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  1. Article ; Online: Academic medicine should lead the way on gender equity: but it doesn't.

    Mathieson, Peter W

    Postgraduate medical journal

    2017  Volume 93, Issue 1106, Page(s) 717–718

    MeSH term(s) Humans ; Medicine
    Language English
    Publishing date 2017-08-04
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 80325-x
    ISSN 1469-0756 ; 0032-5473
    ISSN (online) 1469-0756
    ISSN 0032-5473
    DOI 10.1136/postgradmedj-2017-134931
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  2. Article ; Online: Immunosuppression for membranous nephropathy - Authors' reply.

    Mathieson, Peter W

    Lancet (London, England)

    2013  Volume 381, Issue 9884, Page(s) 2163

    MeSH term(s) Chlorambucil/therapeutic use ; Cyclosporine/therapeutic use ; Glomerulonephritis, Membranous/drug therapy ; Humans ; Immunosuppressive Agents/therapeutic use ; Prednisolone/therapeutic use
    Chemical Substances Immunosuppressive Agents ; Chlorambucil (18D0SL7309) ; Cyclosporine (83HN0GTJ6D) ; Prednisolone (9PHQ9Y1OLM)
    Language English
    Publishing date 2013-06-18
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(13)61436-1
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  3. Article: The podocyte cytoskeleton in health and in disease.

    Mathieson, Peter W

    Clinical kidney journal

    2012  Volume 5, Issue 6, Page(s) 498–501

    Abstract: The podocyte is a key cell in the selective filtering action of the glomerular capillary wall. Podocyte injury is of pathogenetic and prognostic significance in human glomerular disease; podocyte repair and regeneration are important therapeutic targets. ...

    Abstract The podocyte is a key cell in the selective filtering action of the glomerular capillary wall. Podocyte injury is of pathogenetic and prognostic significance in human glomerular disease; podocyte repair and regeneration are important therapeutic targets. In particular, podocyte function is dependent on the cells' actin cytoskeleton: this maintains their complex structure. Alterations in the actin cytoskeleton arise from a variety of genetic and acquired causes. Therapeutic agents that are beneficial in proteinuric disease may act at least partly by restoring the cell shape via effects on the actin cytoskeleton. Recent studies of podocytes in vivo and in vitro are described, highlighting clinically relevant observations and those that help us understand the ways in which we may harness nature's own mechanisms to repair and/or renew these specialized glomerular cells, with a particular focus on their actin cytoskeleton. Drugs that have beneficial effects on podocytes can improve our ability to treat important renal diseases including diabetic nephropathy. Currently available agents can be applied in this way and the rapid progress in the study of podocytes is highlighting new therapeutic targets that can bring even more specificity.
    Language English
    Publishing date 2012-11-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfs153
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  4. Article ; Online: The podocyte as a target for therapies--new and old.

    Mathieson, Peter W

    Nature reviews. Nephrology

    2011  Volume 8, Issue 1, Page(s) 52–56

    Abstract: Injury to the podocyte results in proteinuria and often leads to progressive kidney disease. As podocytes have limited ability to repair and/or regenerate, the extent of podocyte injury is a major prognostic determinant in diabetic nephropathy and other ... ...

    Abstract Injury to the podocyte results in proteinuria and often leads to progressive kidney disease. As podocytes have limited ability to repair and/or regenerate, the extent of podocyte injury is a major prognostic determinant in diabetic nephropathy and other common causes of end-stage renal disease. Therapies aimed at preventing or limiting podocyte injury and/or at promoting podocyte repair or regeneration therefore have major potential clinical and economic benefits. Many current therapies--including glucocorticosteroids and calcineurin antagonists--have potent effects on podocytes. The nonspecific natures of these agents lead to undesirable systemic adverse effects: an agent with a more specific focus on podocytes would cause less treatment-associated morbidity. Recent years have seen dramatic advances in our understanding of podocyte biology and in particular regulation of its actin cytoskeleton, the major determinant of the complex architecture on which these cells depend for their function. This advance has allowed the identification of potential therapeutic targets and the next few years should see the development and testing of specific therapies aimed at the podocyte. Thus we are about to move from a situation where some of our 'blunderbuss' older therapies fortuitously happened to have beneficial effects on podocytes to a new era where advances in biological knowledge about a key cell type in the kidney will allow targeted drug design. As well as being intellectually more satisfying, every reason exists to believe that patients of the future will benefit and that the scourge of progressive kidney disease will be more effectively tackled.
    MeSH term(s) Humans ; Immunosuppressive Agents/pharmacology ; Immunosuppressive Agents/therapeutic use ; Kidney Diseases/etiology ; Kidney Diseases/pathology ; Kidney Diseases/therapy ; Plasma Exchange ; Podocytes/drug effects ; Podocytes/pathology ; Podocytes/physiology
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2011-11-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/nrneph.2011.171
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  5. Article ; Online: Podocyte actin in health, disease and treatment.

    Mathieson, Peter W

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2010  Volume 25, Issue 6, Page(s) 1772–1773

    MeSH term(s) Actins/genetics ; Actins/physiology ; Animals ; Cyclosporine/therapeutic use ; Cytoskeleton/physiology ; Cytoskeleton/ultrastructure ; Glomerulosclerosis, Focal Segmental/drug therapy ; Glomerulosclerosis, Focal Segmental/genetics ; Glomerulosclerosis, Focal Segmental/pathology ; Glomerulosclerosis, Focal Segmental/physiopathology ; Humans ; Mice ; Microscopy, Electron, Transmission ; Mutant Proteins/genetics ; Mutant Proteins/physiology ; Podocytes/physiology ; Podocytes/ultrastructure
    Chemical Substances Actins ; Mutant Proteins ; Cyclosporine (83HN0GTJ6D)
    Language English
    Publishing date 2010-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfq121
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    Zs.MO 329: Show issues

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  6. Article: Membranous nephropathy.

    Mathieson, Peter W

    Clinical medicine (London, England)

    2010  Volume 12, Issue 5, Page(s) 461–466

    MeSH term(s) Adrenocorticotropic Hormone/therapeutic use ; Antibodies/blood ; Antibodies, Monoclonal, Murine-Derived/therapeutic use ; Glomerulonephritis, Membranous/diagnosis ; Glomerulonephritis, Membranous/epidemiology ; Glomerulonephritis, Membranous/etiology ; Glomerulonephritis, Membranous/therapy ; Hormones/therapeutic use ; Humans ; Immunosuppressive Agents/therapeutic use ; Kidney Transplantation ; Neprilysin/immunology ; Prognosis ; Receptors, Phospholipase A2/immunology ; Recurrence ; Rituximab ; Steroids/therapeutic use
    Chemical Substances Antibodies ; Antibodies, Monoclonal, Murine-Derived ; Hormones ; Immunosuppressive Agents ; Receptors, Phospholipase A2 ; Steroids ; Rituximab (4F4X42SYQ6) ; Adrenocorticotropic Hormone (9002-60-2) ; Neprilysin (EC 3.4.24.11)
    Language English
    Publishing date 2010-03-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2048646-7
    ISSN 1473-4893 ; 1470-2118
    ISSN (online) 1473-4893
    ISSN 1470-2118
    DOI 10.7861/clinmedicine.12-5-461
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    Zs.A 5439: Show issues Location:
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  7. Article ; Online: Update on the podocyte.

    Mathieson, Peter W

    Current opinion in nephrology and hypertension

    2009  Volume 18, Issue 3, Page(s) 206–211

    Abstract: Purpose of review: The podocyte is a key cell in the selective filtering action of the glomerular capillary wall. Podocyte injury is of pathogenetic and prognostic significance in human glomerular disease; podocyte repair and regeneration are important ... ...

    Abstract Purpose of review: The podocyte is a key cell in the selective filtering action of the glomerular capillary wall. Podocyte injury is of pathogenetic and prognostic significance in human glomerular disease; podocyte repair and regeneration are important therapeutic targets. This article will review recent advances in understanding the complex biology, structure and function of the podocyte and the related clinical implications.
    Recent findings: Recent studies of podocytes in vivo and in vitro are described, highlighting clinically relevant observations and those that help us to understand the ways in which we may harness nature's own mechanisms to repair and/or renew these specialized glomerular cells.
    Summary: Drugs that have beneficial effects on podocytes can improve our ability to treat important renal diseases, including diabetic nephropathy. Currently available agents can be harnessed in this way and the rapid progress in the study of podocytes is highlighting new therapeutic targets that can bring even more specificity.
    MeSH term(s) Animals ; Cell Transplantation ; Humans ; Kidney Diseases/drug therapy ; Kidney Diseases/pathology ; Kidney Glomerulus/anatomy & histology ; Kidney Glomerulus/pathology ; Kidney Glomerulus/physiology ; MicroRNAs/genetics ; Nephrotic Syndrome/metabolism ; Podocytes/drug effects ; Podocytes/pathology ; Podocytes/physiology ; Proteins/metabolism ; Renal Agents/pharmacology ; Renal Agents/therapeutic use
    Chemical Substances MicroRNAs ; Proteins ; Renal Agents
    Language English
    Publishing date 2009-04-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1151092-4
    ISSN 1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
    ISSN (online) 1473-6543 ; 1535-3842
    ISSN 1062-4813 ; 1062-4821
    DOI 10.1097/mnh.0b013e328326f3ca
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    Zs.A 3686: Show issues Location:
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  8. Article ; Online: Podocyte-specific gene mutations are coming of age.

    Mathieson, Peter W

    Journal of the American Society of Nephrology : JASN

    2008  Volume 19, Issue 2, Page(s) 190–191

    MeSH term(s) Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Membrane Proteins/genetics ; Mutation ; Nephrotic Syndrome/genetics ; Podocytes/physiology ; Proteinuria/genetics
    Chemical Substances Intracellular Signaling Peptides and Proteins ; Membrane Proteins ; NPHS2 protein
    Language English
    Publishing date 2008-02
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2007121341
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  9. Article ; Online: Proteinuria and immunity--an overstated relationship?

    Mathieson, Peter W

    The New England journal of medicine

    2008  Volume 359, Issue 23, Page(s) 2492–2494

    MeSH term(s) 14-3-3 Proteins/metabolism ; Actins/metabolism ; Animals ; Calcineurin Inhibitors ; Cyclosporine/pharmacology ; Cyclosporine/therapeutic use ; Cytoskeleton/metabolism ; Humans ; Immunosuppressive Agents/pharmacology ; Immunosuppressive Agents/therapeutic use ; Mice ; Microfilament Proteins/metabolism ; Phosphorylation/drug effects ; Podocytes/cytology ; Podocytes/drug effects ; Proteinuria/drug therapy ; Proteinuria/immunology ; T-Lymphocytes
    Chemical Substances 14-3-3 Proteins ; Actins ; Calcineurin Inhibitors ; Immunosuppressive Agents ; Microfilament Proteins ; SYNPO protein, human ; Synpo protein, mouse ; Cyclosporine (83HN0GTJ6D)
    Language English
    Publishing date 2008-12-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMcibr0806881
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  10. Article ; Online: Is low-dose ciclosporin an effective treatment for membranous nephropathy with nephrotic syndrome?

    Mathieson, Peter W

    Nature clinical practice. Nephrology

    2007  Volume 3, Issue 4, Page(s) 190–191

    Language English
    Publishing date 2007-02-20
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 2228557-X
    ISSN 1745-8331 ; 1745-8323
    ISSN (online) 1745-8331
    ISSN 1745-8323
    DOI 10.1038/ncpneph0436
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