LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 5 of total 5

Search options

  1. Article ; Online: Correlating structure and photophysical properties in thiazolo[5,4-

    Shibu, Abhishek / Jones, Sean / Tolley, P Lane / Diaz, David / Kwiatkowski, Carly O / Jones, Daniel S / Shivas, Jessica M / Foley, Jonathan J / Schmedake, Thomas A / Walter, Michael G

    Materials advances

    2023  Volume 4, Issue 23, Page(s) 6321–6332

    Abstract: There is a growing demand for new fluorescent small molecule dyes for solid state applications in the photonics and optoelectronics industry. Thiazolo[5,4- ...

    Abstract There is a growing demand for new fluorescent small molecule dyes for solid state applications in the photonics and optoelectronics industry. Thiazolo[5,4-
    Language English
    Publishing date 2023-10-20
    Publishing country England
    Document type Journal Article
    ISSN 2633-5409
    ISSN (online) 2633-5409
    DOI 10.1039/d3ma00686g
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Xrn1 is a deNADding enzyme modulating mitochondrial NAD-capped RNA.

    Sharma, Sunny / Yang, Jun / Grudzien-Nogalska, Ewa / Shivas, Jessica / Kwan, Kelvin Y / Kiledjian, Megerditch

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 889

    Abstract: The existence of non-canonical nicotinamide adenine diphosphate (NAD) 5'-end capped RNAs is now well established. Nevertheless, the biological function of this nucleotide metabolite cap remains elusive. Here, we show that the yeast Saccharomyces ... ...

    Abstract The existence of non-canonical nicotinamide adenine diphosphate (NAD) 5'-end capped RNAs is now well established. Nevertheless, the biological function of this nucleotide metabolite cap remains elusive. Here, we show that the yeast Saccharomyces cerevisiae cytoplasmic 5'-end exoribonuclease Xrn1 is also a NAD cap decapping (deNADding) enzyme that releases intact NAD and subsequently degrades the RNA. The significance of Xrn1 deNADding is evident in a deNADding deficient Xrn1 mutant that predominantly still retains its 5'-monophosphate exonuclease activity. This mutant reveals Xrn1 deNADding is necessary for normal growth on non-fermenting sugar and is involved in modulating mitochondrial NAD-capped RNA levels and may influence intramitochondrial NAD levels. Our findings uncover a contribution of mitochondrial NAD-capped RNAs in overall NAD regulation with the deNADding activity of Xrn1 fulfilling a central role.
    MeSH term(s) Exoribonucleases/genetics ; Exoribonucleases/metabolism ; Mitochondria/genetics ; NAD/genetics ; RNA Caps/genetics ; RNA Caps/metabolism ; RNA Stability/genetics ; RNA, Messenger/genetics ; RNA, Mitochondrial/genetics ; RNA-Binding Proteins/metabolism ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism
    Chemical Substances RNA Caps ; RNA, Messenger ; RNA, Mitochondrial ; RNA-Binding Proteins ; Rai1 protein, S cerevisiae ; Saccharomyces cerevisiae Proteins ; NAD (0U46U6E8UK) ; RAT1 protein, S cerevisiae (147883-15-6) ; Exoribonucleases (EC 3.1.-) ; XRN1 protein, S cerevisiae (EC 3.1.11.-)
    Language English
    Publishing date 2022-02-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-28555-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Arp2/3 mediates early endosome dynamics necessary for the maintenance of PAR asymmetry in Caenorhabditis elegans.

    Shivas, Jessica M / Skop, Ahna R

    Molecular biology of the cell

    2012  Volume 23, Issue 10, Page(s) 1917–1927

    Abstract: The widely conserved Arp2/3 complex regulates branched actin dynamics that are necessary for a variety of cellular processes. In Caenorhabditis elegans, the actin cytoskeleton has been extensively characterized in its role in establishing PAR asymmetry; ... ...

    Abstract The widely conserved Arp2/3 complex regulates branched actin dynamics that are necessary for a variety of cellular processes. In Caenorhabditis elegans, the actin cytoskeleton has been extensively characterized in its role in establishing PAR asymmetry; however, the contributions of actin to the maintenance of polarity before the onset of mitosis are less clear. Endocytic recycling has emerged as a key mechanism in the dynamic stabilization of cellular polarity, and the large GTPase dynamin participates in the stabilization of cortical polarity during maintenance phase via endocytosis in C. elegans. Here we show that disruption of Arp2/3 function affects the formation and localization of short cortical actin filaments and foci, endocytic regulators, and polarity proteins during maintenance phase. We detect actin associated with events similar to early endosomal fission, movement of endosomes into the cytoplasm, and endosomal movement from the cytoplasm to the plasma membrane, suggesting the involvement of actin in regulating processes at the early endosome. We also observe aberrant accumulations of PAR-6 cytoplasmic puncta near the centrosome along with early endosomes. We propose a model in which Arp2/3 affects the efficiency of rapid endocytic recycling of polarity cues that ultimately contributes to their stable maintenance.
    MeSH term(s) Actin Cytoskeleton/metabolism ; Actin-Related Protein 2/genetics ; Actin-Related Protein 2/metabolism ; Animals ; Caenorhabditis elegans/cytology ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cell Membrane/metabolism ; Cell Polarity ; Down-Regulation ; Dynamins/metabolism ; Endocytosis ; Endosomes ; GTP-Binding Proteins/genetics ; GTP-Binding Proteins/metabolism ; Gene Knockdown Techniques ; Microtubules/metabolism ; Mitosis ; Protein Kinase C/metabolism ; Protein Transport ; Protein-Serine-Threonine Kinases ; RNA Interference ; Time-Lapse Imaging ; rab5 GTP-Binding Proteins/metabolism
    Chemical Substances Actin-Related Protein 2 ; Caenorhabditis elegans Proteins ; Cell Cycle Proteins ; arx-2 protein, C elegans ; cdc-42 protein, C elegans ; par-6 protein, C elegans ; PAR-3 protein, C elegans (EC 2.7.11.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; PKC-3 protein (EC 2.7.11.13) ; Protein Kinase C (EC 2.7.11.13) ; GTP-Binding Proteins (EC 3.6.1.-) ; rab5 GTP-Binding Proteins (EC 3.6.5.2) ; Dynamins (EC 3.6.5.5)
    Language English
    Publishing date 2012-03-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1098979-1
    ISSN 1939-4586 ; 1059-1524
    ISSN (online) 1939-4586
    ISSN 1059-1524
    DOI 10.1091/mbc.E12-01-0006
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2853: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 410: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Polarity and endocytosis: reciprocal regulation.

    Shivas, Jessica M / Morrison, Holly A / Bilder, David / Skop, Ahna R

    Trends in cell biology

    2010  Volume 20, Issue 8, Page(s) 445–452

    Abstract: The establishment and maintenance of polarized plasma membrane domains is essential for cellular function and proper development of organisms. The molecules and pathways involved in determining cell polarity are remarkably well conserved between animal ... ...

    Abstract The establishment and maintenance of polarized plasma membrane domains is essential for cellular function and proper development of organisms. The molecules and pathways involved in determining cell polarity are remarkably well conserved between animal species. Historically, exocytic mechanisms have received primary emphasis among trafficking routes responsible for cell polarization. Accumulating evidence now reveals that endocytosis plays an equally important role in the proper localization of key polarity proteins. Intriguingly, some polarity proteins can also regulate the endocytic machinery. Here, we review emerging evidence for the reciprocal regulation between polarity proteins and endocytic pathways, and discuss possible models for how these distinct processes could interact to create separate cellular domains.
    MeSH term(s) Animals ; Cell Membrane/physiology ; Cell Polarity ; Embryo, Nonmammalian/cytology ; Embryo, Nonmammalian/physiology ; Endocytosis ; Epithelial Cells/cytology ; Epithelial Cells/physiology ; Membrane Proteins/physiology ; Oocytes/cytology ; Oocytes/physiology
    Chemical Substances Membrane Proteins
    Language English
    Publishing date 2010-05-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 30122-x
    ISSN 1879-3088 ; 0962-8924
    ISSN (online) 1879-3088
    ISSN 0962-8924
    DOI 10.1016/j.tcb.2010.04.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.MG 25: Show issues
    Zs.MO 113: Show issues
    Zs.A 3410: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Dynamin participates in the maintenance of anterior polarity in the Caenorhabditis elegans embryo.

    Nakayama, Yuji / Shivas, Jessica M / Poole, Daniel S / Squirrell, Jayne M / Kulkoski, Jennifer M / Schleede, Justin B / Skop, Ahna R

    Developmental cell

    2009  Volume 16, Issue 6, Page(s) 889–900

    Abstract: Cell polarity is crucial for the generation of cell diversity. Recent evidence suggests that the actin cytoskeleton plays a key role in establishment of embryonic polarity, yet the mechanisms that maintain polarity cues in particular membrane domains ... ...

    Abstract Cell polarity is crucial for the generation of cell diversity. Recent evidence suggests that the actin cytoskeleton plays a key role in establishment of embryonic polarity, yet the mechanisms that maintain polarity cues in particular membrane domains during development remain unclear. Dynamin, a large GTPase, functions in both endocytosis and actin dynamics. Here, the Caenorhabditis elegans dynamin ortholog, DYN-1, maintains anterior polarity cues. DYN-1-GFP foci are enriched in the anterior cortex in a manner dependent on the anterior polarity proteins, PAR-6 and PKC-3. Membrane internalization and actin comet formation are enriched in the anterior, and are dependent on DYN-1. PAR-6-labeled puncta are also internalized from cortical accumulations of DYN-1-GFP. Our results demonstrate a mechanism for the spatial and temporal regulation of endocytosis in the anterior of the embryo, contributing to the precise localization and maintenance of polarity factors within a dynamic plasma membrane.
    MeSH term(s) Actins/metabolism ; Animals ; Biomarkers/metabolism ; Caenorhabditis elegans/cytology ; Caenorhabditis elegans/embryology ; Caenorhabditis elegans Proteins/metabolism ; Cell Membrane/metabolism ; Cell Polarity ; Dynamins/metabolism ; Embryo, Nonmammalian/cytology ; Embryo, Nonmammalian/enzymology ; Endocytosis ; Gene Deletion ; Protein Transport ; Spindle Apparatus/metabolism
    Chemical Substances Actins ; Biomarkers ; Caenorhabditis elegans Proteins ; Dyn-1 protein, C elegans (EC 3.6.5.5) ; Dynamins (EC 3.6.5.5)
    Language English
    Publishing date 2009-06-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2009.04.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5742: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 76: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top