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  1. Article ; Online: Hypereosinophilia following aspirin desensitization for aspirin-exacerbated respiratory disease.

    Pitlick, Mitchell M / Pongdee, Thanai

    The journal of allergy and clinical immunology. In practice

    2022  Volume 10, Issue 8, Page(s) 2187–2190.e1

    MeSH term(s) Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Aspirin/adverse effects ; Asthma, Aspirin-Induced/therapy ; Desensitization, Immunologic ; Humans ; Sinusitis
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2022-05-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2022.05.005
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7086: Show issues Location:
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  2. Article: Combining Biologics Targeting Eosinophils (IL-5/IL-5R), IgE, and IL-4/IL-13 in Allergic and Inflammatory Diseases.

    Pitlick, Mitchell M / Pongdee, Thanai

    The World Allergy Organization journal

    2022  Volume 15, Issue 11, Page(s) 100707

    Abstract: The indications for biologic therapy are expanding. Patients may benefit from different biologics for separate conditions or one condition with multiple pathogenic mechanisms targeted by different biologics. We sought to determine the frequency and ... ...

    Abstract The indications for biologic therapy are expanding. Patients may benefit from different biologics for separate conditions or one condition with multiple pathogenic mechanisms targeted by different biologics. We sought to determine the frequency and safety of combining biologics targeting IgE, IL-5, IL-5R, and IL-4/IL-13 in patients referred to a large academic health system through retrospective chart review. Between January 1, 2015 and July 31, 2021, 25 patients receiving multiple biologics simultaneously were identified. Combinations included omalizumab + mepolizumab (n = 11), omalizumab + dupilumab (n = 6), omalizumab + benralizumab (n = 4), mepolizumab + dupilumab (n = 3), and omalizumab + dupilumab + mepolizumab (n = 1). Sixteen patients were receiving multiple biologics for the same condition, most commonly asthma (n = 10). Nine patients were treated for separate conditions, with chronic spontaneous urticaria and atopic dermatitis being the most common combination (n = 3). The median duration of combination biologic use was 17.5 months. There were no reports of anaphylaxis, other allergic reaction, immune dysfunction, pneumonia, or development of malignancy. The use of multiple biologics appears to be well tolerated in this case series. Prospective study is needed to better determine the efficacy, safety, and cost-effectiveness of this approach.
    Language English
    Publishing date 2022-10-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2581968-9
    ISSN 1939-4551
    ISSN 1939-4551
    DOI 10.1016/j.waojou.2022.100707
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  3. Article ; Online: Multi-Site Microbiome Composition in Atopic Dermatitis: A Case-Control Study.

    Pitlick, Mitchell M / Johnson, Stephen / Mullakary, Roshini M / Taneja, Veena / Joshi, Avni Y

    Annals of dermatology

    2024  Volume 36, Issue 1, Page(s) 53–55

    Language English
    Publishing date 2024-02-07
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 1012662-4
    ISSN 2005-3894 ; 1013-9087
    ISSN (online) 2005-3894
    ISSN 1013-9087
    DOI 10.5021/ad.22.117
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2800: Show issues Location:
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  4. Article ; Online: Analysis of spirometry measurements as predictors of aspirin desensitization outcomes.

    Pitlick, Mitchell M / Divekar, Rohit

    The journal of allergy and clinical immunology. In practice

    2021  Volume 9, Issue 6, Page(s) 2495–2497.e2

    MeSH term(s) Anti-Inflammatory Agents, Non-Steroidal ; Aspirin/adverse effects ; Asthma, Aspirin-Induced/diagnosis ; Asthma, Aspirin-Induced/epidemiology ; Desensitization, Immunologic ; Drug Hypersensitivity/diagnosis ; Drug Hypersensitivity/epidemiology ; Humans ; Spirometry
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2021-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2021.01.025
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7086: Show issues Location:
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  5. Article ; Online: Perioperative Anaphylaxis.

    Pitlick, Mitchell M / Volcheck, Gerald W

    Immunology and allergy clinics of North America

    2021  Volume 42, Issue 1, Page(s) 145–159

    Abstract: Perioperative anaphylaxis is a potentially life-threatening and under-recognized event most commonly caused by antibiotics, neuromuscular blocking agents, dyes, latex, and disinfectants. This review provides updates in the epidemiology and pathogenesis ... ...

    Abstract Perioperative anaphylaxis is a potentially life-threatening and under-recognized event most commonly caused by antibiotics, neuromuscular blocking agents, dyes, latex, and disinfectants. This review provides updates in the epidemiology and pathogenesis of perioperative anaphylaxis, discusses culprit agents, and highlights the tenets of management including a comprehensive allergy evaluation.
    MeSH term(s) Anaphylaxis/diagnosis ; Anaphylaxis/epidemiology ; Anaphylaxis/etiology ; Anti-Bacterial Agents ; Drug Hypersensitivity/diagnosis ; Drug Hypersensitivity/epidemiology ; Drug Hypersensitivity/therapy ; Humans ; Neuromuscular Blocking Agents/adverse effects
    Chemical Substances Anti-Bacterial Agents ; Neuromuscular Blocking Agents
    Language English
    Publishing date 2021-11-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92606-1
    ISSN 1557-8607 ; 0889-8561
    ISSN (online) 1557-8607
    ISSN 0889-8561
    DOI 10.1016/j.iac.2021.09.002
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  6. Article ; Online: Graded coronavirus disease 2019 vaccine administration: A safe alternative to vaccine avoidance.

    Pitlick, Mitchell M / Gonzalez-Estrada, Alexei / Park, Miguel A

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2022  Volume 128, Issue 6, Page(s) 731–733

    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Humans ; SARS-CoV-2 ; Vaccines
    Chemical Substances COVID-19 Vaccines ; Vaccines
    Language English
    Publishing date 2022-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2022.02.024
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  7. Article ; Online: Safety and tolerability of Evusheld in patients with CVID: The Mayo Clinic experience.

    Squire, Jacqueline D / Pitlick, Mitchell M / Freeman, Catherine M / Joshi, Avni Y

    The journal of allergy and clinical immunology. Global

    2023  Volume 2, Issue 2, Page(s) 100081

    Abstract: Background: The past 2 years of the COVID-19 pandemic brought with it many unknowns for patients with immunodeficiency. Because of the concern for severe infection in those with immunocompromise, patients have been eager for effective prevention, ... ...

    Abstract Background: The past 2 years of the COVID-19 pandemic brought with it many unknowns for patients with immunodeficiency. Because of the concern for severe infection in those with immunocompromise, patients have been eager for effective prevention, vaccination, and treatment strategies. Preexposure prophylaxis provides another means of prevention in those with immunocompromise. A combination of tixagevimab and cilgavimab (Evusheld [AstraZeneca Cambridge, United Kingdom]) was granted emergency use authorization for preexposure prophylaxis at the end of 2021, but questions remained regarding how this would be tolerated and the side effects associated with its use.
    Objectives: Our aim was to evaluate the safety and tolerability of Evusheld in patients with CVID from our tri-site institution.
    Methods: We performed an institutional review board-approved, retrospective chart review of patients with common variable immunodeficiency (CVID) who received Evusheld before March 26, 2022.
    Results: Of the 45 patients with CVID who received Evusheld, 41 (91%) received the recommended full dose of 600 mg. The majority of patients (39 of 45 [87%]) tolerated Evusheld without adverse events. The adverse events reported included immediate injection site pain, fatigue and cough, an episode of shingles, and chest pain.
    Conclusions: This is an initial report on the safety and tolerability of Evusheld injections in patients with CVID. The majority of patients tolerated the injections without adverse events. For patients with reported chest pain, the results of a subsequent cardiac workup were negative. The efficacy of Evusheld could not be evaluated owing to the short median follow-up of this study (19 days).
    Language English
    Publishing date 2023-02-08
    Publishing country United States
    Document type Journal Article
    ISSN 2772-8293
    ISSN (online) 2772-8293
    DOI 10.1016/j.jacig.2023.100081
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  8. Article ; Online: Considerations for asthma management and viral transmission in the era of COVID-19.

    Pitlick, Mitchell M / Joshi, Avni Y

    Allergy and asthma proceedings

    2020  Volume 42, Issue 1, Page(s) 93–96

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Asthma/complications ; Asthma/therapy ; COVID-19/therapy ; COVID-19/transmission ; Child ; Humans ; Male ; SARS-CoV-2/pathogenicity
    Language English
    Publishing date 2020-12-23
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1312445-6
    ISSN 1539-6304 ; 1088-5412
    ISSN (online) 1539-6304
    ISSN 1088-5412
    DOI 10.2500/aap.2021.42.200111
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1804: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Current and emerging biologic therapies targeting eosinophilic disorders.

    Pitlick, Mitchell M / Li, James T / Pongdee, Thanai

    The World Allergy Organization journal

    2022  Volume 15, Issue 8, Page(s) 100676

    Abstract: Eosinophilic disorders include a wide array of conditions in which eosinophils play a primary pathophysiologic role. While historically treated with corticosteroids and immunosuppressants, knowledge of eosinophil biology has led to the development of ... ...

    Abstract Eosinophilic disorders include a wide array of conditions in which eosinophils play a primary pathophysiologic role. While historically treated with corticosteroids and immunosuppressants, knowledge of eosinophil biology has led to the development of several biologics targeting eosinophils. In this review, we discuss the current US Food and Drug Administration (FDA) approved eosinophil-specific biologics targeting IL-5 (mepolizumab and reslizumab) and IL-5R (benralizumab) along with biologics under investigation targeting siglec-8 (lirentelimab). We discuss efficacy and safety data from trials of these medications in conditions including eosinophilic asthma, hypereosinophilic syndrome (HES), eosinophilic granulomatosis with polyangiitis (EGPA), chronic rhinosinusitis with nasal polyposis (CRSwNP), eosinophilic esophagitis (EoE), and eosinophilic gastrointestinal disease (EGID). Additionally, we discuss case reports utilizing these medications in conditions including drug reaction with eosinophilia and systemic symptoms (DRESS), allergic bronchopulmonary aspergillosis (ABPA), and eosinophilic pneumonia, among others. While eosinophilic targeting biologic therapy has been successful in eosinophilic asthma, HES, EGPA, and CRSwNP leading to FDA approval for these conditions, trials treating EoE and EGID have been disappointing to date. Given the increasing number of trials utilizing these biologics, it will be imperative for the allergist-immunologist to stay up to date on the latest treatment options to provide the most optimal care for eosinophilic disorders.
    Language English
    Publishing date 2022-07-31
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2581968-9
    ISSN 1939-4551
    ISSN 1939-4551
    DOI 10.1016/j.waojou.2022.100676
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  10. Article ; Online: Delayed systemic urticarial reactions following mRNA COVID-19 vaccination.

    Pitlick, Mitchell M / Joshi, Avni Y / Gonzalez-Estrada, Alexei / Chiarella, Sergio E

    Allergy and asthma proceedings

    2022  Volume 43, Issue 1, Page(s) 40–43

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Female ; Histamine Antagonists/therapeutic use ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Urticaria/chemically induced ; Urticaria/diagnosis ; Vaccination/adverse effects ; Vaccine Excipients/adverse effects ; Vaccines, Synthetic/adverse effects ; mRNA Vaccines/adverse effects
    Chemical Substances COVID-19 Vaccines ; Histamine Antagonists ; Vaccine Excipients ; Vaccines, Synthetic ; mRNA Vaccines
    Language English
    Publishing date 2022-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1312445-6
    ISSN 1539-6304 ; 1088-5412
    ISSN (online) 1539-6304
    ISSN 1088-5412
    DOI 10.2500/aap.2022.43.210101
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