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  1. Article: Department of Practice of Medicine: Conducted by Professor Allen J. Smith, A. M, M. D., Medical Department University of Texas, Galveston.

    Smith, Allen J

    Daniel's Texas medical journal

    2023  Volume 8, Issue 10, Page(s) 404–407

    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Journal Article
    ISSN 0892-8487
    ISSN 0892-8487
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Department of Practice of Medicine: Conducted by Professor Allen J. Smith, A. M., M. D., Medical Department University of Texas, Galveston.

    Smith, Allen J

    Daniel's Texas medical journal

    2023  Volume 8, Issue 11, Page(s) 450–453

    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Journal Article
    ISSN 0892-8487
    ISSN 0892-8487
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Department of Practice of Medicine: Conducted by Prof. Allen J. Smith, A. M., M. D., Medical Department University of Texas, Galveston.

    Smith, Allen J

    Daniel's Texas medical journal

    2023  Volume 8, Issue 9, Page(s) 352–356

    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Journal Article
    ISSN 0892-8487
    ISSN 0892-8487
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Department of Practice of Medicine: Conducted by Prof. Allen J. Smith, A. M., M. D., Medical Department University of Texas, Galveston.

    Smith, Allen J

    Daniel's Texas medical journal

    2023  Volume 8, Issue 8, Page(s) 314–318

    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Journal Article
    ISSN 0892-8487
    ISSN 0892-8487
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Kategorien

    Order via subito

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  5. Article ; Online: Is Exercise the Best Medicine during a COVID-19 Pandemic? Comment on Constandt, B.; Thibaut, E.; De Bosscher, V.; Scheerder, J.; Ricour, M.; Willem, A. Exercising in Times of Lockdown: An Analysis of the Impact of COVID-19 on Levels and Patterns of Exercise among Adults in Belgium.

    Hew-Butler, Tamara / Smith-Hale, Valerie / Van Sumeren, Matthew / Sabourin, Jordan / Levy, Phillip

    International journal of environmental research and public health

    2020  Volume 17, Issue 16

    Abstract: From Constandt et al.'s survey of 13,515 Belgium respondents, regular physical activity can be successfully initiated and sustained during a lockdown, with appropriate social distancing measures. Documentation that 77% of highly active people and 58% of ... ...

    Abstract From Constandt et al.'s survey of 13,515 Belgium respondents, regular physical activity can be successfully initiated and sustained during a lockdown, with appropriate social distancing measures. Documentation that 77% of highly active people and 58% of low active people exercised as much or more following the institution of a nationwide lockdown was impressive, given that the cases of COVID-19 were accelerating at that time. The Belgian government's central promotion of exercise, to boost both the mental and physical health of the population, likely contributed to the health, tolerance, and ultimate success of lockdown. In this commentary, we wish to pose a follow-up query which highlights the potential detrimental effects of intense exercise (competition) performed without social distancing measures. The proposed graphical abstract elucidates these possible risks, in contrast to the favorable results outlined in Constandt et al.'s study.
    MeSH term(s) Adult ; Belgium ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Humans ; Pandemics ; Pneumonia, Viral ; Public Health ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-08
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph17165730
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Commentary on viewpoint article by A H Henderson, M J Lewis, A M Shah, and J A Smith (April, pages 305-8)

    Palmer, R M / Smith, R E

    Cardiovascular research

    1992  Volume 26, Issue 6, Page(s) 638

    MeSH term(s) Animals ; Biological Factors/physiology ; Humans ; Myocardial Contraction/physiology ; Nitric Oxide/metabolism
    Chemical Substances Biological Factors ; Nitric Oxide (31C4KY9ESH) ; endocardin (77538-22-8)
    Language English
    Publishing date 1992-06
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/26.6.638
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 565: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Re: Tonkin, M. A. On the classification of congenital thumb hypoplasia. J Hand Surg Eur. 2014, 39: 948-55.

    Smith, P

    The Journal of hand surgery, European volume

    2015  Volume 40, Issue 4, Page(s) 427

    MeSH term(s) Hand Deformities/classification ; Humans ; Thumb/abnormalities
    Language English
    Publishing date 2015-05
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 2272801-6
    ISSN 2043-6289 ; 1753-1934
    ISSN (online) 2043-6289
    ISSN 1753-1934
    DOI 10.1177/1753193415571502
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1940: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: A correction to the research article titled: "Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells" by A. S. Little, K. Balmanno, M. J. Sale, S. Newman, J. R. Dry, M. Hampson, P. A. W. Edwards, P. D. Smith, S. J. Cook.

    Little, Annette S / Balmanno, Kathryn / Sale, Matthew J / Newman, Scott / Dry, Jonathan R / Hampson, Mark / Edwards, Paul A W / Smith, Paul D / Cook, Simon J

    Science signaling

    2011  Volume 4, Issue 170, Page(s) er2

    Abstract: The acquisition of resistance to protein kinase inhibitors is a growing problem in cancer treatment. We modeled acquired resistance to the MEK1/2 (mitogen-activated or extracellular signal–regulated protein kinase kinases 1 and 2) inhibitor selumetinib ( ... ...

    Abstract The acquisition of resistance to protein kinase inhibitors is a growing problem in cancer treatment. We modeled acquired resistance to the MEK1/2 (mitogen-activated or extracellular signal–regulated protein kinase kinases 1 and 2) inhibitor selumetinib (AZD6244) in colorectal cancer cell lines harboring mutations in BRAF (COLO205 and HT29 lines) or KRAS (HCT116 and LoVo lines). AZD6244-resistant derivatives were refractory to AZD6244-induced cell cycle arrest and death and exhibited a marked increase in ERK1/2 (extracellular signal–regulated kinases 1 and 2) pathway signaling and cyclin D1 abundance when assessed in the absence of inhibitor. Genomic sequencing revealed no acquired mutations in MEK1 or MEK2, the primary target of AZD6244. Rather, resistant lines showed a marked up-regulation of their respective driving oncogenes, BRAF600E or KRAS13D, due to intrachromosomal amplification. Inhibition of BRAF reversed resistance to AZD6244 in COLO205 cells, which suggested that combined inhibition of MEK1/2 and BRAF may reduce the likelihood of acquired resistance in tumors with BRAF600E. Knockdown of KRAS reversed AZD6244 resistance in HCT116 cells as well as reduced the activation of ERK1/2 and protein kinase B; however, the combined inhibition of ERK1/2 and phosphatidylinositol 3-kinase signaling had little effect on AZD6244 resistance, suggesting that additional KRAS effector pathways contribute to this process. Microarray analysis identified increased expression of an 18-gene signature previously identified as reflecting MEK1/2 pathway output in resistant cells. Thus, amplification of the driving oncogene (BRAF600E or KRAS13D) can drive acquired resistance to MEK1/2 inhibitors by increasing signaling through the ERK1/2 pathway. However, up-regulation of KRAS13D leads to activation of multiple KRAS effector pathways, underlining the therapeutic challenge posed by KRAS mutations. These results may have implications for the use of combination therapies.
    MeSH term(s) Benzimidazoles ; Cell Cycle/drug effects ; Cell Death/drug effects ; Cell Line, Tumor ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/enzymology ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Drug Resistance, Neoplasm/genetics ; Gene Amplification ; Genes, ras ; Humans ; MAP Kinase Signaling System/drug effects ; MAP Kinase Signaling System/genetics ; Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors ; Phosphatidylinositol 3-Kinases/antagonists & inhibitors ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins B-raf/genetics ; Proto-Oncogene Proteins p21(ras) ; Up-Regulation ; ras Proteins/genetics
    Chemical Substances AZD 6244 ; Benzimidazoles ; KRAS protein, human ; Proto-Oncogene Proteins ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; Mitogen-Activated Protein Kinase Kinases (EC 2.7.12.2) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; ras Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2011-06-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Corrected and Republished Article
    ZDB-ID 2417226-1
    ISSN 1937-9145 ; 1945-0877
    ISSN (online) 1937-9145
    ISSN 1945-0877
    DOI 10.1126/scisignal.4170er2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Is Exercise the Best Medicine during a COVID-19 Pandemic? Comment on Constandt, B.; Thibaut, E.; De Bosscher, V.; Scheerder, J.; Ricour, M.; Willem, A. Exercising in Times of Lockdown

    Tamara Hew-Butler / Valerie Smith-Hale / Matthew Van Sumeren / Jordan Sabourin / Phillip Levy

    International Journal of Environmental Research and Public Health, Vol 17, Iss 5730, p

    An Analysis of the Impact of COVID-19 on Levels and Patterns of Exercise among Adults in Belgium. Int. J. Environ. Res. Public Health 2020, 17 , 4144

    2020  Volume 5730

    Abstract: From Constandt et al.’s survey of 13,515 Belgium respondents, regular physical activity can be successfully initiated and sustained during a lockdown, with appropriate social distancing measures. Documentation that 77% of highly active people and 58% of ... ...

    Abstract From Constandt et al.’s survey of 13,515 Belgium respondents, regular physical activity can be successfully initiated and sustained during a lockdown, with appropriate social distancing measures. Documentation that 77% of highly active people and 58% of low active people exercised as much or more following the institution of a nationwide lockdown was impressive, given that the cases of COVID-19 were accelerating at that time. The Belgian government’s central promotion of exercise, to boost both the mental and physical health of the population, likely contributed to the health, tolerance, and ultimate success of lockdown. In this commentary, we wish to pose a follow-up query which highlights the potential detrimental effects of intense exercise (competition) performed without social distancing measures. The proposed graphical abstract elucidates these possible risks, in contrast to the favorable results outlined in Constandt et al.’s study.
    Keywords COVID-19 ; exercise ; pandemic ; Medicine ; R ; covid19
    Subject code 796
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Article: J. Donald M. Gass, MD: Festschrift editorial.

    Flynn, John T / Clarkson, John G / Curtin, Victor T / Flynn, Harry W / Hurtes, Reva / Smith, J Lawton

    American journal of ophthalmology

    2004  Volume 137, Issue 3, Page(s) 480–550

    MeSH term(s) History, 20th Century ; History, 21st Century ; Humans ; Ophthalmology/history ; United States
    Language English
    Publishing date 2004-03
    Publishing country United States
    Document type Biography ; Festschrift ; Historical Article
    ZDB-ID 80030-2
    ISSN 1879-1891 ; 0002-9394
    ISSN (online) 1879-1891
    ISSN 0002-9394
    DOI 10.1016/j.ajo.2003.11.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ul I Zs.39: Show issues Location:
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