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Article ; Online: Applying hypnotic associative - dissociative techniques in psychotherapy for psychosomatic symptoms.

Meyerson, Joseph / Konichezky, Andres

The American journal of clinical hypnosis

2024 , Page(s) 1–10

Abstract: Patients experiencing psychosomatic symptoms frequently have difficulty obtaining correct treatment. They are often reluctant to partially attribute their symptoms to psychological factors and, as a result, delay referrals to mental health professionals. ...

Abstract	Patients experiencing psychosomatic symptoms frequently have difficulty obtaining correct treatment. They are often reluctant to partially attribute their symptoms to psychological factors and, as a result, delay referrals to mental health professionals. Furthermore, the dropout rate from therapy is high and relapses are common. Hypnosis is a complex psycho-physiological phenomenon. Hence, hypnotic psychotherapy may play an important role in managing and treating psychosomatic symptoms and disorders that involve both the mind and body. In the current study, we propose a clinically oriented, four-phase, hypnotic approach, the hypnotic associative-dissociative approach (HADA), which may be useful in encouraging more patients with psychosomatic problems to engage in psychotherapy, thereby achieving effective long-term effects.
Language	English
Publishing date	2024-04-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	219387-5
ISSN	2160-0562 ; 0002-9157
ISSN (online)	2160-0562
ISSN	0002-9157
DOI	10.1080/00029157.2024.2337625
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Article ; Online: Implementation Documentation and Process Assessment of the PharmNet Intervention: Observational Report.

Eldridge, Lori Ann / Meyerson, Beth E / Agley, Jon

JMIR formative research

2024 Volume 8, Page(s) e54077

Abstract: Background: The number of overdose deaths in the United States involving opioids continues to exceed 100,000 per year. This has precipitated ongoing declarations of a public health emergency. Harm reduction approaches, such as promoting awareness of, ... ...

Abstract	Background: The number of overdose deaths in the United States involving opioids continues to exceed 100,000 per year. This has precipitated ongoing declarations of a public health emergency. Harm reduction approaches, such as promoting awareness of, ensuring access to, and fostering willingness to use naloxone to reverse opioid overdose, are a key component of a larger national strategy to address the crisis. In addition, overdose reversal with naloxone directly and immediately saves lives. Because of pharmacies' ubiquity and pharmacists' extensive clinical training, community pharmacies are well-positioned, in principle, to facilitate naloxone access and education. Objective: In 2022, a single-site pilot study of PharmNet, a community pharmacy intervention incorporating naloxone distribution, awareness building, and referral, showed promising outcomes for both naloxone and resource distribution in the community. As a next step, this study was intended to be a pilot randomized controlled trial of PharmNet in 7 pharmacies. However, due to circumstances outside of the study team's control, data collection was unable to be fully completed as planned. In keeping with open research standards, we transparently report all available data from the study and discuss trial barriers and processes. We do so both to provide insights that may inform similar studies and to avoid the "file-drawer" (publication bias) problem, which can skew the aggregated scholarly literature through nonpublication of registered trial results or selective publication of findings affirming authors' hypotheses. Methods: This paper reports an in-depth implementation study assessment, provides the available observational data, and discusses implementation considerations for similar studies in independent (eg, nonchain) community pharmacies. Results: Retrospective assessment of study outcomes and fidelity data provided for robust discussion around how resource differences in independent community pharmacies (vs well-resourced chain pharmacies), as well as high demands on staff, can affect intervention implementation, even when leadership is highly supportive. Conclusions: Community pharmacies, particularly independent community pharmacies, may require more support than anticipated to be successful when implementing a new intervention into practice, even if it might affect estimates of real-world effectiveness. Further implementation science research is needed specific to independent community pharmacies. All study elements are outlined in the International Registered Report Identifier (IRRID) PRR1-10.2196/42373. Although this paper reports results associated with that registration, results and conclusions should not be given the weight assigned to findings from a preregistered study. International registered report identifier (irrid): RR2-10.2196/42373.
Language	English
Publishing date	2024-03-18
Publishing country	Canada
Document type	Journal Article
ISSN	2561-326X
ISSN (online)	2561-326X
DOI	10.2196/54077
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Article ; Online: Correction: Implementation Documentation and Process Assessment of the PharmNet Intervention: Observational Report.

Eldridge, Lori Ann / Meyerson, Beth E / Agley, Jon

JMIR formative research

2024 Volume 8, Page(s) e59427

Abstract: This corrects the article DOI: 10.2196/54077.]. ...

Abstract	[This corrects the article DOI: 10.2196/54077.].
Language	English
Publishing date	2024-04-11
Publishing country	Canada
Document type	Published Erratum
ISSN	2561-326X
ISSN (online)	2561-326X
DOI	10.2196/59427
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Article ; Online: Self-Talk Monitoring and Utilization for Enhancing Hypnotic Induction.

Meyerson, Joseph

The American journal of clinical hypnosis

2017 Volume 60, Issue 2, Page(s) 149–158

Abstract: In contemporary hypnosis, language constitutes the hypnotist's rudimentary instrument for developing and utilizing the hypnotic trance. In the current article, the author proposes a theoretical and clinical approach for using patient self-talk during ... ...

Abstract	In contemporary hypnosis, language constitutes the hypnotist's rudimentary instrument for developing and utilizing the hypnotic trance. In the current article, the author proposes a theoretical and clinical approach for using patient self-talk during hypnotic induction by discussing the influence of self-talk on consciousness regulation. The article includes some historical background on the use of language during hypnotic communication and demonstrates some clinical applications of patients self-talk in the process of hypnotic induction.
Language	English
Publishing date	2017-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	219387-5
ISSN	2160-0562 ; 0002-9157
ISSN (online)	2160-0562
ISSN	0002-9157
DOI	10.1080/00029157.2017.1289465
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Article ; Online: Decreased CD177

Alayed, Khaled / Meyerson, Howard J

Leukemia research

2021 Volume 112, Page(s) 106752

Abstract: A decreased percentage of ... ...

Abstract	A decreased percentage of CD177
MeSH term(s)	Acute Disease ; Aged ; Core Binding Factor Alpha 2 Subunit/genetics ; DNA-Binding Proteins/genetics ; Dioxygenases/genetics ; Female ; Flow Cytometry/methods ; GPI-Linked Proteins/metabolism ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Isoantigens/metabolism ; Leukemia, Myeloid/genetics ; Leukemia, Myeloid/metabolism ; Leukemia, Myeloid/pathology ; Leukocyte Count ; Male ; Middle Aged ; Mutation ; Myelodysplastic Syndromes/genetics ; Myelodysplastic Syndromes/metabolism ; Myelodysplastic Syndromes/pathology ; Neutrophils/metabolism ; Neutrophils/pathology ; Nucleophosmin/genetics ; Receptors, Cell Surface/metabolism ; Splicing Factor U2AF/genetics
Chemical Substances	CD177 protein, human ; Core Binding Factor Alpha 2 Subunit ; DNA-Binding Proteins ; GPI-Linked Proteins ; Isoantigens ; NPM1 protein, human ; Receptors, Cell Surface ; Splicing Factor U2AF ; U2AF1 protein, human ; Nucleophosmin (117896-08-9) ; Dioxygenases (EC 1.13.11.-) ; TET2 protein, human (EC 1.13.11.-)
Language	English
Publishing date	2021-11-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752396-8
ISSN	1873-5835 ; 0145-2126
ISSN (online)	1873-5835
ISSN	0145-2126
DOI	10.1016/j.leukres.2021.106752
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Article: The Influence of Family Milieu on Dental Anxiety in Adolescents-A Cross-Sectional Study.

Uziel, Nir / Meyerson, Joseph / Kuskasy, Moataz / Gilon, Efrat / Eli, Ilana

Journal of clinical medicine

2023 Volume 12, Issue 6

Abstract: Parents play a significant role in the development of dental anxiety in their adolescent children. This cross-sectional study aimed to evaluate the influence of family milieu on adolescents' dental anxiety. The level of dental anxiety (Dental Anxiety ... ...

Abstract	Parents play a significant role in the development of dental anxiety in their adolescent children. This cross-sectional study aimed to evaluate the influence of family milieu on adolescents' dental anxiety. The level of dental anxiety (Dental Anxiety Scale-DAS) was evaluated in 100 adolescent dental patients (ages 13-18 years) and their parents. Parents supplied information about family demographics and their personal experiences of dental treatment. Concomitantly, the family's behavior was observed during the dental encounter. The adolescents' mean DAS score was 9.83 ± 2.05. Adolescents' DAS was higher when their parents' memories from their own dental encounters were negative. A positive correlation was found between adolescents' dental anxiety and that of their father (r = 0.52,
Language	English
Publishing date	2023-03-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12062174
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Article ; Online: Pilot implementation of the PharmNet naloxone program in an independent pharmacy.

Eldridge, Lori A / Meyerson, Beth E / Agley, Jon

Journal of the American Pharmacists Association : JAPhA

2022 Volume 63, Issue 1, Page(s) 374–382.e12

Abstract: Background: The U.S. overdose epidemic has continued to escalate with more than 100,000 deaths per year in the past several years, most of which involve opioids. Widespread availability of naloxone is part of a national solution to the crisis, and ... ...

Abstract	Background: The U.S. overdose epidemic has continued to escalate with more than 100,000 deaths per year in the past several years, most of which involve opioids. Widespread availability of naloxone is part of a national solution to the crisis, and community pharmacies are well-poised to facilitate such distribution and provide additional harm reduction services. Objectives: The primary objectives of this study were to (a) examine the usability of each of the separate intervention components prepared for PharmNet, (b) observe intervention fidelity through regularly scheduled site visits, and (c) explore the association between PharmNet implementation and the volume of naloxone sales and distribution in the pilot site. Practice description: Here, we describe a carefully designed and tailored pharmacy harm reduction intervention called PharmNet that is designed to maximize harm reduction impact while minimizing utilization of pharmacist resources. It is a pragmatic awareness, service provision, and referral program that was developed through careful, iterative feasibility studies with pharmacists. Practice innovation: PharmNet procedures include tools and steps to create awareness (e.g., yard signs and messaging for patients, reminder tools for pharmacists), facilitation of naloxone delivery from nonprofits, and provision of referral cards featuring local resources. Evaluation methods: Evaluation included direct data collection and randomly scheduled fidelity site visits. Results: The intervention was associated with an increase of 3.33 naloxone doses/mo being dispensed at cost (34.4% relative increase) and an overall increase of 9.33 naloxone doses/mo being dispensed via any mechanism (96.48% relative increase). Around 2.85 referral cards were issued to patients daily. Intervention fidelity was moderate, and the study provides valuable information for how to modify the study prior to a randomized trial. Conclusion: With modifications informed by this pilot study, the PharmNet intervention merits a randomized trial to determine whether it causes increased naloxone dispensing in independent community pharmacies.
MeSH term(s)	Humans ; Naloxone/therapeutic use ; Pharmacies ; Pilot Projects ; Pharmaceutical Services ; Drug Overdose/drug therapy ; Pharmacists ; Pharmacy ; Narcotic Antagonists/therapeutic use ; Opioid-Related Disorders/drug therapy ; Opioid-Related Disorders/complications
Chemical Substances	Naloxone (36B82AMQ7N) ; Narcotic Antagonists
Language	English
Publishing date	2022-09-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2118585-2
ISSN	1544-3450 ; 1544-3191 ; 1086-5802
ISSN (online)	1544-3450
ISSN	1544-3191 ; 1086-5802
DOI	10.1016/j.japh.2022.09.004
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Article ; Online: The myth of hypnosis: the need for remythification.

Meyerson, Joseph

The International journal of clinical and experimental hypnosis

2014 Volume 62, Issue 3, Page(s) 378–393

Abstract: Myths or misconceptions concerning hypnosis are regarded among the major barriers to effective implementation of hypnosis. Contemporary hypnotherapists are expected to elicit patients' misconceptions and to provide explanations that distinguish between ... ...

Abstract	Myths or misconceptions concerning hypnosis are regarded among the major barriers to effective implementation of hypnosis. Contemporary hypnotherapists are expected to elicit patients' misconceptions and to provide explanations that distinguish between mystical and scientific perceptions of hypnosis and that offer a picture of the state of the art of hypnosis. Dealing with misconceptions on a rational and cognitive level seems to have the ability to change a patient's conscious knowledge and understanding of hypnosis. Nevertheless, deeply rooted and emotionally saturated misbeliefs with historical-cultural origins still prevail. This article focuses on the prehypnotic phase of therapy and proposes remythification to deal with the myth of hypnosis. This approach aims to promote the hypnotherapeutic process by utilizing myth-related misconceptions.
MeSH term(s)	Culture ; Dissociative Disorders/psychology ; Humans ; Hypnosis ; Mysticism ; Mythology ; Patient Acceptance of Health Care/psychology ; Patient Education as Topic ; Suggestion
Language	English
Publishing date	2014
Publishing country	England
Document type	Journal Article
ZDB-ID	218267-1
ISSN	1744-5183 ; 0020-7144
ISSN (online)	1744-5183
ISSN	0020-7144
DOI	10.1080/00207144.2014.901090
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Article: Bifunctional small molecules that induce nuclear localization and targeted transcriptional regulation.

Gibson, William J / Sadagopan, Ananthan / Shoba, Veronika M / Choudhary, Amit / Meyerson, Matthew / Schreiber, Stuart L

bioRxiv : the preprint server for biology

2023

Abstract: The aberrant localization of proteins in cells is a key factor in the development of various diseases, including cancer and neurodegenerative disease. To better understand and potentially manipulate protein localization for therapeutic purposes, we ... ...

Abstract	The aberrant localization of proteins in cells is a key factor in the development of various diseases, including cancer and neurodegenerative disease. To better understand and potentially manipulate protein localization for therapeutic purposes, we engineered bifunctional compounds that bind to proteins in separate cellular compartments. We show these compounds induce nuclear import of cytosolic cargoes, using nuclear-localized BRD4 as a "carrier" for co-import and nuclear trapping of cytosolic proteins. We use this system to calculate kinetic constants for passive diffusion across the nuclear pore and demonstrate single-cell heterogeneity in response to these bifunctional molecules, with cells requiring high carrier to cargo expression for complete import. We also observe incorporation of cargoes into BRD4-containing condensates. Proteins shown to be substrates for nuclear transport include oncogenic mutant nucleophosmin (NPM1c) and mutant PI3K catalytic subunit alpha (PIK3CA
Language	English
Publishing date	2023-07-07
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.07.07.548101
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Article ; Online: Side scatter ratio of the CD105-positive and CD105-negative red blood cell fractions is useful for the detection of low-grade myelodysplastic neoplasms by flow cytometry.

Wang, Zijan / Ciarlini, Pedro C / Oduro, Kwadwo A / Gadde, Ramya / O'Neill, Stacey / Zhao, Chen / Meyerson, Howard J

American journal of clinical pathology

2024

Abstract: ... specimens.: Methods: Ten RBC parameters incorporating CD105 or SSC combined with the Meyerson-Alayed ...

Abstract	Objectives: We assessed the utility of red blood cell (RBC) CD105 and side scatter (SSC) parameters by flow cytometry for the detection of low-grade myelodysplastic neoplasms (MDS) in bone marrow specimens. Methods: Ten RBC parameters incorporating CD105 or SSC combined with the Meyerson-Alayed scoring system (MASS) metrics were retrospectively evaluated by flow cytometry for utility in detecting low-grade MDS (n = 56) compared with cytopenic controls (n = 86). Results: Myelodysplastic neoplasms were associated with 7 of the RBC parameters in univariate analysis. Multivariate analysis using cutoff values based on optimal and 95% specificity levels of the RBC metrics and the MASS parameters revealed the SSC ratio of CD105-positive and CD105-negative RBC fractions (CD105+/- SSC); the percentage and coefficient of variation of the CD105-positive fraction of RBCs (CD105%, CD105+CV) emerged as significant RBC variables. Two simple scoring schemes using these RBC values along with MASS parameters were identified: 1 using CD105+/- SSC, CD105%, and CD105+CV combined with the percentage of CD177-positive granulocytes (CD177%), myeloblast percentage (CD34%), and granulocyte SSC (GranSSC), and the other incorporating CD105+/- SSC, CD105+CV, CD177%, CD34%, GranSSC, and B-cell progenitor percentage. Both demonstrated a sensitivity of approximately 80%, with a specificity of roughly 90% for the detection of MDS compared with cytopenic controls. Conclusions: The red blood cell parameter, CD105+/- SSC, appears to be beneficial in the evaluation of low-grade MDS by flow cytometry.
Language	English
Publishing date	2024-04-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2944-0
ISSN	1943-7722 ; 0002-9173
ISSN (online)	1943-7722
ISSN	0002-9173
DOI	10.1093/ajcp/aqae021
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