LIVIVO - Search results -

Search results

Result 1 - 10 of total 13

Search options

Article ; Online: Vegetation restoration altered the soil organic carbon composition and favoured its stability in a Robinia pseudoacacia plantation.

Su, Zhuoxia / Zhong, Yangquanwei / Zhu, Xiaoyue / Wu, Yang / Shen, Zhifeng / Shangguan, Zhouping

2023 Volume 899, Page(s) 165665

Abstract: Soil organic carbon (SOC) stabilization is vital for the mitigation of global climate change and retention of soil carbon stocks. However, there are knowledge gaps on how SOC sources and stabilization respond to vegetation restoration. Therefore, we ... ...

Abstract	Soil organic carbon (SOC) stabilization is vital for the mitigation of global climate change and retention of soil carbon stocks. However, there are knowledge gaps on how SOC sources and stabilization respond to vegetation restoration. Therefore, we investigated lignin phenol and amino sugar biomarkers, SOC physical fractions and chemical structure in one farmland and four stands of a Robinia pseudoacacia plantation. We observed that the content of SOC increased with afforestation, but the different biomarkers had different contributions to SOC. Compared to farmland, the contribution of lignin phenols to SOC decreased in the plantations, whereas there was no difference among the four stand ages, likely resulting from the balance between increasing lignin derivation input and increasing lignin degradation. Conversely, vegetation restoration increased the content of microbial necromass carbon (MNC) and the contribution of MNC to SOC, mainly because microbial residue decomposition was inhibited by decreasing the activity of leucine aminopeptidase, while microbial necromass preservation was promoted by adjusting soil variables (soil water content, clay, pH and total nitrogen). In addition, vegetation restoration increased the particulate organic carbon (POC), mineral-associated organic carbon (MAOC) pools and the O-alkyl C intensify. Overall, vegetation restoration affected SOC composition by regulating lignin phenols and microbial necromass and also altered SOC stabilization by increasing the physically stable MAOC pool during late afforestation. The results of this study suggest that more attention should be given to SOC sequestration and stability during late vegetation restoration.
MeSH term(s)	Soil/chemistry ; Carbon/analysis ; Robinia/metabolism ; Lignin/metabolism ; Clay ; Minerals/metabolism ; China
Chemical Substances	Soil ; Carbon (7440-44-0) ; Lignin (9005-53-2) ; Clay (T1FAD4SS2M) ; Minerals
Language	English
Publishing date	2023-07-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.165665
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 949: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Vegetation restoration altered the soil organic carbon composition and favoured its stability in a Robinia pseudoacacia plantation

Su, Zhuoxia / Zhong, Yangquanwei / Zhu, Xiaoyue / Wu, Yang / Shen, Zhifeng / Shangguan, Zhouping

Science of the Total Environment. 2023 July 19, p.165665-

2023 , Page(s) 165665–

Abstract	Soil organic carbon (SOC) stabilization is vital for the mitigation of global climate change and retention of soil carbon stocks. However, there are knowledge gaps on how SOC sources and stabilization respond to vegetation restoration. Therefore, we investigated lignin phenol and amino sugar biomarkers, SOC physical fractions and chemical structure in one farmland and four stands of a Robinia pseudoacacia plantation. We observed that the content of SOC increased with afforestation, but the different biomarkers had different contributions to SOC. Compared to farmland, the contribution of lignin phenols to SOC decreased in the plantations, whereas there was no difference among the four stand ages, likely resulting from the balance between increasing lignin derivation input and increasing lignin degradation. Conversely, vegetation restoration increased the content of microbial necromass carbon (MNC) and the contribution of MNC to SOC, mainly because microbial residue decomposition was inhibited by decreasing the activity of leucine aminopeptidase, while microbial necromass preservation was promoted by adjusting soil variables (soil water content, clay, pH and total nitrogen). In addition, vegetation restoration increased the particulate organic carbon (POC), mineral-associated organic carbon (MAOC) pools and the O-alkyl C intensify. Overall, vegetation restoration affected SOC composition by regulating lignin phenols and microbial necromass and also altered SOC stabilization by increasing the physically stable MAOC pool during late afforestation. The results of this study suggest that more attention should be given to SOC sequestration and stability during late vegetation restoration.
Keywords	Robinia pseudoacacia ; afforestation ; agricultural land ; biomarkers ; carbon sequestration ; chemical structure ; clay ; climate change ; ecological restoration ; environment ; leucyl aminopeptidase ; lignin ; necromass ; pH ; particulate organic carbon ; phenol ; soil organic carbon ; soil water content ; sugars ; total nitrogen ; Lignin phenols ; Microbial necromass ; Organic carbon fractions ; Nuclear magnetic resonance ; Soil organic carbon stabilization
Language	English
Dates of publication	2023-0719
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.165665
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 74/341: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Polycomb group proteins: Novel molecules associated with ultraviolet A-induced photoaging of human skin.

Wu, Zhuoxia / Zhang, Lianbo

Experimental and therapeutic medicine

2017 Volume 14, Issue 3, Page(s) 2554–2562

Abstract: Epigenetic repressor polycomb group (PcG) proteins are thought to serve a role in a number of cellular processes, including carcinogenesis, senescence, apoptosis and DNA repair. In the present study, long-wave ultraviolet A (UVA) was used to irradiate ... ...

Abstract	Epigenetic repressor polycomb group (PcG) proteins are thought to serve a role in a number of cellular processes, including carcinogenesis, senescence, apoptosis and DNA repair. In the present study, long-wave ultraviolet A (UVA) was used to irradiate human skin fibroblasts (HSFs) and embryonic skin fibroblasts (ESFs) in order to simulate photoaging of the skin. The results of cell proliferation, apoptosis, hyaluronic acid (HA) content and reverse transcription-quantitative polymerase chain reaction assays revealed that the expression levels of genes encoding key PcG proteins (
Language	English
Publishing date	2017-07-19
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2017.4807
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Renal-clearable and biodegradable black phosphorus quantum dots for photoacoustic imaging of kidney dysfunction.

Zhang, Wangning / Shen, Zhuoxia / Wu, Yan / Zhang, Wenze / Zhang, Tiange / Yu, Bo-Yang / Zheng, Xianchuang / Tian, Jiangwei

Analytica chimica acta

2022 Volume 1204, Page(s) 339737

Abstract: The kidney is a vital organ and susceptible to various diseases. Photoacoustic (PA) imaging provides a powerful technique for studying kidney dysfunction, for which many smart photoacoustic imaging agents have been developed. But the complete clearance ... ...

Abstract	The kidney is a vital organ and susceptible to various diseases. Photoacoustic (PA) imaging provides a powerful technique for studying kidney dysfunction, for which many smart photoacoustic imaging agents have been developed. But the complete clearance of the introduced contrast agents after imaging remains to be challenging, leading to long-term toxicity concerns. In this study, we synthesized black phosphorous quantum dots (BPQDs) with ultra-small size (1.74 ± 0.23 nm after surface modification) and strong PA signal for imaging kidney dysfunction. Importantly, the renal-clearance property and biodegradability of the developed BPQDs help circumvent the long-term toxicity issue for in vivo studies. Based on these BPQDs, both acute kidney injury and chronic kidney disease were successfully detected in the living mice by PA imaging, with higher detection sensitivity than the clinical serum indices examination method. This BPQDs-based PA imaging method should have a promising potential for the early diagnosis of kidney dysfunction in clinic.
MeSH term(s)	Animals ; Contrast Media ; Kidney/diagnostic imaging ; Mice ; Phosphorus ; Photoacoustic Techniques ; Quantum Dots/toxicity
Chemical Substances	Contrast Media ; Phosphorus (27YLU75U4W)
Language	English
Publishing date	2022-03-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1483436-4
ISSN	1873-4324 ; 0003-2670
ISSN (online)	1873-4324
ISSN	0003-2670
DOI	10.1016/j.aca.2022.339737
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Gene expression profiling analysis: the effect of hydrocortisone on keloid fibroblasts by bioinformatics.

Zhang, Lianbo / Qin, Haiyan / Wu, Zhuoxia / Chen, Wanying / Zhang, Guang

The Journal of dermatological treatment

2018 Volume 30, Issue 2, Page(s) 200–205

Abstract: Background: We aimed to explore potential molecular basis of keloid formation and response mechanism of keloid to hydrocortisone (HC).: Methods: Transcriptional profile of GSE7890 which contained five normal scars with no HC treatment (NNHC), four ... ...

Abstract	Background: We aimed to explore potential molecular basis of keloid formation and response mechanism of keloid to hydrocortisone (HC). Methods: Transcriptional profile of GSE7890 which contained five normal scars with no HC treatment (NNHC), four normal scars treated with HC (NHC), five keloids with no HC treatment (KNHC), and five keloids treated with HC (KHC) samples was downloaded to identify differentially expressed genes (DEGs). Based on DEGs, hierarchical cluster analysis and pathway enrichment analysis were performed. Then, identification of characteristic pathway was performed, followed by calculation of pathway deviation score. Results: Compared to NNHC group, total 1603 DEGs in NHC group, 895 DEGs in KHC group, and 832 DEGs in KNHC group were identified. Hierarchical cluster analysis revealed these four groups could be well distinguished. Total three pathways included cytokine-cytokine receptor interactions were significantly different between KNHC and NNHC groups. Besides, MAPK signaling pathway, endocytosis, and apoptosis were selected between KHC and KNHC groups. Genes of vascular endothelial growth factor C (VEGFC), tenascin C (TNC), and jun proto-oncogene (JUN) were selected as important DEGs in KHC, KNHC, and NHC groups, respectively. Conclusions: VEGF and TNC were, respectively, involved in KHC and KNHC in the mechanism of focal adhesion. JUN might be a potential molecular marker related to normal scar.
MeSH term(s)	Cluster Analysis ; Computational Biology/methods ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Gene Expression Profiling ; Humans ; Hydrocortisone/pharmacology ; Keloid/drug therapy ; Tenascin/genetics ; Vascular Endothelial Growth Factor C/genetics
Chemical Substances	Tenascin ; Vascular Endothelial Growth Factor C ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2018-09-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1036299-x
ISSN	1471-1753 ; 0954-6634
ISSN (online)	1471-1753
ISSN	0954-6634
DOI	10.1080/09546634.2018.1484559
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2627: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Identification of the potential targets for keloid and hypertrophic scar prevention.

Zhang, Lianbo / Qin, Haiyan / Wu, Zhuoxia / Chen, Wanying / Zhang, Guang

The Journal of dermatological treatment

2018 Volume 29, Issue 6, Page(s) 600–605

Abstract: Purpose: We aimed to explore the molecular mechanism of pathologic skin scar and novel target for scar prevention.: Materials and methods: Microarray data derived from keloid and hypertrophic scar were downloaded from ArrayExpress database. The ... ...

Abstract	Purpose: We aimed to explore the molecular mechanism of pathologic skin scar and novel target for scar prevention. Materials and methods: Microarray data derived from keloid and hypertrophic scar were downloaded from ArrayExpress database. The common differentially expressed genes (DEGs) in keloid and hypertrophic scar samples were investigated by function and pathway analysis. The protein-protein interaction (PPI) network was constructed and the modules were screened. Results: There were a total of 485 DEGs related with skin scar, including 247 up-regulated genes and 238 down-regulated genes. The up-regulated genes were closely related with Rho protein signal transduction, cytoskeleton organization, and Ras protein signal transduction related biological process. The down-regulated genes were enriched in sterol metabolic process, fatty acid metabolic process, and steroid metabolic process. PPI network was constructed with 680 protein pairs and modules 1 and 2 were screened out. Fos proto-oncogene (FOS) and early growth response 1 (EGR1) were significant transcriptional factors in the two modules. Conclusions: FOS and EGR1 may be potential targets for skin scar prevention.
MeSH term(s)	Cicatrix, Hypertrophic/metabolism ; Cicatrix, Hypertrophic/pathology ; Cicatrix, Hypertrophic/prevention & control ; Databases, Genetic ; Down-Regulation ; Humans ; Keloid/metabolism ; Keloid/pathology ; Keloid/prevention & control ; Protein Interaction Maps/genetics ; Proto-Oncogene Proteins c-fos/genetics ; Proto-Oncogene Proteins c-fos/metabolism ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Transcriptome ; Up-Regulation
Chemical Substances	NAB1 protein, human ; Proto-Oncogene Proteins c-fos ; Repressor Proteins
Language	English
Publishing date	2018-01-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1036299-x
ISSN	1471-1753 ; 0954-6634
ISSN (online)	1471-1753
ISSN	0954-6634
DOI	10.1080/09546634.2017.1421309
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2627: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Pathogenic genes related to the progression of actinic keratoses to cutaneous squamous cell carcinoma.

Zhang, Lianbo / Qin, Haiyan / Wu, Zhuoxia / Chen, Wanying / Zhang, Guang

International journal of dermatology

2018 Volume 57, Issue 10, Page(s) 1208–1217

Abstract: Background: Actinic keratosis (AK) is an incipient form of cutaneous squamous cell carcinoma (cSCC). Understanding the differentially expressed genes between AK and cSCC states would be helpful for the early prevention and treatment of cSCC. ... ...

Abstract	Background: Actinic keratosis (AK) is an incipient form of cutaneous squamous cell carcinoma (cSCC). Understanding the differentially expressed genes between AK and cSCC states would be helpful for the early prevention and treatment of cSCC. Consequently, this study aimed to screen the key genes associated with the progression of AK to cSCC. Methods: The microarray dataset GSE45216 was downloaded from the Gene Expression Omnibus, which included 10 AK and 30 primary cSCC skin tissue samples. Differentially expressed genes (DEGs) in cSCC samples, compared to those in AK, were identified. Gene co-expression relationships were investigated, followed by miRNA prediction. The potential functions of the co-expressed genes were predicted by gene ontology (GO) and pathway enrichment analyses. In addition, the transcription factors and drug molecules, significantly related to the co-expressed genes, were obtained. Results: A total of 320 DEGs were identified in the cSCC group, relative to the AK group. Moreover, 96 DEGs and 2,390 connecting edges were identified in the gene co-expression network. An miRNA regulatory network was constructed, including 96 DEGs and 16 miRNAs. In addition, three co-expression network modules were obtained; EIF4EBP1, SNX17, PRPF4, NXT1, and UBA5 were significant nodes in the modules. Conclusions: EIF4EBP1, SNX17, PRPF4, NXT1, and UBA5 may be the pathogenic genes contributing to the development of cSCC from AK.
MeSH term(s)	Carcinoma, Squamous Cell/genetics ; Cell Transformation, Neoplastic/genetics ; Disease Progression ; Gene Expression ; Gene Ontology ; Gene Regulatory Networks ; Humans ; Keratosis, Actinic/genetics ; Keratosis, Actinic/pathology ; MicroRNAs/genetics ; Skin Neoplasms/genetics
Chemical Substances	MicroRNAs
Language	English
Publishing date	2018-08-13
Publishing country	England
Document type	Journal Article
ZDB-ID	412254-9
ISSN	1365-4632 ; 0011-9059 ; 1461-1244
ISSN (online)	1365-4632
ISSN	0011-9059 ; 1461-1244
DOI	10.1111/ijd.14131
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ui VI Zs.189: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Surgical correction of residual facial deformity following conservative excision of a giant maxillary ossifying fibroma: A case report.

Wu, Zhuoxia / Xing, Yunlong / Liu, Xin / Chen, Wanying / Kong, Jiao / Wu, Ronghui / Zhang, Lianbo

Medicine

2018 Volume 97, Issue 47, Page(s) e13186

Abstract: Rationale: Ossifying fibroma (OF) is a benign fibro-osseous lesion that can develop in the oral and maxillofacial region. OF is more common in females and has a marked predilection for the mandible, occurring rarely in the maxilla. Lesions grow slowly ... ...

Abstract	Rationale: Ossifying fibroma (OF) is a benign fibro-osseous lesion that can develop in the oral and maxillofacial region. OF is more common in females and has a marked predilection for the mandible, occurring rarely in the maxilla. Lesions grow slowly and are usually asymptomatic until growth produces an obvious swelling, pain, paresthesia, and facial deformity. With low rates of recurrence, treatment is usually curettage or resection. Very large lesions that invade other organs and that cannot be completely removed should be excised conservatively. Patient concerns: We present a case of a 46-year-old female with a very large fibro-osseous lesion arising from the maxilla who was more concerned about the facial appearance and requested conservative treatment for economic reasons. Diagnoses: The pathological results based on conservative excision of the lesion confirmed the diagnosis of OF. Interventions: We chose conservative excision via the Weber-Ferguson approach and followed up every 6 months. Facial deformity correction was performed 2 years postoperatively and right lower eyelid ectropion correction 3 years after the primary excision. Outcomes: The ectropion deformity in the right lower eyelid improved dramatically with a better facial appearance and no obvious swelling. Lessons: Treatment programs for OF should be individualized based on the size, growth rate, invasion, and interference with facial function and esthetics. If lesions grow slowly, we suppose that it is feasible to excise conservatively when reconstruction cannot be performed due to esthetic and functional problems. Also regular postoperative follow-up is necessary to detect recurrence, and to improve facial appearance as required.
MeSH term(s)	Adult ; Cicatrix/surgery ; Esthetics ; Eyelids/surgery ; Face/pathology ; Face/surgery ; Facial Asymmetry/surgery ; Female ; Fibroma, Ossifying/pathology ; Fibroma, Ossifying/surgery ; Humans ; Lip/surgery ; Maxillary Neoplasms/pathology ; Maxillary Neoplasms/surgery ; Postoperative Complications/pathology ; Postoperative Complications/surgery ; Reconstructive Surgical Procedures/methods
Language	English
Publishing date	2018-09-10
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000013186
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.171: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Changes of Transforming Growth Factor-β1 and Extracellular Matrix in the Wound Healing Process of Rats Infected With Pseudomonas aeruginosa.

Zhang, Lianbo / Wu, Zhuoxia / Qin, Haiyan / Chen, Wanying / Zhang, Guang

Wounds : a compendium of clinical research and practice

2014 Volume 26, Issue 10, Page(s) 293–300

Abstract: Objective: This work aims to investigate the changes of transforming growth factor-β1 (TGF-β1) and extracellular matrix (ECM) proteins in rats with chronic skin ulcers infected with Pseudomonas aeruginosa.: Methods: Forty-eight female Wistar rats, ... ...

Abstract	Objective: This work aims to investigate the changes of transforming growth factor-β1 (TGF-β1) and extracellular matrix (ECM) proteins in rats with chronic skin ulcers infected with Pseudomonas aeruginosa. Methods: Forty-eight female Wistar rats, aged 8 weeks, were randomly divided into a simple cutaneous wound group (group A) and a cutaneous wound plus Pseudomonas aeruginosa inoculation group (group B). On postoperative days 1, 3, 7, and 10, hematoxylin and eosin staining, real-time polymerase chain reaction, immunohistochemistry (IHC), and enzyme-linked immunosorbent assay (ELISA) methods were used to detect the epithelization rate, the mRNA, and the protein expressions of matrix metalloproteinases (MMP) 2, MMP-9, tissue inhibitors of metalloproteinases (TIMP)-1, and TGF-β1. Results: Compared with group A, the expression of TGF-β1 and the epithelization rate were delayed in group B. At 3 days postoperation, the expression of collagen III was reduced in group B. At 7 days postoperation, MMP-9 had an extremely high expression but collagen and TIMP-1 had a low expression. Seven days after being infected with Pseudomonas aeruginosa, the expression of TGF-β1 was reduced in the wounded skin of rats, and the dissolved ECM was much more than that synthesized in wounds. Conclusion: The authors' experiments suggest the wounded skin tissue infected with Pseudomonas aeruginosa delayed the expression of TGF-β1, and then caused a change in the ECM biology relevant to fibrosis and regeneration, thus affecting the wound healing process.
Language	English
Publishing date	2014-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1214936-6
ISSN	1943-2704 ; 1044-7946
ISSN (online)	1943-2704
ISSN	1044-7946
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4153: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Distribution and clinical significance of circulating tumor cells in nasopharyngeal carcinoma.

Si, Yongfeng / Lan, Guiping / Deng, Zhuoxia / Wang, Yongli / Lu, Yan / Qin, Yangda / Huang, Bo / Yang, Yong / Weng, Jingjin / Han, Xing / Zhang, Benjian / Qin, Ying / Xiong, Weimin / Li, Bing / Wu, Shiyang

Japanese journal of clinical oncology

2016 Volume 46, Issue 7, Page(s) 622–630

Abstract: Objective: Nasopharyngeal carcinoma is one of the leading malignancies with obscure etiology. Circulating tumor cells have been showed to intimately correlate with characteristics in different kinds of cancer. But links between circulating tumor cells ... ...

Abstract	Objective: Nasopharyngeal carcinoma is one of the leading malignancies with obscure etiology. Circulating tumor cells have been showed to intimately correlate with characteristics in different kinds of cancer. But links between circulating tumor cells and nasopharyngeal carcinoma were still lacking. Therefore, we explored circulating tumor cells' distribution in nasopharyngeal carcinoma and their possible associations with nasopharyngeal carcinoma. Methods: Firstly, we found that the positive ratio of circulating tumor cells is extremely high in four stages of nasopharyngeal carcinoma. Meanwhile, positive ratios of mesenchymal circulating tumor cells were higher in early stages of nasopharyngeal carcinoma. Apart from epithelial circulating tumor cells, total, hybrid and mesenchymal circulating tumor cells were correlated with nasopharyngeal carcinoma clinical stage. Results: Our results showed that hybrid and mesenchymal circulating tumor cells were associated with nasopharyngeal carcinoma metastasis (both distant and lymph node) and smoking. Meanwhile, hybrid circulating tumor cells expressed the highest Epstein-Barr virus proteins and deoxyribonucleic acid in three types of circulating tumor cells. Moreover, we found that Epstein-Barr virus proteins viral-caspid antigen-immunoglobulin A (VCA/IgA) and early antigen-immunoglobulin A (EA/IgA), but not Epstein-Barr virus-deoxyribonucleic acid, had a closed association with nasopharyngeal carcinoma metastasis. However, Epstein-Barr virus hallmarks failed to associate with other nasopharyngeal carcinoma characteristics. Furthermore, we confirmed that matrix metalloproteinase 9 existed in circulating tumor cells and expressed most in mesenchymal circulating tumor cells. In addition, matrix metalloproteinase 9-expressed extent in hybrid circulating tumor cells is somewhat different from epithelial and mesenchymal circulating tumor cells in matrix metalloproteinase 9-positive circulating tumor cells. Nevertheless, matrix metalloproteinase 9 had no relationship with other nasopharyngeal carcinoma characteristics. Finally, our results showed that circulating tumor cells were decreased in patients after therapies. Conclusion: Taken together, circulating tumor cells were tightly correlated with nasopharyngeal carcinoma characteristics. In addition, Epstein-Barr virus was associated with nasopharyngeal carcinoma metastasis. Of note, decreased circulating tumor cells indicated a favorable curative effect in nasopharyngeal carcinoma patients.
MeSH term(s)	Aged ; Antibodies, Viral/blood ; Antigens, Viral/analysis ; Carcinoma ; Epstein-Barr Virus Infections/complications ; Female ; Humans ; Male ; Middle Aged ; Nasopharyngeal Carcinoma ; Nasopharyngeal Neoplasms/blood ; Nasopharyngeal Neoplasms/pathology ; Nasopharyngeal Neoplasms/virology ; Neoplasm Metastasis/pathology ; Neoplastic Cells, Circulating/pathology
Chemical Substances	Antibodies, Viral ; Antigens, Viral
Language	English
Publishing date	2016-05-09
Publishing country	England
Document type	Journal Article
ZDB-ID	190978-2
ISSN	1465-3621 ; 0368-2811
ISSN (online)	1465-3621
ISSN	0368-2811
DOI	10.1093/jjco/hyw046
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1298: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito