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  1. Article ; Online: Pneumococcal coinfection in COVID-19 patients.

    Toombs, Jessica M / Van den Abbeele, Koenraad / Democratis, Jane / Mandal, Amit K J / Missouris, Constantinos G

    Journal of medical virology

    2020  Volume 93, Issue 1, Page(s) 177–179

    MeSH term(s) Aged, 80 and over ; COVID-19/complications ; Coinfection/microbiology ; Coinfection/virology ; Fatal Outcome ; Humans ; Male ; Pneumonia, Pneumococcal/complications ; SARS-CoV-2 ; Streptococcus pneumoniae
    Keywords covid19
    Language English
    Publishing date 2020-07-17
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26278
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: COVID-19 in three people living with HIV in the United Kingdom.

    Toombs, Jessica M / Van den Abbeele, Koenraad / Democratis, Jane / Merricks, Rhona / Mandal, Amit K J / Missouris, Constantinos G

    Journal of medical virology

    2020  Volume 93, Issue 1, Page(s) 107–109

    MeSH term(s) COVID-19/complications ; COVID-19/epidemiology ; Coinfection ; Female ; HIV Infections/complications ; HIV Infections/epidemiology ; HIV-1 ; Humans ; Male ; Middle Aged ; SARS-CoV-2 ; United Kingdom/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-06-29
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26178
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Pneumococcal coinfection in COVID‐19 patients

    Toombs, Jessica M. / Van den Abbeele, Koenraad / Democratis, Jane / Mandal, Amit K. J. / Missouris, Constantinos G.

    Journal of Medical Virology ; ISSN 0146-6615 1096-9071

    2020  

    Keywords Virology ; Infectious Diseases ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1002/jmv.26278
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article ; Online: The QuantuMDx Q-POC SARS-CoV-2 RT-PCR assay for rapid detection of COVID-19 at point-of-care: preliminary evaluation of a novel technology.

    Caffry, Jessica / Selby, Matthew / Barr, Katie / Morgan, George / McGurk, David / Scully, Philip / Park, Catherine / Caridis, Anna-Maria / Southworth, Emily / Morrison, Jack / Clark, David J / Davies, Benedict M O / Eckersley, Nicholas M / Groppelli, Elisabetta / Kirwan, Daniela E / Monahan, Irene / Augustin, Yolanda / Toombs, Colin / Planche, Tim /
    Staines, Henry M / Krishna, Sanjeev

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 9827

    Abstract: Accurate and rapid point-of-care (PoC) diagnostics are critical to the control of the COVID-19 pandemic. The current standard for accurate diagnosis of SARS-CoV-2 is laboratory-based reverse transcription polymerase chain reaction (RT-PCR) assays. Here, ... ...

    Abstract Accurate and rapid point-of-care (PoC) diagnostics are critical to the control of the COVID-19 pandemic. The current standard for accurate diagnosis of SARS-CoV-2 is laboratory-based reverse transcription polymerase chain reaction (RT-PCR) assays. Here, a preliminary prospective performance evaluation of the QuantuMDx Q-POC SARS-CoV-2 RT-PCR assay is reported. Between November 2020 and March 2021, 49 longitudinal combined nose/throat (NT) swabs from 29 individuals hospitalised with RT-PCR confirmed COVID-19 were obtained at St George's Hospital, London. In addition, 101 mid-nasal (MN) swabs were obtained from healthy volunteers in June 2021. These samples were used to evaluate the Q-POC SARS-CoV-2 RT-PCR assay. The primary analysis was to compare the sensitivity and specificity of the Q-POC test against a reference laboratory-based RT-PCR assay. The overall sensitivity of the Q-POC test compared with the reference test was 96.88% (83.78- 99.92% CI) for a cycle threshold (Ct) cut-off value for the reference test of 35 and 80.00% (64.35-90.95% CI) without altering the reference test's Ct cut-off value of 40. The Q-POC test is a sensitive, specific and rapid PoC test for SARS-CoV-2 at a reference Ct cut-off value of 35. The Q-POC test provides an accurate option for RT-PCR at PoC without the need for sample pre-processing and laboratory handling, enabling rapid diagnosis and clinical triage in acute care and other settings.
    MeSH term(s) Humans ; COVID-19/diagnosis ; SARS-CoV-2/genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Point-of-Care Systems ; Pandemics ; Prospective Studies ; COVID-19 Testing ; Clinical Laboratory Techniques ; Sensitivity and Specificity
    Language English
    Publishing date 2023-06-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-35479-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: COVID-19 in three people living with HIV in the United Kingdom

    Toombs, Jessica M / Van den Abbeele, Koenraad / Democratis, Jane / Merricks, Rhona / Mandal, Amit K J / Missouris, Constantinos G

    J. med. virol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #598648
    Database COVID19

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    Inter-library loan at ZB MED

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  7. Article ; Online: COVID‐19 in three people living with HIV in the United Kingdom

    Toombs, Jessica M. / Van den Abbeele, Koenraad / Democratis, Jane / Merricks, Rhona / Mandal, Amit K. J. / Missouris, Constantinos G.

    Journal of Medical Virology ; ISSN 0146-6615 1096-9071

    2020  

    Keywords Virology ; Infectious Diseases ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1002/jmv.26178
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article: COVID-19 in 3 people living with HIV in the United Kingdom

    Toombs, Jessica M / Van den Abbeele, Koenraad / Democratis, Jane / Merricks, Rhona / Mandal, Amit K J / Missouris, Constantinos G

    J. med. virol

    Abstract: We would like to report the clinical characteristics of 3 people living with HIV (PLWH) in the United Kingdom within the context of coronavirus disease 2019 (COVID-19). Our institution serves a population of 500,000 with a prevalence of HIV at 0.34%. At ... ...

    Abstract We would like to report the clinical characteristics of 3 people living with HIV (PLWH) in the United Kingdom within the context of coronavirus disease 2019 (COVID-19). Our institution serves a population of 500,000 with a prevalence of HIV at 0.34%. At of the time of writing, 5th June 2020, only 3 PLWH tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on nasopharyngeal swab specimen using Real-Time Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR) have required admission to hospital. This article is protected by copyright. All rights reserved.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32542706
    Database COVID19

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: The QuantuMDx Q-POC SARS-CoV-2 RT-PCR assay for rapid detection of COVID-19 at point-of-care: preliminary evaluation of a novel technology

    Caffry, Jessica / Selby, Matthew / Barr, Katie / Morgan, George / McGurk, David / Scully, Philip / Park, Catherine / Caridis, Anna-Maria / Southworth, Emily / Morrison, Jack / Clark, David J / Eckersley, Nicholas M / Groppelli, Elisabetta / Kirwan, Daniela E / Monahan, Irene / Augustin, Yolanda / Toombs, Colin / Planche, Tim / Staines, Henry M /
    Krishna, Sanjeev

    medRxiv

    Abstract: Background: Accurate, affordable, and rapid point-of-care (PoC) diagnostics are critical to the global control and management of the COVID-19 pandemic. The current standard for accurate diagnosis of SARS-CoV-2 is laboratory-based reverse transcription ... ...

    Abstract Background: Accurate, affordable, and rapid point-of-care (PoC) diagnostics are critical to the global control and management of the COVID-19 pandemic. The current standard for accurate diagnosis of SARS-CoV-2 is laboratory-based reverse transcription polymerase chain reaction (RT-PCR). Here, we report a preliminary prospective performance evaluation of the QuantuMDx Q-POC SARS CoV-2 RT-PCR assay. Methods: Between November 2020 and March 2021, we obtained 49 longitudinal nose and throat swabs from 29 individuals hospitalised with RT-PCR confirmed COVID-19 at St Georges9 NHS Foundation Trust, London (UK). In addition, we obtained 101 mid nasal swabs from healthy volunteers in June 2021. We then used these samples to evaluate the Q-POC SARS-CoV-2 RT-PCR assay. The primary analysis was to compare the sensitivity and specificity of the Q-POC test against a reference laboratory-based RT-PCR assay. Results: The overall sensitivity of the Q-POC test compared with the reference test was 96.88% (83.78%- 99.92% CI) for a cycle threshold (Ct) cut-off value for the reference test of 35 and 80.00% (64.35% to 90.95% CI) without altering the reference test9s Ct cut-off value of 40. Conclusions: The Q-POC test is a sensitive, specific and rapid point-of-care test for SARS-CoV-2 at a reference Ct cut-off value of 35. The Q-POC test provides an accurate and afforda-ble option for RT-PCR at point-of-care without the need for sample pre-processing and laboratory handling. The Q-POC test would enable rapid diagnosis and clinical triage in acute care and other settings.
    Keywords covid19
    Language English
    Publishing date 2021-07-14
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2021.07.12.21260119
    Database COVID19

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  10. Article ; Online: RIPOSTE: a framework for improving the design and analysis of laboratory-based research.

    Masca, Nicholas Gd / Hensor, Elizabeth Ma / Cornelius, Victoria R / Buffa, Francesca M / Marriott, Helen M / Eales, James M / Messenger, Michael P / Anderson, Amy E / Boot, Chris / Bunce, Catey / Goldin, Robert D / Harris, Jessica / Hinchliffe, Rod F / Junaid, Hiba / Kingston, Shaun / Martin-Ruiz, Carmen / Nelson, Christopher P / Peacock, Janet / Seed, Paul T /
    Shinkins, Bethany / Staples, Karl J / Toombs, Jamie / Wright, Adam Ka / Teare, M Dawn

    eLife

    2015  Volume 4

    Abstract: Lack of reproducibility is an ongoing problem in some areas of the biomedical sciences. Poor experimental design and a failure to engage with experienced statisticians at key stages in the design and analysis of experiments are two factors that ... ...

    Abstract Lack of reproducibility is an ongoing problem in some areas of the biomedical sciences. Poor experimental design and a failure to engage with experienced statisticians at key stages in the design and analysis of experiments are two factors that contribute to this problem. The RIPOSTE (Reducing IrreProducibility in labOratory STudiEs) framework has been developed to support early and regular discussions between scientists and statisticians in order to improve the design, conduct and analysis of laboratory studies and, therefore, to reduce irreproducibility. This framework is intended for use during the early stages of a research project, when specific questions or hypotheses are proposed. The essential points within the framework are explained and illustrated using three examples (a medical equipment test, a macrophage study and a gene expression study). Sound study design minimises the possibility of bias being introduced into experiments and leads to higher quality research with more reproducible results.
    MeSH term(s) Biomedical Research/methods ; Biomedical Research/trends ; Data Interpretation, Statistical ; Reproducibility of Results ; Research Design/standards
    Language English
    Publishing date 2015-05-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.05519
    Database MEDical Literature Analysis and Retrieval System OnLINE

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