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  1. Article ; Online: Molecular Orientation of Carboxylate Anions at the Water-Air Interface Studied with Heterodyne-Detected Vibrational Sum-Frequency Generation.

    Korotkevich, Alexander A / Moll, Carolyn J / Versluis, Jan / Bakker, Huib J

    The journal of physical chemistry. B

    2023  Volume 127, Issue 20, Page(s) 4544–4553

    Abstract: The carboxylate anion group plays an important role in many (bio)chemical systems and polymeric materials. In this work, we study the orientation of carboxylate anions with various aliphatic and aromatic substituents at the water-air interface by probing ...

    Abstract The carboxylate anion group plays an important role in many (bio)chemical systems and polymeric materials. In this work, we study the orientation of carboxylate anions with various aliphatic and aromatic substituents at the water-air interface by probing the carboxylate stretch vibrations with heterodyne-detected vibrational sum-frequency generation spectroscopy in different polarization configurations. We find that carboxylate groups with small aliphatic substituents show a large tilt angle with respect to the surface normal and that this angle decreases with increasing size of the substituent. We further use the information about the orientation of the carboxylate group to determine the hyperpolarizability components of this group.
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5207
    ISSN (online) 1520-5207
    DOI 10.1021/acs.jpcb.2c08992
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  2. Article ; Online: Molecular orientation of small carboxylates at the water-air interface.

    Moll, Carolyn J / Korotkevich, Alexander A / Versluis, Jan / Bakker, Huib J

    Physical chemistry chemical physics : PCCP

    2022  Volume 24, Issue 17, Page(s) 10134–10139

    Abstract: We study the properties of formate ( ... ...

    Abstract We study the properties of formate (HCOO
    MeSH term(s) Carboxylic Acids ; Formates ; Ions/chemistry ; Spectrum Analysis ; Water/chemistry
    Chemical Substances Carboxylic Acids ; Formates ; Ions ; Water (059QF0KO0R)
    Language English
    Publishing date 2022-05-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d1cp05471f
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  3. Article ; Online: Author Correction: Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission.

    Liu, Tianyang / Shilliday, Fiona / Cook, Alexander D / Zeeshan, Mohammad / Brady, Declan / Tewari, Rita / Sutherland, Colin J / Roberts, Anthony J / Moores, Carolyn A

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 1124

    Language English
    Publishing date 2023-02-27
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-36854-w
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  4. Article ; Online: A call for multidisciplinary cesarean delivery analgesia care.

    Weiniger, Carolyn F / Ioscovich, Alexander / Butwick, Alexander J

    American journal of obstetrics & gynecology MFM

    2019  Volume 1, Issue 3, Page(s) 100033

    MeSH term(s) Analgesia, Obstetrical ; Cesarean Section ; Female ; Humans ; Pain ; Pregnancy
    Language English
    Publishing date 2019-08-05
    Publishing country United States
    Document type Letter ; Comment
    ISSN 2589-9333
    ISSN (online) 2589-9333
    DOI 10.1016/j.ajogmf.2019.100033
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  5. Article ; Online: Assessing interventions to encourage primary care health workers to recommend influenza vaccination and the impact on vaccination uptake for persons with Non-Communicable diseases in China.

    Fan, Jing / Song, Ying / Cong, Shu / Millman, Alexander J / Wang, Ning / Greene, Carolyn / Zhang, Ran / Zhou, Suizan / Fang, Liwen

    Vaccine

    2024  Volume 42, Issue 4, Page(s) 879–890

    Abstract: Background: Influenza vaccination coverage is low among persons with non-communicable diseases (NCDs) in China. Chinese health workers (HWs) do not routinely recommend influenza vaccination despite evidence that recommendations increase vaccine uptake. ... ...

    Abstract Background: Influenza vaccination coverage is low among persons with non-communicable diseases (NCDs) in China. Chinese health workers (HWs) do not routinely recommend influenza vaccination despite evidence that recommendations increase vaccine uptake. This study aims to assess whether interventions increased primary care HWs' recommendation for influenza vaccination and measure their impact on influenza vaccine uptake in persons with NCDs.
    Methods: We conducted a cluster randomized controlled study in public primary healthcare clinics in Hubei from November 2018 through April 2019. In the intervention clinics, primary care HWs received training on the benefits of influenza vaccination and were asked to recommend influenza vaccine in routine primary healthcare for persons with NCDs. In the control clinics, primary care HWs did not receive training and provided standard services. We conducted questionnaire surveys before and after the intervention to collect information about recommendations made and receipt of influenza vaccines.
    Results: A total of 896 primary care HWs and 4552 persons with NCDs were included. After intervention, a higher percentage of HWs recommended influenza vaccines in intervention clinics compared to control clinics. Vaccinated primary care HWs were more likely to recommend vaccination. Persons with NCDs reported higher influenza vaccination coverage in intervention than control clinics, and primary care HWs' recommendation increased vaccination uptake among persons with NCDs.
    Conclusions: Vaccinated primary care HWs were more likely to recommend influenza vaccination than unvaccinated HWs. Promoting primary care HWs' vaccination and encouraging them to recommend influenza vaccination during routine primary healthcare could increase influenza vaccine receipt among persons with NCDs. Registration number ChiCTR2200067140.
    MeSH term(s) Humans ; Influenza Vaccines ; Influenza, Human/prevention & control ; Noncommunicable Diseases ; Vaccination ; China ; Primary Health Care
    Chemical Substances Influenza Vaccines
    Language English
    Publishing date 2024-01-16
    Publishing country Netherlands
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2024.01.015
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  6. Article ; Online: Differential in vivo roles of Mpl cytoplasmic tyrosine residues in murine hematopoiesis and myeloproliferative disease.

    Behrens, Kira / Kauppi, Maria / Viney, Elizabeth M / Kueh, Andrew J / Hyland, Craig D / Willson, Tracy A / Salleh, Liam / de Graaf, Carolyn A / Babon, Jeffrey J / Herold, Marco J / Nicola, Nicos A / Alexander, Warren S

    Leukemia

    2024  

    Abstract: Thrombopoietin (Tpo), which binds to its specific receptor, the Mpl protein, is the major cytokine regulator of megakaryopoiesis and circulating platelet number. Tpo binding to Mpl triggers activation of Janus kinase 2 (Jak2) and phosphorylation of the ... ...

    Abstract Thrombopoietin (Tpo), which binds to its specific receptor, the Mpl protein, is the major cytokine regulator of megakaryopoiesis and circulating platelet number. Tpo binding to Mpl triggers activation of Janus kinase 2 (Jak2) and phosphorylation of the receptor, as well as activation of several intracellular signalling cascades that mediate cellular responses. Three tyrosine (Y) residues in the C-terminal region of the Mpl intracellular domain have been implicated as sites of phosphorylation required for regulation of major Tpo-stimulated signalling pathways: Mpl-Y565, Mpl-Y599 and Mpl-Y604. Here, we have introduced mutations in the mouse germline and report a consistent physiological requirement for Mpl-Y599, mutation of which resulted in thrombocytopenia, deficient megakaryopoiesis, low hematopoietic stem cell (HSC) number and function, and attenuated responses to myelosuppression. We further show that in models of myeloproliferative neoplasms (MPN), where Mpl is required for pathogenesis, thrombocytosis was dependent on intact Mpl-Y599. In contrast, Mpl-Y565 was required for negative regulation of Tpo responses; mutation of this residue resulted in excess megakaryopoiesis at steady-state and in response to myelosuppression, and exacerbated thrombocytosis associated with MPN.
    Language English
    Publishing date 2024-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 807030-1
    ISSN 1476-5551 ; 0887-6924
    ISSN (online) 1476-5551
    ISSN 0887-6924
    DOI 10.1038/s41375-024-02219-5
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  7. Article ; Online: Morphological and functional changes in placentas from prolonged pregnancies.

    Carroll, Amber / Desforges, Michelle / Jones, Carolyn J P / Heazell, Alexander E P

    Placenta

    2022  Volume 125, Page(s) 29–35

    Abstract: Prolonged pregnancy describes a pregnancy that progresses beyond 42 weeks' gestation (294 days). In humans, prolonged pregnancy is associated with increasing perinatal mortality, neonatal compromise and birth by Caesarean section. The underpinning ... ...

    Abstract Prolonged pregnancy describes a pregnancy that progresses beyond 42 weeks' gestation (294 days). In humans, prolonged pregnancy is associated with increasing perinatal mortality, neonatal compromise and birth by Caesarean section. The underpinning reasons behind these increased risks are unknown; one potential explanation is reduced placental function due to ageing processes. This review describes the structural and functional changes seen in prolonged pregnancy in humans and in animal models. Prolonged pregnancies are associated with reduced placental growth, leading to an increase in fetal to placental weight ratio. Microscopic changes include aggregation of syncytiotrophoblast nuclei, reduced villous vascularity with a concomitant impairment of trophoblast transport processes (reduced pinocytosis); this is associated with increased evidence of oxidative stress, with downstream consequences including cellular senescence, autophagy and apoptosis; importantly many of these changes are similar to fetal growth restriction and pre-eclampsia. Thus, we argue that these observations provide evidence of ageing within the placenta, which may initially be adaptive but can become pathological leading to a reduction in placental function. This provides a biological basis for the increased risk of adverse outcomes observed in prolonged pregnancies. Greater insight into the effects and risks of placental ageing may be useful to guide clinicians on the management of prolonged pregnancies.
    MeSH term(s) Animals ; Cesarean Section/adverse effects ; Female ; Fetal Growth Retardation/pathology ; Humans ; Placenta/pathology ; Pre-Eclampsia/pathology ; Pregnancy ; Pregnancy, Prolonged/pathology
    Language English
    Publishing date 2022-01-16
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 603951-0
    ISSN 1532-3102 ; 0143-4004
    ISSN (online) 1532-3102
    ISSN 0143-4004
    DOI 10.1016/j.placenta.2022.01.009
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  8. Article ; Online: Restoring faith in conservation action: Maintaining wild genetic diversity through the Tasmanian devil insurance program.

    Farquharson, Katherine A / McLennan, Elspeth A / Cheng, Yuanyuan / Alexander, Lauren / Fox, Samantha / Lee, Andrew V / Belov, Katherine / Hogg, Carolyn J

    iScience

    2022  Volume 25, Issue 7, Page(s) 104474

    Abstract: Conservation breeding programs aim to maintain 90% wild genetic diversity, but rarely assess functional diversity. Here, we compare both genome-wide and functional diversity (in over 500 genes) of Tasmanian devils ( ...

    Abstract Conservation breeding programs aim to maintain 90% wild genetic diversity, but rarely assess functional diversity. Here, we compare both genome-wide and functional diversity (in over 500 genes) of Tasmanian devils (
    Language English
    Publishing date 2022-05-26
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2022.104474
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  9. Article ; Online: Implementation of a geriatric care bundle for older adults with acute burns.

    Oehlers, Julia / Blayney, Carolyn / Tate, Jo / Cheng, Alexander / Tucker, Andrew / Reed, May J / Stewart, Barclay T / Arbabi, Saman / O'Connell, Kathleen / Powelson, Elisabeth / Pham, Tam N

    Burns : journal of the International Society for Burn Injuries

    2024  Volume 50, Issue 4, Page(s) 841–849

    Abstract: Background: Frailty and comorbidities are important outcome determinants in older patients (age ≥65) with burns. A Geriatric Burn Bundle (Geri-B) was implemented in 2019 at a regional burn center to standardize care for older adults. Components included ...

    Abstract Background: Frailty and comorbidities are important outcome determinants in older patients (age ≥65) with burns. A Geriatric Burn Bundle (Geri-B) was implemented in 2019 at a regional burn center to standardize care for older adults. Components included frailty screening and protocolized geriatric co-management, malnutrition screening with nutritional support, and geriatric-centered pain regimens.
    Methods: This study aimed to qualitatively evaluate the implementation of Geri-B using the Proctor Framework. From June-August 2022, older burn-injured patients, burn nurses, and medical staff providers (attending physicians and advanced practice providers) were surveyed and interviewed. Transcribed interviews were coded and thematically analyzed. From May 2022 to August 2023, the number of inpatient visits aged 65 + with a documented frailty screening was monitored.
    Results: The study included 23 participants (10 providers, 13 patients). Participants highly rated Geri-B in all implementation domains. Most providers rated geriatric care effectiveness as 'good' or 'excellent' after Geri-B implementation. Providers viewed it as a reminder to tailor geriatric care and a safeguard against substandard geriatric care. Staffing shortages, insufficient protocol training, and learning resources were reported as implementation barriers. Many providers advocated for better bundle integration into the hospital electronic health record (EHR) (e.g., frailty screening tool, automatic admission order sets). Most patients felt comfortable being asked about their functional status with strong patient support for therapy services. The average frailty screening completion rate from May 2022 to August 2023 was 86%.
    Conclusions: Geri-B was perceived as valuable for the care of older burn patients and may serve as a framework for other burn centers.
    MeSH term(s) Humans ; Burns/therapy ; Aged ; Male ; Female ; Geriatric Assessment/methods ; Frailty ; Patient Care Bundles/methods ; Aged, 80 and over ; Burn Units/organization & administration ; Pain Management/methods ; Malnutrition/therapy ; Frail Elderly ; Nutritional Support/methods
    Language English
    Publishing date 2024-02-29
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 197308-3
    ISSN 1879-1409 ; 0305-4179
    ISSN (online) 1879-1409
    ISSN 0305-4179
    DOI 10.1016/j.burns.2024.02.022
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  10. Article ; Online: COVID-19-associated Lung Microvascular Endotheliopathy: A "From the Bench" Perspective.

    Joffre, Jérémie / Rodriguez, Lauren / Matthay, Zachary A / Lloyd, Elliot / Fields, Alexander T / Bainton, Roland J / Kurien, Philip / Sil, Anita / Calfee, Carolyn S / Woodruff, Prescott G / Erle, David J / Hendrickson, Carolyn / Krummel, Matthew F / Langelier, Charles R / Matthay, Michael A / Kornblith, Lucy Z / Hellman, Judith

    American journal of respiratory and critical care medicine

    2022  Volume 206, Issue 8, Page(s) 961–972

    Abstract: Rationale: ...

    Abstract Rationale:
    MeSH term(s) Biomarkers/metabolism ; COVID-19 ; Endothelial Cells/metabolism ; Humans ; Inflammation Mediators/metabolism ; Lung ; Plasminogen Activator Inhibitor 1/metabolism ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/metabolism ; Vascular Diseases/metabolism ; Vascular Endothelial Growth Factor A/metabolism
    Chemical Substances Biomarkers ; Inflammation Mediators ; Plasminogen Activator Inhibitor 1 ; Spike Glycoprotein, Coronavirus ; Vascular Endothelial Growth Factor A ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2022-05-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202107-1774OC
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