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  1. Article ; Online: Novel Regulatory Roles of Hydrogen Sulfide in Health and Disease.

    Szabo, Csaba

    Biomolecules

    2022  Volume 12, Issue 10

    Abstract: Following Prof [ ... ]. ...

    Abstract Following Prof [...].
    MeSH term(s) Hydrogen Sulfide ; Gasotransmitters
    Chemical Substances Hydrogen Sulfide (YY9FVM7NSN) ; Gasotransmitters
    Language English
    Publishing date 2022-09-25
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12101372
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  2. Article ; Online: Spatial Distribution of the Rural Development Programme in Relation to Population Retention between 2015 and 2019

    Szabó Csaba

    Acta Universitatis Sapientiae: European and Regional Studies, Vol 20, Iss 1, Pp 32-

    2021  Volume 47

    Abstract: The common agricultural policy accounts for more than 38% of the European Union’s budget. In the 2014–2020 cycle, 8.9 billion euros went in Hungary to the first pillar and 4.1 billion euros to the second pillar for rural development, the mobilization of ... ...

    Abstract The common agricultural policy accounts for more than 38% of the European Union’s budget. In the 2014–2020 cycle, 8.9 billion euros went in Hungary to the first pillar and 4.1 billion euros to the second pillar for rural development, the mobilization of which was coordinated by the Rural Development Programme. The second pillar of the Common Agricultural Policy plays an important role in catching up with the lagging and depopulated Hungarian countryside. It serves key objectives such as sustainable environmental management, strengthening and diversifying the rural economy, or a fair standard of living. In my dissertation, I explore the territorial distribution of the payments of the rural development programme between 2015 and 2019 and how it affects unemployment and incomes.
    Keywords payments ; development programme ; income ; unemployment ; spatial distribution ; Political science ; J
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Hydrogen Sulfide, an Emerging Regulator of Acid-Sensing Ion Channels.

    Szabo, Csaba

    Function (Oxford, England)

    2021  Volume 2, Issue 2, Page(s) zqab014

    MeSH term(s) Hydrogen Sulfide/metabolism ; Acid Sensing Ion Channels/genetics ; Signal Transduction ; MAP Kinase Signaling System ; Durable Medical Equipment
    Chemical Substances Hydrogen Sulfide (YY9FVM7NSN) ; Acid Sensing Ion Channels
    Language English
    Publishing date 2021-03-15
    Publishing country England
    Document type Research Support, Non-U.S. Gov't ; Journal Article ; Comment
    ISSN 2633-8823
    ISSN (online) 2633-8823
    DOI 10.1093/function/zqab014
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  4. Article ; Online: Hydrogen Sulfide, an Endogenous Stimulator of Mitochondrial Function in Cancer Cells.

    Szabo, Csaba

    Cells

    2021  Volume 10, Issue 2

    Abstract: Hydrogen sulfide ( ... ...

    Abstract Hydrogen sulfide (H
    MeSH term(s) Animals ; DNA Repair ; DNA, Mitochondrial/metabolism ; Humans ; Hydrogen Sulfide/metabolism ; Mitochondria/metabolism ; Mitochondrial Dynamics ; Neoplasms/enzymology ; Neoplasms/metabolism ; Neoplasms/pathology
    Chemical Substances DNA, Mitochondrial ; Hydrogen Sulfide (YY9FVM7NSN)
    Language English
    Publishing date 2021-01-22
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10020220
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  5. Article ; Online: ROMAN DACIA IN THE DIGITAL ERA

    Csaba Szabó

    Journal of Ancient History and Archaeology, Vol 7, Iss

    2020  Volume 2

    Abstract: The study of Roman Dacia in the last two centuries produced thousands of articles, studies, monographs and proceedings and revealed at least 3800 archaeological sites from the short period of existence of the province between 106-270 AD. The large ... ...

    Abstract The study of Roman Dacia in the last two centuries produced thousands of articles, studies, monographs and proceedings and revealed at least 3800 archaeological sites from the short period of existence of the province between 106-270 AD. The large quantity of material evidence – epigraphic, figurative, ceramic, architectural and numismatic – is constantly growing due to the numerous rescue excavations in the last two decades. The emergence of digital humanities and the possibilities of digital era created new perspectives in cataloguing, collecting and presenting archaeological big data. The article presents some of the major results of digital humanities focusing on the digitization of the materiality of Roman Dacia.
    Keywords digital humanities ; roman dacia ; roman religion ; sanctuaries ; danubian provinces ; Archaeology ; CC1-960 ; Ancient history ; D51-90
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Mega Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Hydrogen Sulfide, an Endogenous Stimulator of Mitochondrial Function in Cancer Cells

    Csaba Szabo

    Cells, Vol 10, Iss 220, p

    2021  Volume 220

    Abstract: Hydrogen sulfide (H 2 S) has a long history as toxic gas and environmental hazard; inhibition of cytochrome c oxidase (mitochondrial Complex IV) is viewed as a primary mode of its cytotoxic action. However, studies conducted over the last two decades ... ...

    Abstract Hydrogen sulfide (H 2 S) has a long history as toxic gas and environmental hazard; inhibition of cytochrome c oxidase (mitochondrial Complex IV) is viewed as a primary mode of its cytotoxic action. However, studies conducted over the last two decades unveiled multiple biological regulatory roles of H 2 S as an endogenously produced mammalian gaseous transmitter. Cystathionine -lyase (CSE), cystathionine β-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (3-MST) are currently viewed as the principal mammalian H 2 S-generating enzymes. In contrast to its inhibitory (toxicological) mitochondrial effects, at lower (physiological) concentrations, H 2 S serves as a stimulator of electron transport in mammalian mitochondria, by acting as an electron donor—with sulfide:quinone oxidoreductase (SQR) being the immediate electron acceptor. The mitochondrial roles of H 2 S are significant in various cancer cells, many of which exhibit high expression and partial mitochondrial localization of various H 2 S producing enzymes. In addition to the stimulation of mitochondrial ATP production, the roles of endogenous H 2 S in cancer cells include the maintenance of mitochondrial organization (protection against mitochondrial fission) and the maintenance of mitochondrial DNA repair (via the stimulation of the assembly of mitochondrial DNA repair complexes). The current article overviews the state-of-the-art knowledge regarding the mitochondrial functions of endogenously produced H 2 S in cancer cells.
    Keywords bioenergetics ; ATP ; gasotransmitters ; DNA repair ; Biology (General) ; QH301-705.5
    Subject code 570 ; 610
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: The re-emerging pathophysiological role of the cystathionine-β-synthase - hydrogen sulfide system in Down syndrome.

    Szabo, Csaba

    The FEBS journal

    2020  Volume 287, Issue 15, Page(s) 3150–3160

    Abstract: Down syndrome (DS) is associated with significant perturbances in many morphological and biochemical features. Cystathionine-β-synthase (CBS) is one of the key mammalian enzymes that is responsible for the biological production of the gaseous transmitter ...

    Abstract Down syndrome (DS) is associated with significant perturbances in many morphological and biochemical features. Cystathionine-β-synthase (CBS) is one of the key mammalian enzymes that is responsible for the biological production of the gaseous transmitter hydrogen sulfide (H
    MeSH term(s) Animals ; Cystathionine beta-Synthase/metabolism ; Down Syndrome/physiopathology ; Energy Metabolism ; Humans ; Hydrogen Sulfide/metabolism ; Oxygen Consumption
    Chemical Substances Cystathionine beta-Synthase (EC 4.2.1.22) ; Hydrogen Sulfide (YY9FVM7NSN)
    Language English
    Publishing date 2020-02-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.15214
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 260: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Enhancing Cell Penetration Efficiency of Cyclic Oligoarginines Using Rigid Scaffolds.

    Bató, Csaba / Szabó, Ildikó / Bánóczi, Zoltán

    Pharmaceutics

    2023  Volume 15, Issue 6

    Abstract: Delivering therapeutic agents into cells has always been a major challenge. In recent years, cyclization emerged as a tool for designing CPPs to increase their internalization and stability. Cyclic ring(s) can protect the peptide from enzymatic ... ...

    Abstract Delivering therapeutic agents into cells has always been a major challenge. In recent years, cyclization emerged as a tool for designing CPPs to increase their internalization and stability. Cyclic ring(s) can protect the peptide from enzymatic degradation, so cyclic peptides remain intact. Therefore they can be good carrier molecules. In this work, the preparation and investigation of efficient cyclic CPPs are described. Different oligoarginines were designed to conjugate with rigid aromatic scaffolds or form disulfide bonds. The reaction between the scaffolds and the peptides forms stable thioether bonds, constraining the peptide into a cyclic structure. The constructs presented very efficient internalization on cancerous cell lines. Our peptides use more than one endocytic pathway for cellular uptake. In this way, short peptides, which can compete with the penetration of well-known CPPs such as octaarginine (Arg
    Language English
    Publishing date 2023-06-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15061736
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  9. Book: Cell death

    Szabó, Csaba

    the role of poly (ADP-ribose) polymerase ; [the role of PARP]

    (Pharmacology & toxicology series)

    2000  

    Author's details ed. by Csaba Szabó
    Series title Pharmacology & toxicology series
    Keywords Cell Death / physiology ; DNA Damage ; DNA Repair ; NAD+ ADP-Ribosyltransferase / physiology ; Oxidative Stress / physiology
    Language English
    Size 338 S. : Ill., graph. Darst.
    Publisher CRC Press
    Publishing place Boca Raton u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT012848540
    ISBN 0-8493-2267-7 ; 978-0-8493-2267-9
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2000 A 5128 order for loan Magazin

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  10. Article: The effect of electrical stimulation of skeletal muscle on cardioprotection and on muscle-derived myokine levels in rats: A pilot study.

    Szabó, Márton R / Csont, Tamás / Csonka, Csaba

    Physiology international

    2023  Volume 110, Issue 2, Page(s) 135–149

    Abstract: Electrical muscle stimulation (EMS) is a widely used method in sports and rehabilitation therapies to simulate physical exercise. EMS treatment via skeletal muscle activity improves the cardiovascular functions and the overall physical condition of the ... ...

    Abstract Electrical muscle stimulation (EMS) is a widely used method in sports and rehabilitation therapies to simulate physical exercise. EMS treatment via skeletal muscle activity improves the cardiovascular functions and the overall physical condition of the patients. However, the cardioprotective effect of EMS has not been proven so far, therefore, the aim of this study was to investigate the potential cardiac conditioning effect of EMS in an animal model. Low-frequency 35-min EMS was applied to the gastrocnemius muscle of male Wistar rats for three consecutive days. Their isolated hearts were then subjected to 30 min global ischemia and 120 min reperfusion. At the end of reperfusion cardiac specific creatine kinase (CK-MB) and lactate dehydrogenase (LDH) enzyme release and myocardial infarct size were determined. Additionally, skeletal muscle-driven myokine expression and release were also assessed. Phosphorylation of cardioprotective signaling pathway members AKT, ERK1/2, and STAT3 proteins were also measured. EMS significantly attenuated cardiac LDH and CK-MB enzyme activities in the coronary effluents at the end of the ex vivo reperfusion. EMS treatment considerably altered the myokine content of the stimulated gastrocnemius muscle without altering circulating myokine levels in the serum. Additionally, phosphorylation of cardiac AKT, ERK1/2, and STAT3 was not significantly different in the two groups. Despite the lack of significant infarct size reduction, the EMS treatment seems to influence the course of cellular damage due to ischemia/reperfusion and favorably modifies skeletal muscle myokine expressions. Our results suggest that EMS may have a protective effect on the myocardium, however, further optimization is required.
    MeSH term(s) Rats ; Male ; Animals ; Pilot Projects ; Proto-Oncogene Proteins c-akt/metabolism ; Rats, Sprague-Dawley ; Myocardial Reperfusion Injury/metabolism ; Myocardial Reperfusion Injury/prevention & control ; Rats, Wistar ; Apoptosis ; Myocardium/metabolism ; Muscle, Skeletal/metabolism
    Chemical Substances Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2023-05-05
    Publishing country Hungary
    Document type Journal Article
    ZDB-ID 2896288-6
    ISSN 2498-602X
    ISSN 2498-602X
    DOI 10.1556/2060.2023.00198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.361: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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