CoV-2, with half maximal inhibitory concentrations (IC₅₀) determined in the ng/mL range. Our user-friendly and reliable technology could be employed in biomedical and pharmaceutical laboratories to accelerate, cheapen, and simplify the development of effective immunotherapies for COVID-19 and other serious infectious diseases or cancer.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; analytical methods ; biomimetics ; biosensors ; cell membranes ; medicine ; monoclonal antibodies ; neutralization ; therapeutics ; Surface plasmon resonance ; COVID-19 ; Immunotherapy ; Neutralization assay ; Supported lipid bilayer ; Label-free analysis
Language	English
Dates of publication	2023-0208
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version ; Use and reproduction
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2023.115137
Database	NAL-Catalogue (AGRICOLA)

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