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Article ; Online: The New Phytologist Tansley Medal 2022 - Leander D. L. Anderegg and Moi Exposito-Alonso.

Slater, Holly / Dolan, Liam

2023 Volume 237, Issue 6, Page(s) 1939–1940

MeSH term(s)	Botany ; Awards and Prizes ; Soil
Chemical Substances	Soil
Language	English
Publishing date	2023-02-16
Publishing country	England
Document type	Editorial
ZDB-ID	208885-x
ISSN	1469-8137 ; 0028-646X
ISSN (online)	1469-8137
ISSN	0028-646X
DOI	10.1111/nph.18741
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Phenotypic characteristics of asthma and morbidity are associated with distinct longitudinal changes in L-arginine metabolism.

Althoff, Meghan Dolan / Peterson, Ryan / McGrath, Max / Jin, Ying / Grasemann, Hartmut / Sharma, Sunita / Federman, Alex / Wisnivesky, Juan Pablo / Holguin, Fernando

BMJ open respiratory research

2023 Volume 10, Issue 1

Abstract: Background: The L-arginine metabolome is dysregulated in asthma, though it is not understood how ... longitudinal changes in L-arginine metabolism differ among asthma phenotypes and relate to disease outcomes ... Objectives: To determine the longitudinal associations between phenotypic characteristics with L-arginine ...

Abstract	Background: The L-arginine metabolome is dysregulated in asthma, though it is not understood how longitudinal changes in L-arginine metabolism differ among asthma phenotypes and relate to disease outcomes. Objectives: To determine the longitudinal associations between phenotypic characteristics with L-arginine metabolites and their relationships with asthma morbidity. Methods: This is a prospective cohort study of 321 patients with asthma followed semiannually for over 18 months with assessments of plasma L-arginine metabolites, asthma control, spirometry, quality of life and exacerbations. Metabolite concentrations and ratios were transformed using the natural logarithm. Results: There were many differences in L-arginine metabolism among asthma phenotypes in the adjusted models. Increasing body mass index was associated with increased asymmetric dimethylarginine (ADMA) and depleted L-citrulline. Latinx was associated with increased metabolism via arginase, with higher L-ornithine, proline and L-ornithine/L-citrulline levels, and was found to have higher L-arginine availability compared with white race. With respect to asthma outcomes, increasing L-citrulline was associated with improved asthma control and increasing L-arginine and L-arginine/ADMA were associated with improved quality of life. Increased variability in L-arginine, L-arginine/ADMA, L-arginine/L-ornithine and L-arginine availability index over 12 months were associated with increased exacerbations, OR 4.70 (95% CI 1.35 to 16.37), OR 8.69 (95% CI 1.98 to 38.08), OR 4.17 (95% CI 1.40 to 12.41) and OR 4.95 (95% CI 1.42 to 17.16), respectively. Conclusions: Our findings suggest that L-arginine metabolism is associated with multiple measures of asthma control and may explain, in part, the relationship between age, race/ethnicity and obesity with asthma outcomes.
MeSH term(s)	Humans ; Citrulline ; Prospective Studies ; Quality of Life ; Asthma/epidemiology ; Phenotype ; Morbidity ; Arginine/metabolism ; Ornithine
Chemical Substances	Citrulline (29VT07BGDA) ; Arginine (94ZLA3W45F) ; Ornithine (E524N2IXA3)
Language	English
Publishing date	2023-06-02
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2736454-9
ISSN	2052-4439 ; 2052-4439
ISSN (online)	2052-4439
ISSN	2052-4439
DOI	10.1136/bmjresp-2023-001683
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Article ; Online: Protease-Catalyzed l‑Aspartate Oligomerization

Fan Yang / Filbert Totsingan / Elliott Dolan / Sagar D. Khare / Richard A. Gross

ACS Omega, Vol 5, Iss 9, Pp 4403-

Substrate Selectivity and Computational Modeling

2020 Volume 4414

Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2020-02-01T00:00:00Z
Publisher	American Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Protease-Catalyzed l-Aspartate Oligomerization: Substrate Selectivity and Computational Modeling.

Yang, Fan / Totsingan, Filbert / Dolan, Elliott / Khare, Sagar D / Gross, Richard A

ACS omega

2020 Volume 5, Issue 9, Page(s) 4403–4414

Abstract: ... to convert l-aspartate diethyl ester (Et ...

Abstract	Poly(aspartic acid) (PAA) is a biodegradable water-soluble anionic polymer that can potentially replace poly(acrylic acid) for industrial applications and has shown promise for regenerative medicine and drug delivery. This paper describes an efficient and sustainable route that uses protease catalysis to convert l-aspartate diethyl ester (Et
Language	English
Publishing date	2020-02-25
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.9b03290
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Article: Characterization of polyphenol oxidase from blueberry (Vaccinium corymbosum L.).

Siddiq, M / Dolan, K D

Food chemistry

2017 Volume 218, Page(s) 216–220

Abstract: Polyphenol oxidase (PPO) was extracted and characterized from high-bush blueberries. PPO showed an optimum activity at pH 6.1-6.3 and 35°C, with the enzyme showing significant activity over a wide temperature range (25-60°C). Catechol was the most ... ...

Abstract	Polyphenol oxidase (PPO) was extracted and characterized from high-bush blueberries. PPO showed an optimum activity at pH 6.1-6.3 and 35°C, with the enzyme showing significant activity over a wide temperature range (25-60°C). Catechol was the most readily oxidized substrate followed by 4-methylcatechol, DL-DOPA, and dopamine. Blueberry PPO showed a K
MeSH term(s)	Antioxidants/pharmacology ; Ascorbic Acid/pharmacology ; Blueberry Plants/enzymology ; Blueberry Plants/growth & development ; Bronchoconstrictor Agents/pharmacology ; Catechol Oxidase/drug effects ; Catechol Oxidase/metabolism ; Catechols/metabolism ; Color ; Cysteine/pharmacology ; Hydrogen-Ion Concentration ; Kinetics ; Substrate Specificity ; Sulfites/pharmacology ; Temperature
Chemical Substances	Antioxidants ; Bronchoconstrictor Agents ; Catechols ; Sulfites ; 4-methylcatechol (12GLI7JGB3) ; sodium metabisulfite (4VON5FNS3C) ; Catechol Oxidase (EC 1.10.3.1) ; Cysteine (K848JZ4886) ; catechol (LF3AJ089DQ) ; Ascorbic Acid (PQ6CK8PD0R)
Language	English
Publishing date	2017-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2016.09.061
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Article ; Online: Phenotypic characteristics of asthma and morbidity are associated with distinct longitudinal changes in L-arginine metabolism

Alex Federman / Ryan Peterson / Ying Jin / Sunita Sharma / Fernando Holguin / Hartmut Grasemann / Meghan Dolan Althoff / Max McGrath / Juan Pablo Wisnivesky

BMJ Open Respiratory Research, Vol 10, Iss

2023 Volume 1

Abstract: Background The L-arginine metabolome is dysregulated in asthma, though it is not understood how ... longitudinal changes in L-arginine metabolism differ among asthma phenotypes and relate to disease outcomes ... Objectives To determine the longitudinal associations between phenotypic characteristics with L-arginine ...

Abstract	Background The L-arginine metabolome is dysregulated in asthma, though it is not understood how longitudinal changes in L-arginine metabolism differ among asthma phenotypes and relate to disease outcomes.Objectives To determine the longitudinal associations between phenotypic characteristics with L-arginine metabolites and their relationships with asthma morbidity.Methods This is a prospective cohort study of 321 patients with asthma followed semiannually for over 18 months with assessments of plasma L-arginine metabolites, asthma control, spirometry, quality of life and exacerbations. Metabolite concentrations and ratios were transformed using the natural logarithm.Results There were many differences in L-arginine metabolism among asthma phenotypes in the adjusted models. Increasing body mass index was associated with increased asymmetric dimethylarginine (ADMA) and depleted L-citrulline. Latinx was associated with increased metabolism via arginase, with higher L-ornithine, proline and L-ornithine/L-citrulline levels, and was found to have higher L-arginine availability compared with white race. With respect to asthma outcomes, increasing L-citrulline was associated with improved asthma control and increasing L-arginine and L-arginine/ADMA were associated with improved quality of life. Increased variability in L-arginine, L-arginine/ADMA, L-arginine/L-ornithine and L-arginine availability index over 12 months were associated with increased exacerbations, OR 4.70 (95% CI 1.35 to 16.37), OR 8.69 (95% CI 1.98 to 38.08), OR 4.17 (95% CI 1.40 to 12.41) and OR 4.95 (95% CI 1.42 to 17.16), respectively.Conclusions Our findings suggest that L-arginine metabolism is associated with multiple measures of asthma control and may explain, in part, the relationship between age, race/ethnicity and obesity with asthma outcomes.
Keywords	Medicine ; R ; Diseases of the respiratory system ; RC705-779
Subject code	571
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Reduced retort processing time improves canning quality of fast-cooking dry beans (Phaseolus vulgaris L.).

Bassett, Amber / Dolan, Kirk D / Cichy, Karen

Journal of the science of food and agriculture

2020 Volume 100, Issue 10, Page(s) 3995–4004

Abstract: Background: While it is generally accepted that fast-cooking germplasm benefits consumers, benefits to the canning industry have not been established. Genotypes with good canning quality withstand the canning process while remaining intact with good ... ...

Abstract	Background: While it is generally accepted that fast-cooking germplasm benefits consumers, benefits to the canning industry have not been established. Genotypes with good canning quality withstand the canning process while remaining intact with good appearance, but canning protocols used by breeders typically involve long processing times that may overcook some genotypes. The goal of this study was to identify whether cooking time influences canning quality in dry beans and whether reducing processing time could improve canning quality of fast-cooking genotypes. Results: A set of 20 yellow bean genotypes including Ervilha, PI527538 and 18 derived recombinant inbred lines were selected for their varied cooking times. By comparing the genotypes processed across five retort times, differences in canning quality were identified. All genotypes performed better when processed for less time than the standard 45 min, but canning quality was highest at 10 min for fast- and medium-cooking genotypes and 15 min for slow-cooking genotypes. Cooking time was correlated positively with texture and intactness and negatively with washed-drained weights, indicating that slower cooking beans have higher canning quality. Color changed with retort processing such that longer times produced darker beans with more red and yellow. Conclusions: While fast-cooking beans exhibited lower canning quality at standard processing times, reduced retort processing time allowed them to meet quality standards while still maintaining food safety. By accounting for cooking time as a component of canning quality, breeders can develop varieties that are convenient and cost efficient for preparation for both consumers and the canning industry. Published 2020. This article is a U.S. Government work and is in the public domain in the USA.
MeSH term(s)	Cooking/methods ; Genotype ; Hot Temperature ; Phaseolus/chemistry ; Phaseolus/classification ; Seeds/chemistry ; Time Factors
Language	English
Publishing date	2020-05-19
Publishing country	England
Document type	Evaluation Study ; Journal Article
ZDB-ID	184116-6
ISSN	1097-0010 ; 0022-5142
ISSN (online)	1097-0010
ISSN	0022-5142
DOI	10.1002/jsfa.10444
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Article: Characterization of polyphenol oxidase from blueberry (Vaccinium corymbosum L.)

Siddiq, M / K.D. Dolan

Food chemistry. 2017 Mar. 01, v. 218

2017

Abstract: ... Ascorbic acid, sodium diethyldithiocarbamic acid, L-cysteine, and sodium metabisulfite were effective inhibitors ...

Abstract	Polyphenol oxidase (PPO) was extracted and characterized from high-bush blueberries. PPO showed an optimum activity at pH 6.1–6.3 and 35°C, with the enzyme showing significant activity over a wide temperature range (25–60°C). Catechol was the most readily oxidized substrate followed by 4-methylcatechol, DL-DOPA, and dopamine. Blueberry PPO showed a Km of 15mM and Vmax of 2.57 ΔA420nm/min×10−1, determined with catechol. PPO was completely inactivated in 20min at 85°C, however, after 30minat 75°C it showed about 10% residual activity. Thermal treatment at 55 and 65°C for 30min resulted in the partial inactivation of PPO. Ascorbic acid, sodium diethyldithiocarbamic acid, L-cysteine, and sodium metabisulfite were effective inhibitors of PPO at 1.0mM. Benzoic acid and cinnamic acid series inhibitors showed relatively weak inhibition of PPO (21.8–27.6%), even at as high as 2.0mM concentration.
Keywords	ascorbic acid ; benzoic acid ; blueberries ; catechol ; catechol oxidase ; cinnamic acid ; cysteine ; dopamine ; heat treatment ; pH ; sodium metabisulfite ; temperature ; Vaccinium corymbosum
Language	English
Dates of publication	2017-0301
Size	p. 216-220.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2016.09.061
Database	NAL-Catalogue (AGRICOLA)

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Article: Reduced retort processing time improves canning quality of fast‐cooking dry beans (Phaseolus vulgaris L.)

Bassett, Amber / Dolan, Kirk D / Cichy, Karen

Journal of the science of food and agriculture. 2020 Aug., v. 100, no. 10

2020

Abstract: BACKGROUND: While it is generally accepted that fast‐cooking germplasm benefits consumers, benefits to the canning industry have not been established. Genotypes with good canning quality withstand the canning process while remaining intact with good ... ...

Abstract	BACKGROUND: While it is generally accepted that fast‐cooking germplasm benefits consumers, benefits to the canning industry have not been established. Genotypes with good canning quality withstand the canning process while remaining intact with good appearance, but canning protocols used by breeders typically involve long processing times that may overcook some genotypes. The goal of this study was to identify whether cooking time influences canning quality in dry beans and whether reducing processing time could improve canning quality of fast‐cooking genotypes. RESULTS: A set of 20 yellow bean genotypes including Ervilha, PI527538 and 18 derived recombinant inbred lines were selected for their varied cooking times. By comparing the genotypes processed across five retort times, differences in canning quality were identified. All genotypes performed better when processed for less time than the standard 45 min, but canning quality was highest at 10 min for fast‐ and medium‐cooking genotypes and 15 min for slow‐cooking genotypes. Cooking time was correlated positively with texture and intactness and negatively with washed‐drained weights, indicating that slower cooking beans have higher canning quality. Color changed with retort processing such that longer times produced darker beans with more red and yellow. CONCLUSIONS: While fast‐cooking beans exhibited lower canning quality at standard processing times, reduced retort processing time allowed them to meet quality standards while still maintaining food safety. By accounting for cooking time as a component of canning quality, breeders can develop varieties that are convenient and cost efficient for preparation for both consumers and the canning industry. Published 2020. This article is a U.S. Government work and is in the public domain in the USA.
Keywords	Phaseolus vulgaris ; canning ; canning industry ; canning quality ; color ; cooking ; cost effectiveness ; dry beans ; food safety ; genotype ; germplasm ; inbred lines ; processing time ; retort pouches ; texture
Language	English
Dates of publication	2020-08
Size	p. 3995-4004.
Publishing place	John Wiley & Sons, Ltd.
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	184116-6
ISSN	1097-0010 ; 0022-5142
ISSN (online)	1097-0010
ISSN	0022-5142
DOI	10.1002/jsfa.10444
Database	NAL-Catalogue (AGRICOLA)

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Article: Effect of pectinolytic and cellulytic enzymes on the physical, chemical, and antioxidant properties of blueberry (Vaccinium corymbosum L.) juice

Siddiq, M. / Dolan, K. D. / Perkins-Veazie, P. / Collins, J. K.

LWT - food science and technology

2018 Volume 92, Issue -, Page(s) 127

Language	English
Document type	Article
ZDB-ID	2169058-3
ISSN	0023-6438
Database	Current Contents Nutrition, Environment, Agriculture

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