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  1. Article: Essay von Diethard Tautz: Das Pneu-Syndrom der Forschungs-Bürokratie

    Tautz, Diethard

    Laborjournal

    2022  Volume 29, Issue 10, Page(s) 28

    Language German
    Document type Article
    ZDB-ID 1237282-1
    ISSN 1612-8354
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4842: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Quo vadis, Bioforschung? Diethard Tautz über Fehler in der Forschungsförderung

    Tautz, Diethard

    Laborjournal

    2003  Volume -, Issue 12, Page(s) 38

    Language German
    Document type Article
    ZDB-ID 1237282-1
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4842: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Quo vadis, Bioforschung: Der Kölner Diethard Tautz träumt eines Nachts von Forschungsförderung. Natürlich ist alles besser als in Wirklichkeit

    Tautz, Diethard

    Laborjournal

    2002  Volume -, Issue 4, Page(s) 46

    Language German
    Document type Article
    ZDB-ID 1237282-1
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4842: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Editorial.

    Tautz, Diethard

    Roux's archives of developmental biology : the official organ of the EDBO

    2017  Volume 205, Issue 7-8, Page(s) 321

    Language English
    Publishing date 2017-03-16
    Publishing country Germany
    Document type Editorial
    ZDB-ID 14096-x
    ISSN 0930-035X ; 0340-0794
    ISSN 0930-035X ; 0340-0794
    DOI 10.1007/BF00377211
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Ub I Zs.58: Show issues Location:
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  5. Article ; Online: Testing the accuracy of 3D automatic landmarking via genome-wide association studies.

    Savriama, Yoland / Tautz, Diethard

    G3 (Bethesda, Md.)

    2022  Volume 12, Issue 2

    Abstract: Various advances in 3D automatic phenotyping and landmark-based geometric morphometric methods have been made. While it is generally accepted that automatic landmarking compromises the capture of the biological variation, no studies have directly tested ... ...

    Abstract Various advances in 3D automatic phenotyping and landmark-based geometric morphometric methods have been made. While it is generally accepted that automatic landmarking compromises the capture of the biological variation, no studies have directly tested the actual impact of such landmarking approaches in analyses requiring a large number of specimens and for which the precision of phenotyping is crucial to extract an actual biological signal adequately. Here, we use a recently developed 3D atlas-based automatic landmarking method to test its accuracy in detecting QTLs associated with craniofacial development of the house mouse skull and lower jaws for a large number of specimens (circa 700) that were previously phenotyped via a semiautomatic landmarking method complemented with manual adjustment. We compare both landmarking methods with univariate and multivariate mapping of the skull and the lower jaws. We find that most significant SNPs and QTLs are not recovered based on the data derived from the automatic landmarking method. Our results thus confirm the notion that information is lost in the automated landmarking procedure although somewhat dependent on the analyzed structure. The automatic method seems to capture certain types of structures slightly better, such as lower jaws whose shape is almost entirely summarized by its outline and could be assimilated as a 2D flat object. By contrast, the more apparent 3D features exhibited by a structure such as the skull are not adequately captured by the automatic method. We conclude that using 3D atlas-based automatic landmarking methods requires careful consideration of the experimental question.
    MeSH term(s) Algorithms ; Animals ; Genome-Wide Association Study/methods ; Head/anatomy & histology ; Imaging, Three-Dimensional/standards ; Mandible/anatomy & histology ; Mice ; Quantitative Trait Loci/genetics ; Skull/anatomy & histology
    Language English
    Publishing date 2022-03-05
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2629978-1
    ISSN 2160-1836 ; 2160-1836
    ISSN (online) 2160-1836
    ISSN 2160-1836
    DOI 10.1093/g3journal/jkab443
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Effects of Sequence Length and Composition of Random Sequence Peptides on the Growth of

    Castro, Johana F / Tautz, Diethard

    Genes

    2021  Volume 12, Issue 12

    Abstract: We study the potential for ... ...

    Abstract We study the potential for the
    MeSH term(s) Amino Acid Sequence ; Base Composition ; Escherichia coli/genetics ; Escherichia coli/growth & development ; Evolution, Molecular ; Peptide Library ; Peptides/metabolism
    Chemical Substances Peptide Library ; Peptides
    Language English
    Publishing date 2021-11-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes12121913
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The imprinted lncRNA

    Keshavarz, Maryam / Tautz, Diethard

    publication RETRACTED

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 10

    Abstract: Mammalian genomes include many maternally and paternally imprinted genes. Most of these are also expressed in the brain, and several have been implicated in regulating specific behavioral traits. Here, we have used a knockout approach to study the ... ...

    Abstract Mammalian genomes include many maternally and paternally imprinted genes. Most of these are also expressed in the brain, and several have been implicated in regulating specific behavioral traits. Here, we have used a knockout approach to study the function of
    MeSH term(s) Animals ; Brain/metabolism ; Female ; Genomic Imprinting ; Male ; Mating Preference, Animal ; Mice ; Mice, Knockout ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Transcriptome
    Chemical Substances RNA, Long Noncoding
    Language English
    Publishing date 2021-03-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Retracted Publication
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2022172118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Tracing the Origin and Evolutionary Fate of Recent Gene Retrocopies in Natural Populations of the House Mouse.

    Zhang, Wenyu / Tautz, Diethard

    Molecular biology and evolution

    2021  Volume 39, Issue 2

    Abstract: Although the contribution of retrogenes to the evolution of genes and genomes has long been recognized, the evolutionary patterns of very recently derived retrocopies that are still polymorphic within natural populations have not been much studied so far. ...

    Abstract Although the contribution of retrogenes to the evolution of genes and genomes has long been recognized, the evolutionary patterns of very recently derived retrocopies that are still polymorphic within natural populations have not been much studied so far. We use here a set of 2,025 such retrocopies in nine house mouse populations from three subspecies (Mus musculus domesticus, M. m. musculus, and M. m. castaneus) to trace their origin and evolutionary fate. We find that ancient house-keeping genes are significantly more likely to generate retrocopies than younger genes and that the propensity to generate a retrocopy depends on its level of expression in the germline. Although most retrocopies are detrimental and quickly purged, we focus here on the subset that appears to be neutral or even adaptive. We show that retrocopies from X-chromosomal parental genes have a higher likelihood to reach elevated frequencies in the populations, confirming the notion of adaptive effects for "out-of-X" retrogenes. Also, retrocopies in intergenic regions are more likely to reach higher population frequencies than those in introns of genes, implying a more detrimental effect when they land within transcribed regions. For a small subset of retrocopies, we find signatures of positive selection, indicating they were involved in a recent adaptation process. We show that the population-specific distribution pattern of retrocopies is phylogenetically informative and can be used to infer population history with a better resolution than with SNP markers.
    MeSH term(s) Animals ; Evolution, Molecular ; Genome ; Mice
    Language English
    Publishing date 2021-12-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 998579-7
    ISSN 1537-1719 ; 0737-4038
    ISSN (online) 1537-1719
    ISSN 0737-4038
    DOI 10.1093/molbev/msab360
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Zs.A 2137: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Frequent lineage-specific substitution rate changes support an episodic model for protein evolution.

    Prabh, Neel / Tautz, Diethard

    G3 (Bethesda, Md.)

    2021  Volume 11, Issue 12

    Abstract: Since the inception of the molecular clock model for sequence evolution, the investigation of protein divergence has revolved around the question of a more or less constant change of amino acid sequences, with specific overall rates for each family. ... ...

    Abstract Since the inception of the molecular clock model for sequence evolution, the investigation of protein divergence has revolved around the question of a more or less constant change of amino acid sequences, with specific overall rates for each family. Although anomalies in clock-like divergence are well known, the assumption of a constant decay rate for a given protein family is usually taken as the null model for protein evolution. However, systematic tests of this null model at a genome-wide scale have lagged behind, despite the databases' enormous growth. We focus here on divergence rate comparisons between very closely related lineages since this allows clear orthology assignments by synteny and reliable alignments, which are crucial for determining substitution rate changes. We generated a high-confidence dataset of syntenic orthologs from four ape species, including humans. We find that despite the appearance of an overall clock-like substitution pattern, several hundred protein families show lineage-specific acceleration and deceleration in divergence rates, or combinations of both in different lineages. Hence, our analysis uncovers a rather dynamic history of substitution rate changes, even between these closely related lineages, implying that one should expect that a large fraction of proteins will have had a history of episodic rate changes in deeper phylogenies. Furthermore, each of the lineages has a separate set of particularly fast diverging proteins. The genes with the highest percentage of branch-specific substitutions are ADCYAP1 in the human lineage (9.7%), CALU in chimpanzees (7.1%), SLC39A14 in the internal branch leading to humans and chimpanzees (4.1%), RNF128 in gorillas (9%), and S100Z in gibbons (15.2%). The mutational pattern in ADCYAP1 suggests a biased mutation process, possibly through asymmetric gene conversion effects. We conclude that a null model of constant change can be problematic for predicting the evolutionary trajectories of individual proteins.
    MeSH term(s) Animals ; Evolution, Molecular ; Genome ; Hominidae ; Humans ; Pan troglodytes/genetics ; Phylogeny
    Language English
    Publishing date 2021-09-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2629978-1
    ISSN 2160-1836 ; 2160-1836
    ISSN (online) 2160-1836
    ISSN 2160-1836
    DOI 10.1093/g3journal/jkab333
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Effects of the Expression of Random Sequence Clones on Growth and Transcriptome Regulation in

    Bhave, Devika / Tautz, Diethard

    Genes

    2021  Volume 13, Issue 1

    Abstract: Comparative genomic analyses have provided evidence that new genetic functions can emerge out of random nucleotide sequences. Here, we apply a direct experimental approach to study the effects of plasmids harboring random sequence inserts under the ... ...

    Abstract Comparative genomic analyses have provided evidence that new genetic functions can emerge out of random nucleotide sequences. Here, we apply a direct experimental approach to study the effects of plasmids harboring random sequence inserts under the control of an inducible promoter. Based on data from previously described experiments dealing with the growth of clones within whole libraries, we extracted specific clones that had shown either negative, neutral or positive effects on relative cell growth. We analyzed these individually with respect to growth characteristics and the impact on the transcriptome. We find that candidate clones for negative peptides lead to growth arrest by eliciting a general stress response. Overexpression of positive clones, on the other hand, does not change the exponential growth rates of hosts, and they show a growth advantage over a neutral clone when tested in direct competition experiments. Transcriptomic changes in positive clones are relatively moderate and specific to each clone. We conclude from our experiments that random sequence peptides are indeed a suitable source for the de novo evolution of genetic functions.
    MeSH term(s) Clone Cells/metabolism ; Clone Cells/microbiology ; Escherichia coli/genetics ; Escherichia coli/growth & development ; Escherichia coli Infections/genetics ; Escherichia coli Infections/microbiology ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Gene Expression Regulation, Bacterial ; Mutation ; Plasmids ; Promoter Regions, Genetic ; Transcriptome
    Chemical Substances Escherichia coli Proteins
    Language English
    Publishing date 2021-12-24
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes13010053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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