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  1. Book ; Online: The Role of Light in Abiotic Stress Acclimation

    Janda, Tibor / Hideg, Éva / Vankova, Radomira / Hideg, Éva / Vankova, Radomira

    2020  

    Keywords Science: general issues ; Botany & plant sciences ; abiotic stress ; carbon balance ; crosstalk ; drought ; light ; osmotic stress ; photoinhibition ; temperature
    Size 1 electronic resource (118 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021229973
    ISBN 9782889636280 ; 2889636283
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Crosstalk between Light- and Temperature-Mediated Processes under Cold and Heat Stress Conditions in Plants.

    Janda, Tibor / Prerostová, Sylva / Vanková, Radomíra / Darkó, Éva

    International journal of molecular sciences

    2021  Volume 22, Issue 16

    Abstract: Extreme temperatures are among the most important stressors limiting plant growth and development. Results indicate that light substantially influences the acclimation processes to both low and high temperatures, and it may affect the level of stress ... ...

    Abstract Extreme temperatures are among the most important stressors limiting plant growth and development. Results indicate that light substantially influences the acclimation processes to both low and high temperatures, and it may affect the level of stress injury. The interaction between light and temperature in the regulation of stress acclimation mechanisms is complex, and both light intensity and spectral composition play an important role. Higher light intensities may lead to overexcitation of the photosynthetic electron transport chain; while different wavelengths may act through different photoreceptors. These may induce various stress signalling processes, leading to regulation of stomatal movement, antioxidant and osmoregulation capacities, hormonal actions, and other stress-related pathways. In recent years, we have significantly expanded our knowledge in both light and temperature sensing and signalling. The present review provides a synthesis of results for understanding how light influences the acclimation of plants to extreme low or high temperatures, including the sensing mechanisms and molecular crosstalk processes.
    MeSH term(s) Cold-Shock Response ; Heat-Shock Response ; Photosynthesis ; Plants/metabolism ; Plants/radiation effects ; Signal Transduction ; Sunlight
    Language English
    Publishing date 2021-08-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22168602
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Synthesis and anti-trypanosomal evaluation of novel N-branched acyclic nucleoside phosphonates bearing 7-aryl-7-deazapurine nucleobase.

    Vaňková, Karolína / Doleželová, Eva / Tloušťová, Eva / Hocková, Dana / Zíková, Alena / Janeba, Zlatko

    European journal of medicinal chemistry

    2022  Volume 239, Page(s) 114559

    Abstract: A series of novel 7-aryl-7-deazaadenine-based N-branched acyclic nucleoside phosphonates (aza-ANPs) has been prepared using the optimized Suzuki cross-coupling reaction as the key synthetic step. The final free phosphonates 15a-h were inactive, due to ... ...

    Abstract A series of novel 7-aryl-7-deazaadenine-based N-branched acyclic nucleoside phosphonates (aza-ANPs) has been prepared using the optimized Suzuki cross-coupling reaction as the key synthetic step. The final free phosphonates 15a-h were inactive, due to their inefficient transport across cell membranes, but they inhibited Trypanosoma brucei adenine phosphoribosyltransferase (TbrAPRT1) with K
    MeSH term(s) Nucleosides/pharmacology ; Organophosphonates/pharmacology ; Prodrugs/pharmacology ; Purines ; Trypanosoma brucei brucei
    Chemical Substances 7-deazapurine ; Nucleosides ; Organophosphonates ; Prodrugs ; Purines
    Language English
    Publishing date 2022-06-23
    Publishing country France
    Document type Journal Article
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2022.114559
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 784: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Editorial: The Role of Light in Abiotic Stress Acclimation.

    Janda, Tibor / Hideg, Éva / Vanková, Radomíra

    Frontiers in plant science

    2020  Volume 11, Page(s) 184

    Language English
    Publishing date 2020-02-25
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2711035-7
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2020.00184
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Crosstalk between Light- and Temperature-Mediated Processes under Cold and Heat Stress Conditions in Plants

    Tibor Janda / Sylva Prerostová / Radomíra Vanková / Éva Darkó

    International Journal of Molecular Sciences, Vol 22, Iss 8602, p

    2021  Volume 8602

    Abstract: Extreme temperatures are among the most important stressors limiting plant growth and development. Results indicate that light substantially influences the acclimation processes to both low and high temperatures, and it may affect the level of stress ... ...

    Abstract Extreme temperatures are among the most important stressors limiting plant growth and development. Results indicate that light substantially influences the acclimation processes to both low and high temperatures, and it may affect the level of stress injury. The interaction between light and temperature in the regulation of stress acclimation mechanisms is complex, and both light intensity and spectral composition play an important role. Higher light intensities may lead to overexcitation of the photosynthetic electron transport chain; while different wavelengths may act through different photoreceptors. These may induce various stress signalling processes, leading to regulation of stomatal movement, antioxidant and osmoregulation capacities, hormonal actions, and other stress-related pathways. In recent years, we have significantly expanded our knowledge in both light and temperature sensing and signalling. The present review provides a synthesis of results for understanding how light influences the acclimation of plants to extreme low or high temperatures, including the sensing mechanisms and molecular crosstalk processes.
    Keywords acclimation ; climate change ; cold ; heat ; light ; photosynthesis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 580
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Low-molecular weight chitosan enhances antibacterial effect of antibiotics and permeabilizes cytoplasmic membrane of Staphylococcus epidermidis biofilm cells.

    Kašparová, Petra / Zmuda, Martin / Vaňková, Eva / Maťátková, Olga / Masák, Jan

    Folia microbiologica

    2021  Volume 66, Issue 6, Page(s) 983–996

    Abstract: This study evaluated the effect of low-molecular weight chitosan on Staphylococcus epidermidis, a common colonizer of joint implants and other prosthetic devices. We have also attempted to elucidate its mechanism of action. Chitosan was found to be ... ...

    Abstract This study evaluated the effect of low-molecular weight chitosan on Staphylococcus epidermidis, a common colonizer of joint implants and other prosthetic devices. We have also attempted to elucidate its mechanism of action. Chitosan was found to be effective against both the planktonic and biofilm cells (MIC
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents ; Biofilms ; Cell Membrane ; Chitosan/pharmacology ; Microbial Sensitivity Tests ; Molecular Weight ; Staphylococcus epidermidis
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents ; Chitosan (9012-76-4)
    Language English
    Publishing date 2021-07-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 240503-9
    ISSN 1874-9356 ; 0015-5632
    ISSN (online) 1874-9356
    ISSN 0015-5632
    DOI 10.1007/s12223-021-00898-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 845: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: The Role of Steroidomics in the Diagnosis of Alzheimer's Disease and Type 2 Diabetes Mellitus.

    Vaňková, Markéta / Velíková, Marta / Vejražková, Daniela / Včelák, Josef / Lukášová, Petra / Rusina, Robert / Vaňková, Hana / Jarolímová, Eva / Kancheva, Radmila / Bulant, Josef / Horáčková, Lenka / Bendlová, Běla / Hill, Martin

    International journal of molecular sciences

    2023  Volume 24, Issue 10

    Abstract: Epidemiological studies suggest an association between Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM). This study aimed to investigate the pathophysiological markers of AD vs. T2DM for each sex separately and propose models that would ... ...

    Abstract Epidemiological studies suggest an association between Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM). This study aimed to investigate the pathophysiological markers of AD vs. T2DM for each sex separately and propose models that would distinguish control, AD, T2DM, and AD-T2DM comorbidity groups. AD and T2DM differed in levels of some circulating steroids (measured mostly by GC-MS) and in other observed characteristics, such as markers of obesity, glucose metabolism, and liver function tests. Regarding steroid metabolism, AD patients (both sexes) had significantly higher sex hormone binding globulin (SHBG), cortisol, and 17-hydroxy progesterone, and lower estradiol and 5α-androstane-3α,17β-diol, compared to T2DM patients. However, compared to healthy controls, changes in the steroid spectrum (especially increases in levels of steroids from the C21 group, including their 5α/β-reduced forms, androstenedione, etc.) were similar in patients with AD and patients with T2DM, though more expressed in diabetics. It can be assumed that many of these steroids are involved in counter-regulatory protective mechanisms that mitigate the development and progression of AD and T2DM. In conclusion, our results demonstrated the ability to effectively differentiate AD, T2DM, and controls in both men and women, distinguish the two pathologies from each other, and differentiate patients with AD and T2DM comorbidities.
    MeSH term(s) Male ; Humans ; Female ; Alzheimer Disease/metabolism ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/epidemiology ; Steroids/metabolism ; Androstenedione ; Comorbidity
    Chemical Substances Steroids ; Androstenedione (409J2J96VR)
    Language English
    Publishing date 2023-05-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24108575
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Combined effect of lasioglossin LL-III derivative with azoles against Candida albicans virulence factors: biofilm formation, phospholipases, proteases and hemolytic activity.

    Vaňková, Eva / Kašparová, Petra / Dulíčková, Nikola / Čeřovský, Václav

    FEMS yeast research

    2020  Volume 20, Issue 3

    Abstract: Candida albicans has several virulence factors at its disposal, including yeast-hyphal transition associated with biofilm formation, phospholipases, proteases and hemolytic activity, all of which contribute to its pathogenesis. We used synthetic ... ...

    Abstract Candida albicans has several virulence factors at its disposal, including yeast-hyphal transition associated with biofilm formation, phospholipases, proteases and hemolytic activity, all of which contribute to its pathogenesis. We used synthetic derivative LL-III/43 of antimicrobial peptide lasioglossin LL-III to enhance effect of azoles on attenuation of C. albicans virulence factors. LL-III/43 was able to inhibit initial adhesion or biofilm formation of C. albicans strains at 50 µM. Azoles, however, were ineffective at this concentration. Using fluorescently labeled LL-III/43, we observed that peptide covered C. albicans cells, partially penetrated through their membranes and then accumulated inside cells. LL-III/43 (25 µM) in combination with clotrimazole prevented biofilm formation already at 3.1 µM clotrimazole. Neither LL-III/43 nor azoles were able to significantly inhibit phospholipases, proteases, or hemolytic activity of C. albicans. LL-III/43 (25 µM) and clotrimazole (50 µM) in combination decreased production of these virulence factors, and it completely attenuated its hemolytic activity. Scanning electron microscopy showed that LL-III/43 (50 µM) prevented C. albicans biofilm formation on Ti-6Al-4 V alloy used in orthopedic surgeries and combination of LL-III/43 (25 µM) with clotrimazole (3.1 µM) prevented biofilm formation on urinary catheters. Therefore, mixture of LL-III/43 and clotrimazole is suitable candidate for future pharmaceutical research.
    MeSH term(s) Antifungal Agents/pharmacology ; Antimicrobial Cationic Peptides/chemical synthesis ; Antimicrobial Cationic Peptides/pharmacokinetics ; Azoles/pharmacology ; Biofilms/drug effects ; Biofilms/growth & development ; Candida albicans/drug effects ; Erythrocytes/drug effects ; Hemolysis/drug effects ; Humans ; Hydrophobic and Hydrophilic Interactions/drug effects ; Peptide Hydrolases/metabolism ; Phospholipases/antagonists & inhibitors ; Virulence Factors
    Chemical Substances Antifungal Agents ; Antimicrobial Cationic Peptides ; Azoles ; Virulence Factors ; lasioglossin III ; Phospholipases (EC 3.1.-) ; Peptide Hydrolases (EC 3.4.-)
    Language English
    Publishing date 2020-04-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2036775-2
    ISSN 1567-1364 ; 1567-1356
    ISSN (online) 1567-1364
    ISSN 1567-1356
    DOI 10.1093/femsyr/foaa020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5454: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Silver nanoparticles with plasma-polymerized hexamethyldisiloxane coating on 3D printed substrates are non-cytotoxic and effective against respiratory pathogens.

    Machková, Anna / Vaňková, Eva / Obrová, Klára / Fürhacker, Paola / Košutová, Tereza / Lion, Thomas / Hanuš, Jan / Scholtz, Vladimír

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1217617

    Abstract: Due to the emerging resistance of microorganisms and viruses to conventional treatments, the importance of self-disinfecting materials is highly increasing. Such materials could be silver or its nanoparticles (AgNPs), both of which have been studied for ... ...

    Abstract Due to the emerging resistance of microorganisms and viruses to conventional treatments, the importance of self-disinfecting materials is highly increasing. Such materials could be silver or its nanoparticles (AgNPs), both of which have been studied for their antimicrobial effect. In this study, we compared the biological effects of AgNP coatings with and without a plasma-polymerized hexamethyldisiloxane (ppHMDSO) protective film to smooth silver or copper coatings under three ambient conditions that mimic their potential medical use (dry or wet environments and an environment simulating the human body). The coatings were deposited on 3D printed polylactic acid substrates by DC magnetron sputtering, and their surface morphology was visualized using scanning electron microscopy. Cytotoxicity of the samples was evaluated using human lung epithelial cells A549. Furthermore, antibacterial activity was determined against the Gram-negative pathogenic bacterium
    Language English
    Publishing date 2023-08-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1217617
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Sensitivity, specificity and positive predictive value of ALEX2 multiplex examination in patients suffering from atopic dermatitis and reaction to tomatoes

    Čelakovská, Jarmila / Čermákova, Eva / Vaňková, Radka / Boudková, Petra / Andrýs, Ctirad / Krejsek, Jan

    Food and Agricultural Immunology. 2023 Dec. 31, v. 34, no. 1 p.2257398-

    2023  

    Abstract: The aim of the study is to evaluate the clinical reactions to tomatoes in atopic dermatitis (AD) patients, and to analyse the results of specific IgE to allergens of tomatoes and to molecular components of pollen, seeds, fruits, vegetables and latex with ...

    Abstract The aim of the study is to evaluate the clinical reactions to tomatoes in atopic dermatitis (AD) patients, and to analyse the results of specific IgE to allergens of tomatoes and to molecular components of pollen, seeds, fruits, vegetables and latex with the use of ALEX2 Allergy Xplorer test. According to our results, 15% of AD patients suffer from clinical reactions to tomatoes; we confirmed the low sensitivity and low positive predictive value of specific IgE to molecular component Sola l 6 and allergen extract Sola l, the specificity of this test is higher. The significantly higher sensitisation to other nonspecific lipid transfer proteins is observed in patients sensitised to tomato allergens. An elimination diet and an exposure test are recommended to detect a reaction to tomatoes. ALEX2 Allergy Xplorer test gives us a comprehensive picture of sensitisation and the possibility of evaluation of cross-reacting allergens.
    Keywords allergens ; atopic dermatitis ; elimination diets ; latex ; lipids ; pollen ; tomatoes ; Clinical reaction to tomatoes ; ALEX2 Allergy Xplorer ; specific IgE
    Language English
    Dates of publication 2023-1231
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 1015019-5
    ISSN 1465-3443 ; 0954-0105
    ISSN (online) 1465-3443
    ISSN 0954-0105
    DOI 10.1080/09540105.2023.2257398
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 5001: Show issues

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