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Article ; Online: COVID-19 self-testing in Brazil and the imminent risk of underreporting cases.

Oliveira, Laura Alves Ribeiro / Bortolini, Miguel Junior Sordi / Taketomi, Ernesto Akio / Resende, Rafael de Oliveira

Revista da Sociedade Brasileira de Medicina Tropical

2023 Volume 56, Page(s) e02872023

MeSH term(s)	Humans ; Brazil/epidemiology ; COVID-19 ; Self-Testing ; COVID-19 Testing
Language	English
Publishing date	2023-10-20
Publishing country	Brazil
Document type	Letter
ZDB-ID	1038126-0
ISSN	1678-9849 ; 0037-8682
ISSN (online)	1678-9849
ISSN	0037-8682
DOI	10.1590/0037-8682-00287-2023
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Article: Distinct Adverse Reactions to mRNA, Inactivated Virus, and Adenovirus Vector COVID-19 Vaccines: Insights from a Cohort Study on Atopic and Non-Atopic Subjects in Brazil.

Oliveira, Laura Alves Ribeiro / Correa, Alessandro Sousa / de Jesus, Thiago Alves / Bortolini, Miguel Junior Sordi / Taketomi, Ernesto Akio / Resende, Rafael de Oliveira

Vaccines

2024 Volume 12, Issue 4

Abstract: The emergence of COVID-19 caused by SARS-CoV-2 prompted an unprecedented global response to develop vaccines at an accelerated pace. Messenger RNA (mRNA) and adenovirus vector vaccines emerged as the frontrunners in global immunization efforts, ... ...

Abstract	The emergence of COVID-19 caused by SARS-CoV-2 prompted an unprecedented global response to develop vaccines at an accelerated pace. Messenger RNA (mRNA) and adenovirus vector vaccines emerged as the frontrunners in global immunization efforts, significantly reducing hospitalization, severity, and mortality, supplemented by inactivated virus-based vaccines in developing countries. However, concerns regarding adverse effects, including allergic reactions, have been raised. This study aimed to investigate the adverse effects following COVID-19 vaccination, particularly in atopic and non-atopic individuals. A cohort of 305 volunteers receiving BNT162, ChAdOx1, or CoronaVac vaccines were assessed based on a Skin Prick Test (SPT), specific IgE levels, and clinical history of asthma and rhinitis. Adverse effects were self-reported and scored across the different vaccination shots. The results indicated a notable presence of mild adverse effects following the first and third doses, regardless of vaccine type. ChAdOx1 recipients experienced more adverse effects compared to those receiving BNT162 and CoronaVac, including headaches, muscle pain, fever, chills, nausea, and flu-like symptoms. Atopic individuals receiving ChAdOx1 reported more adverse effects, such as muscle pain, fever, and chills, compared to non-atopic individuals. Conversely, headaches were more frequently reported in non-atopic individuals receiving BNT162 compared to atopic individuals. No anaphylaxis or allergic reactions were reported, indicating valuable evidence supporting the safety of COVID-19 vaccination in individuals with respiratory allergies. This study highlights the importance of understanding vaccine-related adverse effects, particularly in vulnerable populations, to inform vaccination strategies and address safety concerns in global immunization campaigns.
Language	English
Publishing date	2024-04-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines12040408
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Article ; Online: Brazilian guidelines for allergen immunotherapy in the treatment of allergic rhinitis.

Aarestrup, Fernando Monteiro / Lira, Geórgia Véras de Araújo Gueiros / Taketomi, Ernesto Akio / Gagete, Elaine / Rosário Filho, Nelson Augusto / Rizzo, Maria Cândida / Solé, Dirceu / Rubini, Norma de Paula Motta / Sarinho, Emanuel Savio Cavalcanti / Bernardo, Wanderley Marques

Revista da Associacao Medica Brasileira (1992)

2023 Volume 69, Issue 5, Page(s) e2023D695

MeSH term(s)	Humans ; Brazil ; Rhinitis, Allergic/therapy ; Desensitization, Immunologic
Language	English
Publishing date	2023-06-02
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	731969-1
ISSN	1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
ISSN (online)	1806-9282
ISSN	0104-4230 ; 0004-5241 ; 0102-843X
DOI	10.1590/1806-9282.2023D695
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Article ; Online: COVID-19 scenario and recommendations on the continuity of immunobiological therapy in patients with atopic asthma in Brazil and Latin America.

de Oliveira Resende, Rafael / José de Oliveira, Vinícius / Sousa Correa, Alessandro / Trica de Araújo, Pedro / Akio Taketomi, Ernesto

Expert review of respiratory medicine

2022 Volume 16, Issue 2, Page(s) 211–220

Abstract: Introduction: With the abrupt establishment of the COVID-19 pandemic, treatment for immunological diseases may be influenced by the SARS-CoV-2 infection. Immunobiologics play a pivotal role in the management of severe symptoms of allergy, and an opinion ...

Abstract	Introduction: With the abrupt establishment of the COVID-19 pandemic, treatment for immunological diseases may be influenced by the SARS-CoV-2 infection. Immunobiologics play a pivotal role in the management of severe symptoms of allergy, and an opinion regarding the continuity of this treatment during the COVID-19 pandemic must be issued. Areas covered: In Brazil and other countries, patients with severe asthma have been included in the priority groups for COVID-19 vaccination, even those who are undergoing immunobiological therapy. Data are insufficient to support the influence of this therapy on severe COVID-19. Therapeutic strategies for asthma and guidelines/statements of the main societies of Allergy in Latin America on the continuity of treatment with immunobiologics during the COVID-19 pandemic were obtained from the institutional websites and papers published up to September 2021. Expert opinion: Although the association between asthma and COVID-19 has been under investigation, immunobiological treatment should follow the consensus-based statements recommending the maintenance of the therapy unless the patient is infected by the SARS-CoV-2. However, it must be closely followed by the medical assistant.
MeSH term(s)	Asthma/epidemiology ; Asthma/therapy ; Brazil/epidemiology ; COVID-19/epidemiology ; COVID-19 Vaccines ; Humans ; Latin America/epidemiology ; Pandemics ; SARS-CoV-2
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2022-01-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2479146-5
ISSN	1747-6356 ; 1747-6348
ISSN (online)	1747-6356
ISSN	1747-6348
DOI	10.1080/17476348.2022.2027758
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Article ; Online: Reply: To PMID 24299565.

Taketomi, Ernesto Akio / Cunha-Junior, Jair Pereira / Silva, Deise Aparecida de Oliveira

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

2014 Volume 25, Issue 4, Page(s) 417–418

MeSH term(s)	Animals ; Desensitization, Immunologic/methods ; Female ; Humans ; Hypersensitivity/therapy ; Male ; Mucous Membrane/immunology
Language	English
Publishing date	2014-06
Publishing country	England
Document type	Comment ; Letter
ZDB-ID	1057059-7
ISSN	1399-3038 ; 0905-6157 ; 0906-5784
ISSN (online)	1399-3038
ISSN	0905-6157 ; 0906-5784
DOI	10.1111/pai.12253
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Article: Good clinical practice recommendations in allergen immunotherapy: Position paper of the Brazilian Association of Allergy and Immunology - ASBAI.

Aarestrup, Fernando Monteiro / Taketomi, Ernesto Akio / Santos Galvão, Clóvis Eduardo / Gagete, Elaine / Nóbrega Machado Arruda, Anna Caroline / Alves, Gil Bardini / Véras de Araújo Gueiros Lira, Geórgia / Gonçalves, Marcos Reis / Couto Miziara, Mariana Graça / Maranhão Casado, Sidney Souteban / Curi, Simone Valladão / Rufino Pereira, Veridiana Aun / Sales, Valéria / Solé, Dirceu / de Paula Motta Rubini, Norma / Cavalcanti Sarinho, Emanuel Savio

The World Allergy Organization journal

2022 Volume 15, Issue 10, Page(s) 100697

Abstract: Background: Allergen Immunotherapy (AIT) represents one of the pillars in the treatment of allergic diseases. AIT is the only therapeutic strategy with curative potential, promoting the reduction of drug use and long-term symptom control even after the ... ...

Abstract	Background: Allergen Immunotherapy (AIT) represents one of the pillars in the treatment of allergic diseases. AIT is the only therapeutic strategy with curative potential, promoting the reduction of drug use and long-term symptom control even after the end of the treatment. The European Academy of Allergy, Asthma and Immunology (EAACI) guidelines, position papers of World Allergy Organization (WAO), and the US Practice Parameters are the leading official documents that set scientific standard for the use of AIT in the world. The use of AIT in Brazil has specific regional conditions due to the pattern of allergen sensitization, as well as genetic, socioeconomic, and cultural characteristics, climate conditions, and the availability of allergenic extracts. The most prevalent house dust mites are Objective: According to the current scientific literature adapted to the Brazilian reality, this position paper aims to establish the main recommendations for the good clinical practice parameters for AIT in Brazil. Methods: A systematic review using the Pub Med and Cochrane databases was performed, and the websites of major allergy and immunology organizations were consulted. The research was limited to English language literature and was conducted between March 30, 2002, and March 30, 2022. The terms used for the research were: Allergen Immunotherapy, sublingual immunotherapy (SLIT), subcutaneous immunotherapy (SCIT), venom-specific immunotherapy (VIT), and allergen extract. Results: The several recommendations that establish the clinical practices for AIT recommended by the main Allergy, Asthma and Immunology world organizations were analyzed and adapted to the Brazilian situation. Conclusion: This position paper establishes the main recommendations for the effective clinical practice of AIT in Brazil, using current knowledge of evidence-based medicine and precision medicine.
Language	English
Publishing date	2022-09-24
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2581968-9
ISSN	1939-4551
ISSN	1939-4551
DOI	10.1016/j.waojou.2022.100697
Database	MEDical Literature Analysis and Retrieval System OnLINE

2019 Volume 2019, Page(s) 9840890

Abstract: Background: House dust mites are important allergen sources and some of these allergenic proteins may contain carbohydrate moieties, which are able to be isolated using lectins, as Concanavalin A (ConA). This study aimed to investigate allergenicity ( ... ...

Abstract	Background: House dust mites are important allergen sources and some of these allergenic proteins may contain carbohydrate moieties, which are able to be isolated using lectins, as Concanavalin A (ConA). This study aimed to investigate allergenicity (IgE) and antigenicity (IgG1 and IgG4) of ConA-unbound and ConA-bound Material and methods: We obtained mannose-enriched and mannose-depleted fractions from Dpt by ConA affinity chromatography. Both ConA-bound and ConA-unbound fractions were evaluated by ELISA and Western Blotting for specific IgE, IgG1, and IgG4 reactivity with sera obtained from 95 mite-allergic patients (DP+) and 92 nonallergic (NA) subjects. Inhibition ELISA was used to assess cross-reactivity between Dpt extract and its fractions. Results: Among the DP+ patients, no difference was found between ConA-unbound and ConA-bound fractions regarding the levels of specific IgE, IgG1, and IgG4. Nonallergic subjects had the same levels of specific IgG1 to both ConA-unbound and ConA-bound fractions, although for specific IgG4, values were higher for ConA-bound. A positive correlation was found among specific IgE, IgG1, and IgG4 levels when Dpt was compared to ConA-unbound and ConA-bound fractions. Recognition of crude Dpt by IgE, IgG1, and IgG4 was highly inhibited by ConA-unbound and ConA-bound fractions. Western Blotting revealed a broad spectrum of bands ranging from 14 to 116 kDa recognized by specific IgE and IgG4. However, IgG1 reached higher frequency values on high molecular weight polypeptides. Conclusion: ConA-unbound and ConA-bound fractions derived from
MeSH term(s)	Adult ; Allergens/chemistry ; Allergens/immunology ; Animals ; Concanavalin A/chemistry ; Concanavalin A/immunology ; Dermatophagoides pteronyssinus/chemistry ; Dermatophagoides pteronyssinus/immunology ; Enzyme-Linked Immunosorbent Assay ; Female ; Glycosylation ; Healthy Volunteers ; Humans ; Hypersensitivity/immunology ; Immunoglobulin E/chemistry ; Immunoglobulin E/immunology ; Immunoglobulin G/chemistry ; Immunoglobulin G/immunology ; Male ; Middle Aged ; Plant Extracts/chemistry ; Plant Extracts/immunology ; Pyroglyphidae/chemistry ; Pyroglyphidae/immunology
Chemical Substances	Allergens ; Immunoglobulin G ; Plant Extracts ; Concanavalin A (11028-71-0) ; Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2019-07-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2019/9840890
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Article ; Online: IgE, IgG1, and IgG4 Reactivity to Dermatophagoides pteronyssinus Glycosylated Extract in Allergic Patients

Rafael de Oliveira Resende / Leandro Hideki Ynoue / Juliana Silva Miranda / Karine Cristine de Almeida / Deise Aparecida de Oliveira Silva / Monica Camargo Sopelete / Ronaldo Alves / Margareth Leitão Gennari-Cardoso / Ernesto Akio Taketomi

BioMed Research International, Vol

2019 Volume 2019

Abstract: Background. House dust mites are important allergen sources and some of these allergenic proteins may contain carbohydrate moieties, which are able to be isolated using lectins, as Concanavalin A (ConA). This study aimed to investigate allergenicity (IgE) ...

Abstract	Background. House dust mites are important allergen sources and some of these allergenic proteins may contain carbohydrate moieties, which are able to be isolated using lectins, as Concanavalin A (ConA). This study aimed to investigate allergenicity (IgE) and antigenicity (IgG1 and IgG4) of ConA-unbound and ConA-bound Dermatophagoides pteronyssinus (Dpt) crude extracts using sera of mite-allergic patients as well as inhibition capacity of antibody binding. Material and Methods. We obtained mannose-enriched and mannose-depleted fractions from Dpt by ConA affinity chromatography. Both ConA-bound and ConA-unbound fractions were evaluated by ELISA and Western Blotting for specific IgE, IgG1, and IgG4 reactivity with sera obtained from 95 mite-allergic patients (DP+) and 92 nonallergic (NA) subjects. Inhibition ELISA was used to assess cross-reactivity between Dpt extract and its fractions. Results. Among the DP+ patients, no difference was found between ConA-unbound and ConA-bound fractions regarding the levels of specific IgE, IgG1, and IgG4. Nonallergic subjects had the same levels of specific IgG1 to both ConA-unbound and ConA-bound fractions, although for specific IgG4, values were higher for ConA-bound. A positive correlation was found among specific IgE, IgG1, and IgG4 levels when Dpt was compared to ConA-unbound and ConA-bound fractions. Recognition of crude Dpt by IgE, IgG1, and IgG4 was highly inhibited by ConA-unbound and ConA-bound fractions. Western Blotting revealed a broad spectrum of bands ranging from 14 to 116 kDa recognized by specific IgE and IgG4. However, IgG1 reached higher frequency values on high molecular weight polypeptides. Conclusion. ConA-unbound and ConA-bound fractions derived from D. pteronyssinus crude extract revealed important components involved in the IgE recognition in allergic patients as well as IgG1 and/or IgG4 in allergic and healthy subjects.
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
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Article ; Online: IgE AND IgG antibody responses to Dermatophagoides pteronyssinus in dogs with demodicosis and atopic dermatitis

Maria Cecília Oliveira / Ana Cláudia Arantes Marquez Pajuaba / José Eugênio Diniz Bastos / José Roberto Mineo / Fabiana Parreira Souza / Ester Cristina Borges Araújo / Marcos Paulo Oliveira Almeida / Deise Aparecida Oliveira Silva / Ernesto Akio Taketomi / Neide Maria Silva

Bioscience Journal, Vol 36, Iss

2020 Volume 6

Abstract: Canine demodicosis is a common inflammatory parasitic skin disease caused by Demodex mites. House dust mites, such as Dermatophagoides spp., play an important role in the pathogenesis of canine atopic dermatitis (AD). The goal of this experimental work ... ...

Abstract	Canine demodicosis is a common inflammatory parasitic skin disease caused by Demodex mites. House dust mites, such as Dermatophagoides spp., play an important role in the pathogenesis of canine atopic dermatitis (AD). The goal of this experimental work was to investigate whether demodectic dogs could be previously exposed/sensitized to house dust mites’ antigens. First the prevalence of demodicosis in a southeastern region of Brazil was investigated by analyzing clinical files of dogs that were admitted to a Veterinary Hospital. Subsequently, the IgG responses to Dermatophagoides pteronyssinus (Dp) and Dermatophagoides farinae (Df) and IgE to D. pteronyssinus (Dp) were evaluated in two groups, AD or demodicosis dogs. Additionally, the major IgE-binding Dp proteins that are recognized by sera from dogs with demodicosis and AD were evaluated. A total of 2,599 clinical files were analyzed to identify the major parasitic skin diseases in dogs from this region, considering the age, sex and breed of the animals. The epidemiological study identified 111 animals with skin diseases; from these 20.7% presented demodicosis. Afterwards, serum samples were obtained from another groups of demodicosis, AD, and healthy dogs, and analyzed for Dp and Df-specific IgG, and IgE antibody levels, Dp IgG avidity by ELISA and IgE-binding Dp-specific proteins by immunoblot. IgG and IgE antibodies to Dp were detected in sera from additional groups of dogs with AD, demodicosis or healthy, with higher IgE levels to Dp in AD than demodectic or healthy dogs. IgG to Df was detected, despite with smaller levels compared to Dp in sera from demodectic dogs, and also in healthy dogs. Immunoblot showed IgE-binding to Dp proteins in sera of dogs with demodicosis and AD; with strong reactivity for the 72 and 116 kDa antigens detected by sera from demodicosis dogs. However, sera from healthy dogs >12 months old also presented reactivity to these bands. In conclusion, the detection of Dp-IgG and IgE antibodies in sera from demodectic dogs indicates ...
Keywords	Demodex canis ; Demodicosis ; Dermatophagoides pteronyssinus ; . IgG. IgE ; Dogs ; Agriculture ; S ; Biology (General) ; QH301-705.5
Subject code	630
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	Universidade Federal de Uberlândia
Document type	Article ; Online
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Article ; Online: IgE AND IgG antibody responses to Dermatophagoides pteronyssinus in dogs with demodicosis and atopic dermatitis

Bioscience Journal, Vol 36, Iss

2020 Volume 6

Abstract	Canine demodicosis is a common inflammatory parasitic skin disease caused by Demodex mites. House dust mites, such as Dermatophagoides spp., play an important role in the pathogenesis of canine atopic dermatitis (AD). The goal of this experimental work was to investigate whether demodectic dogs could be previously exposed/sensitized to house dust mites’ antigens. First the prevalence of demodicosis in a southeastern region of Brazil was investigated by analyzing clinical files of dogs that were admitted to a Veterinary Hospital. Subsequently, the IgG responses to Dermatophagoides pteronyssinus (Dp) and Dermatophagoides farinae (Df) and IgE to D. pteronyssinus (Dp) were evaluated in two groups, AD or demodicosis dogs. Additionally, the major IgE-binding Dp proteins that are recognized by sera from dogs with demodicosis and AD were evaluated. A total of 2,599 clinical files were analyzed to identify the major parasitic skin diseases in dogs from this region, considering the age, sex and breed of the animals. The epidemiological study identified 111 animals with skin diseases; from these 20.7% presented demodicosis. Afterwards, serum samples were obtained from another groups of demodicosis, AD, and healthy dogs, and analyzed for Dp and Df-specific IgG, and IgE antibody levels, Dp IgG avidity by ELISA and IgE-binding Dp-specific proteins by immunoblot. IgG and IgE antibodies to Dp were detected in sera from additional groups of dogs with AD, demodicosis or healthy, with higher IgE levels to Dp in AD than demodectic or healthy dogs. IgG to Df was detected, despite with smaller levels compared to Dp in sera from demodectic dogs, and also in healthy dogs. Immunoblot showed IgE-binding to Dp proteins in sera of dogs with demodicosis and AD; with strong reactivity for the 72 and 116 kDa antigens detected by sera from demodicosis dogs. However, sera from healthy dogs >12 months old also presented reactivity to these bands. In conclusion, the detection of Dp-IgG and IgE antibodies in sera from demodectic dogs indicates ...
Keywords	demodex canis ; demodicosis ; dermatophagoides pteronyssinus ; . igg. ige ; dogs ; Agriculture ; S ; Biology (General) ; QH301-705.5
Subject code	630
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	Universidade Federal de Uberlândia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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