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  1. Article ; Online: Combinatorial Lanthipeptides from a Ruminant Bacterium.

    Donadio, Stefano

    Cell chemical biology

    2016  Volume 23, Issue 2, Page(s) 204–205

    Abstract: New tools and molecules are spurring a renewed interest in natural products. In this issue of Cell Chemical Biology, Zhao and van der Donk (2016) report a single lantibiotic cluster encoding different α- and β-peptides, each with its dedicated processing ...

    Abstract New tools and molecules are spurring a renewed interest in natural products. In this issue of Cell Chemical Biology, Zhao and van der Donk (2016) report a single lantibiotic cluster encoding different α- and β-peptides, each with its dedicated processing enzyme. A number of clever experiments led to in vitro production of these molecules.
    MeSH term(s) Amino Acid Sequence ; Animals ; Anti-Bacterial Agents/biosynthesis ; Bacteria/metabolism ; Bacterial Proteins/genetics ; Bacteriocins ; Biological Products ; Combinatorial Chemistry Techniques ; Computational Biology ; Genes, Bacterial ; Molecular Sequence Data ; Multigene Family ; Peptides/chemistry ; Protein Processing, Post-Translational ; Ruminants/metabolism
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; Bacteriocins ; Biological Products ; Peptides
    Language English
    Publishing date 2016-02-18
    Publishing country United States
    Document type Comment ; Journal Article
    ISSN 2451-9456
    ISSN (online) 2451-9456
    DOI 10.1016/j.chembiol.2016.02.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Biomarkers of neurodegeneration in isolated and antidepressant-related rapid eye movement sleep behavior disorder.

    Biscarini, Francesco / Pizza, Fabio / Vandi, Stefano / Incensi, Alex / Antelmi, Elena / Donadio, Vincenzo / Ferri, Raffaele / Liguori, Rocco / Plazzi, Giuseppe

    European journal of neurology

    2024  , Page(s) e16260

    Abstract: Background and purpose: This study compared the features of isolated rapid eye movement (REM) sleep behavior disorder (iRBD) and antidepressant-related REM sleep behaviour disorder (RBD) with the aim of highlighting markers that might distinguish the ... ...

    Abstract Background and purpose: This study compared the features of isolated rapid eye movement (REM) sleep behavior disorder (iRBD) and antidepressant-related REM sleep behaviour disorder (RBD) with the aim of highlighting markers that might distinguish the two entities.
    Methods: The observational cohort study included RBD patients with and without antidepressant use (antiD+ and antiD- patients, respectively), without cognitive impairment and parkinsonism. Clinical features of RBD, subtle motor and non-motor symptoms of parkinsonism, sleep architecture, REM atonia index, dopamine transporter-single photon emission computed tomography (DAT-SPECT) and skin biopsies for the intraneuronal alpha-synuclein (α-syn), were evaluated in the baseline work-up.
    Results: Thirty-nine patients, 10 antiD+ and 29 antiD-, were included. AntiD+ patients (more frequently female) reported more psychiatric symptoms, less violent dream enactment, and less frequent hyposmia. Dermal α-syn was detected in 93.1% of antiD- versus 30% of antiD+ patients (p = 0.00024). No differences appeared in other motor and non-motor symptoms, Movement Disorder Society-Unified Parkinson's Disease Rating Scale part III score, DAT-SPECT, or polysomnographic features.
    Conclusions: Patients with antidepressant-related RBD have clinical and neuropathological features suggesting a lower risk of evolution than those with iRBD.
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 1280785-0
    ISSN 1468-1331 ; 1351-5101 ; 1471-0552
    ISSN (online) 1468-1331
    ISSN 1351-5101 ; 1471-0552
    DOI 10.1111/ene.16260
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    Zs.A 4738: Show issues Location:
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    Zs.MO 592: Show issues

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  3. Article ; Online: Megalochelin, a Tridecapeptide Siderophore from a Talented Streptomycete.

    Vind, Kristiina / Brunati, Cristina / Simone, Matteo / Sosio, Margherita / Donadio, Stefano / Iorio, Marianna

    ACS chemical biology

    2023  Volume 18, Issue 4, Page(s) 861–874

    Abstract: Streptomycetes are bacteria known for their extraordinary biosynthetic capabilities. Herein, we describe the genome and metabolome of a particularly talented strain, Streptomyces ID71268. Its 8.4-Mbp genome harbors 32 bioinformatically predicted ... ...

    Abstract Streptomycetes are bacteria known for their extraordinary biosynthetic capabilities. Herein, we describe the genome and metabolome of a particularly talented strain, Streptomyces ID71268. Its 8.4-Mbp genome harbors 32 bioinformatically predicted biosynthetic gene clusters (BGCs), out of which 10 are expressed under a single experimental condition. In addition to five families of known metabolites with previously assigned BGCs (nigericin, azalomycin F, ectoine, SF2766, and piericidin), we were able to predict BGCs for three additional metabolites: streptochlorin, serpetene, and marinomycin. The strain also produced two families of presumably novel metabolites, one of which was associated with growth inhibitory activity against the human opportunistic pathogen
    MeSH term(s) Hydroxybenzoates/chemistry ; Imidazoles ; Iron/metabolism ; Mass Spectrometry ; Multigene Family ; Siderophores/chemistry ; Peptides/chemistry ; Streptomyces/chemistry ; Acinetobacter baumannii/metabolism
    Chemical Substances Hydroxybenzoates ; Imidazoles ; Iron (E1UOL152H7) ; Siderophores ; Peptides
    Language English
    Publishing date 2023-03-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1554-8937
    ISSN (online) 1554-8937
    DOI 10.1021/acschembio.2c00958
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  4. Article ; Online: LptD depletion disrupts morphological homeostasis and upregulates carbohydrate metabolism in

    Frisinger, Frida Svanberg / Jana, Bimal / Ortiz-Marquez, Juan C / van Opijnen, Tim / Donadio, Stefano / Guardabassi, Luca

    FEMS microbes

    2023  Volume 4, Page(s) xtad013

    Abstract: ... In a ... ...

    Abstract In a previous
    Language English
    Publishing date 2023-08-10
    Publishing country England
    Document type Journal Article
    ISSN 2633-6685
    ISSN (online) 2633-6685
    DOI 10.1093/femsmc/xtad013
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  5. Book ; Online: Non-Fourier heat transport in nanosystems

    Benenti, Giuliano / Donadio, Davide / Lepri, Stefano / Livi, Roberto

    2022  

    Abstract: Energy transfer in small nanosized systems can be very different from that in their macroscopic counterparts due to reduced dimensionality, interaction with surfaces, disorder, and large fluctuations. Those ingredients may induce non-diffusive heat ... ...

    Abstract Energy transfer in small nanosized systems can be very different from that in their macroscopic counterparts due to reduced dimensionality, interaction with surfaces, disorder, and large fluctuations. Those ingredients may induce non-diffusive heat transfer that requires to be taken into account on small scales. We provide an overview of the recent advances in this field from the points of view of nonequilibrium statistical mechanics and atomistic simulations. We summarize the underlying basic properties leading to violations of the standard diffusive picture of heat transport and its universal features, with some historical perspective. We complete this scenario by illustrating also the effects of long-range interaction and integrability on non-diffusive transport. Then we discuss how all of these features can be exploited for thermal management, rectification and to improve the efficiency of energy conversion. We conclude with a review on recent achievements in atomistic simulations of anomalous heat transport in single polymers, nanotubes and two-dimensional materials. A short account of the existing experimental literature is also given.}

    Comment: Invited review article, La Rivista del Nuovo Cimento, to appear
    Keywords Condensed Matter - Statistical Mechanics ; Condensed Matter - Mesoscale and Nanoscale Physics
    Subject code 612
    Publishing date 2022-12-19
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: In Silico Prediction and Prioritization of Novel Selective Antimicrobial Drug Targets in

    Svanberg Frisinger, Frida / Jana, Bimal / Donadio, Stefano / Guardabassi, Luca

    Antibiotics (Basel, Switzerland)

    2021  Volume 10, Issue 6

    Abstract: Novel antimicrobials interfering with pathogen-specific targets can minimize the risk of perturbations of the gut microbiota (dysbiosis) during therapy. We employed an in silico approach to identify essential proteins ... ...

    Abstract Novel antimicrobials interfering with pathogen-specific targets can minimize the risk of perturbations of the gut microbiota (dysbiosis) during therapy. We employed an in silico approach to identify essential proteins in
    Language English
    Publishing date 2021-05-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics10060632
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  7. Article ; Online: Modeling heat transport in crystals and glasses from a unified lattice-dynamical approach.

    Isaeva, Leyla / Barbalinardo, Giuseppe / Donadio, Davide / Baroni, Stefano

    Nature communications

    2019  Volume 10, Issue 1, Page(s) 3853

    Abstract: We introduce a novel approach to model heat transport in solids, based on the Green-Kubo theory of linear response. It naturally bridges the Boltzmann kinetic approach in crystals and the Allen-Feldman model in glasses, leveraging interatomic force ... ...

    Abstract We introduce a novel approach to model heat transport in solids, based on the Green-Kubo theory of linear response. It naturally bridges the Boltzmann kinetic approach in crystals and the Allen-Feldman model in glasses, leveraging interatomic force constants and normal-mode linewidths computed at mechanical equilibrium. At variance with molecular dynamics, our approach naturally and easily accounts for quantum mechanical effects in energy transport. Our methodology is carefully validated against results for crystalline and amorphous silicon from equilibrium molecular dynamics and, in the former case, from the Boltzmann transport equation.
    Language English
    Publishing date 2019-08-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-019-11572-4
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  8. Article ; Online: Megalochelin, a Tridecapeptide Siderophore from a Talented Streptomycete

    Vind, Kristiina / Brunati, Cristina / Simone, Matteo / Sosio, Margherita / Donadio, Stefano / Iorio, Marianna

    Acs Chemical Biology

    2023  Volume 18, Issue 4

    Abstract: Streptomycetes are bacteria known for their extraordinary biosynthetic capabilities. Herein, we describe the genome and metabolome of a particularly talented strain, Streptomyces ID71268. Its 8.4-Mbp genome harbors 32 bioinformatically predicted ... ...

    Abstract Streptomycetes are bacteria known for their extraordinary biosynthetic capabilities. Herein, we describe the genome and metabolome of a particularly talented strain, Streptomyces ID71268. Its 8.4-Mbp genome harbors 32 bioinformatically predicted biosynthetic gene clusters (BGCs), out of which 10 are expressed under a single experimental condition. In addition to five families of known metabolites with previously assigned BGCs (nigericin, azalomycin F, ectoine, SF2766, and piericidin), we were able to predict BGCs for three additional metabolites: streptochlorin, serpetene, and marinomycin. The strain also produced two families of presumably novel metabolites, one of which was associated with growth inhibitory activity against the human opportunistic pathogen Acinetobacter baumannii in an iron-dependent manner. Bioassay-guided fractionation, followed by extensive liquid chromatography-mass spectrometry (LC-MS) and NMR analyses, established that the molecule responsible for the observed antibacterial activity is an unusual tridecapeptide siderophore with a ring-and-tail structure: the heptapeptide ring is formed through a C-C bond between a 2,3-dihydroxybenzoate (DHB) cap on Gly1 and the imidazole moiety of His7, while the hexapeptide tail is sufficient for binding iron. This molecule, named megalochelin, is the largest known siderophore. The megalochelin BGC encodes a 13-module nonribosomal peptide synthetase for the synthesis of the tridecapeptide, and a copper-dependent oxidase, likely responsible for the DHB-imidazole cross-link, whereas the genes for synthesis of the DHB starter unit are apparently specified in trans by a different BGC. Our results suggest that prolific producers of specialized metabolites may conceal hidden treasures within a background of known compounds.
    Keywords Life Science
    Subject code 540
    Language English
    Publishing country nl
    Document type Article ; Online
    ISSN 1554-8929
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Planomonospora

    Zdouc, Mitja M / Iorio, Marianna / Maffioli, Sonia I / Crüsemann, Max / Donadio, Stefano / Sosio, Margherita

    Journal of natural products

    2021  Volume 84, Issue 2, Page(s) 204–219

    Abstract: Despite an excellent track record, microbial drug discovery suffers from high rates of rediscovery. Better workflows for the rapid investigation of complex extracts are needed to increase throughput and to allow early prioritization of samples. In ... ...

    Abstract Despite an excellent track record, microbial drug discovery suffers from high rates of rediscovery. Better workflows for the rapid investigation of complex extracts are needed to increase throughput and to allow early prioritization of samples. In addition, systematic characterization of poorly explored strains is seldomly performed. Here, we report a metabolomic study of 72 isolates belonging to the rare actinomycete genus
    MeSH term(s) Actinobacteria/chemistry ; Actinobacteria/classification ; Chromatography, Liquid ; Genome, Bacterial ; Metabolomics ; Multigene Family ; Phylogeny ; Siderophores ; Tandem Mass Spectrometry
    Chemical Substances Siderophores
    Language English
    Publishing date 2021-01-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.0c00807
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1144: Show issues Location:
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  10. Article ; Online: Clinical criteria and diagnostic assessment of fibromyalgia: position statement of the Italian Society of Neurology-Neuropathic Pain Study Group.

    Devigili, G / Di Stefano, G / Donadio, V / Frattale, I / Mantovani, E / Nolano, M / Occhipinti, G / Provitera, V / Quitadamo, S / Tamburin, S / Toscano, A / Tozza, S / Truini, A / Valeriani, M / de Tommaso, M

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2023  Volume 44, Issue 7, Page(s) 2561–2574

    Abstract: Background: The role of central and/or peripheral nervous system dysfunction is basically fundamental in fibromyalgia.: Aim: The aim of this position statement on behalf of the Neuropathic Pain Study Group of the Italian Society of Neurology is to ... ...

    Abstract Background: The role of central and/or peripheral nervous system dysfunction is basically fundamental in fibromyalgia.
    Aim: The aim of this position statement on behalf of the Neuropathic Pain Study Group of the Italian Society of Neurology is to give practical guidelines for the clinical and instrumental assessment of fibromyalgia (FM) in the neurological clinical practice, taking into consideration recent studies.
    Methods: Criteria for study selection and consideration were original studies, case-controls design, use of standardized methodologies for clinical practice, and FM diagnosis with ACR criteria (2010, 2011, 2016).
    Results: ACR criteria were revised. For diagnostic procedure of small-fiber pathology, 47 studies were totally considered. Recent diagnostic criteria should be applied (ACR, 2016). A rheumatologic visit seems mandatory. The involvement of small fibers should request at least 2 among HRV + SSR and/or laser-evoked responses and/or skin biopsy and/or corneal confocal microscopy, eventually followed by monitoring of metabolic and/or immunological/ and or/paraneoplastic basis, to be repeated at 1-year follow-up.
    Conclusions: The correct diagnostic approach to FM could promote the exclusion of the known causes of small-fiber impairment. The research toward common genetic factors would be useful to promote a more specific therapeutic approach.
    MeSH term(s) Humans ; Fibromyalgia/diagnosis ; Neuralgia/diagnosis ; Skin ; Peripheral Nervous System/pathology ; Neurology
    Language English
    Publishing date 2023-05-24
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-023-06836-3
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