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  1. Article ; Online: A PREGNANT WOMAN WITH AN EXTRA CARDIAC CAVITY: AN ACQUIRED IATROGENIC COMPLICATION - A CASE REPORT AND LITERATURE REVIEW.

    Bigdelu, Leila / Maadarani, Ossama

    European journal of case reports in internal medicine

    2023  Volume 10, Issue 2, Page(s) 3757

    Abstract: According to the modified World Health Organization (WHO) classification, mechanical valves pose a high maternal risk and complications for pregnant women with heart disease. Left atrial appendage aneurysm (LAAA) is a rare condition that can manifest ... ...

    Abstract According to the modified World Health Organization (WHO) classification, mechanical valves pose a high maternal risk and complications for pregnant women with heart disease. Left atrial appendage aneurysm (LAAA) is a rare condition that can manifest clinically in several ways or remain silent for a long time and can be either congenital or acquired. We present the case of a pregnant woman who had a LAAA discovered several years after her last mitral valve replacement.
    Learning points: Left atrial appendage aneurysm is a rare entity and, in most cases, is congenital due to poor myocardial contractility of dysplastic pectinate muscles.Clinical manifestations range from an asymptomatic course with an incidental finding on echocardiography up to serious sequelae such as cardioembolic manifestations.The treatment approach includes a conservative strategy using anticoagulation and a surgical strategy with aneurysmectomy.
    Language English
    Publishing date 2023-02-09
    Publishing country Italy
    Document type Journal Article
    ISSN 2284-2594
    ISSN (online) 2284-2594
    DOI 10.12890/2023_003757
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Tirzepatide-Induced Ketoacidosis in Non-Diabetic Patients.

    Iqbal, Pathan Mohamad Rafe / Maadarani, Ossama Sajeh / Bitar, Zouheir Ibrahim

    European journal of case reports in internal medicine

    2024  Volume 11, Issue 4, Page(s) 4357

    Abstract: Background: Tirzepatide is a novel glucagon-like peptide 1/glucose-dependent insulinotropic peptide (GLP-1/GIP) receptor agonist. It was recently approved for diabetes control and weight reduction in non-diabetic patients.: Case description: We ... ...

    Abstract Background: Tirzepatide is a novel glucagon-like peptide 1/glucose-dependent insulinotropic peptide (GLP-1/GIP) receptor agonist. It was recently approved for diabetes control and weight reduction in non-diabetic patients.
    Case description: We report the first case of ketoacidosis after the use of tirzepatide in an obese non-diabetic patient, secondary to the possibility of starvation ketoacidosis and insulin resistance.
    Conclusion: The dual-acting GLP-1 and GIP receptor agonists, tirzepatide, can induce ketoacidosis in obese non-diabetic patients.
    Learning points: The dual-acting GLP-1 and GIP receptor agonists can cause ketoacidosis in obese non-diabetic patients.Ketoacidosis induced by tirzepatide is serious, and physicians should be aware of this complication and be alert to early symptoms, check serum and urine ketone levels, and stop medication.
    Language English
    Publishing date 2024-03-11
    Publishing country Italy
    Document type Journal Article
    ISSN 2284-2594
    ISSN (online) 2284-2594
    DOI 10.12890/2024_004357
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A pregnant woman with an extra cardiac cavity

    Leila Bigdelu / Ossama Maadarani

    European Journal of Case Reports in Internal Medicine (2023)

    an acquired iatrogenic complication— A case report and literature review

    2023  

    Abstract: According to the modified World Health Organization (WHO) classification, mechanical valves pose a high maternal risk and complications for pregnant women with heart disease. Left atrial appendage aneurysm (LAAA) is a rare condition that can manifest ... ...

    Abstract According to the modified World Health Organization (WHO) classification, mechanical valves pose a high maternal risk and complications for pregnant women with heart disease. Left atrial appendage aneurysm (LAAA) is a rare condition that can manifest clinically in several ways or remain silent for a long time and can be either congenital or acquired. We present the case of a pregnant woman who had a LAAA discovered several years after her last mitral valve replacement.
    Keywords left atrium ; left atrial appendage aneurysm ; mechanical mitral prosthesis ; Medicine ; R
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher SMC MEDIA SRL
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Cardiac Hydatid Disease with Palpitations as the Only Presenting Complaint: The Egg in the Nest.

    Azari, Ali / Bigdelu, Leila / Maadarani, Ossama / Bitar, Zouheir

    European journal of case reports in internal medicine

    2023  Volume 10, Issue 5, Page(s) 3886

    Abstract: Hydatid disease, also known as cystic echinococcosis, is a parasitic infection caused by the larval stage of : Learning points: Isolated cardiac hydatid disease is rare and accounts for only 0.5-2% of cases among infected patients.Cardiac hydatidosis ... ...

    Abstract Hydatid disease, also known as cystic echinococcosis, is a parasitic infection caused by the larval stage of
    Learning points: Isolated cardiac hydatid disease is rare and accounts for only 0.5-2% of cases among infected patients.Cardiac hydatidosis may present with a wide variety of clinical manifestations ranging from no symptoms to sudden death; palpitations may be the only complaint.Surgical excision is the treatment of choice for cardiac hydatid disease to avoid high-risk complications.
    Language English
    Publishing date 2023-04-27
    Publishing country Italy
    Document type Journal Article
    ISSN 2284-2594
    ISSN (online) 2284-2594
    DOI 10.12890/2023_003886
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Point of Care Ultrasound Used to Diagnose Nontyphoidal Endocarditis.

    Alqallaf, Zahraa Y / Maadarani, Ossama S / Elhabibi, Mohamed E / Abdelfatah, Mohamad / Bitar, Zouheir I

    POCUS journal

    2024  Volume 9, Issue 1, Page(s) 29–32

    Abstract: Point of care ultrasound (POCUS) can make an expedited diagnosis, which might lead to early correct management. POCUS should be used in a systemic and integrated approach to evaluate multiple organs in patients with sepsis and septic shock. We present a ... ...

    Abstract Point of care ultrasound (POCUS) can make an expedited diagnosis, which might lead to early correct management. POCUS should be used in a systemic and integrated approach to evaluate multiple organs in patients with sepsis and septic shock. We present a rare case of sepsis due to nontyphoidal Salmonella endocarditis with splenic abscess in which a multiorgan POCUS examination led to expedited treatment.
    Language English
    Publishing date 2024-04-22
    Publishing country Canada
    Document type Case Reports
    ISSN 2369-8543
    ISSN (online) 2369-8543
    DOI 10.24908/pocus.v9i1.16937
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Recurrent High-Risk Pulmonary Thromboembolism Treated with Repeated Thrombolytic Therapy Could be Helpful for Certain Patients: A Case Report and Review of the Literature.

    Bigdelu, Leila / Ebrahimi, Negar / Maadarani, Ossama

    European journal of case reports in internal medicine

    2023  Volume 10, Issue 9, Page(s) 4042

    Abstract: Acute pulmonary thromboembolism (PTE) is considered the third most frequent acute cardiovascular syndrome behind myocardial infarction and stroke, with annual incidence rates ranging from 39 to 115 per 100,000 people and ranking high among the causes of ... ...

    Abstract Acute pulmonary thromboembolism (PTE) is considered the third most frequent acute cardiovascular syndrome behind myocardial infarction and stroke, with annual incidence rates ranging from 39 to 115 per 100,000 people and ranking high among the causes of cardiovascular mortality. High-risk PTE is characterised by haemodynamic instability and encompasses clinical manifestations such as cardiac arrest, obstructive shock and persistent hypotension. The European Society of Cardiology (ESC) recommends a reperfusion strategy with systemic thrombolytic therapy for high-risk PTE under class I, level B if there are no contraindications. Overall, unsuccessful thrombolytic therapy and recurrent PTE have been reported in 8% of patients with high-risk PTE. The guidelines recommend surgical pulmonary embolectomy if thrombolysis is contraindicated or has failed. The position of repeated thrombolytic therapy as a treatment option in patients with recurrent high-risk PTE, especially in situations with a lack of surgical expertise or resources, was not mentioned in the guidelines. We report the case of a patient who suffered a recurrent high-risk PTE and was treated with repeated thrombolytic therapy that was effective and resulted in excellent outcomes.
    Learning points: Acute pulmonary thromboembolism (PTE) is a serious medical condition and widespread disease with well-recognised morbidity and mortality.Systemic thrombolytic therapy should be the first choice in patients with high-risk PTE without contraindication.Repeated thrombolytic therapy in recurrent high-risk PTE might be effective in patients with low risk of bleeding as an alternative to surgical embolectomy or catheter-directed therapy.
    Language English
    Publishing date 2023-08-25
    Publishing country Italy
    Document type Journal Article
    ISSN 2284-2594
    ISSN (online) 2284-2594
    DOI 10.12890/2023_004042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Spontaneous Recovery of Isolated Advanced Heart Block in Patient with Celiac Disease by Starting a Strict Gluten Free Diet: A Case Report and Review of the Literature.

    Maadarani, Ossama / Bigdelu, Leila / Bitar, Zouheir / Alhabibi, Mohammad / Kabbara, Hosni

    European journal of case reports in internal medicine

    2023  Volume 10, Issue 9, Page(s) 4012

    Abstract: Cardiac conduction disorder may have a wide range of aetiology and can manifest with symptomatic bradycardia and syncope. Celiac disease is a malabsorptive long-term autoimmune disorder where the small intestine is the primarily affected organ due to ... ...

    Abstract Cardiac conduction disorder may have a wide range of aetiology and can manifest with symptomatic bradycardia and syncope. Celiac disease is a malabsorptive long-term autoimmune disorder where the small intestine is the primarily affected organ due to gluten intolerance in genetically predisposed individuals. The associations between celiac disease and cardiac pathology are uncommon. We report a case of a 50-year-old woman with a known case of celiac disease who presented with a symptomatic cardiac conduction abnormality that improved with a gluten-free diet.
    Learning points: Celiac disease is a malabsorptive long-term autoimmune disorder where the small intestine is the primarily affected organ due to gluten intolerance and affects 1% of the general population.Cardiovascular pathology, including dilated cardiomyopathy, myocarditis, arrhythmias, and premature atherosclerosis, was found to be more prevalent in patients with celiac disease than in others without celiac disease.The association of celiac disease with isolated advanced atrioventricular conduction abnormality is rare and a gluten-free diet may help improve the conduction abnormality.
    Language English
    Publishing date 2023-08-09
    Publishing country Italy
    Document type Journal Article
    ISSN 2284-2594
    ISSN (online) 2284-2594
    DOI 10.12890/2023_004012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Coronary Cameral Fistula Manifested as Angina Pectoris in a 40-Year Old Female.

    Bigdelu, Leila / Azari, Ali / Heidari-Bakavoli, Ali / Maadarani, Ossama

    European journal of case reports in internal medicine

    2023  Volume 10, Issue 12, Page(s) 4150

    Abstract: Coronary cameral fistula (CCF) is defined as an abnormal connection between the coronary artery and any cardiac chamber. It usually appears due to abnormal embryogenesis and represents less than 1% of the population. Most CCF cases are asymptomatic, ... ...

    Abstract Coronary cameral fistula (CCF) is defined as an abnormal connection between the coronary artery and any cardiac chamber. It usually appears due to abnormal embryogenesis and represents less than 1% of the population. Most CCF cases are asymptomatic, however large CCFs may cause symptoms and complications. We present a case of a young female with symptomatic CCF suspected on echocardiography and confirmed by computed tomography coronary angiography. She was successfully treated surgically with total improvement of symptoms.
    Learning points: Coronary cameral fistula (CCF) is an abnormal communication between the coronary arteries and cardiac chambers. Most fistulas are asymptomatic, however, large CCFs can cause symptoms.CCF can cause angina pectoris due to the coronary steal phenomenon, and may require surgical intervention.Coronary computed tomography angiography is a highly sensitive method for detecting coronary artery fistulas noninvasively.
    Language English
    Publishing date 2023-11-14
    Publishing country Italy
    Document type Journal Article
    ISSN 2284-2594
    ISSN (online) 2284-2594
    DOI 10.12890/2023_004150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Antipsychotic drugs may contribute to venous thromboembolism - a case report and review literature.

    Hajjiah, Adnan / Maadarani, Ossama / Bitar, Zouheir / Alfasam, Khaled / Hanna, Boutros / Elhabibi, Mohamad

    JRSM open

    2023  Volume 14, Issue 1, Page(s) 20542704221132142

    Abstract: Use of antipsychotic drugs has been associated with increased risk of venous thromboembolism in several observational studies with unclear mechanism. We present a case of a patient who experienced a significant event of venous thromboembolism after a few ...

    Abstract Use of antipsychotic drugs has been associated with increased risk of venous thromboembolism in several observational studies with unclear mechanism. We present a case of a patient who experienced a significant event of venous thromboembolism after a few months exposure to atypical antipsychotic drug for his bipolar mood disorders.
    Language English
    Publishing date 2023-01-06
    Publishing country England
    Document type Case Reports
    ZDB-ID 2762955-7
    ISSN 2054-2704
    ISSN 2054-2704
    DOI 10.1177/20542704221132142
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Successful Thrombolytic Therapy Using Ultraslow Low-Dose Infusion During Pregnancy for Mitral Mechanical Valve Thrombosis: A Case Series and Review of the Literature.

    Bigdelu, Leila / Maadarani, Ossama / Yadolh, Asal / Bitar, Zouheir / Azadi, Nadia

    European journal of case reports in internal medicine

    2023  Volume 10, Issue 5, Page(s) 3856

    Abstract: According to the modified World Health Organization (WHO) classification, pregnant women with mechanical valves face a very high risk of complications (Risk Category III). Mechanical valve thrombosis is a serious complication that significantly increases ...

    Abstract According to the modified World Health Organization (WHO) classification, pregnant women with mechanical valves face a very high risk of complications (Risk Category III). Mechanical valve thrombosis is a serious complication that significantly increases during pregnancy due to multiple mechanisms. Thrombolytic therapy has recently been used as a first-line treatment for mechanical valve thrombosis during pregnancy. However, the consensus regarding the optimal treatment strategy, type, dose and route of administration was unclear. We present three cases of mechanical mitral valve thrombosis during pregnancy treated successfully with repeated doses of ultraslow infusion of low-dose tissue-type plasminogen activator (t-PA) alteplase. We also present a review of the literature on this subject.
    Learning points: Pregnancy in women with mechanical heart valves significantly increases the risk of maternal mortality or severe morbidity.Non-compliance with anticoagulant therapy and/or less frequent monitoring of therapeutic levels during pregnancy can result in serious complications such as valve thrombosis and thromboembolism.Thrombolytic therapy with low-dose tissue-type plasminogen activator can be an attractive alternative to surgical valve replacement and medical treatment in appropriately selected pregnant women with thrombosis of a mechanical valve.
    Language English
    Publishing date 2023-04-06
    Publishing country Italy
    Document type Journal Article
    ISSN 2284-2594
    ISSN (online) 2284-2594
    DOI 10.12890/2023_003856
    Database MEDical Literature Analysis and Retrieval System OnLINE

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