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Article ; Online: INSIDE-T

Mehran Naseri-Rad / Ronny Berndtsson / Ursula S. McKnight / Magnus Persson / Kenneth M. Persson

Sustainability, Vol 13, Iss 7596, p

A Groundwater Contamination Transport Model for Sustainability Assessment in Remediation Practice

2021 Volume 7596

Abstract: ... about the efficiency of each remediation method based on their experiences in similar cases. INSIDE-T uses trend ... measure can then be quantified based on the underlying SA tool (INSIDE). INSIDE-T was applied to a site ... a much lower sustainability score overall. INSIDE-T outcomes enable site managers to test and evaluate ...

Abstract	Current sustainability assessment (SA) tools to help deal with contaminated groundwater sites are inherently subjective and hardly applied. One reason may be lack of proper tools for addressing contaminant spread which are basically objective. To fill this gap, there is a need for contaminant transport models that provide site managers with needed room for applying their judgments and considerations about the efficiency of each remediation method based on their experiences in similar cases. INSIDE-T uses trend analysis and inverse modeling to estimate transport parameters. It then simulates contaminant transport both with and without the inclusion of remedial actions in a transparent way. The sustainability of each remedy measure can then be quantified based on the underlying SA tool (INSIDE). INSIDE-T was applied to a site in south Sweden, contaminated with pentachlorophenol. Simulation scenarios were developed to enable comparison between various remediation strategies and combinations of these. The application indicated that natural attenuation was not a viable option within the timeframe of interest. Although pump-and-treat combined with a permeable reactive barrier was found to be just as effective as bioremediation after five years, it received a much lower sustainability score overall. INSIDE-T outcomes enable site managers to test and evaluate different scenarios, a necessity in participatory decision-making practices such as remediation projects.
Keywords	sustainable remediation ; contaminant transport ; contaminated sites ; decision support system ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	690
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Engineering Vaccines for Tissue-Resident Memory T Cells.

Knight, Frances C / Wilson, John T

Advanced therapeutics

2021 Volume 4, Issue 4

Abstract: In recent years, tissue-resident memory T cells (T ...

Abstract	In recent years, tissue-resident memory T cells (T
Language	English
Publishing date	2021-01-20
Publishing country	Germany
Document type	Journal Article
ISSN	2366-3987
ISSN (online)	2366-3987
DOI	10.1002/adtp.202000230
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Article: A Comparison of T

McGarry, Bryony L / Damion, Robin A / Chew, Isabel / Knight, Michael J / Harston, George Wj / Carone, Davide / Jezzard, Peter / Sitaram, Amith / Muir, Keith W / Clatworthy, Philip / Kauppinen, Risto A

Journal of central nervous system disease

2020 Volume 12, Page(s) 1179573520943314

Abstract: Background: T: Methods: A total of 35 patients underwent 3T (3 Tesla) MRI (<9-hour symptom ... onset). Diffusion-weighted (DWI), apparent diffusion coefficient (ADC), T: Results: The T ... Conclusions: Quantitative T ...

Abstract	Background: T Methods: A total of 35 patients underwent 3T (3 Tesla) MRI (<9-hour symptom onset). Diffusion-weighted (DWI), apparent diffusion coefficient (ADC), T Results: The T Conclusions: Quantitative T
Language	English
Publishing date	2020-09-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2586873-1
ISSN	1179-5735
ISSN	1179-5735
DOI	10.1177/1179573520943314
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Article ; Online: Longitudinal plasma proteomics in CAR T-cell therapy patients implicates neutrophils and NETosis in the genesis of CRS.

Blood advances

2024 Volume 8, Issue 6, Page(s) 1422–1426

MeSH term(s)	Humans ; Immunotherapy, Adoptive/adverse effects ; Neutrophils ; Proteomics ; Receptors, Chimeric Antigen ; Cytokines
Chemical Substances	Receptors, Chimeric Antigen ; Cytokines
Language	English
Publishing date	2024-01-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2023010728
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Zs.A 7153: Show issues

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Article ; Online: Quantifying T

Damion, Robin A / Knight, Michael J / McGarry, Bryony L / Bosnell, Rose / Jezzard, Peter / Harston, George Wj / Carone, Davide / Kennedy, James / El-Tawil, Salwa / Elliot, Jennifer / Muir, Keith W / Clatworthy, Philip / Kauppinen, Risto A

Physics in medicine and biology

2019 Volume 64, Issue 9, Page(s) 95016

Abstract: ... decreases in ischaemia, highlighting a lesion in acute stroke patients. The MRI T ...

Abstract	The apparent diffusion coefficient (ADC) of cerebral water, as measured by diffusion MRI, rapidly decreases in ischaemia, highlighting a lesion in acute stroke patients. The MRI T
MeSH term(s)	Diffusion Magnetic Resonance Imaging/methods ; Female ; Gray Matter/diagnostic imaging ; Humans ; Male ; Middle Aged ; Stroke/diagnostic imaging ; White Matter/diagnostic imaging
Language	English
Publishing date	2019-04-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/ab1442
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Article: Enhancing the effectiveness of γδ T cells by mRNA transfection of chimeric antigen receptors or bispecific T cell engagers.

Becker, Scott A / Petrich, Brian G / Yu, Bing / Knight, Kristopher A / Brown, Harrison C / Raikar, Sunil S / Doering, Christopher B / Spencer, H Trent

Molecular therapy oncolytics

2023 Volume 29, Page(s) 145–157

Abstract: Adoptive cell therapy (ACT) utilizing γδ T cells is becoming a promising option for the treatment ... antigen receptors (CARs) or combination treatments with bispecific T cell engagers, have improved the specificity ... Here, we test whether electroporation of γδ T cells with CAR or secreted bispecific T cell engager ...

Abstract	Adoptive cell therapy (ACT) utilizing γδ T cells is becoming a promising option for the treatment of cancer, because it offers an off-the-shelf allogeneic product that is safe, potent, and clinically effective. Approaches to engineer or enhance immune-competent cells for ACT, like expression of chimeric antigen receptors (CARs) or combination treatments with bispecific T cell engagers, have improved the specificity and cytotoxic potential of ACTs and have shown great promise in preclinical and clinical settings. Here, we test whether electroporation of γδ T cells with CAR or secreted bispecific T cell engager (sBite) mRNA is an effective approach to improve the cytotoxicity of γδ T cells. Using a CD19-specific CAR, approximately 60% of γδ T cells are modified after mRNA electroporation and these cells show potent anticancer activity
Language	English
Publishing date	2023-05-22
Publishing country	United States
Document type	Journal Article
ISSN	2372-7705
ISSN	2372-7705
DOI	10.1016/j.omto.2023.05.007
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Article ; Online: Large clones of pre-existing T cells drive early immunity against SARS-COV-2 and LCMV infection.

Milighetti, Martina / Peng, Yanchun / Tan, Cedric / Mark, Michal / Nageswaran, Gayathri / Byrne, Suzanne / Ronel, Tahel / Peacock, Tom / Mayer, Andreas / Chandran, Aneesh / Rosenheim, Joshua / Whelan, Matthew / Yao, Xuan / Liu, Guihai / Felce, Suet Ling / Dong, Tao / Mentzer, Alexander J / Knight, Julian C / Balloux, Francois /

Greenstein, Erez / Reich-Zeliger, Shlomit / Pade, Corinna / Gibbons, Joseph M / Semper, Amanda / Brooks, Tim / Otter, Ashley / Altmann, Daniel M / Boyton, Rosemary J / Maini, Mala K / McKnight, Aine / Manisty, Charlotte / Treibel, Thomas A / Moon, James C / Noursadeghi, Mahdad / Chain, Benny

iScience

2023 Volume 26, Issue 6, Page(s) 106937

Abstract: T cell responses precede antibody and may provide early control of infection. We analyzed ... the clonal basis of this rapid response following SARS-COV-2 infection. We applied T cell receptor (TCR ... sequencing to define the trajectories of individual T cell clones immediately. In SARS-COV-2 PCR+ individuals ...

Abstract	T cell responses precede antibody and may provide early control of infection. We analyzed the clonal basis of this rapid response following SARS-COV-2 infection. We applied T cell receptor (TCR) sequencing to define the trajectories of individual T cell clones immediately. In SARS-COV-2 PCR+ individuals, a wave of TCRs strongly but transiently expand, frequently peaking the same week as the first positive PCR test. These expanding TCR CDR3s were enriched for sequences functionally annotated as SARS-COV-2 specific. Epitopes recognized by the expanding TCRs were highly conserved between SARS-COV-2 strains but not with circulating human coronaviruses. Many expanding CDR3s were present at high frequency in pre-pandemic repertoires. Early response TCRs specific for lymphocytic choriomeningitis virus epitopes were also found at high frequency in the preinfection naive repertoire. High-frequency naive precursors may allow the T cell response to respond rapidly during the crucial early phases of acute viral infection.
Language	English
Publishing date	2023-05-22
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2023.106937
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Article ; Online: HERV1-env Induces Unfolded Protein Response Activation in Autoimmune Liver Disease: A Potential Mechanism for Regulatory T Cell Dysfunction.

Subramanian, Kumar / Paul, Saikat / Libby, Andrew / Patterson, Jordan / Arterbery, Adam / Knight, James / Castaldi, Christopher / Wang, Guilin / Avitzur, Yaron / Martinez, Mercedes / Lobritto, Steve / Deng, Yanhong / Geliang, Gan / Kroemer, Alexander / Fishbein, Thomas / Mason, Andrew / Dominguez-Villar, Margarita / Mariappan, Malaiyalam / Ekong, Udeme D

Journal of immunology (Baltimore, Md. : 1950)

2023 Volume 210, Issue 6, Page(s) 732–744

Abstract: Regulatory T cells (Tregs) are not terminally differentiated but can acquire effector properties ...

Abstract	Regulatory T cells (Tregs) are not terminally differentiated but can acquire effector properties. Here we report an increased expression of human endogenous retrovirus 1 (HERV1-env) proteins in Tregs of patients with de novo autoimmune hepatitis and autoimmune hepatitis, which induces endoplasmic reticulum (ER) stress. HERV1-env-triggered ER stress activates all three branches (IRE1, ATF6, and PERK) of the unfolded protein response (UPR). Our coimmunoprecipitation studies show an interaction between HERV1-env proteins and the ATF6 branch of the UPR. The activated form of ATF6α activates the expression of RORC and STAT3 by binding to promoter sequences and induces IL-17A production. Silencing of HERV1-env results in recovery of Treg suppressive function. These findings identify ER stress and UPR activation as key factors driving Treg plasticity (species: human).
MeSH term(s)	Humans ; Hepatitis, Autoimmune ; T-Lymphocytes, Regulatory ; Endogenous Retroviruses ; Unfolded Protein Response ; Endoplasmic Reticulum Stress ; Liver Diseases ; eIF-2 Kinase ; Activating Transcription Factor 6
Chemical Substances	eIF-2 Kinase (EC 2.7.11.1) ; Activating Transcription Factor 6
Language	English
Publishing date	2023-01-31
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.2100186
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Article ; Online: Single cell spatial analysis reveals inflammatory foci of immature neutrophil and CD8 T cells in COVID-19 lungs.

Weeratunga, Praveen / Denney, Laura / Bull, Joshua A / Repapi, Emmanouela / Sergeant, Martin / Etherington, Rachel / Vuppussetty, Chaitanya / Turner, Gareth D H / Clelland, Colin / Woo, Jeongmin / Cross, Amy / Issa, Fadi / de Andrea, Carlos Eduardo / Melero Bermejo, Ignacio / Sims, David / McGowan, Simon / Zurke, Yasemin-Xiomara / Ahern, David J / Gamez, Eddie C /

Whalley, Justin / Richards, Duncan / Klenerman, Paul / Monaco, Claudia / Udalova, Irina A / Dong, Tao / Antanaviciute, Agne / Ogg, Graham / Knight, Julian C / Byrne, Helen M / Taylor, Stephen / Ho, Ling-Pei

Nature communications

2023 Volume 14, Issue 1, Page(s) 7216

Abstract: ... CD8 T cells, megakaryocytes and monocytes co-located with regenerating alveolar progenitors and ... endothelium. Of note, a highly active cluster of immature neutrophils and CD8 T cells, is found spatially ...

Abstract	Single cell spatial interrogation of the immune-structural interactions in COVID -19 lungs is challenging, mainly because of the marked cellular infiltrate and architecturally distorted microstructure. To address this, we develop a suite of mathematical tools to search for statistically significant co-locations amongst immune and structural cells identified using 37-plex imaging mass cytometry. This unbiased method reveals a cellular map interleaved with an inflammatory network of immature neutrophils, cytotoxic CD8 T cells, megakaryocytes and monocytes co-located with regenerating alveolar progenitors and endothelium. Of note, a highly active cluster of immature neutrophils and CD8 T cells, is found spatially linked with alveolar progenitor cells, and temporally with the diffuse alveolar damage stage. These findings offer further insights into how immune cells interact in the lungs of severe COVID-19 disease. We provide our pipeline [Spatial Omics Oxford Pipeline (SpOOx)] and visual-analytical tool, Multi-Dimensional Viewer (MDV) software, as a resource for spatial analysis.
MeSH term(s)	Humans ; Neutrophils ; COVID-19 ; CD8-Positive T-Lymphocytes ; Lung ; T-Lymphocytes, Cytotoxic
Language	English
Publishing date	2023-11-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-42421-0
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Article ; Online: The Chickahominy T.R.U.T.H. (Trust, Research, Understand, Teach, and Heal) Project-A Tribal Community-Academic Partnership for Understanding the Impact of Structural Factors on Perceived Cancer Risk in Rural Virginia.

Tossas, Katherine Y / Owens, Bianca D / Reitzel, Savannah / Wilt, Jacqueline Knight / Mejía, Paula Tatiana Rivera / Hunley, Rachel / Groesbeck, Haley / Boucher, Hillary / Schifano, Katelyn / Brown, Susann L / Adkins, Dana / Adkins, Stephen / Thomson, Maria D

International journal of environmental research and public health

2024 Volume 21, Issue 3

Abstract: ... T.R.U.T.H. (Trust, Research, Understand, Teach, and Heal) Project was created as a community ...

Abstract	In 2022, the Virginia Chickahominy Indian Tribe partnered with Virginia Commonwealth University Massey Comprehensive Cancer Center to investigate concerns about a potential cancer cluster near a local landfill. While investigating cancer clusters is complex due to long latency and multifactorial causes, the community's concerns about structural factors driving cancer risk warrant exploration. Thus, the Chickahominy T.R.U.T.H. (Trust, Research, Understand, Teach, and Heal) Project was created as a community-academic partnership to (1) identify structural factors and barriers associated with perceived cancer risk and care; (2) assess cancer knowledge, care access gaps, and perceived risks, including testing private and community water sources; (3) develop and deploy culturally tailored cancer education and resource navigation, including groundwater safety education, policies, and remediation. We will conduct 150 in-person interviews and water tests among residents within a four-mile radius of the landfill, and deploy 1000 structured questionnaires among Charles City County residents. In this paper, we provide an overview of the ongoing project design, development, and progress in support of the project's objectives. This collaborative investigation aims to address cancer health disparities, enhance research and health policy advocacy, and honor the sacred knowledge of an underserved community, laying the groundwork for a long-term partnership to guide future research questions.
MeSH term(s)	Humans ; Virginia/epidemiology ; Trust ; Health Education ; Surveys and Questionnaires ; Water ; Community-Based Participatory Research ; Neoplasms/epidemiology
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2024-02-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph21030262
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