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Article ; Online: Perfused human organs versus Mary Shelley's Frankenstein.

Leung, Lawrence

Journal of translational medicine

2009 Volume 7, Page(s) 9

Abstract: Novel drugs have to go through mandatory pre-clinical testing before they can be approved for use in clinical trials. In essence, it is a form of bench-to-bedside (N2B) translational medicine, but the wastage rate of target candidates is immensely high. ... ...

Abstract	Novel drugs have to go through mandatory pre-clinical testing before they can be approved for use in clinical trials. In essence, it is a form of bench-to-bedside (N2B) translational medicine, but the wastage rate of target candidates is immensely high. Effects seen in vitro often do not translate to in vivo human settings. The search is on for better models closer to human physiology to be used in pre-clinical drug screening. The Ex Vivo Metrics system has been introduced where a human organ is harvested and revitalized in a controlled environment suitable for testing of both drug efficacy and potential toxicity. This commentary expresses the author's views regarding this technology of perfused human organs.
MeSH term(s)	Animals ; Biomedical Research ; Clinical Medicine ; Drug Evaluation, Preclinical/methods ; Humans ; In Vitro Techniques ; Perfusion
Language	English
Publishing date	2009-01-23
Publishing country	England
Document type	Editorial
ISSN	1479-5876
ISSN (online)	1479-5876
DOI	10.1186/1479-5876-7-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Reliability and validity of the Chinese (Queen Mary Hospital, Hong Kong version) of the Disabilities of the Arm, Shoulder and Hand on patients with upper extremity musculoskeletal disorders in Hong Kong.

K Y Chan, Rebecca / Leung, Y C / K L Leung, Frankie / X S Fang, Christian / K P Cheung, Amy / K C Lau, Tony / K M Fung, Jo Kamen

Hong Kong journal of occupational therapy : HKJOT

2019 Volume 32, Issue 1, Page(s) 62–68

Abstract: ... equivalence. The version was officially known as Chinese (Queen Mary Hospital, Hong Kong version) DASH ... r = -.503) of SF-36.: Conclusion: The Chinese (Queen Mary Hospital, Hong Kong version ...

Abstract	Objective: This study aimed to translate, culturally adopt and validate a Chinese version of the Disabilities of the Arm, Shoulder and Hand (DASH) for use in patients with upper extremity musculoskeletal diseases in Hong Kong. Methods: We followed a standard five-stage process: forward translation, synthesis, backward translation, expert panel review and field-testing to achieve linguistic and conceptual equivalence. The version was officially known as Chinese (Queen Mary Hospital, Hong Kong version) DASH. (Chinese QMH,HK version DASH) (http://www.dash.iwh.on.ca/sites/dash/public/translations/DASH_Chinese_HK_2013.pdf). Results: Its internal consistency was then evaluated with 138 participants suffering from upper extremity musculoskeletal conditions. The results were high in DASH-Disability/Symptom module (DASH-DS) (Cronbach alpha 0.97), DASH-Work module (DASH-W) (Cronbach alpha 0.97) and DASH-Sports / Performing Arts module (DASH-SM) (Cronbach alpha 0.99). The test-retest reliability was evaluated with a subgroup of participants who had completed the Chinese (QMH,HK version) DASH on two occasions, with a median interval of 6.5 days. The results were excellent among DASH-DS Intraclass Correlation Coefficient (ICC) = 0.98 and DASH-W (ICC = 0.90). Good test-retest reliability was found in DASH-SM (ICC = 0.89). Construct validity of DASH-DS showed good correlation with the sub-domains of physical functioning (r = -.564) and social functioning (r = -.544) of the Short Form 36 Health Survey (SF-36). Similarly, construct validity of DASH-W also showed good correlation with the sub-domains of physical functioning (r = -.510) and bodily pain (r = -.503) of SF-36. Conclusion: The Chinese (Queen Mary Hospital, Hong Kong version) Disabilities of the Arm, Shoulder and Hand is considered as a reliable and valid instrument that can provide a standardised measure of patient-centred outcomes for patients with upper extremity musculoskeletal disorders in Hong Kong.
Language	English
Publishing date	2019-05-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2202253-3
ISSN	1876-4398 ; 1569-1861
ISSN (online)	1876-4398
ISSN	1569-1861
DOI	10.1177/1569186119849502
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Article: Laparoscopic nephrectomy: an early experience at Queen Mary Hospital.

Cheung, M C / Lee, F C W / Chu, S M / Leung, Y L / Wong, B B W / Ho, K L / Tam, P C

Hong Kong medical journal = Xianggang yi xue za zhi

2005 Volume 11, Issue 1, Page(s) 7–11

Abstract: ... data collection.: Setting: Queen Mary Hospital, Hong Kong.: Patients: Transperitoneal laparoscopic ...

Abstract	Objective: To report our early experience of laparoscopic nephrectomy. Design: Prospective data collection. Setting: Queen Mary Hospital, Hong Kong. Patients: Transperitoneal laparoscopic nephrectomies were performed on 40 patients between July 1997 and December 2002. Main outcome measures: Demographic and perioperative data including operating time, blood loss, postoperative pain score, analgesic requirement, complications, time to resume oral intake, ambulatory state, and length of hospital stay. Results: Laparoscopic nephrectomy was performed for 21 solid renal masses, five transitional cell carcinomas, and 14 non-functioning kidneys. Seven (17.5%) patients had previous abdominal surgery. The mean body mass index of the patients was 23.9 kg/m(2) and the mean operating time was 229 minutes. The mean estimated blood loss was 370 mL, and two patients required conversion to open surgery because of intra-operative bleeding. Other complications include diaphragmatic injury, port-site bleeding, chyle leakage, bleeding peptic ulcer, and myocardial ischaemia. The postoperative mean analgesic requirement was 26 mg of morphine sulphate equivalent. The mean time for patients to resume oral diet and full ambulation was 1.3 and 2.8 days, respectively, and the mean length of hospital stay was 6.7 days. The mean diameter of the solid renal tumour was 4.1 cm and the surgical margins of all resected specimen for malignant tumours were negative. Conclusion: Laparoscopic nephrectomy is a safe and efficacious approach for resection of benign non-functioning kidneys and malignant renal tumours.
MeSH term(s)	Blood Loss, Surgical ; Body Mass Index ; Female ; Humans ; Intraoperative Complications ; Kidney Neoplasms/surgery ; Laparoscopy ; Male ; Middle Aged ; Nephrectomy/methods ; Pain Measurement ; Postoperative Complications ; Postoperative Period ; Prospective Studies ; Time Factors ; Ureteral Obstruction/surgery
Language	English
Publishing date	2005-02
Publishing country	China
Document type	Journal Article
ZDB-ID	1239255-8
ISSN	1024-2708
ISSN	1024-2708
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Article ; Online: Perfused human organs versus Mary Shelley's Frankenstein

Leung Lawrence

Journal of Translational Medicine, Vol 7, Iss 1, p

2009 Volume 9

Abstract: Abstract Novel drugs have to go through mandatory pre-clinical testing before they can be approved for use in clinical trials. In essence, it is a form of bench-to-bedside (N2B) translational medicine, but the wastage rate of target candidates is ... ...

Abstract	Abstract Novel drugs have to go through mandatory pre-clinical testing before they can be approved for use in clinical trials. In essence, it is a form of bench-to-bedside (N2B) translational medicine, but the wastage rate of target candidates is immensely high. Effects seen in vitro often do not translate to in vivo human settings. The search is on for better models closer to human physiology to be used in pre-clinical drug screening. The Ex Vivo Metrics © system has been introduced where a human organ is harvested and revitalized in a controlled environment suitable for testing of both drug efficacy and potential toxicity. This commentary expresses the author's views regarding this technology of perfused human organs.
Keywords	Medicine ; R
Language	English
Publishing date	2009-01-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Alcohol and health.

Schooling, C Mary / Leung, Gabriel M

Lancet (London, England)

2022 Volume 400, Issue 10365, Page(s) 1765

MeSH term(s)	Humans ; Ethanol
Chemical Substances	Ethanol (3K9958V90M)
Language	English
Publishing date	2022-11-17
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	3306-6
ISSN	1474-547X ; 0023-7507 ; 0140-6736
ISSN (online)	1474-547X
ISSN	0023-7507 ; 0140-6736
DOI	10.1016/S0140-6736(22)02124-9
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Zs.MG 94: Show issues

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Article ; Online: Early-life exposure to ambient air pollution with cardiovascular risk factors in adolescents: Findings from the "Children of 1997" Hong Kong birth cohort.

Shi, Wenming / Schooling, C Mary / Leung, Gabriel M / Zhao, Jie V

The Science of the total environment

2024 Volume 921, Page(s) 171119

Abstract: Background: Long-term exposure to ambient air pollution is associated with cardiovascular disease (CVD) risk. Little is known about the impact of early-life exposure to air pollutants on CVD risk factors in late adolescence, which may track into ... ...

Abstract	Background: Long-term exposure to ambient air pollution is associated with cardiovascular disease (CVD) risk. Little is known about the impact of early-life exposure to air pollutants on CVD risk factors in late adolescence, which may track into adulthood. To clarify, we examined this question in a unique setting with high air pollution and a high level of economic development. Methods: This study leveraged the "Children of 1997" Hong Kong birth cohort (N = 8327), including here 3350 participants. We estimated ambient air pollutant exposure including inhalable particulate matter (PM Results: Early life exposed had little association with glucose metabolism, blood pressure or body mass index, but after considering multiple comparisons early exposure to PM Conclusions: Our study suggested sex-specific associations of early-life PM
MeSH term(s)	Male ; Child ; Female ; Humans ; Adolescent ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/chemically induced ; Hong Kong/epidemiology ; Birth Cohort ; Risk Factors ; Air Pollution/analysis ; Air Pollutants/analysis ; Particulate Matter/analysis ; Nitrogen Dioxide/analysis ; Nitric Oxide ; Heart Disease Risk Factors ; Environmental Exposure/analysis
Chemical Substances	Air Pollutants ; Particulate Matter ; Nitrogen Dioxide (S7G510RUBH) ; Nitric Oxide (31C4KY9ESH)
Language	English
Publishing date	2024-02-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2024.171119
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Article: E-bibliotherapy for improving the psychological well-being of informal caregivers of people with dementia: a randomized controlled trial protocol.

Wang, Shanshan / Qin, Jing / Cheung, Daphne Sze Ki / Tyrovolas, Stefanos / Leung, Sze Him Isaac / Leung, Angela Yee Man / Davidson, Patricia Mary

BMC nursing

2024 Volume 23, Issue 1, Page(s) 84

Abstract: Background: Providing informal care for individuals with dementia is frequently a challenging and demanding experience that can have detrimental effects on the psychological well-being of caregivers. Regrettably, community-based caregiver services often ...

Abstract	Background: Providing informal care for individuals with dementia is frequently a challenging and demanding experience that can have detrimental effects on the psychological well-being of caregivers. Regrettably, community-based caregiver services often prove inadequate, highlighting the necessity for innovative approaches to support caregivers. Aim: To test the efficacy of e-bibliotherapy in improving the psychological well-being of informal caregivers of people with dementia. Method: The study is divided into two phases. In phase 1, the research team will co-design the e-bibliotherapy app with caregivers. In phase 2, a randomized controlled trial will be conducted among 192 informal caregivers of people with dementia in Hong Kong. Caregivers will be randomly assigned to either the e-bibliotherapy group or the control group using simple randomization. Outcome measures will encompass caregivers' psychological well-being, caregiving appraisal, mental health, saliva cortisol levels as an indicator of stress, and health-related quality of life for caregivers. Data will be collected at baseline, immediately post intervention, and 3 months and 6 months post intervention. General linear mixed model will be employed to analyze intervention effects. Qualitative interviews will be undertaken to explore caregiver experiences within this study and evaluate intervention acceptability using conventional content analysis methods. Discussion: This study represents a pioneering effort in utilizing e-bibliotherapy to enhance the psychological well-being of informal caregivers of individuals with dementia, addressing the existing gap in caregiver services and facilitating knowledge dissemination within the community. Trial registration: The trial has been registered on ClinicalTrial.gov (Ref: NCT05927805).
Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2091496-9
ISSN	1472-6955
ISSN	1472-6955
DOI	10.1186/s12912-024-01706-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Response to COVID-19 in Breast Imaging.

Moy, Linda / Toth, Hildegard K / Newell, Mary S / Plecha, Donna / Leung, Jessica W T / Harvey, Jennifer A

Journal of breast imaging

2024 Volume 2, Issue 3, Page(s) 180–185

Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article
ISSN	2631-6129
ISSN (online)	2631-6129
DOI	10.1093/jbi/wbaa025
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Article ; Online: A Continuing Educational Program Supporting Health Professionals to Manage Grief and Loss.

Esplen, Mary Jane / Wong, Jiahui / Vachon, Mary L S / Leung, Yvonne

Current oncology (Toronto, Ont.)

2022 Volume 29, Issue 3, Page(s) 1461–1474

Abstract: Health professionals working in oncology face the challenge of a stressful work environment along with impacts of providing care to those suffering from a life-threatening illness and encountering high levels of patient loss. Longitudinal exposure to ... ...

Abstract	Health professionals working in oncology face the challenge of a stressful work environment along with impacts of providing care to those suffering from a life-threatening illness and encountering high levels of patient loss. Longitudinal exposure to loss and suffering can lead to grief, which over time can lead to the development of compassion fatigue (CF). Prevalence rates of CF are significant, yet health professionals have little knowledge on the topic. A six-week continuing education program aimed to provide information on CF and support in managing grief and loss and consisted of virtual sessions, case-based learning, and an online community of practice. Content included personal, health system, and team-related risk factors; protective variables associated with CF; grief models; and strategies to help manage grief and loss and to mitigate against CF. Participants also developed personal plans. Pre- and post-course evaluations assessed confidence, knowledge, and overall satisfaction. A total of 189 health professionals completed the program (90% nurses). Reported patient loss was high (58.8% > 10 deaths annually; 12.2% > 50). Improvements in confidence and knowledge across several domains (p < 0.05) related to managing grief and loss were observed, including use of grief assessment tools, risk factors for CF, and strategies to mitigate against CF. Satisfaction level post-program was high. An educational program aiming to improve knowledge of CF and management of grief and loss demonstrated benefit.
MeSH term(s)	Burnout, Professional ; Compassion Fatigue ; Grief ; Humans
Language	English
Publishing date	2022-02-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol29030123
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Article ; Online: Neonates are more vulnerable to symptomatic SARS-CoV-2 infection than children: a matched cohort study in Brazil.

Leung, Char / Selle, Luisamanda / de Paiva, Karina Mary / Haas, Patricia

World journal of pediatrics : WJP

2022 Volume 18, Issue 6, Page(s) 437–442

MeSH term(s)	Brazil/epidemiology ; COVID-19 ; Child ; Cohort Studies ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical ; SARS-CoV-2
Language	English
Publishing date	2022-03-18
Publishing country	Switzerland
Document type	Letter
ZDB-ID	2236681-7
ISSN	1867-0687 ; 1708-8569
ISSN (online)	1867-0687
ISSN	1708-8569
DOI	10.1007/s12519-022-00542-4
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