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Article ; Online: San-wei-tan-xiang capsule attenuates atherosclerosis by increasing lysosomal activity in adipose tissue macrophages.

Ye, Heng / Wang, Gang / Wang, Xuchao / Wang, Lin / Ni, Wei / Chen, Linjian / Zhu, Yifan / Zhao, Longshan / Xiong, Zhili / Wang, Yan / Dai, Cuilian / Liu, Binbin

Journal of ethnopharmacology

2023 Volume 312, Page(s) 116444

Abstract: ... of lipids and regulation of macrophage cholesterol efflux (MCE). San-wei-tan-xiang (SWTX) capsule ...

Abstract	Ethnopharmacological relevance: Dyslipidemia is the leading risk factor of atherosclerosis (AS). Adipose tissue macrophages (ATMs) can regulate postprandial cholesterol levels via uptake and hydrolyzation of lipids and regulation of macrophage cholesterol efflux (MCE). San-wei-tan-xiang (SWTX) capsule, a Traditional Chinese medicine, exerts clinical benefits in patients with atherosclerotic cardiovascular diseases. Aim of the study: This work is aimed to evaluate the chemical ingredients and mechanisms of SWTX in anti-AS. Materials and methods: The chemical ingredients of SWTX identified by liquid chromatography coupled with tandem mass spectrometry were used for network pharmacological analysis. The atheroprotective function of SWTX was evaluated in ApoE Results: The chemical ingredients identified in SWTX were predicated to be important for lipid metabolism and AS. Animals studies suggested that SWTX effectively attenuated the atherosclerotic plaque growth, elevated postprandial HDL cholesterol levels, elevated the proportion of Tim4 and CD36-expressed ATMs, and upregulated the uptake of lipid and lysosomal activity in ATMs. SWTX-induced elevation of postprandial HDL cholesterol levels was dependent on increased lysosomal activity, since chloroquine, an inhibitor of lysosomal function, blocked the effect of SWTX. Lastly, some predicated bioactive compounds in SWTX can elevate lysosomal activity in vitro. Conclusion: SWTX could attenuate atherosclerotic plaque formation by elevating lysosomal activity and enhancing MCE in ATMs.
MeSH term(s)	Mice ; Animals ; Plaque, Atherosclerotic/metabolism ; Cholesterol, HDL ; Atherosclerosis/drug therapy ; Atherosclerosis/prevention & control ; Atherosclerosis/etiology ; Macrophages ; Cholesterol/metabolism ; Lysosomes/metabolism ; Apolipoproteins E
Chemical Substances	Cholesterol, HDL ; Cholesterol (97C5T2UQ7J) ; Apolipoproteins E
Language	English
Publishing date	2023-04-13
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116444
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Article ; Online: San-wei-tan-xiang capsule attenuates atherosclerosis by increasing lysosomal activity in adipose tissue macrophages

Ye, Heng / Wang, Gang / Wang, Xuchao / Wang, Lin / Ni, Wei / Chen, Linjian / Zhu, Yifan / Zhao, Longshan / Xiong, Zhili / Wang, Yan / Dai, Cuilian / Liu, Binbin

Journal of Ethnopharmacology. 2023 Aug., v. 312 p.116444-

2023

Abstract: ... of macrophage cholesterol efflux (MCE). San-wei-tan-xiang (SWTX) capsule, a Traditional Chinese medicine, exerts ...

Abstract	Dyslipidemia is the leading risk factor of atherosclerosis (AS). Adipose tissue macrophages (ATMs) can regulate postprandial cholesterol levels via uptake and hydrolyzation of lipids and regulation of macrophage cholesterol efflux (MCE). San-wei-tan-xiang (SWTX) capsule, a Traditional Chinese medicine, exerts clinical benefits in patients with atherosclerotic cardiovascular diseases. This work is aimed to evaluate the chemical ingredients and mechanisms of SWTX in anti-AS. The chemical ingredients of SWTX identified by liquid chromatography coupled with tandem mass spectrometry were used for network pharmacological analysis. The atheroprotective function of SWTX was evaluated in ApoE⁻/⁻ mice fed a cholesterol-enriched diet. The chemical ingredients identified in SWTX were predicated to be important for lipid metabolism and AS. Animals studies suggested that SWTX effectively attenuated the atherosclerotic plaque growth, elevated postprandial HDL cholesterol levels, elevated the proportion of Tim4 and CD36-expressed ATMs, and upregulated the uptake of lipid and lysosomal activity in ATMs. SWTX-induced elevation of postprandial HDL cholesterol levels was dependent on increased lysosomal activity, since chloroquine, an inhibitor of lysosomal function, blocked the effect of SWTX. Lastly, some predicated bioactive compounds in SWTX can elevate lysosomal activity in vitro. SWTX could attenuate atherosclerotic plaque formation by elevating lysosomal activity and enhancing MCE in ATMs.
Keywords	Oriental traditional medicine ; adipose tissue ; atherosclerosis ; chloroquine ; diet ; high density lipoprotein cholesterol ; hyperlipidemia ; lipid metabolism ; liquid chromatography ; macrophages ; risk factors ; tandem mass spectrometry ; Adipose tissue macrophage ; Lysosomal activity ; Postprandial cholesterol level ; San-wei-tan-xiang capsule
Language	English
Dates of publication	2023-08
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116444
Database	NAL-Catalogue (AGRICOLA)

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Article: The Leaf Essential Oil of Acorus macrospadiceus (Yam.) F. N. Wei & Y. K. Li from Vietnam: Chemical Composition and Antimicrobial Activity

Dung, Nguyen Anh / Huong, Le Thi / Dai, Do Ngoc / Ogunwande, Isiaka Ajani

Journal of essential oil-bearing plants. 2021 July 04, v. 24, no. 4

2021

Abstract: ... from the leaves of Acorus macrospadiceus (Yam.) F. N. Wei & Y. K. Li from Vietnam were reported. The yield ...

Abstract	In the present communication, the composition and antimicrobial activity of essential oil from the leaves of Acorus macrospadiceus (Yam.) F. N. Wei & Y. K. Li from Vietnam were reported. The yield of the essential oil was 0.25 % (w/w). The main constituents of the essential oil were β-caryophyllene (31.1 %), α-selinene (12.6 %), α-asarone (12.0 %) and α-humulene (8.0 %). The essential oil displayed anti-candidal activity against Candida albicans ATCC 10231 with a minimum inhibitory concentration (MIC) value of 8.67 μg/ mL. In addition, the essential oil exhibited a broad spectrum of antimicrobial activity against the other tested microorganisms with MIC in the range 17.33 μg/mL (Enterococcus faecalis ATCC 299212) to 100.33 μg/mL (Escherichia coli ATCC 25922). The antimicrobial activities of A. macrospadiceus are being reported for the first time.
Keywords	Acorus ; Candida albicans ; Enterococcus faecalis ; Escherichia coli ; antimicrobial properties ; chemical composition ; essential oils ; leaves ; minimum inhibitory concentration ; yams ; Vietnam
Language	English
Dates of publication	2021-0704
Size	p. 745-752.
Publishing place	Taylor & Francis
Document type	Article
ISSN	0976-5026
DOI	10.1080/0972060X.2021.1978871
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Article ; Online: A Randomized, Double-Blind, Multicenter, Placebo-Controlled Trial of Qi-Zhi-Wei-Tong Granules on Postprandial Distress Syndrome-Predominant Functional Dyspepsia.

Su, Qing / Chen, Sheng-Liang / Wang, Hua-Hong / Liang, Lie-Xin / Dai, Ning / Lyu, Bin / Zhang, Jun / Wang, Rong-Quan / Zhang, Ya-Li / Yu, Yue / Liu, Jin-Song / Hou, Xiao-Hua

Chinese medical journal

2018 Volume 131, Issue 13, Page(s) 1549–1556

Abstract: ... the efficacy and safety of Qi-Zhi-Wei-Tong granules in patients with postprandial distress syndrome (PDS ... treatment period, in which they were randomly assigned to be treated with either Qi-Zhi-Wei-Tong granules or ... depression symptoms were also scored and compared.: Results: (1) The total effective rates in the Qi-Zhi-Wei-Tong ...

Abstract	Background: Functional dyspepsia (FD) is a common upper gastrointestinal disorder worldwide, but the current treatments for FD are still unsatisfactory. The aims of this study were to investigate the efficacy and safety of Qi-Zhi-Wei-Tong granules in patients with postprandial distress syndrome (PDS)-predominant FD. Methods: The study was conducted as a randomized, double-blinded, multicenter, placebo-controlled design in 197 patients with PDS. All participants received placebo treatment for 1 week. Patients whose total symptom score decreased by <50% after the placebo treatment were recruited into the 4-week treatment period, in which they were randomly assigned to be treated with either Qi-Zhi-Wei-Tong granules or placebo. The patients were then followed for 2 weeks without any treatment. Dyspeptic symptoms were scored at weeks 2 and 4 during the random treatment period and 2 weeks after the treatment. Anxiety and depression symptoms were also scored and compared. Results: (1) The total effective rates in the Qi-Zhi-Wei-Tong granules group at weeks 2 and 4 during the random treatment period and 2 weeks after treatment were all significantly higher than those in the placebo group (38.82% vs. 8.75%, P < 0.001; 69.14% vs. 16.25%, P < 0.001; 77.65% vs. 21.25%, P < 0.001). (2) The total dyspeptic symptoms scores in the Qi-Zhi-Wei-Tong granules group at weeks 2 and 4 and 2 weeks after treatment were significantly lower than those in the placebo group. (3) The severity and frequency of each dyspeptic symptom at weeks 2 and 4 and the follow-up period were all significantly lower than those in the placebo group. (4) The anxiety scores in the Qi-Zhi-Wei-Tong granules group were significantly lower than those in the placebo group. (5) Qi-Zhi-Wei-Tong granules did not have more adverse effects than the placebo. Conclusion: Qi-Zhi-Wei-Tong granules offer significant symptomatic improvement in PDS with no more adverse effects than placebo. Trial registration: https://clinicaltrials.gov/, NCT02460601.
MeSH term(s)	Adult ; Double-Blind Method ; Drugs, Chinese Herbal ; Dyspepsia/therapy ; Female ; Humans ; Male ; Middle Aged ; Qi ; Treatment Outcome
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2018-08-01
Publishing country	China
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	127089-8
ISSN	2542-5641 ; 0366-6999 ; 1002-0187
ISSN (online)	2542-5641
ISSN	0366-6999 ; 1002-0187
DOI	10.4103/0366-6999.235118
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Article ; Online: A Randomized, Double-Blind, Multicenter, Placebo-Controlled Trial of Qi-Zhi-Wei-Tong Granules on Postprandial Distress Syndrome-Predominant Functional Dyspepsia

Qing Su / Sheng-Liang Chen / Hua-Hong Wang / Lie-Xin Liang / Ning Dai / Bin Lyu / Jun Zhang / Rong-Quan Wang / Ya-Li Zhang / Yue Yu / Jin-Song Liu / Xiao-Hua Hou

Chinese Medical Journal, Vol 131, Iss 13, Pp 1549-

2018 Volume 1556

Abstract: ... the efficacy and safety of Qi-Zhi-Wei-Tong granules in patients with postprandial distress syndrome (PDS ... treatment period, in which they were randomly assigned to be treated with either Qi-Zhi-Wei-Tong granules or ... depression symptoms were also scored and compared. Results: (1) The total effective rates in the Qi-Zhi-Wei-Tong ...

Abstract	Background: Functional dyspepsia (FD) is a common upper gastrointestinal disorder worldwide, but the current treatments for FD are still unsatisfactory. The aims of this study were to investigate the efficacy and safety of Qi-Zhi-Wei-Tong granules in patients with postprandial distress syndrome (PDS)-predominant FD. Methods: The study was conducted as a randomized, double-blinded, multicenter, placebo-controlled design in 197 patients with PDS. All participants received placebo treatment for 1 week. Patients whose total symptom score decreased by <50% after the placebo treatment were recruited into the 4-week treatment period, in which they were randomly assigned to be treated with either Qi-Zhi-Wei-Tong granules or placebo. The patients were then followed for 2 weeks without any treatment. Dyspeptic symptoms were scored at weeks 2 and 4 during the random treatment period and 2 weeks after the treatment. Anxiety and depression symptoms were also scored and compared. Results: (1) The total effective rates in the Qi-Zhi-Wei-Tong granules group at weeks 2 and 4 during the random treatment period and 2 weeks after treatment were all significantly higher than those in the placebo group (38.82% vs. 8.75%, P < 0.001; 69.14% vs. 16.25%, P < 0.001; 77.65% vs. 21.25%, P < 0.001). (2) The total dyspeptic symptoms scores in the Qi-Zhi-Wei-Tong granules group at weeks 2 and 4 and 2 weeks after treatment were significantly lower than those in the placebo group. (3) The severity and frequency of each dyspeptic symptom at weeks 2 and 4 and the follow-up period were all significantly lower than those in the placebo group. (4) The anxiety scores in the Qi-Zhi-Wei-Tong granules group were significantly lower than those in the placebo group. (5) Qi-Zhi-Wei-Tong granules did not have more adverse effects than the placebo. Conclusion: Qi-Zhi-Wei-Tong granules offer significant symptomatic improvement in PDS with no more adverse effects than placebo. Trial Registration: https://clinicaltrials.gov/, NCT02460601.
Keywords	Clinical Trial ; Functional Dyspepsia ; Postprandial Distress Syndrome ; Qi-Zhi-Wei-Tong Granules ; Medicine ; R
Subject code	610
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Wolters Kluwer
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Dynamic monitoring of blood-brain barrier integrity using water exchange index (WEI) during mannitol and CO2 challenges in mouse brain.

Huang, Shuning / Farrar, Christian T / Dai, Guangping / Kwon, Seon Joo / Bogdanov, Alexei A / Rosen, Bruce R / Kim, Young R

NMR in biomedicine

2012 Volume 26, Issue 4, Page(s) 376–385

Abstract: ... To estimate WER, we have recently devised a powerful new method using a water exchange index (WEI) biomarker ... and demonstrated BBB disruption in an acute stroke model. Here, we confirm that WEI is sensitive ... doses of a hyperosmolar solution. In addition, we have examined the sensitivity and accuracy of WEI ...

Abstract	The integrity of the blood-brain barrier (BBB) is critical to normal brain function. Traditional techniques for the assessment of BBB disruption rely heavily on the spatiotemporal analysis of extravasating contrast agents. However, such methods based on the leakage of relatively large molecules are not suitable for the detection of subtle BBB impairment or for the performance of repeated measurements in a short time frame. Quantification of the water exchange rate constant (WER) across the BBB using strictly intravascular contrast agents could provide a much more sensitive method for the quantification of the BBB integrity. To estimate WER, we have recently devised a powerful new method using a water exchange index (WEI) biomarker and demonstrated BBB disruption in an acute stroke model. Here, we confirm that WEI is sensitive to even very subtle changes in the integrity of the BBB caused by: (i) systemic hypercapnia and (ii) low doses of a hyperosmolar solution. In addition, we have examined the sensitivity and accuracy of WEI as a biomarker of WER using computer simulation. In particular, the dependence of the WEI-WER relation on changes in vascular blood volume, T1 relaxation of cellular magnetization and transcytolemmal water exchange was explored. Simulated WEI was found to vary linearly with WER for typically encountered exchange rate constants (1-4 Hz), regardless of the blood volume. However, for very high WER (>5 Hz), WEI became progressively more insensitive to increasing WER. The incorporation of transcytolemmal water exchange, using a three-compartment tissue model, helped to extend the linear WEI regime to slightly higher WER, but had no significant effect for most physiologically important WERs (WER < 4 Hz). Variation in cellular T1 had no effect on WEI. Using both theoretical and experimental approaches, our study validates the utility of the WEI biomarker for the monitoring of BBB integrity.
MeSH term(s)	Animals ; Blood Volume/drug effects ; Blood-Brain Barrier/drug effects ; Blood-Brain Barrier/physiology ; Carbon Dioxide/pharmacology ; Computer Simulation ; Magnetic Resonance Imaging ; Male ; Mannitol/pharmacology ; Mice, Inbred C57BL ; Water/chemistry
Chemical Substances	Water (059QF0KO0R) ; Carbon Dioxide (142M471B3J) ; Mannitol (3OWL53L36A)
Language	English
Publishing date	2012-10-11
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1000976-0
ISSN	1099-1492 ; 0952-3480
ISSN (online)	1099-1492
ISSN	0952-3480
DOI	10.1002/nbm.2871
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Article: [Study on the best concentration of combination of the effects of the four original constituents of liu-wei di-huang pill on the proliferation and differentiation of rat preadipocyte].

Dai, Bing / Li, Xing-Feng / Xiao, Zi-Zeng / Shen, Ke-Jia / Zhao, Jing / Peng, Liu

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials

2010 Volume 33, Issue 12, Page(s) 1904–1908

Abstract: ... Peoniflorin, Paeonol) of Liu-wei Di-huang pills on the proliferation and differentiation of rat preadipocyte ... The combination of four original constituents of Liu-wei Di-huang pills could stimulate rat preadipocyte ... of the four original constituents of Liu-wei Di-huang pills on the proliferation and differentiation of rat ...

Abstract	Objective: To investigate the effects of four original constituents (Loganin, Morroniside, Peoniflorin, Paeonol) of Liu-wei Di-huang pills on the proliferation and differentiation of rat preadipocyte, and optimize the best concentration by the orthogonal test. Methods: The rat preadipocytes were cultured, then above four original constituents according to 4 factors and 3 levels to make L9 (3(4)) orthogonal test, and the control was performed at the same time. The proliferation of preadipocytes was determined by MTT method, and the accumulation of cellular lipid was determined by Oil Red O staining, the differences between factors and variances were compared by the value of absorbance. Results: The combination of four original constituents of Liu-wei Di-huang pills could stimulate rat preadipocyte proliferation and inhibited its lipid accumulation. Both the effects were highly significant (P < 0.01) with the combination of A3 B1 C3 D2; Compared with the monosomic group, the effects of the A3 B1 C3 D2 was highly significant (P < 0.01). Conclusion: Compared with the monosomic group, the effects of the combination of the four original constituents of Liu-wei Di-huang pills on the proliferation and differentiation of rat preadipocyte were highly significant. This combination consists of Loganin, morroniside with high doses, Paeonol, Peoniflorin with mid-dose and low-dose, respectively. Regnesent the overall regulatory role of synergy and officiencg.
MeSH term(s)	Acetophenones/administration & dosage ; Acetophenones/pharmacology ; Adipocytes/cytology ; Adipocytes/drug effects ; Animals ; Benzoates/administration & dosage ; Benzoates/pharmacology ; Bridged-Ring Compounds/administration & dosage ; Bridged-Ring Compounds/pharmacology ; Cell Differentiation/drug effects ; Cell Proliferation/drug effects ; Cells, Cultured ; Drug Combinations ; Drug Synergism ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Fats/metabolism ; Glucosides/administration & dosage ; Glucosides/pharmacology ; Glycosides/administration & dosage ; Glycosides/pharmacology ; Iridoids/administration & dosage ; Iridoids/pharmacology ; Male ; Monoterpenes ; Plants, Medicinal/chemistry ; Rats ; Rats, Wistar
Chemical Substances	Acetophenones ; Benzoates ; Bridged-Ring Compounds ; Drug Combinations ; Drugs, Chinese Herbal ; Fats ; Glucosides ; Glycosides ; Iridoids ; Liuwei Dihuang Decoction ; Monoterpenes ; morroniside ; peoniflorin (21AIQ4EV64) ; paeonol (3R834EPI82) ; loganin (H7WJ16Q93C)
Language	Chinese
Publishing date	2010-12
Publishing country	China
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1001-4454
ISSN	1001-4454
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Article: Effects of Lu-Duo-Wei capsules on superoxide dismutase activity and contents of malondialdehyde and lipofuscin in the brain of the housefly.

Cui, X / Dai, X G / Li, W B / Zhang, B L / Fang, Y Z

The American journal of Chinese medicine

2000 Volume 28, Issue 2, Page(s) 259–262

Abstract: The biochemical actions of Lu-Duo-Wei capsules and tea polyphenol in relation to their antioxidant ... at the 60th day in the experimental period whereas Lu-Duo-Wei showed more obvious effects on SOD than tea ... of lipofuscin accumulation were decreased by the effect of Lu-Duo-Wei at the 20th, 40th, 50th and 60th days ...

Abstract	The biochemical actions of Lu-Duo-Wei capsules and tea polyphenol in relation to their antioxidant capability have been compared in the male housefly, Musca domestica. It was found that tea polyphenol had the effect of increasing the activity of superoxide dismutase (SOD) in the brain of the housefly only at the 60th day in the experimental period whereas Lu-Duo-Wei showed more obvious effects on SOD than tea polyphenol irrespective of experimental days. Moreover, the contents of malondialdehyde (MDA) and the rate of lipofuscin accumulation were decreased by the effect of Lu-Duo-Wei at the 20th, 40th, 50th and 60th days, while the similar effect of tea polyphenol on the content of MDA and lipofuscin was observed only at the 40th day. These results indicated that the biochemical actions of Lu-Duo-Wei in antiaging was much stronger than those of tea polyphenol, the mechanism of which was probably related to the synergistic effect of its involved antioxidants and others as well as the exclusive promotion of SOD biosynthesis/or a reduction of free radical-induced damage of the enzyme.
MeSH term(s)	Analysis of Variance ; Animals ; Brain/drug effects ; Brain/enzymology ; Brain/metabolism ; Capsules ; Drugs, Chinese Herbal/pharmacology ; Flavonoids ; Houseflies ; Lipofuscin/metabolism ; Male ; Malondialdehyde/metabolism ; Phenols/pharmacology ; Polymers/pharmacology ; Polyphenols ; Superoxide Dismutase/drug effects ; Tea
Chemical Substances	Capsules ; Drugs, Chinese Herbal ; Flavonoids ; Lipofuscin ; Phenols ; Polymers ; Polyphenols ; Tea ; lu-duo-wei ; Malondialdehyde (4Y8F71G49Q) ; Superoxide Dismutase (EC 1.15.1.1)
Language	English
Publishing date	2000
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	193085-0
ISSN	0192-415X ; 0090-2942
ISSN	0192-415X ; 0090-2942
DOI	10.1142/S0192415X00000301
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Article: Effects of lu-duo-wei capsule on prolonging life span of housefly and Drosophila melanogaster.

Cui, X / Dai, X G / Li, W B / Zhang, B L / Fang, Y Z

The American journal of Chinese medicine

1999 Volume 27, Issue 3-4, Page(s) 407–413

Abstract: Lu-Duo-Wei capsule is a product of Chinese medicine having high efficacy in scavenging superoxide ... and hydroxyl radicals. It contains antioxidants, which may increase longevity, but whether Lu-Duo-Wei ... capsule has such an effect is unknown. In this study, supplementing the basic diet with Lu-Duo-Wei ...

Abstract	Lu-Duo-Wei capsule is a product of Chinese medicine having high efficacy in scavenging superoxide and hydroxyl radicals. It contains antioxidants, which may increase longevity, but whether Lu-Duo-Wei capsule has such an effect is unknown. In this study, supplementing the basic diet with Lu-Duo-Wei resulted in prolonging the life span of houseflies and fruit flies. Moreover, the effect of prolonging the life span of houseflies by Lu-Duo-Wei was significantly higher than that of tea polyphenol. The result not only confirms our previous report but also supports the free radical theory of aging.
MeSH term(s)	Animals ; Drosophila melanogaster/physiology ; Drugs, Chinese Herbal/pharmacology ; Female ; Houseflies/physiology ; Life Expectancy ; Male ; Phenols/pharmacology ; Time Factors
Chemical Substances	Drugs, Chinese Herbal ; Phenols ; lu-duo-wei
Language	English
Publishing date	1999
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	193085-0
ISSN	0192-415X ; 0090-2942
ISSN	0192-415X ; 0090-2942
DOI	10.1142/S0192415X9900046X
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Article ; Online: The removal of a monopterus albus from the colon by using colonoscopy.

Zhu, Zhiyong / Dai, Pinhong / Wei, Gang / Wang, Yaping

Asian journal of surgery

2024

Language	English
Publishing date	2024-01-25
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2024.01.080
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