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Article ; Online: Antifungal and anti-inflammatory potential of eschweilenol C-rich fraction derived from Terminalia fagifolia Mart.

Rodrigues de Araújo, Alyne / Iles, Bruno / de Melo Nogueira, Kerolayne / Dias, Jhones do Nascimento / Plácido, Alexandra / Rodrigues, Artur / Albuquerque, Patrícia / Silva-Pereira, Ildinete / Socodatto, Renato / Portugal, Camila C / Relvas, João B / Costa Véras, Leiz Maria / Dalmatti Alves Lima, Filipe Camargo / Batagin-Neto, Augusto / Rolim Medeiros, Jand-Venes / Moreira Nunes, Paulo Humberto / Eaton, Peter / de Souza de Almeida Leite, José Roberto

Journal of ethnopharmacology

2019 Volume 240, Page(s) 111941

Abstract: ... The antibiofilm potential against biofilms of C. albicans was also tested. The anti-inflammatory potential ... in the Galleria mellonella and human erythrocytes models.: Results: Eschweilenol C was identified as the major constituent ... with lipopolysaccharide. The theoretical studies showed structural similarity between eschweilenol C and indomethacin and ...

Abstract	Ethnopharmacological relevance: Folk knowledge transmitted between generations allows traditional populations to maintain the use of medicinal plants for the treatment of several diseases. In this context, the species Terminalia fagifolia Mart., native to Brazil, is used for the treatment of chronic and infectious diseases. Plants rich in secondary metabolites, such as this species and their derivatives, may represent therapeutic alternatives for the treatment of diseases that reduce the quality of life of people. Aim of the study: The aim of this study was to evaluate the antifungal and anti-inflammatory potential of aqueous fraction from ethanolic extract of T. fagifolia, with in silico study of the major compound of the fraction. Material and methods: The phytochemical study of the aqueous fraction was performed by HPLC, LC/MS and NMR. The antifungal activity was evaluated against yeasts, by determination of the minimum inhibitory concentration and minimum fungicidal concentration. The effect on Candida albicans was analyzed by AFM. The antibiofilm potential against biofilms of C. albicans was also tested. The anti-inflammatory potential of the aqueous fraction was evaluated in vivo by the carrageenan-induced paw edema and peritonitis. A microglial model of LPS-induced neuroinflammation was also studied. Further insights on the activation mechanism were studied using quantum chemistry computer simulations. Toxicity was evaluated in the Galleria mellonella and human erythrocytes models. Results: Eschweilenol C was identified as the major constituent of the aqueous fraction of the ethanolic extract of T. fagifolia. The aqueous fraction was active against all Candida strains used (sensitive and resistant to Fluconazole) with MICs ranging from 1000 to 0.4 μg/mL. By AFM it was possible to observe morphological alterations in treated Candida cells. The fraction significantly (p < 0.05) inhibited paw edema and decreased levels of malondialdehyde induced by carrageenan. In a microglial cell model, aqueous fraction demonstrated the ability to inhibit NF-κB after induction with lipopolysaccharide. The theoretical studies showed structural similarity between eschweilenol C and indomethacin and an excellent antioxidant potential. The aqueous fraction did not present toxicity in the studied models. Conclusion: The results indicate that the aqueous fraction of T. fagifolia has potential for biomedical applications with low toxicity. This finding can be attributed to the predominance of eschweilenol C in the aqueous fraction.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Candida albicans/drug effects ; Candida albicans/growth & development ; Carrageenan ; Cryptococcus neoformans/drug effects ; Cryptococcus neoformans/growth & development ; Edema/chemically induced ; Edema/drug therapy ; Ellagic Acid/pharmacology ; Ellagic Acid/therapeutic use ; Erythrocytes/drug effects ; Female ; Heterocyclic Compounds, 4 or More Rings/pharmacology ; Heterocyclic Compounds, 4 or More Rings/therapeutic use ; Humans ; Male ; Mice ; Microbial Sensitivity Tests ; Microglia/drug effects ; Microglia/metabolism ; NF-kappa B/metabolism ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Terminalia
Chemical Substances	Anti-Inflammatory Agents ; Antifungal Agents ; Heterocyclic Compounds, 4 or More Rings ; NF-kappa B ; Plant Extracts ; eschweilenol C ; Ellagic Acid (19YRN3ZS9P) ; Carrageenan (9000-07-1)
Language	English
Publishing date	2019-05-15
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2019.111941
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Article: Antifungal and anti-inflammatory potential of eschweilenol C-rich fraction derived from Terminalia fagifolia Mart

Journal of ethnopharmacology. 2019 Aug. 10, v. 240

2019

Abstract: ... The antibiofilm potential against biofilms of C. albicans was also tested. The anti-inflammatory potential ... in the Galleria mellonella and human erythrocytes models.Eschweilenol C was identified as the major constituent ... with lipopolysaccharide. The theoretical studies showed structural similarity between eschweilenol C and indomethacin and ...

Abstract	Folk knowledge transmitted between generations allows traditional populations to maintain the use of medicinal plants for the treatment of several diseases. In this context, the species Terminalia fagifolia Mart., native to Brazil, is used for the treatment of chronic and infectious diseases. Plants rich in secondary metabolites, such as this species and their derivatives, may represent therapeutic alternatives for the treatment of diseases that reduce the quality of life of people.The aim of this study was to evaluate the antifungal and anti-inflammatory potential of aqueous fraction from ethanolic extract of T. fagifolia, with in silico study of the major compound of the fraction.The phytochemical study of the aqueous fraction was performed by HPLC, LC/MS and NMR. The antifungal activity was evaluated against yeasts, by determination of the minimum inhibitory concentration and minimum fungicidal concentration. The effect on Candida albicans was analyzed by AFM. The antibiofilm potential against biofilms of C. albicans was also tested. The anti-inflammatory potential of the aqueous fraction was evaluated in vivo by the carrageenan-induced paw edema and peritonitis. A microglial model of LPS-induced neuroinflammation was also studied. Further insights on the activation mechanism were studied using quantum chemistry computer simulations. Toxicity was evaluated in the Galleria mellonella and human erythrocytes models.Eschweilenol C was identified as the major constituent of the aqueous fraction of the ethanolic extract of T. fagifolia. The aqueous fraction was active against all Candida strains used (sensitive and resistant to Fluconazole) with MICs ranging from 1000 to 0.4 μg/mL. By AFM it was possible to observe morphological alterations in treated Candida cells. The fraction significantly (p < 0.05) inhibited paw edema and decreased levels of malondialdehyde induced by carrageenan. In a microglial cell model, aqueous fraction demonstrated the ability to inhibit NF-κB after induction with lipopolysaccharide. The theoretical studies showed structural similarity between eschweilenol C and indomethacin and an excellent antioxidant potential. The aqueous fraction did not present toxicity in the studied models.The results indicate that the aqueous fraction of T. fagifolia has potential for biomedical applications with low toxicity. This finding can be attributed to the predominance of eschweilenol C in the aqueous fraction.
Keywords	Candida albicans ; Galleria mellonella ; Terminalia ; anti-inflammatory activity ; antifungal properties ; antioxidant activity ; biofilm ; carrageenan ; computer simulation ; edema ; erythrocytes ; fluconazole ; high performance liquid chromatography ; humans ; indomethacin ; infectious diseases ; lipopolysaccharides ; malondialdehyde ; medicinal plants ; minimum inhibitory concentration ; models ; neuroglia ; nuclear magnetic resonance spectroscopy ; peritonitis ; phytochemicals ; quality of life ; secondary metabolites ; therapeutics ; toxicity ; traditional medicine ; transcription factor NF-kappa B ; yeasts ; Brazil
Language	English
Dates of publication	2019-0810
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2019.111941
Database	NAL-Catalogue (AGRICOLA)

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Article: Identification of Eschweilenol C in derivative of Terminalia fagifolia Mart. and green synthesis of bioactive and biocompatible silver nanoparticles

de Araujo, Alyne Rodrigues / Ramos-Jesus, Joilson / de Oliveira, Taiane Maria / de Carvalho, Andressa Maria A / Nunes, Paulo Humberto M / Daboit, Tatiane Caroline / Carvalho, Ana P / Barroso, Maria Fátima / de Almeida, Miguel Peixoto / Plácido, Alexandra / Rodrigues, Artur / Portugal, Camila C / Socodato, Renato / Relvas, João B / Delerue-Matos, Cristina / da Silva, Durcilene Alves / Eaton, Peter / de Souza de A. Leite, José Roberto

Industrial crops and products. 2019 Oct. 01, v. 137

2019

Abstract: ... for biological applications. Eschweilenol C, a compound derivative ellagic acid was identified as the main ... constituent of the aqueous fraction of the ethanolic extract of Terminalia fagifolia Mart. by NMR analysis ...

Abstract	A green synthetic route was developed to prepare silver nanoparticles (AgNPs) in aqueous solution for biological applications. Eschweilenol C, a compound derivative ellagic acid was identified as the main constituent of the aqueous fraction of the ethanolic extract of Terminalia fagifolia Mart. by NMR analysis. In the green synthesis, the ethanolic extract of T. fagifolia and its aqueous fraction were used to promote silver reduction and nanoparticle stabilization. The synthesized AgNPs presented a spherical or polygonal morphology shape by TEM analysis and AgNPs showed high levels of antioxidant and considerable antibacterial and antifungal activities. Synthesized nanoparticles presented significant antioxidant activity by sequestration of DPPH and ABTS radicals, in addition to iron reduction (FRAP assay) and measurement of antioxidant capacity in ORAC units, in addition, AgNP synthesized with the aqueous fraction also demonstrated antioxidant potential in microglial cells. Gram-positive and Gram-negative bacteria were susceptible to growth inhibition by the nanoparticles, among which the AgNPs formed by the ethanolic extract was the most effective. The data obtained by AFM images suggested that AgNPs could lead to the lysis of bacteria and subsequent death. The antifungal assays showed high efficiency against yeasts and dermatophytes. This work represents the first description of antifungal activity by AgNPs against Fonsecaea pedrosoi, the etiologic agent of chromoblastomycosis. In relation to biocompatibility, the AgNPs induced lower haemolysis than AgNO3.
Keywords	2,2-diphenyl-1-picrylhydrazyl ; Gram-negative bacteria ; Terminalia ; antifungal properties ; antioxidant activity ; aqueous solutions ; biocompatibility ; death ; ellagic acid ; free radicals ; hemolysis ; iron ; keratinophilic fungi ; nanoparticles ; nanosilver ; neuroglia ; nuclear magnetic resonance spectroscopy ; silver ; silver nitrate ; transmission electron microscopy ; yeasts
Language	English
Dates of publication	2019-1001
Size	p. 52-65.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1132158-1
ISSN	1872-633X ; 0926-6690
ISSN (online)	1872-633X
ISSN	0926-6690
DOI	10.1016/j.indcrop.2019.05.012
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Article ; Online: Further Cautions When Modeling the Public Health Impact of Infectious Diseases.

Vanhems, Philippe / Nunes, Marta C

American journal of public health

2022 Volume 112, Issue 11, Page(s) e1–e2

MeSH term(s)	Communicable Diseases/epidemiology ; Humans ; Public Health
Language	English
Publishing date	2022-10-08
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	121100-6
ISSN	1541-0048 ; 0090-0036 ; 0002-9572
ISSN (online)	1541-0048
ISSN	0090-0036 ; 0002-9572
DOI	10.2105/AJPH.2022.307086
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Article ; Online: Epidemiology of community-acquired pneumonia caused by S treptococcus pneumoniae in older adults: a narrative review.

Elias, Christelle / Nunes, Marta C / Saadatian-Elahi, Mitra

Current opinion in infectious diseases

2024 Volume 37, Issue 2, Page(s) 144–153

Abstract: Purpose of review: This review covers updated perspectives on different aspects of pneumococcal community-acquired pneumonia (pCAP), including the epidemiology, clinical presentation, risk factors, antibiotic treatment, and existing preventive ... ...

Abstract	Purpose of review: This review covers updated perspectives on different aspects of pneumococcal community-acquired pneumonia (pCAP), including the epidemiology, clinical presentation, risk factors, antibiotic treatment, and existing preventive strategies in older adults. Recent findings: pCAP remains the most prevalent condition among lower respiratory tract infections in the older adults according to Global Burden of Diseases 2019. Older adults can display atypical symptoms such as confusion, general clinical deterioration, new onset of and exacerbation of underlying illness that might trigger clinical suspicion of pCAP. Older adults with pCAP often experience increased disease severity and a higher risk of pulmonary complications compared with younger individuals, owing to age-related changes in immunity and a higher prevalence of comorbidities. Vaccination stands fundamental for prevention, emphasizing the need for effective immunization strategies, specifically tailored for older adults. There is a pressing need to reinforce efforts aimed at boosting pneumococcal vaccination rates. Summary: Despite a high morbidity and mortality, the burden of pCAP, in particular hospital admission and occurrence of invasive infections, among the elderly population is not sufficiently documented. This review findings emphasize the substantial burden of pCAP in this vulnerable population, driven by factors such as advancing age and underlying comorbidities. The emergence of antibiotic-resistant pneumococcal strains further complicates treatment decisions and highlights the importance of tailored approaches for managing pCAP in older adults.
MeSH term(s)	Humans ; Aged ; Pneumonia, Pneumococcal/epidemiology ; Pneumonia, Pneumococcal/prevention & control ; Streptococcus pneumoniae ; Respiratory Tract Infections/epidemiology ; Hospitalization ; Comorbidity ; Community-Acquired Infections/epidemiology ; Community-Acquired Infections/prevention & control ; Pneumococcal Vaccines ; Pneumococcal Infections/epidemiology ; Pneumococcal Infections/prevention & control
Chemical Substances	Pneumococcal Vaccines
Language	English
Publishing date	2024-02-05
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	645085-4
ISSN	1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
ISSN (online)	1473-6527 ; 1535-3877
ISSN	0951-7375 ; 1355-834X
DOI	10.1097/QCO.0000000000001005
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Article ; Online: COVID-19 vaccines in pregnancy.

Nunes, Marta C / Madhi, Shabir A

Trends in molecular medicine

2022 Volume 28, Issue 8, Page(s) 662–680

Abstract: COVID-19 caused by SARS-CoV-2 coronavirus has been associated with severe illness in pregnant women. Furthermore, COVID-19 during pregnancy is associated with adverse fetal outcomes including preterm labor. Pregnant women were largely excluded from ... ...

Abstract	COVID-19 caused by SARS-CoV-2 coronavirus has been associated with severe illness in pregnant women. Furthermore, COVID-19 during pregnancy is associated with adverse fetal outcomes including preterm labor. Pregnant women were largely excluded from initial clinical trials investigating the safety and efficacy of COVID-19 vaccines; however, they have since been included as part of the routine roll-out of these vaccines. This narrative review synthesizes the evidence on the safety, immunogenicity, and effectiveness predominantly of the mRNA COVID-19 vaccines which have been most widely used in pregnant women.
MeSH term(s)	COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; COVID-19 Vaccines/immunology ; Female ; Humans ; Immunogenicity, Vaccine ; Infant, Newborn ; Pregnancy ; Pregnancy Complications, Infectious/prevention & control ; SARS-CoV-2
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2022-05-03
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2036490-8
ISSN	1471-499X ; 1471-4914
ISSN (online)	1471-499X
ISSN	1471-4914
DOI	10.1016/j.molmed.2022.04.012
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Article ; Online: Assessing New York City's COVID-19 Vaccine Rollout Strategy: A Case for Risk-Informed Distribution.

Schwalbe, Nina / Nunes, Marta C / Cutland, Clare / Wahl, Brian / Reidpath, Daniel

Journal of urban health : bulletin of the New York Academy of Medicine

2024

Abstract: This study reviews the impact of eligibility policies in the early rollout of the COVID-19 vaccine on coverage and probable outcomes, with a focus on New York City. We conducted a retrospective ecological study assessing age 65+, area-level income, ... ...

Abstract	This study reviews the impact of eligibility policies in the early rollout of the COVID-19 vaccine on coverage and probable outcomes, with a focus on New York City. We conducted a retrospective ecological study assessing age 65+, area-level income, vaccination coverage, and COVID-19 mortality rates, using linked Census Bureau data and New York City Health administrative data aggregated at the level of modified zip code tabulation areas (MODZCTA). The population for this study was all individuals in 177 MODZCTA in New York City. Population data were obtained from Census Bureau and New York City Health administrative data. The total mortality rate was examined through an ordinary least squares (OLS) regression model, using area-level wealth, the proportion of the population aged 65 and above, and the vaccination rate among this age group as predictors. Low-income areas with high proportions of older people demonstrated lower coverage rates (mean vaccination rate 52.8%; maximum coverage 67.9%) than wealthier areas (mean vaccination rate 74.6%; maximum coverage 99% in the wealthiest quintile) in the first 3 months of vaccine rollout and higher mortality over the year. Despite vaccine shortages, many younger people accessed vaccines ahead of schedule, particularly in high-income areas (mean coverage rate 60% among those 45-64 years in the wealthiest quintile). A vaccine program that prioritized those at greatest risk of COVID-19-associated morbidity and mortality would have prevented more deaths than the strategy that was implemented. When rolling out a new vaccine, policymakers must account for local contexts and conditions of high-risk population groups. If New York had focused limited vaccine supply on low-income areas with high proportions of residents 65 or older, overall mortality might have been lower.
Language	English
Publishing date	2024-04-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1435288-6
ISSN	1468-2869 ; 1099-3460
ISSN (online)	1468-2869
ISSN	1099-3460
DOI	10.1007/s11524-024-00853-z
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Article ; Online: RSV lower respiratory tract infection and lung health in the first 2 years of life.

Verwey, Charl / Nunes, Marta C

The Lancet. Global health

2020 Volume 8, Issue 10, Page(s) e1247–e1248

MeSH term(s)	Female ; Humans ; Parturition ; Pregnancy ; Respiratory Syncytial Virus Infections ; Respiratory Syncytial Viruses ; Respiratory Tract Infections
Language	English
Publishing date	2020-09-21
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	2723488-5
ISSN	2214-109X ; 2214-109X
ISSN (online)	2214-109X
ISSN	2214-109X
DOI	10.1016/S2214-109X(20)30303-X
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Article ; Online: Vaccinating Mothers to Protect Their Babies Against Influenza.

Cohen, Cheryl / Nunes, Marta C

The Journal of infectious diseases

2019 Volume 221, Issue 1, Page(s) 5–7

MeSH term(s)	England ; Female ; Humans ; Infant ; Influenza, Human ; Mothers ; Pregnancy ; Seasons ; Vaccination
Language	English
Publishing date	2019-11-22
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiz387
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Article ; Online: T-cell responses to SARS-CoV-2 in unexposed South African women.

Nunes, Marta C / Johnson, Michael J / Kwatra, Gaurav / Weinberg, Adriana / Madhi, Shabir A

Gates open research

2022 Volume 5, Page(s) 150

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2022-07-13
Publishing country	United States
Document type	Journal Article
ISSN	2572-4754
ISSN (online)	2572-4754
DOI	10.12688/gatesopenres.13373.2
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