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  1. Article ; Online: A cell cycle checkpoint for the endoplasmic reticulum.

    Niwa, Maho

    Biochimica et biophysica acta. Molecular cell research

    2020  Volume 1867, Issue 12, Page(s) 118825

    Abstract: The generation of new cells is one of the most fundamental aspects of cell biology. Proper regulation of the cell cycle is critical for human health, as underscored by many diseases associated with errors in cell cycle regulation, including both cancer ... ...

    Abstract The generation of new cells is one of the most fundamental aspects of cell biology. Proper regulation of the cell cycle is critical for human health, as underscored by many diseases associated with errors in cell cycle regulation, including both cancer and hereditary diseases. A large body of work has identified regulatory mechanisms and checkpoints that ensure accurate and timely replication and segregation of chromosomal DNA. However, few studies have evaluated the extent to which similar checkpoints exist for the division of cytoplasmic components, including organelles. Such checkpoint mechanisms might be crucial for compartments that cannot be generated de novo, such as the endoplasmic reticulum (ER). In this review, we highlight recent work in the model organism Saccharomyces cerevisiae that led to the discovery of such a checkpoint that ensures that cells inherit functional ER into the daughter cell.
    MeSH term(s) Cell Cycle Checkpoints/genetics ; Cell Division/genetics ; Chromosome Segregation/genetics ; DNA Replication/genetics ; Endoplasmic Reticulum/genetics ; Endoplasmic Reticulum Stress/genetics ; Humans ; Saccharomyces cerevisiae/genetics
    Language English
    Publishing date 2020-08-21
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 60-7
    ISSN 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbamcr.2020.118825
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A case of generalized pustular psoriasis with discrepant resolution time between pustules and erythema after treatment with spesolimab.

    Matsuo, Maho / Niwa, Hirofumi / Onishi, Hidenori / Iwata, Hiroaki

    The Journal of dermatology

    2023  Volume 51, Issue 4, Page(s) e127–e128

    MeSH term(s) Humans ; Psoriasis/diagnosis ; Psoriasis/drug therapy ; Antibodies, Monoclonal, Humanized ; Erythema/diagnosis ; Erythema/drug therapy ; Erythema/etiology ; Skin Diseases, Vesiculobullous
    Chemical Substances spesolimab (5IB2J79MCX) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2023-11-13
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.17032
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  3. Article: Papular Umbilicated Granuloma Annulare in a Patient With Systemic Lupus Erythematosus.

    Matsuo, Maho / Niwa, Hirofumi / Iwata, Hiroaki

    Cureus

    2023  Volume 15, Issue 10, Page(s) e47600

    Abstract: Granuloma annulare (GA) is characterized by palisading granuloma, which is histopathologically distinguished by histiocytes arrayed in a palisade configuration encircling insoluble entities associated with degenerated collagen fibrils. The present case ... ...

    Abstract Granuloma annulare (GA) is characterized by palisading granuloma, which is histopathologically distinguished by histiocytes arrayed in a palisade configuration encircling insoluble entities associated with degenerated collagen fibrils. The present case demonstrated multiple cutaneous papules showing palisading granuloma in a patient with SLE. A 39-year-old woman has been taking oral prednisolone daily, hydroxychloroquine sulfate, and belimumab for systemic lupus erythematosus (SLE). A few papules appeared on the lateral side of the left arm and gradually increased around both sides. Physical examination found multiple firm skin-colored papules ranging in diameter from 2 to 3 mm on both forearms. Some of the papules had umbilicated tops. Histopathological examination showed degenerated collagen fibers with mucin deposition surrounded by histiocyte infiltrates in the dermis. These findings are characteristic of palisading granuloma. There are several GA variants, such as generalized, subcutaneous, and perforating GA. We considered several possibilities of the mechanisms underlying characteristic histological changes; atypical generalized GA variants, dermatofibroma, and granuloma associated with cutaneous vasculitis. We made the final diagnosis of papular umbilicated GA in the context of SLE.
    Language English
    Publishing date 2023-10-24
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.47600
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  4. Article ; Online: Reticulons bind sphingolipids to activate the endoplasmic reticulum cell cycle checkpoint, the ER surveillance pathway.

    Piña, Francisco / Yan, Bing / Hu, Junjie / Niwa, Maho

    Cell reports

    2023  Volume 42, Issue 12, Page(s) 113403

    Abstract: The inheritance of a functional endoplasmic reticulum (ER) is ensured by the ER stress surveillance (ERSU) pathway. Here, we made the unexpected discovery that reticulon 1 (Rtn1) and Yop1, well-known ER-curvature-generating proteins, each possess two ... ...

    Abstract The inheritance of a functional endoplasmic reticulum (ER) is ensured by the ER stress surveillance (ERSU) pathway. Here, we made the unexpected discovery that reticulon 1 (Rtn1) and Yop1, well-known ER-curvature-generating proteins, each possess two sphingolipid-binding motifs within their transmembrane domains and that these motifs recognize the ER-stress-induced sphingolipid phytosphingosine (PHS), resulting in an ER inheritance block. Upon binding PHS, Rtn1/Yop1 accumulate on the ER tubule, poised to enter the emerging daughter cell, and cause its misdirection to the bud scars (i.e., previous cell division sites). Amino acid changes in the conserved PHS-binding motifs preclude Rtn1 or Yop1 from binding PHS and diminish their enrichment on the tubular ER, ultimately preventing the ER-stress-induced inheritance block. Conservation of these sphingolipid-binding motifs in human reticulons suggests that sphingolipid binding to Rtn1 and Yop1 represents an evolutionarily conserved mechanism that enables cells to respond to ER stress.
    MeSH term(s) Humans ; Saccharomyces cerevisiae/metabolism ; Sphingolipids/metabolism ; Endoplasmic Reticulum/metabolism ; Cell Cycle Checkpoints ; Endoplasmic Reticulum Stress
    Chemical Substances Sphingolipids
    Language English
    Publishing date 2023-11-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.113403
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  5. Article ; Online: A case of paraneoplastic pemphigus associated with follicular lymphoma positive only for anti-desmoglein 3 antibody.

    Matsuo, Maho / Niwa, Hirofumi / Koga, Hiroshi / Ishii, Norito / Nakamura, Nobuhiko / Iwata, Hiroaki

    The Journal of dermatology

    2023  Volume 51, Issue 5, Page(s) e164–e165

    MeSH term(s) Humans ; Pemphigus/immunology ; Pemphigus/diagnosis ; Pemphigus/pathology ; Pemphigus/complications ; Lymphoma, Follicular/complications ; Lymphoma, Follicular/diagnosis ; Lymphoma, Follicular/immunology ; Lymphoma, Follicular/pathology ; Lymphoma, Follicular/drug therapy ; Paraneoplastic Syndromes/immunology ; Paraneoplastic Syndromes/diagnosis ; Paraneoplastic Syndromes/etiology ; Paraneoplastic Syndromes/pathology ; Desmoglein 3/immunology ; Autoantibodies/blood ; Autoantibodies/immunology ; Male ; Skin/pathology ; Skin/immunology ; Female ; Middle Aged ; Aged
    Chemical Substances Desmoglein 3 ; Autoantibodies ; DSG3 protein, human
    Language English
    Publishing date 2023-12-19
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.17059
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  6. Article ; Online: Oxidative stress and dermatomyositis: Report of d-ROM measurements in 13 cases.

    Matsuo, Maho / Tawada, Chisato / Tanaka, Kayoko / Ichiki, Naohisa / Niwa, Hirofumi / Mizutani, Yoko / Shu, En / Iwata, Hiroaki

    International journal of rheumatic diseases

    2023  Volume 27, Issue 1, Page(s) e14931

    MeSH term(s) Humans ; Dermatomyositis/diagnosis ; Dermatomyositis/drug therapy ; Oxidative Stress ; Reactive Oxygen Species
    Chemical Substances Reactive Oxygen Species
    Language English
    Publishing date 2023-09-28
    Publishing country England
    Document type Letter
    ZDB-ID 2426924-4
    ISSN 1756-185X ; 1756-1841
    ISSN (online) 1756-185X
    ISSN 1756-1841
    DOI 10.1111/1756-185X.14931
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  7. Article ; Online: Regulation of the early stages of endoplasmic reticulum inheritance during ER stress.

    Chao, Jesse T / Pina, Francisco / Niwa, Maho

    Molecular biology of the cell

    2020  Volume 32, Issue 2, Page(s) 109–119

    Abstract: The endoplasmic reticulum (ER) is one of the largest cytoplasmic organelles in eukaryotic cells and plays a role in many cellular processes, such as the production and quality control of secretory protein, lipid synthesis, and calcium homeostasis. The ER ...

    Abstract The endoplasmic reticulum (ER) is one of the largest cytoplasmic organelles in eukaryotic cells and plays a role in many cellular processes, such as the production and quality control of secretory protein, lipid synthesis, and calcium homeostasis. The ER cannot be generated
    MeSH term(s) Endoplasmic Reticulum/genetics ; Endoplasmic Reticulum Stress/genetics ; Inheritance Patterns/genetics ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins/metabolism
    Chemical Substances Saccharomyces cerevisiae Proteins
    Language English
    Publishing date 2020-12-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1098979-1
    ISSN 1939-4586 ; 1059-1524
    ISSN (online) 1939-4586
    ISSN 1059-1524
    DOI 10.1091/mbc.E20-08-0558
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    Zs.MO 410: Show issues

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  8. Article ; Online: Nursing the Follicles.

    Chao, Jesse T / Niwa, Maho

    Developmental cell

    2016  Volume 37, Issue 1, Page(s) 7–8

    Abstract: In a recent issue of Science, Lei and Spradling (2016) uncover how germ cells differentiate into oocytes in mouse embryos. Mouse germ cells form cysts, in which sister cells nurse the developing oocyte by donating their organelles and cytoplasmic ... ...

    Abstract In a recent issue of Science, Lei and Spradling (2016) uncover how germ cells differentiate into oocytes in mouse embryos. Mouse germ cells form cysts, in which sister cells nurse the developing oocyte by donating their organelles and cytoplasmic materials.
    MeSH term(s) Animals ; Female ; Giant Cells/cytology ; Oocytes/cytology ; Oogenesis ; Organelles/physiology
    Language English
    Publishing date 2016-04-04
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2016.03.019
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    Zs.MG 76: Show issues

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  9. Article ; Online: A role for Nup153 in nuclear assembly reveals differential requirements for targeting of nuclear envelope constituents.

    LaJoie, Dollie / Turkmen, Ayse M / Mackay, Douglas R / Jensen, Christopher C / Aksenova, Vasilisa / Niwa, Maho / Dasso, Mary / Ullman, Katharine S

    Molecular biology of the cell

    2022  Volume 33, Issue 13, Page(s) ar117

    Abstract: Assembly of the nucleus following mitosis requires rapid and coordinate recruitment of diverse constituents to the inner nuclear membrane. We have identified an unexpected role for the nucleoporin Nup153 in promoting the continued addition of a subset of ...

    Abstract Assembly of the nucleus following mitosis requires rapid and coordinate recruitment of diverse constituents to the inner nuclear membrane. We have identified an unexpected role for the nucleoporin Nup153 in promoting the continued addition of a subset of nuclear envelope (NE) proteins during initial expansion of nascent nuclei. Specifically, disrupting the function of Nup153 interferes with ongoing addition of B-type lamins, lamin B receptor, and SUN1 early in telophase, after the NE has initially enclosed chromatin. In contrast, effects on lamin A and SUN2 were minimal, pointing to differential requirements for the ongoing targeting of NE proteins. Further, distinct mistargeting phenotypes arose among the proteins that require Nup153 for NE targeting. Thus, disrupting the function of Nup153 in nuclear formation reveals several previously undescribed features important for establishing nuclear architecture: 1) a role for a nuclear basket constituent in ongoing recruitment of nuclear envelope components, 2) two functionally separable phases of NE formation in mammalian cells, and 3) distinct requirements of individual NE residents for continued targeting during the expansion phase of NE reformation.
    MeSH term(s) Animals ; Cell Nucleus/metabolism ; Chromatin/metabolism ; Lamin Type A/metabolism ; Mammals/metabolism ; Membrane Proteins/metabolism ; Mitosis ; Nuclear Envelope/metabolism ; Nuclear Pore Complex Proteins/metabolism
    Chemical Substances Chromatin ; Lamin Type A ; Membrane Proteins ; Nuclear Pore Complex Proteins
    Language English
    Publishing date 2022-08-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1098979-1
    ISSN 1939-4586 ; 1059-1524
    ISSN (online) 1939-4586
    ISSN 1059-1524
    DOI 10.1091/mbc.E22-05-0189
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  10. Article ; Online: The ER Stress Surveillance (ERSU) pathway regulates daughter cell ER protein aggregate inheritance.

    Piña, Francisco J / Niwa, Maho

    eLife

    2015  Volume 4

    Abstract: Stress induced by cytoplasmic protein aggregates can have deleterious consequences for the cell, contributing to neurodegeneration and other diseases. Protein aggregates are also formed within the endoplasmic reticulum (ER), although the fate of ER ... ...

    Abstract Stress induced by cytoplasmic protein aggregates can have deleterious consequences for the cell, contributing to neurodegeneration and other diseases. Protein aggregates are also formed within the endoplasmic reticulum (ER), although the fate of ER protein aggregates, specifically during cell division, is not well understood. By simultaneous visualization of both the ER itself and ER protein aggregates, we found that ER protein aggregates that induce ER stress are retained in the mother cell by activation of the ER Stress Surveillance (ERSU) pathway, which prevents inheritance of stressed ER. In contrast, under conditions of normal ER inheritance, ER protein aggregates can enter the daughter cell. Thus, whereas cytoplasmic protein aggregates are retained in the mother cell to protect the functional capacity of daughter cells, the fate of ER protein aggregates is determined by whether or not they activate the ERSU pathway to impede transmission of the cortical ER during the cell cycle.
    MeSH term(s) Cell Division ; Endoplasmic Reticulum/chemistry ; Endoplasmic Reticulum/metabolism ; Endoplasmic Reticulum/physiology ; Endoplasmic Reticulum Stress ; Protein Aggregates ; Saccharomyces cerevisiae/physiology ; Stress, Physiological
    Chemical Substances Protein Aggregates
    Language English
    Publishing date 2015-09-01
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.06970
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