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  1. Article: Isolation and Identification of Allelopathic Substances from

    Kato-Noguchi, Hisashi / Takahashi, Yuga / Tojo, Shunya / Teruya, Toshiaki

    Plants (Basel, Switzerland)

    2024  Volume 13, Issue 5

    Abstract: The fruit ... ...

    Abstract The fruit of
    Language English
    Publishing date 2024-02-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants13050575
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: MonteCat: A Basin-Hopping-Inspired Catalyst Descriptor Search Algorithm for Machine Learning Models.

    Garcia-Escobar, Fernando / Taniike, Toshiaki / Takahashi, Keisuke

    Journal of chemical information and modeling

    2024  Volume 64, Issue 5, Page(s) 1512–1521

    Abstract: Proposing relevant catalyst descriptors that can relate the information on a catalyst's composition to its actual performance is an ongoing area in catalyst informatics, as it is a necessary step to improve our understanding on the target reactions. ... ...

    Abstract Proposing relevant catalyst descriptors that can relate the information on a catalyst's composition to its actual performance is an ongoing area in catalyst informatics, as it is a necessary step to improve our understanding on the target reactions. Herein, a small descriptor-engineered data set containing 3289 descriptor variables and the performance of 200 catalysts for the oxidative coupling of methane (OCM) is analyzed, and a descriptor search algorithm based on the workflow of the Basin-hopping optimization methodology is proposed to select the descriptors that better fit a predictive model. The algorithm, which can be considered wrapper in nature, consists of the successive generation of random-based modifications to the descriptor subset used in a regression model and adopting them depending on their effect on the model's score. The results are presented after being tested on linear and Support Vector Regression models with average cross-validation
    MeSH term(s) Algorithms ; Machine Learning
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 190019-5
    ISSN 1549-960X ; 0095-2338
    ISSN (online) 1549-960X
    ISSN 0095-2338
    DOI 10.1021/acs.jcim.3c01952
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Waldenström macroglobulinemia diagnosed by bronchoalveolar lavage.

    Sumi, Toshiyuki / Takahashi, Toshiaki / Terai, Kotomi / Chiba, Hirofumi

    Japanese journal of clinical oncology

    2023  Volume 53, Issue 8, Page(s) 738–740

    MeSH term(s) Humans ; Waldenstrom Macroglobulinemia/diagnosis ; Bronchoalveolar Lavage
    Language English
    Publishing date 2023-05-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 190978-2
    ISSN 1465-3621 ; 0368-2811
    ISSN (online) 1465-3621
    ISSN 0368-2811
    DOI 10.1093/jjco/hyad047
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  4. Article ; Online: Lupus nephritis prolongs improvement of serositis in systemic lupus erythematosus.

    Harada, Takuya / Yamashita, Hiroyuki / Nakajima, Sotaro / Kobayashi, Toshiaki / Takahashi, Hiroyuki / Kaneko, Hiroshi

    Joint bone spine

    2024  Volume 91, Issue 4, Page(s) 105727

    Language English
    Publishing date 2024-04-04
    Publishing country France
    Document type Letter
    ZDB-ID 2020487-5
    ISSN 1778-7254 ; 1297-319X
    ISSN (online) 1778-7254
    ISSN 1297-319X
    DOI 10.1016/j.jbspin.2024.105727
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  5. Book: Proteomic biology using LC-MS

    Takahashi, Nobuhiro / Isobe, Toshiaki

    large scale analysis of cellular dynamics and function

    (Wiley-Interscience series on mass spectrometry)

    2008  

    Author's details Nobuhiro Takahashi ; Toshiaki Isobe
    Series title Wiley-Interscience series on mass spectrometry
    Keywords Proteomics / methods ; Chromatography, Liquid / methods
    Language English
    Size X, 254 S. : Ill., graph. Darst.
    Publisher Wiley
    Publishing place Hoboken, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT015391391
    ISBN 978-0-471-66258-7 ; 0-471-66258-5
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2008 A 2999 order for loan Magazin

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  6. Article ; Online: Subcutaneous injection of lidocaine around ischemic ankle provides safe and effective foot analgesia in patients with critical limb ischemia.

    Kanai, Akifumi / Ara, Masatomo / Saito, Ryusei / Mishima, Toshiaki / Takahashi, Yuichiro

    Vascular

    2024  , Page(s) 17085381241238841

    Abstract: Objective: It is often difficult to alleviate foot pain associated with critical limb ischemia (CLI) using common analgesics. Neuraxial block is contraindicated in anticoagulant therapy. This study was designed to determine the response to subcutaneous ... ...

    Abstract Objective: It is often difficult to alleviate foot pain associated with critical limb ischemia (CLI) using common analgesics. Neuraxial block is contraindicated in anticoagulant therapy. This study was designed to determine the response to subcutaneous injection of lidocaine around the network of peripheral nerves around the ankle in patients with CLI pain on anticoagulants and antiplatelets.
    Methods: Sixteen patients with CLI pain in the foot were enrolled in this double-blind placebo-controlled crossover study. Patients were randomized to receive either 2% lidocaine or saline via catheters inserted into the subcutaneous area around the ankle. After recurrence of pain, the patients were crossed over to receive the alternative treatment. Pain was assessed with a numerical rating scale (NRS) before and 15 min after injection. Patients used a descriptive scale to grade pain control and were asked to determine the duration of analgesia in each arm of the study.
    Results: No serious complications including protracted bleeding occurred. Lidocaine significantly decreased the NRS on movement from 10 (6, 10) [median (range)] to 2 (0, 10) (
    Conclusion: Subcutaneous injection of lidocaine around the ischemic ankle affectively alleviated pain in patients with CLI without serious adverse effects under anticoagulant therapy.
    Language English
    Publishing date 2024-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2137151-9
    ISSN 1708-539X ; 1708-5381
    ISSN (online) 1708-539X
    ISSN 1708-5381
    DOI 10.1177/17085381241238841
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  7. Article: A Surgical Technique for Anterior Cruciate Ligament Reconstruction Using Semitendinosus Graft: An All-Inside Transfemoral Approach.

    Takahashi, Toshiaki / Watanabe, Seiji / Ito, Toshio

    Arthroscopy techniques

    2023  Volume 12, Issue 6, Page(s) e975–e982

    Abstract: Given the paucity of reports on all-inside reconstruction procedures via the transfemoral approach, we describe a minimally invasive, all-inside transfemoral technique that enables creating femoral and tibial sockets from the intra-articular cavity. Our ... ...

    Abstract Given the paucity of reports on all-inside reconstruction procedures via the transfemoral approach, we describe a minimally invasive, all-inside transfemoral technique that enables creating femoral and tibial sockets from the intra-articular cavity. Our transfemoral approach makes it possible to sequentially create femoral and tibial sockets using the same reamer bit, while a single drilling guide is set in place. Our custom socket drilling guide was designed to integrate with a tibial tunnel guide, which helped locate the tunnel exit at an anatomically acceptable location. The advantages of this method include easy and precise positioning of the femoral tunnel, narrow tibial tunnel, minimal damage to the intramedullary trabecular bone integrity, and low postoperative risks of pain, bleeding, and infections.
    Language English
    Publishing date 2023-05-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2653101-X
    ISSN 2212-6287
    ISSN 2212-6287
    DOI 10.1016/j.eats.2023.02.035
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  8. Article ; Online: A preliminary therapeutic study of the effects of molecular hydrogen on intestinal dysbiosis and small intestinal injury in high-fat diet-loaded senescence-accelerated mice.

    Takahashi, Sayaka / Nakagawa, Keiichi / Nagata, Wataru / Koizumi, Akiho / Ishizuka, Toshiaki

    Nutrition (Burbank, Los Angeles County, Calif.)

    2024  Volume 122, Page(s) 112372

    Abstract: Objectives: Aging and excessive fat intake may additively induce dysbiosis of the gut microbiota and intestinal inflammatory damage. Here, we analyzed microbiota dysbiosis and intestinal injury in high-fat diet-loaded senescence-accelerated mice (SAMP8). ...

    Abstract Objectives: Aging and excessive fat intake may additively induce dysbiosis of the gut microbiota and intestinal inflammatory damage. Here, we analyzed microbiota dysbiosis and intestinal injury in high-fat diet-loaded senescence-accelerated mice (SAMP8). Additionally, we examined whether treatment with molecular hydrogen could improve the intestinal environment.
    Methods: SAMP8 and SAMR1 (control) mice were first fed a normal diet (ND) or high-fat diet (HFD) for 10 wk (n = 10 each group). Subsequently, HFD was supplemented with a placebo jelly or hydrogen-rich jelly (HRJ) for 4 wk. After treatment, isolated small intestinal tissues were used for hematoxylin and eosin staining, immunofluorescence staining, and thiobarbituric acid reactive substances (TBARS) assay. Furthermore, we analyzed alterations in the microbiota composition in cecal feces using 16S rRNA gene analysis for microbiota profiling. Statistical analyses were performed using unpaired Student's t tests or one-way analysis of variance and Tukey's post hoc test for multiple comparisons.
    Result: HFD feeding reduced the expression of caudal-related homeobox transcription factor 2 (CDX2) and 5-bromo-2'-deoxyuridine (BrdU) and enhanced malondialdehyde (MDA) levels in the small intestine of SAMP8. HRJ treatment improved the reduction in CDX2 and BrdU and enhanced MDA levels. We performed a sequence analysis of the gut microbiota at the genus level and identified 283 different bacterial genera from the 30 samples analyzed in the study. Among them, Parvibacter positively correlated with both HFD intake and aging, whereas 10 bacteria, including Anaerofustis, Anaerosporobacter, Butyricicoccus, and Ruminococcus were negatively correlated with both HFD and aging. HRJ treatment increased Lactinobactor and decreased Akkermansia, Gracilibacter, and Marvinbryantia abundance.
    Conclusion: Our findings suggest that treatment with molecular hydrogen may affect microbiota profiling and suppress intestinal injury in HFD-loaded SAMP8.
    MeSH term(s) Mice ; Animals ; Diet, High-Fat/adverse effects ; Dysbiosis/microbiology ; RNA, Ribosomal, 16S/genetics ; Bromodeoxyuridine/therapeutic use ; Intestine, Small/metabolism ; Intestinal Diseases/drug therapy ; Intestinal Diseases/etiology ; Mice, Inbred C57BL
    Chemical Substances RNA, Ribosomal, 16S ; Bromodeoxyuridine (G34N38R2N1)
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639259-3
    ISSN 1873-1244 ; 0899-9007
    ISSN (online) 1873-1244
    ISSN 0899-9007
    DOI 10.1016/j.nut.2024.112372
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    Zs.A 2290: Show issues Location:
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  9. Article ; Online: Removal of phase residues in electron holography.

    Takahashi, Yoshio / Akashi, Tetsuya / Tanigaki, Toshiaki

    Microscopy (Oxford, England)

    2023  

    Abstract: Electron holography provides quantitative phase information regarding the electromagnetic fields and the morphology of micro- to nano-scale samples. A phase image reconstructed numerically from an electron hologram sometimes includes phase residues, i.e. ...

    Abstract Electron holography provides quantitative phase information regarding the electromagnetic fields and the morphology of micro- to nano-scale samples. A phase image reconstructed numerically from an electron hologram sometimes includes phase residues, i.e. origins of unremovable phase discontinuities, which make it much more difficult to quantitatively analyze local phase values. We developed a method to remove the residues in a phase image by a combination of patching local areas of a hologram and denoising based on machine learning. The small patches for a hologram, which were generated using the spatial frequency information of the own fringe patterns, were pasted at each residue point by an algorithm based on sparse modeling. After successive phase reconstruction, the phase components with no dependency on the vicinity were filtered out by Gaussian process regression. We determined that the phase discontinuities that appeared around phase residues were removed and the phase distributions of an atomic resolution phase image of a Pt nanoparticle were sufficiently restored.
    Language English
    Publishing date 2023-12-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2707496-1
    ISSN 2050-5701 ; 2050-5698
    ISSN (online) 2050-5701
    ISSN 2050-5698
    DOI 10.1093/jmicro/dfad062
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  10. Article ; Online: Thirty-year overview of Japanese autopsy cases of Takayasu arteritis -Results of analysis of Japanese autopsy reports.

    Yokouchi, Yuki / Asakawa, Nanae / Oharaseki, Toshiaki / Takahashi, Kei

    Modern rheumatology

    2023  

    Abstract: Objective: To analyze the trends in Takayasu arteritis (TAK) in Japan during three recent decades based on autopsy reports.: Methods: We extracted TAK cases from the Japanese Pathological Autopsy Reports published during three decades (1991-2000, ... ...

    Abstract Objective: To analyze the trends in Takayasu arteritis (TAK) in Japan during three recent decades based on autopsy reports.
    Methods: We extracted TAK cases from the Japanese Pathological Autopsy Reports published during three decades (1991-2000, 2001-2010, 2011-2020) and compared the data for the number of cases, age, gender ratio, malignant tumor complication rate, and cause of death (COD).
    Results: 322 TAK cases were reported during the 30 years. They represented 0.04-0.06% of the total autopsies, with little variation among the three decades. The peak age at autopsy increased over time: from the 60s for 1991-2010 to the 70s for 2011-2020. The malignant tumor complication rate increased to 12.2%, 18.5%, and 22.7% during the three decades. However, about half of those cases had no metastases, and malignant tumors were rarely directly involved in a TAK patient's death. TAK-associated cardiovascular lesions (ischemic heart disease, aortic lesions) accounted for most deaths.
    Conclusions: Although the age at TAK onset showed little change during the 30 years, the age at autopsy has increased, suggesting that the long-term prognosis has improved. Although the malignant tumor complication rate increased with age, the most common CODs were cardiovascular lesions, which are prognostic factors for TAK.
    Language English
    Publishing date 2023-12-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2078157-X
    ISSN 1439-7609 ; 1439-7595
    ISSN (online) 1439-7609
    ISSN 1439-7595
    DOI 10.1093/mr/road117
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