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  1. Article ; Online: Gastroenterology and hepatology in Croatia – where are we and where are we going?

    Neven Ljubičić / Lucija Virović Jukić

    Acta Clinica Croatica, Vol 60., Iss Supplement 2, Pp 13-

    2021  Volume 14

    Keywords Medicine ; R
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Sestre Milosrdnice University hospital, Institute of Clinical Medical Research
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Gastroenterologija i hepatologija u Hrvatskoj – gdje smo i kamo idemo?

    Neven Ljubičić / Lucija Virović Jukić

    Acta Clinica Croatica, Vol 60., Iss Supplement 2, Pp 15-

    2021  Volume 16

    Keywords Medicine ; R
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Sestre Milosrdnice University hospital, Institute of Clinical Medical Research
    Document type Article ; Online
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  3. Article: Antibiotics Prescribing Pattern and Quality of Prescribing in Croatian Dental Practices-5-Year National Study.

    Petrac, Lucija / Gvozdanovic, Katarina / Perkovic, Vjera / Petek Zugaj, Nikolina / Ljubicic, Neven

    Antibiotics (Basel, Switzerland)

    2024  Volume 13, Issue 4

    Abstract: Purpose: Antibiotic resistance is one of the biggest threats to global health today. The aim of this study was to analyze antibiotic prescribing patterns and quality of prescribing in Croatian dental practices over a 5-year period.: Methods: This is ... ...

    Abstract Purpose: Antibiotic resistance is one of the biggest threats to global health today. The aim of this study was to analyze antibiotic prescribing patterns and quality of prescribing in Croatian dental practices over a 5-year period.
    Methods: This is a retrospective observational study based on the analysis of the electronic prescriptions (medicines in ATC groups J01 and P01) from dental practices in Croatia prescribed from 1 January 2015 to 31 December 2019. Prescriptions were retrieved from the Croatian Health Insurance Fund (HZZO). The analyses included the number of prescriptions, type and quantity of prescribed drugs, indication, and the patient's and prescriber's characteristics.
    Results: The consumption increased from 1.98 DID in 2015, to 2.10 DID in 2019. The most prescribed antibiotic was Amoxicillin with clavulanic acid followed by Amoxicillin, Clindamycin, Metronidazole and Cefalexin. The analyses showed that 29.79% of antibiotics were not prescribed in accordance with the contemporary guidelines for the proper use of antibiotics. Additionally, 22% of antibiotics were prescribed in inconclusive indications.
    Conclusion: The research showed an increase in antibiotic consumption over five years along with unnecessary prescribing of antibiotics in cases with no indications for its use. The development of national guidelines for antibiotic use is necessary.
    Language English
    Publishing date 2024-04-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics13040345
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  4. Article ; Online: Pharmacokinetic Analysis of Ethanol in a Human Study: New Modification of Mathematic Model.

    Zekan, Paulo / Ljubičić, Neven / Blagaić, Vladimir / Dolanc, Ivan / Jonjić, Antonija / Čoklo, Miran / Blagaić, Alenka Boban

    Toxics

    2023  Volume 11, Issue 9

    Abstract: In the pharmacokinetic analysis of ethanol after oral administration, only single- or two-compartment models are used, but their precision in estimating pharmacokinetic parameters might be insufficient. In a recent study, pharmacokinetic analysis using a ...

    Abstract In the pharmacokinetic analysis of ethanol after oral administration, only single- or two-compartment models are used, but their precision in estimating pharmacokinetic parameters might be insufficient. In a recent study, pharmacokinetic analysis using a modified Norberg three-compartment model was performed after oral administration of differently sweetened alcoholic solutions and compared to pharmacokinetic analysis using the classic Widmark model. On three occasions, eight male volunteers consumed differently sweetened alcoholic solutions: non-sweetened, sweetened with sucrose, and sweetened with steviol glycoside. Blood ethanol concentration was determined from samples obtained at t = 15, 30, 60, 90, 120, 180 min after consumption. Pharmacokinetic analysis was performed model independently, using the classic Widmarks model and using the modified Norberg model. Results showed that estimated pharmacokinetic parameters depend on the type of model used. The classic Widmark model in particular overestimated the fraction of absorbed ethanol from the gastrointestinal system to systemic circulation. Furthermore, the type of sweetener also affected pharmacokinetic parameters, although the difference was not statistically significant. In conclusion, the novel pharmacokinetic model, while being more physiological, fits experimental data better and hence is more suitable for modelling real-life alcohol consumption. In addition, the effect of natural non-caloric sweetener steviol glycoside on ethanol pharmacokinetics, analysed for the first time in the current research, might be different when compared to the common-used sweetener sucrose.
    Language English
    Publishing date 2023-09-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics11090793
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  5. Article ; Online: CHRONIC PSEUDO-OBSTRUCTION OF THE SIGMOID COLON: A CASE REPORT.

    Vulić, Ivan / Šestan-Peša, Matija / Mužina Mišić, Dubravka / Pavić, Ivana / Živković, Mario / Budimir, Ivan / Hrabar, Davor / Ljubičić, Neven / Nikolić, Marko

    Acta clinica Croatica

    2023  Volume 61, Issue 4, Page(s) 735–740

    Abstract: Chronic intestinal pseudo-obstruction (CIPO) is a rare syndrome characterized by signs of intestinal obstruction lasting for 6 months or more, in the absence of a definitive cause of obstruction. We report a case of CIPO in a 49-year-old female patient ... ...

    Abstract Chronic intestinal pseudo-obstruction (CIPO) is a rare syndrome characterized by signs of intestinal obstruction lasting for 6 months or more, in the absence of a definitive cause of obstruction. We report a case of CIPO in a 49-year-old female patient with a 6-month history of ongoing irregular bowel movements, manifested as constipation and diarrhea accompanied by abdominal pain and bloated feeling. Contrast-enhanced abdominal computed tomography and magnetic resonance enterography revealed focal thickening of a segment of the lienal flexure and intermittent areas of wider and narrower caliber along the sigmoid colon. No signs of a definitive cause of obstruction were found, but evidence for dolichosigma was revealed, which was later confirmed with colonoscopy. Due to persisting symptoms, the patient agreed to elective resection of the sigmoid colon. Following the procedure, symptoms regressed with a significant improvement in the quality of life. The patient has been regularly monitored in an outpatient setting and reports absence of the symptoms since the procedure. Pathophysiology of the resected section revealed more prominent lymphatic tissue, follicular arrangement, and reactively altered germinal centers, which can suggest CIPO.
    MeSH term(s) Female ; Humans ; Middle Aged ; Colon, Sigmoid/diagnostic imaging ; Colon, Sigmoid/surgery ; Colon, Sigmoid/pathology ; Quality of Life ; Intestinal Obstruction/diagnosis ; Intestinal Obstruction/etiology ; Intestinal Obstruction/surgery ; Intestinal Pseudo-Obstruction/diagnosis ; Intestinal Pseudo-Obstruction/etiology ; Intestinal Pseudo-Obstruction/surgery ; Tomography, X-Ray Computed
    Language English
    Publishing date 2023-10-09
    Publishing country Croatia
    Document type Case Reports
    ZDB-ID 1478635-7
    ISSN 1333-9451 ; 0353-9466
    ISSN (online) 1333-9451
    ISSN 0353-9466
    DOI 10.20471/acc.2022.61.04.23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5057: Show issues Location:
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  6. Article: An unusual cause of chronic back pain: retroperitoneal ganglioneuroma.

    Jurčić, Petra / Budimir, Ivan / Nikolić, Marko / Ljubičić, Neven

    British journal of hospital medicine (London, England : 2005)

    2018  Volume 79, Issue 10, Page(s) 591

    MeSH term(s) Adult ; Back Pain/etiology ; Chronic Pain ; Female ; Ganglioneuroma/complications ; Ganglioneuroma/surgery ; Humans ; Retroperitoneal Neoplasms/complications ; Retroperitoneal Neoplasms/surgery ; Tomography, X-Ray Computed ; Treatment Outcome
    Language English
    Publishing date 2018-10-02
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1750-8460
    ISSN 1750-8460
    DOI 10.12968/hmed.2018.79.10.591
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  7. Article ; Online: Association of chronic inflammation with cardiovascular risk in chronic obstructive pulmonary disease-A cross-sectional study.

    Ljubičić, Đivo / Balta, Vedran / Dilber, Dario / Vražić, Hrvoje / Đikić, Domagoj / Odeh, Dyana / Habek, Jasna Čerkez / Vukovac, Emilija Lozo / Tudorić, Neven

    Health science reports

    2022  Volume 5, Issue 3, Page(s) e586

    Abstract: Background and aims: COPD is progressive lung disease with known higher cardiovascular (CV) risk, mainly attributed to smoking of cigarettes as the main etiological factor of disease. The aim of this study was to compare CV risk in patients with COPD to ...

    Abstract Background and aims: COPD is progressive lung disease with known higher cardiovascular (CV) risk, mainly attributed to smoking of cigarettes as the main etiological factor of disease. The aim of this study was to compare CV risk in patients with COPD to control groups of smokers and non-COPD and to investigate the relation of lung function variables, COPD severity, and smoking with Systemic Coronary Risk Estimation (SCORE) risk calculation, arterial stiffness (AS) values, and biological systemic inflammatory markers.
    Methods: A total of 208 subjects were included in this study: 61 subjects diagnosed with COPD, 83 smokers without COPD, and 64 nonsmokers without COPD. Medical history and clinical data were recorded, including assessment of pulmonary function and AS, calculation of ankle-brachial index, blood analysis, and CV risk assessment by SCORE risk calculation.
    Results: Subjects with COPD had significantly higher values of SCORE calculation of risk, central aortic pressure, AS, and markers of systemic inflammation compared to control groups of smokers and nonsmokers without COPD (
    Conclusion: The results of the research support further identification and research of biological markers and simple specific tests such as arteriography that will enable progress in personalized treatment of patients with COPD and better primary and secondary prevention of comorbidities with the aim of improved treatment outcome.
    Language English
    Publishing date 2022-04-07
    Publishing country United States
    Document type Journal Article
    ISSN 2398-8835
    ISSN (online) 2398-8835
    DOI 10.1002/hsr2.586
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  8. Article ; Online: Liver regeneration as treatment target for severe alcoholic hepatitis.

    Virovic-Jukic, Lucija / Ljubas, Dominik / Stojsavljevic-Shapeski, Sanja / Ljubičić, Neven / Filipec Kanizaj, Tajana / Mikolasevic, Ivana / Grgurevic, Ivica

    World journal of gastroenterology

    2022  Volume 28, Issue 32, Page(s) 4557–4573

    Abstract: Severe alcoholic hepatitis (AH) is a distinct entity in the spectrum of alcohol-related liver disease, with limited treatment options and high mortality. Supportive medical care with corticosteroids in selected patients is the only currently available ... ...

    Abstract Severe alcoholic hepatitis (AH) is a distinct entity in the spectrum of alcohol-related liver disease, with limited treatment options and high mortality. Supportive medical care with corticosteroids in selected patients is the only currently available treatment option, often with poor outcomes. Based on the insights into the pathogenetic mechanisms of AH, which are mostly obtained from animal studies, several new treatment options are being explored. Studies have implicated impaired and deranged liver regeneration processes as one of the culprit mechanisms and a potential therapeutic target. Acknowledging evidence for the beneficial effects of granulocyte colony-stimulating factor (G-CSF) on liver regeneration and immunomodulation in animal models, several human studies investigated its role in the treatment of advanced alcohol-related liver disease and AH. Contrary to the previously published studies suggesting benefits of G-CSF in the outcomes of patients with severe AH, these effects were not confirmed by a recently published multicenter randomized trial, suggesting that other options should rather be pursued. Stem cell transplantation represents another option for improving liver regeneration, but evidence for its efficacy in patients with severe AH and advanced alcohol-related liver disease is still very scarce and unconvincing, with established lack of efficacy in patients with compensated cirrhosis. In this review, we summarize the current knowledge on the pathogenesis and experimental therapies targeting liver regeneration. The lack of high-quality studies and evidence is a major obstacle in further treatment development. New insights into the pathogenesis of not only liver injury, but also liver regeneration processes are mandatory for the development of new treatment options. A reliable experimental model of the pathogenesis of AH and processes involved in liver recovery is still missing, and data obtained from animal studies are essential for future research.
    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Animals ; Focal Nodular Hyperplasia ; Granulocyte Colony-Stimulating Factor/therapeutic use ; Hepatitis, Alcoholic/drug therapy ; Humans ; Liver Diseases/drug therapy ; Liver Regeneration
    Chemical Substances Adrenal Cortex Hormones ; Granulocyte Colony-Stimulating Factor (143011-72-7)
    Language English
    Publishing date 2022-09-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v28.i32.4557
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    Zs.A 6039: Show issues Location:
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  9. Article ; Online: Plexiglas barrier box to improve ERCP safety during the COVID-19 pandemic.

    Ljubicic, Neven / Stojsavljevic-Shapeski, Sanja / Virovic-Jukic, Lucija / Nikolic, Marko

    Gastrointestinal endoscopy

    2020  Volume 92, Issue 2, Page(s) 428–429

    MeSH term(s) COVID-19 ; Cholangiopancreatography, Endoscopic Retrograde ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Humans ; Infectious Disease Transmission, Patient-to-Professional/prevention & control ; Occupational Exposure/prevention & control ; Pandemics/prevention & control ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; Polymethyl Methacrylate
    Chemical Substances Polymethyl Methacrylate (9011-14-7)
    Keywords covid19
    Language English
    Publishing date 2020-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2020.04.020
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    Zs.B 283: Show issues Location:
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  10. Article ; Online: Circulating Tumor Cells in Colorectal Cancer: Detection Systems and Clinical Utility.

    Petrik, József / Verbanac, Donatella / Fabijanec, Marija / Hulina-Tomašković, Andrea / Čeri, Andrea / Somborac-Bačura, Anita / Petlevski, Roberta / Grdić Rajković, Marija / Rumora, Lada / Krušlin, Božo / Štefanović, Mario / Ljubičić, Neven / Baršić, Neven / Hanžek, Antonija / Bočkor, Luka / Ćelap, Ivana / Demirović, Alma / Barišić, Karmela

    International journal of molecular sciences

    2022  Volume 23, Issue 21

    Abstract: Colorectal cancer (CRC) is the third most common cancer worldwide. The high mortality from CRC is mainly related to metastasis affecting distant organs and their function. Dissemination of tumor cells from the primary tumor and hematogeneous spread are ... ...

    Abstract Colorectal cancer (CRC) is the third most common cancer worldwide. The high mortality from CRC is mainly related to metastasis affecting distant organs and their function. Dissemination of tumor cells from the primary tumor and hematogeneous spread are considered crucial in the formation of tumor metastases. The analysis of circulating tumor cells (CTCs) and CTC clusters in the blood can be used for the early detection of invasive cancer. Moreover, CTCs have a prognostic significance in the monitoring of a malignant disease or the response to chemotherapy. This work presents an overview of the research conducted on CTCs with the aim of finding suitable detection systems and assessing the possibility of clinical applications in patients with CRC.
    MeSH term(s) Humans ; Neoplastic Cells, Circulating/pathology ; Cell Count ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/pathology ; Biomarkers, Tumor
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2022-11-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232113582
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