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  1. Book ; Online ; E-Book: Berry bioactive compound by-products

    Khalifa, Ibrahim / Nawaz, Asad

    2023  

    Abstract: Berry Bioactive Compound By-Products explores the phytochemistry, functional properties, health-promoting effects, and food and non-food applications of bioactive compounds in berry processing by-products. The book covers a range of berry processing by- ... ...

    Author's details Ibrahim Khalifa and Asad Nawaz, editors
    Abstract Berry Bioactive Compound By-Products explores the phytochemistry, functional properties, health-promoting effects, and food and non-food applications of bioactive compounds in berry processing by-products. The book covers a range of berry processing by-products, including mulberry, raspberry, blueberry, and many more. The book examines the chemical composition, bioactive compounds, green methods for extraction, metabolism and bioactivity of bioactive components, biorefinery, bioenergy, and zero waste processing, and economic values for each berry's by-products. Edited by world experts, this book is a valuable resource for food scientists, researchers, and students in the fields of functional foods and food science, technology, and bioprocess engineering. Presents systemized and detailed information about each berry by-product Covers the methods for bioactive components extraction, and their functionality, technological aspects, and stability under processing and storage conditions Includes information on processing by-products for mulberry, raspberry, blueberry, strawberry, wolfberry, chokeberry, bilberry, cranberry, grape, cherry, fig, barberry, and black, white, and red currant.
    MeSH term(s) Fruit ; Phytochemicals
    Keywords Berries ; Bioactive compounds
    Subject code 363.7288
    Language English
    Size 1 online resource (212 pages)
    Publisher Academic Press
    Publishing place Kidlington, England
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 9780323956017 ; 9780323956000 ; 0323956017 ; 0323956009
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Enterococcus faecium from chicken feces improves chicken immune response and alleviates Salmonella infections: a pilot study.

    Khalifa, Ashraf / Ibrahim, Hairul Islam Mohamed

    Journal of animal science

    2023  Volume 101

    Abstract: Probiotics reduce the emergence of antibiotic resistance in the livestock industry. Chicken feces are reservoirs of beneficial microbiomes. The aim of this study was to isolate putative probiotics from the intestinal contents of broiler chickens. Five ... ...

    Abstract Probiotics reduce the emergence of antibiotic resistance in the livestock industry. Chicken feces are reservoirs of beneficial microbiomes. The aim of this study was to isolate putative probiotics from the intestinal contents of broiler chickens. Five fecal samples were collected from two poultry farms in Al-Ahsa, Saudi Arabia. Of the 11 morphologically distinct isolates from chicken feces (CF) samples, five isolates displayed positive reactions to Gram staining, catalase, and oxidase tests, and reacted negatively to a hemolytic assay. The isolates CF1, CF2, CF3, CF8, and CF11 were selected for further analysis of probiotic characterization, gastric survival capacity, antibiotic susceptibility, and antimicrobial activity against poultry infected with Salmonella enterica. CF2 and CF11 showed the highest hydrophobic values (> 51% hydrophobic nature). CF1, CF2, and CF11 showed potent antimicrobial activities. The active isolate CF2 was identified as Enterococcus faecium by 16s rRNA sequencing and showed a genetic similarity of 99.1%. An in vivo study was conducted using a chicken model. Enterococcus faecium-fed chickens showed an improved body weight and a lower mortality rate (17-34%). Salmonella enterica colony-forming unit (CFU) invasion in the spleen and thymus was significantly reduced in the E. faecium-fed chickens. The fecal S. enterica load was reduced from CFU 6.8 to 3.9/g in oral-administered E. faecium-fed chickens. Enterococcus faecium-fed chickens showed increased levels (P < 0.01) of butyric acid and reduced levels (P < 0.01) of intestinal interleukin 1 beta, C-reactive protein, and interferon gamma levels compared to those in the S. enterica-infected chicken group. In addition, E. faecium showed significant binding to Caco-2 epithelial cells in vitro and inhibited S. enterica colonization, indicating co-aggregation of E. faecium in epithelial cells. These results revealed that an E. faecium formulation could prevent bacterial infection and improve the quality of broiler chickens.
    MeSH term(s) Animals ; Humans ; Chickens/genetics ; Enterococcus faecium/genetics ; Pilot Projects ; RNA, Ribosomal, 16S ; Caco-2 Cells ; Poultry ; Salmonella Infections, Animal/prevention & control ; Salmonella Infections, Animal/microbiology ; Immunity ; Feces/microbiology ; Anti-Infective Agents ; Anti-Bacterial Agents/pharmacology ; Poultry Diseases/prevention & control ; Poultry Diseases/microbiology ; Probiotics/pharmacology
    Chemical Substances RNA, Ribosomal, 16S ; Anti-Infective Agents ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-01-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390959-1
    ISSN 1525-3163 ; 0021-8812
    ISSN (online) 1525-3163
    ISSN 0021-8812
    DOI 10.1093/jas/skad016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Immunomodulatory Effects of Spherical Date Seed Pills Industrially Fabricated on RAW264.7 Cells.

    Khalifa, Ibrahim / Aldhafiri, Fahad K

    Foods (Basel, Switzerland)

    2023  Volume 12, Issue 4

    Abstract: Dates have been demonstrated to display a variety of bioactivities and are rich in polyphenols. In this work, we assessed the underlying immunomodulatory effects of date seed polyphenol extracts that had been industrially encapsulated and fabricated into ...

    Abstract Dates have been demonstrated to display a variety of bioactivities and are rich in polyphenols. In this work, we assessed the underlying immunomodulatory effects of date seed polyphenol extracts that had been industrially encapsulated and fabricated into commercial pills in RAW264.7 macrophages using the NF-κB and Nrf2 signaling pathways. The outcomes showed that in RAW264.7 cells, the date seed pills effectively stimulated nuclear translocation of NF-E2-related factor 2 (Nrf2) and NF-κB, along with downstream cytokines (IL-1β, TNF-α, IL-6, and IFN-γ), ROS ratios, and SOD activity. It is interesting to note that the encapsulated pills activated Nrf2 nuclear translocation more effectively than the non-encapsulated ones did. Additionally, pills at 50 µg mL
    Language English
    Publishing date 2023-02-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12040784
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Bacillus subtilis

    Khalifa, Ashraf / Ibrahim, Hairul-Islam Mohamed / Sheikh, Abdullah

    Microorganisms

    2023  Volume 11, Issue 7

    Abstract: With the practice of a successful livestock industry using antibiotics, which has continued for more than five decades, researchers have long been interested in finding alternatives to antibiotics for poultry production. Probiotics can potentially reduce ...

    Abstract With the practice of a successful livestock industry using antibiotics, which has continued for more than five decades, researchers have long been interested in finding alternatives to antibiotics for poultry production. Probiotics can potentially reduce enteric diseases in livestock and enhance their productivity. The aim of this study was to isolate putative probiotics from camel milk and test them against
    Language English
    Publishing date 2023-06-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11071719
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Immunomodulatory Effects of Spherical Date Seed Pills Industrially Fabricated on RAW264.7 Cells

    Khalifa, Ibrahim / Aldhafiri, Fahad K.

    Foods. 2023 Feb. 12, v. 12, no. 4

    2023  

    Abstract: Dates have been demonstrated to display a variety of bioactivities and are rich in polyphenols. In this work, we assessed the underlying immunomodulatory effects of date seed polyphenol extracts that had been industrially encapsulated and fabricated into ...

    Abstract Dates have been demonstrated to display a variety of bioactivities and are rich in polyphenols. In this work, we assessed the underlying immunomodulatory effects of date seed polyphenol extracts that had been industrially encapsulated and fabricated into commercial pills in RAW264.7 macrophages using the NF-κB and Nrf2 signaling pathways. The outcomes showed that in RAW264.7 cells, the date seed pills effectively stimulated nuclear translocation of NF-E2–related factor 2 (Nrf2) and NF-κB, along with downstream cytokines (IL-1β, TNF-α, IL-6, and IFN-γ), ROS ratios, and SOD activity. It is interesting to note that the encapsulated pills activated Nrf2 nuclear translocation more effectively than the non-encapsulated ones did. Additionally, pills at 50 µg mL⁻¹ improved immunological responses, but pills at 1000 µg mL⁻¹ prevented macrophages from becoming inflamed. These results showed that the immunomodulatory effects were differently impacted by commercial date seed pills, a finding which was related to the large-scale manufacturing of the pills and the incubation concentrations used. These results also shed light on a new trend of using food byproducts as an innovative supplement.
    Keywords encapsulation ; interleukin-6 ; macrophages ; polyphenols
    Language English
    Dates of publication 2023-0212
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12040784
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Attenuation of Immunogenicity in MOG-Induced Oligodendrocytes by the Probiotic Bacterium

    Khalifa, Ashraf / Ibrahim, Hairul-Islam Mohamed / Sheikh, Abdullah / Khalil, Hany Ezzat

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 10

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Animals ; Cattle ; Female ; Humans ; RNA, Ribosomal, 16S/genetics ; Lactation ; Probiotics/therapeutic use ; Oligodendroglia ; Bacteria ; Lactococcus/genetics
    Chemical Substances RNA, Ribosomal, 16S
    Language English
    Publishing date 2023-09-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59101731
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Probiotic-Fermented Camel Milk Attenuates Neurodegenerative Symptoms via SOX5/miR-218 Axis Orchestration in Mouse Models.

    Khalifa, Ashraf / Ibrahim, Hairul Islam Mohamed / Sheikh, Abdullah / Khalil, Hany Ezzat

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 3

    Abstract: Multiple sclerosis is an autoimmune-mediated myelin damage disorder in the central nervous system that is widespread among neurological patients. It has been demonstrated that several genetic and epigenetic factors control autoimmune encephalomyelitis ( ... ...

    Abstract Multiple sclerosis is an autoimmune-mediated myelin damage disorder in the central nervous system that is widespread among neurological patients. It has been demonstrated that several genetic and epigenetic factors control autoimmune encephalomyelitis (EAE), a murine model of MS, through CD4+ T-cell population quantity. Alterations in the gut microbiota influence neuroprotectiveness via unexplored mechanisms. In this study, the ameliorative effect of
    Language English
    Publishing date 2023-02-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16030357
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Bacillus amyloliquifaciens-

    Ibrahim, Hairul Islam Mohamed / Sheikh, Abdullah / Khalil, Hany Ezzat / Khalifa, Ashraf

    Nutrients

    2023  Volume 15, Issue 3

    Abstract: Multiple sclerosis (MS), a distinct autoimmune neuroinflammatory disorder, affects millions of people worldwide, including Saudi Arabia. Changes in the gut microbiome are linked to the development of neuroinflammation via mechanisms that are not fully ... ...

    Abstract Multiple sclerosis (MS), a distinct autoimmune neuroinflammatory disorder, affects millions of people worldwide, including Saudi Arabia. Changes in the gut microbiome are linked to the development of neuroinflammation via mechanisms that are not fully understood. Prebiotics and probiotics in camel milk that has been fermented have a variety of health benefits. In this study,
    MeSH term(s) Animals ; Mice ; Anti-Inflammatory Agents/therapeutic use ; Bacillus amyloliquefaciens/metabolism ; Camelus ; Cytokines/metabolism ; Encephalomyelitis, Autoimmune, Experimental/drug therapy ; Mice, Inbred C57BL ; Milk ; Multiple Sclerosis ; Myelin-Oligodendrocyte Glycoprotein ; Neuroinflammatory Diseases ; Probiotics
    Chemical Substances Anti-Inflammatory Agents ; Cytokines ; Myelin-Oligodendrocyte Glycoprotein
    Language English
    Publishing date 2023-01-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15030550
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Bacillus amyloliquefaciens

    Khalifa, Ashraf / Sheikh, Abdullah / Ibrahim, Hairul Islam Mohamed

    Nutrients

    2022  Volume 14, Issue 9

    Abstract: Fermented camel's milk has various health beneficial prebiotics and probiotics. This study aimed to evaluate the preventive efficacy ... ...

    Abstract Fermented camel's milk has various health beneficial prebiotics and probiotics. This study aimed to evaluate the preventive efficacy of
    MeSH term(s) Animals ; Bacillus amyloliquefaciens/metabolism ; Camelus/metabolism ; Colitis/chemically induced ; Colitis/prevention & control ; Colon/metabolism ; Cytokines/metabolism ; Disease Models, Animal ; Mice ; Milk/metabolism ; Peroxidase/metabolism ; Proliferating Cell Nuclear Antigen ; Trinitrobenzenesulfonic Acid/toxicity ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Cytokines ; Proliferating Cell Nuclear Antigen ; Tumor Necrosis Factor-alpha ; Trinitrobenzenesulfonic Acid (8T3HQG2ZC4) ; Peroxidase (EC 1.11.1.7)
    Language English
    Publishing date 2022-05-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14091967
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Retraction Note: Effects of genistein on pentylenetetrazole-induced behavioral and neurochemical deficits in ovariectomized rats.

    Elsayed, Amr A / Menze, Esther T / Tadros, Mariane G / Ibrahim, Bassant M M / Sabri, Nagwa A / Khalifa, Amani E

    Naunyn-Schmiedeberg's archives of pharmacology

    2024  Volume 397, Issue 4, Page(s) 2527

    Language English
    Publishing date 2024-03-13
    Publishing country Germany
    Document type Retraction of Publication
    ZDB-ID 121471-8
    ISSN 1432-1912 ; 0028-1298
    ISSN (online) 1432-1912
    ISSN 0028-1298
    DOI 10.1007/s00210-024-03001-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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