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  1. Article: Modulation Technique of Localized Surface Plasmon Resonance of Palladium Nanospheres by Coating with Titanium Dioxide Shell for Application to Photothermal Therapy Agent.

    Hayakawa, Yutaro / Furuya, Masato / Tahara, Hironobu / Kosuge, Yasuhiro / Kimura, Tsuyoshi / Sugawa, Kosuke / Otsuki, Joe

    Nanoscale research letters

    2022  Volume 17, Issue 1, Page(s) 60

    Abstract: Although plasmonic palladium (Pd) nanospheres are thermodynamically stable and have high photothermal conversion due to the free and bound electron coupling associated with the intrinsic high interband transition, they have not attracted attention as a ... ...

    Abstract Although plasmonic palladium (Pd) nanospheres are thermodynamically stable and have high photothermal conversion due to the free and bound electron coupling associated with the intrinsic high interband transition, they have not attracted attention as a photothermal conversion material for next-generation photothermal cancer therapy. This is because the Pd nanospheres generate the localized surface plasmon resonance (LSPR) intrinsically in the ultraviolet region, which is far away from the biological transparent window (750-900 nm). In this study, we controlled the LSP wavelength of Pd nanospheres by coating with high refractive index TiO
    Language English
    Publishing date 2022-06-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2253244-4
    ISSN 1556-276X ; 1931-7573
    ISSN (online) 1556-276X
    ISSN 1931-7573
    DOI 10.1186/s11671-022-03697-1
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  2. Article ; Online: Biophysical Characterization of the Contribution of the Fab Region to the IgG-FcγRIIIa Interaction.

    Kosuge, Hirofumi / Nagatoishi, Satoru / Kiyoshi, Masato / Ishii-Watabe, Akiko / Terao, Yosuke / Ide, Teruhiko / Tsumoto, Kouhei

    Biochemistry

    2022  Volume 62, Issue 2, Page(s) 262–269

    Abstract: The cell-surface receptor FcγRIIIa is crucial to the efficacy of therapeutic antibodies as well as the immune response. The interaction of the Fc region of IgG molecules with FcγRIIIa has been characterized, but until recently, it was thought that the ... ...

    Abstract The cell-surface receptor FcγRIIIa is crucial to the efficacy of therapeutic antibodies as well as the immune response. The interaction of the Fc region of IgG molecules with FcγRIIIa has been characterized, but until recently, it was thought that the Fab regions were not involved in the interaction. To evaluate the influence of the Fab regions in a biophysical context, we carried out surface plasmon resonance analyses using recombinant FcγRIIIa ligands. A van't Hoff analysis revealed that compared to the interaction of the papain-digested Fc fragment with FcγRIIIa, the interaction of commercially available, full-length rituximab with FcγRIIIa had a more favorable binding enthalpy, a less favorable binding entropy, and a slower off rate. Similar results were obtained from analyses of IgG1 molecules and an IgG1-Fc fragment produced by Expi293 cells. For further validation, we also prepared a maltose-binding protein-linked IgG1-Fc fragment (MBP-Fc). The binding enthalpy of MBP-Fc was nearly equal to that of the IgG1-Fc fragment for the interaction with FcγRIIIa, indicating that such alternatives to the Fab domains as MBP do not positively contribute to the IgG-FcγRIIIa interactions. Our investigation strongly suggests that the Fab region directly interacts with FcγRIIIa, resulting in an increase in the binding enthalpy and a decrease in the dissociation rate, at the expense of favorable binding entropy.
    MeSH term(s) Receptors, IgG/chemistry ; Immunoglobulin G/chemistry ; Rituximab/chemistry ; Immunoglobulin Fc Fragments/chemistry ; Thermodynamics ; Surface Plasmon Resonance
    Chemical Substances Receptors, IgG ; Immunoglobulin G ; Rituximab (4F4X42SYQ6) ; Immunoglobulin Fc Fragments
    Language English
    Publishing date 2022-05-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1108-3
    ISSN 1520-4995 ; 0006-2960
    ISSN (online) 1520-4995
    ISSN 0006-2960
    DOI 10.1021/acs.biochem.1c00832
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  3. Article ; Online: Photothermal therapeutic ability of copper open-shell nanostructures that are effective in the second biological transparency window based on symmetry breaking-induced plasmonic properties.

    Sugawa, Kosuke / Suzuki, Arisa / Honda, Jotaro / Yabuki, Taiku / Tahara, Hironobu / Hayakawa, Yutaro / Furuya, Masato / Ikake, Hiroki / Kimura, Tsuyoshi / Kosuge, Yasuhiro / Kurumi, Satoshi / Akiyama, Tsuyoshi / Takase, Kouichi / Otsuki, Joe

    Journal of materials chemistry. B

    2023  Volume 11, Issue 29, Page(s) 6837–6852

    Abstract: In this study, a photothermal therapy agent that works efficiently in the second biological transparency window was developed based on the localized surface plasmon (LSP) resonance of symmetry-broken open-shell nanostructures of low-cost Cu (CuOSNs). The ...

    Abstract In this study, a photothermal therapy agent that works efficiently in the second biological transparency window was developed based on the localized surface plasmon (LSP) resonance of symmetry-broken open-shell nanostructures of low-cost Cu (CuOSNs). The strong LSP resonance and superior photothermal conversion ability in the second biological transparency window were achieved by generating the dipolar bonding mode due to the plasmon hybridization between the nanoshell dipole and the nanohole dipole at the opening edge in CuOSNs derived from the symmetry breaking of a Cu nanoshell. Oxidative dissolution of CuOSNs in water was significantly suppressed by successive coating with the self-assembled monolayer of 16-mercaptohexadecanoic acid and a thin silica layer. Furthermore, the stability in phosphate buffered saline, which models the biological environment, was attained by further coating the nanoparticles with polyethylene glycol. It was demonstrated from
    MeSH term(s) Humans ; Copper/pharmacology ; Copper/chemistry ; HeLa Cells ; Nanostructures/chemistry ; Nanoparticles ; Polyethylene Glycols/chemistry
    Chemical Substances Copper (789U1901C5) ; Polyethylene Glycols (3WJQ0SDW1A)
    Language English
    Publishing date 2023-07-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d3tb00443k
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  4. Article ; Online: Point mutation bias in SARS-CoV-2 variants results in increased ability to stimulate inflammatory responses.

    Kosuge, Masato / Furusawa-Nishii, Emi / Ito, Koyu / Saito, Yoshiro / Ogasawara, Kouetsu

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 17766

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces severe pneumonia and is the cause of a worldwide pandemic. Coronaviruses, including SARS-CoV-2, have RNA proofreading enzymes in their genomes, resulting in fewer gene ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces severe pneumonia and is the cause of a worldwide pandemic. Coronaviruses, including SARS-CoV-2, have RNA proofreading enzymes in their genomes, resulting in fewer gene mutations than other RNA viruses. Nevertheless, variants of SARS-CoV-2 exist and may induce different symptoms; however, the factors and the impacts of these mutations are not well understood. We found that there is a bias to the mutations occurring in SARS-CoV-2 variants, with disproportionate mutation to uracil (U). These point mutations to U are mainly derived from cytosine (C), which is consistent with the substrate specificity of host RNA editing enzymes, APOBECs. We also found the point mutations which are consistent with other RNA editing enzymes, ADARs. For the C-to-U mutations, the context of the upstream uracil and downstream guanine from mutated position was found to be most prevalent. Further, the degree of increase of U in SARS-CoV-2 variants correlates with enhanced production of cytokines, such as TNF-α and IL-6, in cell lines when compared with stimulation by the ssRNA sequence of the isolated virus in Wuhan. Therefore, RNA editing is a factor for mutation bias in SARS-CoV-2 variants, which affects host inflammatory cytokines production.
    MeSH term(s) APOBEC Deaminases/metabolism ; Adenosine Deaminase/metabolism ; Betacoronavirus/classification ; Betacoronavirus/genetics ; Betacoronavirus/immunology ; Betacoronavirus/isolation & purification ; COVID-19 ; Cell Line, Tumor ; Coronavirus Infections/immunology ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Humans ; Interleukin-6/metabolism ; Pandemics ; Phylogeny ; Pneumonia, Viral/immunology ; Pneumonia, Viral/pathology ; Pneumonia, Viral/virology ; Point Mutation ; RNA Editing ; SARS-CoV-2 ; Tumor Necrosis Factor-alpha/metabolism ; Uracil/metabolism
    Chemical Substances Interleukin-6 ; Tumor Necrosis Factor-alpha ; Uracil (56HH86ZVCT) ; Adenosine Deaminase (EC 3.5.4.4) ; APOBEC Deaminases (EC 3.5.4.5)
    Keywords covid19
    Language English
    Publishing date 2020-10-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-74843-x
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  5. Article ; Online: Point mutation bias in SARS-CoV-2 variants results in increased ability to stimulate inflammatory responses

    Masato Kosuge / Emi Furusawa-Nishii / Koyu Ito / Yoshiro Saito / Kouetsu Ogasawara

    Scientific Reports, Vol 10, Iss 1, Pp 1-

    2020  Volume 9

    Abstract: Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces severe pneumonia and is the cause of a worldwide pandemic. Coronaviruses, including SARS-CoV-2, have RNA proofreading enzymes in their genomes, resulting in fewer ... ...

    Abstract Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces severe pneumonia and is the cause of a worldwide pandemic. Coronaviruses, including SARS-CoV-2, have RNA proofreading enzymes in their genomes, resulting in fewer gene mutations than other RNA viruses. Nevertheless, variants of SARS-CoV-2 exist and may induce different symptoms; however, the factors and the impacts of these mutations are not well understood. We found that there is a bias to the mutations occurring in SARS-CoV-2 variants, with disproportionate mutation to uracil (U). These point mutations to U are mainly derived from cytosine (C), which is consistent with the substrate specificity of host RNA editing enzymes, APOBECs. We also found the point mutations which are consistent with other RNA editing enzymes, ADARs. For the C-to-U mutations, the context of the upstream uracil and downstream guanine from mutated position was found to be most prevalent. Further, the degree of increase of U in SARS-CoV-2 variants correlates with enhanced production of cytokines, such as TNF-α and IL-6, in cell lines when compared with stimulation by the ssRNA sequence of the isolated virus in Wuhan. Therefore, RNA editing is a factor for mutation bias in SARS-CoV-2 variants, which affects host inflammatory cytokines production.
    Keywords Medicine ; R ; Science ; Q
    Subject code 572
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
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  6. Article ; Online: Highly sensitive HPLC analysis and biophysical characterization of N-glycans of IgG-Fc domain in comparison between CHO and 293 cells using FcγRIIIa ligand.

    Kosuge, Hirofumi / Nagatoishi, Satoru / Kiyoshi, Masato / Ishii-Watabe, Akiko / Tanaka, Toru / Terao, Yosuke / Oe, Seigo / Ide, Teruhiko / Tsumoto, Kouhei

    Biotechnology progress

    2020  Volume 36, Issue 6, Page(s) e3016

    Abstract: Quality control of monoclonal antibodies is challenging due in part to the diversity of post-translational modifications present. The regulation of the N-glycans of IgG-Fc domain is one of the key factors to maintain the safety and efficacy of antibody ... ...

    Abstract Quality control of monoclonal antibodies is challenging due in part to the diversity of post-translational modifications present. The regulation of the N-glycans of IgG-Fc domain is one of the key factors to maintain the safety and efficacy of antibody drugs. The FcγRIIIa affinity column is an attractive tool for the precise analysis of the N-glycans in IgG-Fc domain. We used the mutant FcγRIIIa, which is produced in Escherichia coli and is therefore not glycosylated, as an affinity reagent to analyze the N-glycans of monoclonal antibodies expressed in Expi293 and ExpiCHO cells. The monoclonal antibodies expressed in these cells showed very different chromatograms, because of differences in terminal galactose residues on the IgG-Fc domains. We also carried out kinetic and thermodynamic analyses to understand the interaction between monoclonal antibodies and the mutant FcγRIIIa. Expi293 cell-derived monoclonal antibodies had higher affinity for the mutant FcγRIIIa than those derived from ExpiCHO cells, due to slower off rates and lower binding entropy loss. Collectively, our results suggest that the FcγRIIIa column can be used to analyze the glycosylation of antibodies rapidly and specifically.
    MeSH term(s) Animals ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/genetics ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/isolation & purification ; CHO Cells ; Chromatography, High Pressure Liquid ; Cricetinae ; Cricetulus ; Galactose/genetics ; Glycosylation ; HEK293 Cells ; Humans ; Immunoglobulin Fc Fragments/chemistry ; Immunoglobulin Fc Fragments/genetics ; Immunoglobulin Fc Fragments/immunology ; Immunoglobulin Fc Fragments/isolation & purification ; Immunoglobulin G/chemistry ; Immunoglobulin G/genetics ; Immunoglobulin G/immunology ; Immunoglobulin G/isolation & purification ; Ligands ; Polysaccharides/chemistry ; Polysaccharides/genetics ; Polysaccharides/isolation & purification ; Protein Processing, Post-Translational/genetics ; Receptors, IgG/genetics ; Receptors, IgG/immunology
    Chemical Substances Antibodies, Monoclonal ; FCGR3A protein, human ; Immunoglobulin Fc Fragments ; Immunoglobulin G ; Ligands ; Polysaccharides ; Receptors, IgG ; Galactose (X2RN3Q8DNE)
    Language English
    Publishing date 2020-07-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 165657-0
    ISSN 1520-6033 ; 8756-7938
    ISSN (online) 1520-6033
    ISSN 8756-7938
    DOI 10.1002/btpr.3016
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    Zs.A 4253: Show issues Location:
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  7. Article: Point mutation bias in SARS-CoV-2 variants results in increased ability to stimulate inflammatory responses

    Kosuge, Masato / Furusawa-Nishii, Emi / Ito, Koyu / Saito, Yoshiro / Ogasawara, Kouetsu

    Sci Rep

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces severe pneumonia and is the cause of a worldwide pandemic. Coronaviruses, including SARS-CoV-2, have RNA proofreading enzymes in their genomes, resulting in fewer gene ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces severe pneumonia and is the cause of a worldwide pandemic. Coronaviruses, including SARS-CoV-2, have RNA proofreading enzymes in their genomes, resulting in fewer gene mutations than other RNA viruses. Nevertheless, variants of SARS-CoV-2 exist and may induce different symptoms; however, the factors and the impacts of these mutations are not well understood. We found that there is a bias to the mutations occurring in SARS-CoV-2 variants, with disproportionate mutation to uracil (U). These point mutations to U are mainly derived from cytosine (C), which is consistent with the substrate specificity of host RNA editing enzymes, APOBECs. We also found the point mutations which are consistent with other RNA editing enzymes, ADARs. For the C-to-U mutations, the context of the upstream uracil and downstream guanine from mutated position was found to be most prevalent. Further, the degree of increase of U in SARS-CoV-2 variants correlates with enhanced production of cytokines, such as TNF-α and IL-6, in cell lines when compared with stimulation by the ssRNA sequence of the isolated virus in Wuhan. Therefore, RNA editing is a factor for mutation bias in SARS-CoV-2 variants, which affects host inflammatory cytokines production.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #882928
    Database COVID19

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  8. Article ; Online: JCS 2020 Guideline Focused Update on Antithrombotic Therapy in Patients With Coronary Artery Disease.

    Nakamura, Masato / Kimura, Kazuo / Kimura, Takeshi / Ishihara, Masaharu / Otsuka, Fumiyuki / Kozuma, Ken / Kosuge, Masami / Shinke, Toshiro / Nakagawa, Yoshihisa / Natsuaki, Masahiro / Yasuda, Satoshi / Akasaka, Takashi / Kohsaka, Shun / Haze, Kazuo / Hirayama, Atsushi

    Circulation journal : official journal of the Japanese Circulation Society

    2020  Volume 84, Issue 5, Page(s) 831–865

    MeSH term(s) Cardiology/standards ; Clinical Decision-Making ; Consensus ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/therapy ; Coronary Thrombosis/etiology ; Coronary Thrombosis/prevention & control ; Fibrinolytic Agents/administration & dosage ; Fibrinolytic Agents/adverse effects ; Hemorrhage/chemically induced ; Humans ; Japan ; Percutaneous Coronary Intervention/adverse effects ; Risk Assessment ; Risk Factors ; Treatment Outcome
    Chemical Substances Fibrinolytic Agents
    Language English
    Publishing date 2020-03-13
    Publishing country Japan
    Document type Journal Article ; Practice Guideline ; Review
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.CJ-19-1109
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  9. Article ; Online: JCS 2022 Guideline Focused Update on Diagnosis and Treatment in Patients With Stable Coronary Artery Disease.

    Nakano, Shintaro / Kohsaka, Shun / Chikamori, Taishiro / Fukushima, Kenji / Kobayashi, Yoshio / Kozuma, Ken / Manabe, Susumu / Matsuo, Hitoshi / Nakamura, Masato / Ohno, Takayuki / Sawano, Mitsuaki / Toda, Koichi / Ueda, Yasunori / Yokoi, Hiroyoshi / Gatate, Yodo / Kasai, Tokuo / Kawase, Yoshiaki / Matsumoto, Naoya / Mori, Hitoshi /
    Nakazato, Ryo / Niimi, Nozomi / Saito, Yuichi / Shintani, Ayumi / Watanabe, Ippei / Watanabe, Yusuke / Ikari, Yuji / Jinzaki, Masahiro / Kosuge, Masami / Nakajima, Kenichi / Kimura, Takeshi

    Circulation journal : official journal of the Japanese Circulation Society

    2022  Volume 86, Issue 5, Page(s) 882–915

    MeSH term(s) Coronary Artery Disease/diagnosis ; Coronary Artery Disease/therapy ; Humans ; Percutaneous Coronary Intervention
    Language English
    Publishing date 2022-03-11
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.CJ-21-1041
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  10. Article ; Online: JCS 2021 Guideline on Radiation Safety in Cardiology.

    Kozuma, Ken / Chikamori, Taishiro / Hashimoto, Jun / Honye, Junko / Ikeda, Takanori / Ishiwata, Sugao / Kato, Mamoru / Kondo, Hiroshi / Matsubara, Kosuke / Matsumoto, Kazuma / Matsumoto, Naoya / Motoyama, Sadako / Obunai, Kotaro / Sakamoto, Hajime / Soejima, Kyoko / Suzuki, Shigeru / Abe, Koichiro / Amano, Hideo / Hioki, Hirofumi /
    Iimori, Takashi / Kawai, Hideki / Kosuge, Hisanori / Nakama, Tatsuya / Suzuki, Yasuyuki / Takeda, Kazuya / Ueda, Akiko / Yamashita, Takashi / Hirao, Kenzo / Kimura, Takeshi / Nagai, Ryozo / Nakamura, Masato / Shimizu, Wataru / Tamaki, Nagara

    Circulation journal : official journal of the Japanese Circulation Society

    2022  Volume 86, Issue 7, Page(s) 1148–1203

    MeSH term(s) Cardiology ; Cardiovascular System ; Humans
    Language English
    Publishing date 2022-04-22
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.CJ-21-0379
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