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  1. Article ; Online: Protective effects of Jing-Si-herbal-tea in inflammatory cytokines-induced cell injury on normal human lung fibroblast

    Wang, Chien-Hao / Yang, Jai-Sing / Chen, Chao-Jung / Su, San-Hua / Yu, Hsin-Yuan / Juan, Yu-Ning / Chiu, Yu-Jen / Ho, Tsung-Jung

    Tzu chi medical journal

    2024  Volume 36, Issue 2, Page(s) 152–165

    Abstract: Objectives: The protective effects and related mechanisms of Jing-Si herbal tea (JSHT) were ...

    Abstract Objectives: The protective effects and related mechanisms of Jing-Si herbal tea (JSHT) were investigated in cellular damage mediated by pro-inflammatory cytokines, including interleukin (IL)-1β, IL-6, and tumor necrosis factor-α, on normal human lung fibroblast by multiomic platform analysis.
    Materials and methods: The
    Results: In
    Conclusion: The findings from our research indicate that JSHT holds promise as a therapeutic agent, potentially offering advantageous outcomes in treating virus infections through various mechanisms. Furthermore, the primary bioactive components in JSHT justify extended research in antiviral drug development, especially in the context of addressing coronavirus.
    Language English
    Publishing date 2024-03-26
    Publishing country India
    Document type Journal Article
    ZDB-ID 2452925-4
    ISSN 2223-8956 ; 2223-8956
    ISSN (online) 2223-8956
    ISSN 2223-8956
    DOI 10.4103/tcmj.tcmj_267_23
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  2. Article ; Online: Human adipose-derived stem cells preconditioned with a novel herbal formulation Jing Shi attenuate doxorubicin-induced cardiac damage.

    Hsieh, Dennis Jine-Yuan / Tsai, Bruce Chi-Kang / Barik, Parthasarathi / Shibu, Marthandam Asokan / Kuo, Chia-Hua / Kuo, Wei-Wen / Lin, Pi-Yu / Shih, Cheng-Yen / Lin, Shinn-Zong / Ho, Tsung-Jung / Huang, Chih-Yang

    Aging

    2023  Volume 15, Issue 17, Page(s) 9167–9181

    Abstract: ... with novel herbal formulation Jing Si (JS) improved protective ability of stem cells against doxorubicin ...

    Abstract Pathological cardiac hypertrophy is a considerable contributor to global disease burden. Chinese herbal medicine (CHM) has been used to treat cardiovascular diseases since antiquity. Enhancing stem cell-mediated recovery through CHM represents a promising approach for protection against doxorubicin (Dox)-induced cardiac hypertrophy. Herein, we investigated whether human adipose-derived stem cells (hADSCs) preconditioned with novel herbal formulation Jing Si (JS) improved protective ability of stem cells against doxorubicin-induced cardiac damage. The effect of JS on hADSC viability and migration capacity was determined via MTT and migration assays, respectively. Co-culture of hADSC or JS-preconditioned hADSCs with H9c2 cells was analyzed with immunoblot, flow cytometry, TUNEL staining, LC3B staining, F-actin staining, and MitoSOX staining. The
    MeSH term(s) Humans ; Animals ; Rats ; Rats, Sprague-Dawley ; Heart ; Stem Cells ; Doxorubicin/toxicity ; Cardiomegaly
    Chemical Substances Doxorubicin (80168379AG)
    Language English
    Publishing date 2023-09-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.205026
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  3. Article ; Online: A strategy for rapid discovery of traceable chemical markers in herbal products using MZmine 2 data processing toolbox: A case of Jing Liqueur.

    Zhou, Jing / Liu, Feng-Jie / Li, Xin-Xin / Li, Ping / Yang, Hua / Liu, Yuan-Cai / Chen, Yan-He / Wei, Chao-Dan / Li, Hui-Jun

    Chinese herbal medicines

    2021  Volume 13, Issue 3, Page(s) 430–438

    Abstract: ... to rapidly screen the traceable markers for herbal product authentication.: Methods: Commercial Jing ... materials to Jing Liqueur product were rapidly screened out. Among them, 52 markers detected by HPLC-QTOF-MS ... of traceable markers was finally generated to ensure the authentication and quality consistency of Jing Liqueur ...

    Abstract Objective: The quality evaluation of herbal products remains a big challenge. Traceable markers are the core concept of the authentication of herbal products. However, the discovery of traceable markers is labor-intensive and time-consuming. The aim of this study is to develop a convenient approach to rapidly screen the traceable markers for herbal product authentication.
    Methods: Commercial Jing Liqueur and its 22 species of herbal ingredients were analyzed using HPLC-QTOF-MS and GC-MS to characterize nonvolatile and volatile chemicals. The acquired data were imported into MZmine 2 software for mass detection, chromatogram building, deconvolution and alignment. The aligned data were exported into a csv file and then traceable markers were selected using the built-in filter function in Excel. Finally, the traceable markers were identified by searching against online databases or publications, some of which were confirmed by reference standards.
    Results: A total of 288 chemical features transferred from herbal materials to Jing Liqueur product were rapidly screened out. Among them, 52 markers detected by HPLC-QTOF-MS were annotated, while nine volatile markers detected by GC-MS were annotated. Moreover, 30 of these markers were confirmed by comparing with reference standards. A chemical fingerprint consisting of traceable markers was finally generated to ensure the authentication and quality consistency of Jing Liqueur.
    Conclusion: A strategy for rapid discovery of traceable markers in herbal products using MZmine 2 software was developed.
    Language English
    Publishing date 2021-05-28
    Publishing country Singapore
    Document type Journal Article
    ISSN 2589-3610
    ISSN (online) 2589-3610
    DOI 10.1016/j.chmed.2021.05.004
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  4. Article ; Online: The Consumption‐Based Carbon Emissions in the Jing‐Jin‐Ji Urban Agglomeration Over China's Economic Transition

    Yangchun Bai / Heran Zheng / Yuli Shan / Jing Meng / Yuan Li

    Earth's Future, Vol 9, Iss 9, Pp n/a-n/a (2021)

    2021  

    Abstract: ... this knowledge gap, we selected Jing‐Jin‐Ji urban agglomeration, one of the economic centers but also featured ... as a case study. Based on the consumption accounting framework, the carbon emissions of Jing‐Jin‐Ji have decreased ... The driving forces show that the emission intensity and production structure have largely reduced Jing‐Jin ...

    Abstract Abstract Since the 2008 financial crisis, China has been undergoing an economic transition consisting of prioritizing green economic and sustainable development instead of rapid growth driven by large‐scale investment. However, there is still a lack of fine print on how subregional effort can contribute to national or full supply chain mitigation plans, especially downscaling to the city level. To bridge this knowledge gap, we selected Jing‐Jin‐Ji urban agglomeration, one of the economic centers but also featured by intensive emission for decades, to analyze the emission variance and driving forces from 2012 to 2015 as a case study. Based on the consumption accounting framework, the carbon emissions of Jing‐Jin‐Ji have decreased by 11.7 Mt CO2 in total over the study period, and most cities showed the similar descending trend. The driving forces show that the emission intensity and production structure have largely reduced Jing‐Jin‐Ji's total due to measurements of economic transition. For instance, Beijing has decreased by 28.7 Mt of emission reduction which led by declined emission intensity. By contrast, per capita demands and growth of its population were the primary forces to increase emissions. To conclude, although the mitigation achievement is undeniable, we should also note that the economic transition has not changed the uneven pattern of selected urban agglomeration so far.
    Keywords consumption‐based carbon emissions ; economic transition ; Jing‐Jin‐Ji urban agglomeration ; multiregional input‐output ; structural decomposition analysis ; Environmental sciences ; GE1-350 ; Ecology ; QH540-549.5
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
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  5. Article ; Online: The genetic assimilation in language borrowing inferred from Jing People.

    Huang, Xiufeng / Zhou, Qinghui / Bin, Xiaoyun / Lai, Shu / Lin, Chaowen / Hu, Rong / Xiao, Jiashun / Luo, Dajun / Li, Yingxiang / Wei, Lan-Hai / Yeh, Hui-Yuan / Chen, Gang / Wang, Chuan-Chao

    American journal of physical anthropology

    2018  Volume 166, Issue 3, Page(s) 638–648

    Abstract: Objectives: The Jing people are a recognized ethnic group in Guangxi, southwest China, who are ... populations into Jing people during their language change due to the very limited genetic information ... of this population.: Materials and methods: We collected blood samples from 37 Jing and 3 Han Chinese individuals ...

    Abstract Objectives: The Jing people are a recognized ethnic group in Guangxi, southwest China, who are the immigrants from Vietnam during the 16th century. They speak Vietnamese but with lots of language borrowings from Cantonese, Zhuang, and Mandarin. However, it's unclear if there is large-scale gene flow from surrounding populations into Jing people during their language change due to the very limited genetic information of this population.
    Materials and methods: We collected blood samples from 37 Jing and 3 Han Chinese individuals from Wanwei, Shanxin, and Wutou islands in Guangxi and genotyped about 600,000 genome-wide single nucleotide polymorphisms (SNPs). We used Principal Component Analysis (PCA), ADMIXTURE analysis, f statistics, qpWave and qpAdm to infer the population genetic structure and admixture.
    Results: Our data revealed that the Jing people are genetically similar to the populations in southwest China and mainland Southeast Asia. But compared with Vietnamese, they show significant evidence of gene flow from surrounding East Asians. The admixture proportion is estimated to be around 35-42% in different Jing groups using southern Han Chinese as a proxy. The majority of the paternal lineages of Jing people are most likely from surrounding East Asians.
    Discussion: We conclude that the formation and language change of present-day Jing people have involved genetic assimilation of surrounding East Asian populations. The language borrowing, in this case, is not only a cultural phenomenon but has involved demic diffusion.
    MeSH term(s) Anthropology, Physical ; Asian Continental Ancestry Group/genetics ; China/ethnology ; Female ; Gene Flow/genetics ; Genetics, Population ; Humans ; Language ; Male ; Principal Component Analysis ; Vietnam/ethnology
    Language English
    Publishing date 2018-02-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 219376-0
    ISSN 1096-8644 ; 0002-9483
    ISSN (online) 1096-8644
    ISSN 0002-9483
    DOI 10.1002/ajpa.23449
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  6. Article ; Online: Anti-type I allergic effects of Jing-Fang powder extracts via PI3K/Akt pathway in vitro and in vivo.

    Yuan, An / Zeng, Jiuseng / Zhou, Hongli / Liu, Qi / Rao, Zhili / Gao, Ming / Liu, Rong / Zeng, Nan

    Molecular immunology

    2021  Volume 135, Page(s) 408–420

    Abstract: Jing-Fang powder (Schizonepeta tenuifolia Briq. and Saposhnikovia divaricata (Turcz.) Schischk ... of screening research on the antiallergic effective parts of Jing-Fang powder, its ethyl acetate extract ...

    Abstract Jing-Fang powder (Schizonepeta tenuifolia Briq. and Saposhnikovia divaricata (Turcz.) Schischk.) was used to treat chronic bronchitis, asthma and chronic urticaria. Based on the preliminary results of screening research on the antiallergic effective parts of Jing-Fang powder, its ethyl acetate extract fractions (JFEE) and isolate D (JFEE-D) showed the best anti-allergic effect. RBL-2H3 cell activation degranulation model and mice passive cutaneous anaphylaxis (PCA) reaction model were used to investigate the effects and mechanisms of JFEE and JFEE-D on IgE-mediated type I allergic reactions. LC-MS was utilized to determine the composition of JFEE and JFEE-D. We found that JFEE and JFEE-D significantly reduced β-HEX, histamine, IL-4, IL-6 levels in cell supernatants, and improved the degree and morphology of cell degranulation. JFEE and JFEE-D significantly inhibited the increase of ear vascular permeability and abnormal increase of serum IgE, TNF-α, IL-6 levels. JFEE and JFEE-D inhibited mRNA expression of PI3K and Akt and down-regulated protein expression of PI3K, Akt, p-Akt, and PLCγ1 in sensitized RBL-2H3 cells. The combined use of JFEE and JFEE-D with pathway inhibitor Wortmannin revealed synergistic down-regulation of PI3K, Akt, and p-Akt protein expression. The combined use of pathway agonist IGF-1, JFEE and JFEE-D down-regulated increase of p-Akt/Akt protein expression. Moreover, JFEE and JFEE-D significantly inhibited protein expression of PI3K, p-Akt and PLCγ1 in PCA model mice. These results show that JFEE and JFEE-D inhibit type I allergic reactions by inhibiting PI3K/Akt signaling pathway.
    MeSH term(s) Anaphylaxis/drug therapy ; Anaphylaxis/prevention & control ; Animals ; Anti-Allergic Agents/pharmacology ; Apiaceae/chemistry ; Asthma/drug therapy ; Bronchitis, Chronic/drug therapy ; Capillary Permeability/drug effects ; Cell Degranulation/drug effects ; Cell Line ; Chronic Urticaria/drug therapy ; Lamiaceae/chemistry ; Mice ; Phosphatidylinositol 3-Kinases/biosynthesis ; Phosphatidylinositol 3-Kinases/metabolism ; Plant Extracts/pharmacology ; Proto-Oncogene Proteins c-akt/biosynthesis ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Wortmannin/pharmacology
    Chemical Substances Anti-Allergic Agents ; Plant Extracts ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Wortmannin (XVA4O219QW)
    Language English
    Publishing date 2021-01-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 424427-8
    ISSN 1872-9142 ; 0161-5890
    ISSN (online) 1872-9142
    ISSN 0161-5890
    DOI 10.1016/j.molimm.2021.01.015
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  7. Article ; Online: A genome-wide single nucleotide polymorphism scan reveals genetic markers associated with fertility rate in Chinese Jing Hong chicken.

    Azmal, Syed Ali / Nan, Jiuhong / Bhuiyan, Ali Akbar / Elokil, Abdelmotaleb Ahmed / Ali, Mohammad Ishaque / Adetula, Adeyinka Abiola / Ma, Shuai / Sun, Chenghao / Han, Zhongdong / Yuan, Jingwei / Li, Shijun

    Poultry science

    2020  Volume 99, Issue 6, Page(s) 2873–2887

    Abstract: ... genetic markers associated with reproductive traits, we calculated fertility rate at 61 to 69 wk (51 D) of Jing ... using 190 Jing Hong hens showed that the 20 SNP in chromosomes 3 and 13 were significantly associated ... with fertility rate. To verify these results, a total of 1900 Jing Hong laying hens from 2 populations (P1 and P2 ...

    Abstract The function of the sperm storage tubules is directly correlated with the fertility of laying hens. However, little is known about the molecular mechanisms regulating the fertility traits in chicken. To identify genetic markers associated with reproductive traits, we calculated fertility rate at 61 to 69 wk (51 D) of Jing Hong chickens parent generation as the phenotype and the genotype were detected by the chicken 600K Affymetrix Axiom High Density single nucleotide polymorphisms (SNP)-array. The genome-wide association study using 190 Jing Hong hens showed that the 20 SNP in chromosomes 3 and 13 were significantly associated with fertility rate. To verify these results, a total of 1900 Jing Hong laying hens from 2 populations (P1 and P2) were further genotyped by polymerase chain reaction-restriction fragments length polymorphisms method. The association analysis results revealed that 12 polymorphisms (AX-75769978, AX-76582632, AX-75730546, AX-75730496, AX-75730588, AX-76530282, AX-76530329, AX-76529310, AX-75769906, AX-75755394, AX-80813697 and AX-76582809) out of 20 showed highly significant effects (P < 0.0001) on fertility rate in P1, P2 and P1+P2. Six haplotypes (TTAA, TTGG, TTAG, CTAA, CTGG, and CTAG) were inferred based on significant loci (AX-75730546 and AX-76530282) also showed significant association with fertility rate, where haplotype CTAG was shown to be markedly associated with the significantly highest (P < 0.0001) fertility rate (in P1, 86.42 ± 0.59; P2, 85.98 ± 0.59 and P1+P2, 86.16 ± 0.42) followed by other haplotypes for the irrespective of population studied. Collectively, we report for the first time that 12 SNP in the chromosomes 3 and 13 were significantly associated with fertility rate during the later stage of egg production, which could be used as the potential genetic markers that would be able to facilitate in the selection and improvement of fertility rate through chicken breeding.
    MeSH term(s) Animals ; Breeding ; Chickens/genetics ; Chickens/growth & development ; Fertility/genetics ; Genetic Markers ; Genome-Wide Association Study/veterinary ; Polymerase Chain Reaction/veterinary ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide
    Chemical Substances Genetic Markers
    Language English
    Publishing date 2020-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 242586-5
    ISSN 1525-3171 ; 0032-5791
    ISSN (online) 1525-3171
    ISSN 0032-5791
    DOI 10.1016/j.psj.2019.12.068
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  8. Article: A genome-wide single nucleotide polymorphism scan reveals genetic markers associated with fertility rate in Chinese Jing Hong chicken

    Azmal, Syed Ali / Nan, Jiuhong / Bhuiyan, Ali Akbar / Elokil, Abdelmotaleb Ahmed / Ali, Mohammad Ishaque / Adetula, Adeyinka Abiola / Ma, Shuai / Sun, Chenghao / Han, Zhongdong / Yuan, Jingwei / Li, Shijun

    Poultry science. 2020 June, v. 99, no. 6

    2020  

    Abstract: ... genetic markers associated with reproductive traits, we calculated fertility rate at 61 to 69 wk (51 D) of Jing ... using 190 Jing Hong hens showed that the 20 SNP in chromosomes 3 and 13 were significantly associated ... with fertility rate. To verify these results, a total of 1900 Jing Hong laying hens from 2 populations (P1 and P2 ...

    Abstract The function of the sperm storage tubules is directly correlated with the fertility of laying hens. However, little is known about the molecular mechanisms regulating the fertility traits in chicken. To identify genetic markers associated with reproductive traits, we calculated fertility rate at 61 to 69 wk (51 D) of Jing Hong chickens parent generation as the phenotype and the genotype were detected by the chicken 600K Affymetrix Axiom High Density single nucleotide polymorphisms (SNP)-array. The genome-wide association study using 190 Jing Hong hens showed that the 20 SNP in chromosomes 3 and 13 were significantly associated with fertility rate. To verify these results, a total of 1900 Jing Hong laying hens from 2 populations (P1 and P2) were further genotyped by polymerase chain reaction–restriction fragments length polymorphisms method. The association analysis results revealed that 12 polymorphisms (AX-75769978, AX-76582632, AX-75730546, AX-75730496, AX-75730588, AX-76530282, AX-76530329, AX-76529310, AX-75769906, AX-75755394, AX-80813697 and AX-76582809) out of 20 showed highly significant effects (P < 0.0001) on fertility rate in P1, P2 and P1+P2. Six haplotypes (TTAA, TTGG, TTAG, CTAA, CTGG, and CTAG) were inferred based on significant loci (AX-75730546 and AX-76530282) also showed significant association with fertility rate, where haplotype CTAG was shown to be markedly associated with the significantly highest (P < 0.0001) fertility rate (in P1, 86.42 ± 0.59; P2, 85.98 ± 0.59 and P1+P2, 86.16 ± 0.42) followed by other haplotypes for the irrespective of population studied. Collectively, we report for the first time that 12 SNP in the chromosomes 3 and 13 were significantly associated with fertility rate during the later stage of egg production, which could be used as the potential genetic markers that would be able to facilitate in the selection and improvement of fertility rate through chicken breeding.
    Keywords breeding ; egg production ; female fertility ; genetic markers ; genome-wide association study ; genotyping ; haplotypes ; laying hens ; loci ; phenotype ; polymerase chain reaction ; reproductive traits ; single nucleotide polymorphism ; spermatozoa
    Language English
    Dates of publication 2020-06
    Size p. 2873-2887.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 242586-5
    ISSN 1525-3171 ; 0032-5791
    ISSN (online) 1525-3171
    ISSN 0032-5791
    DOI 10.1016/j.psj.2019.12.068
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  9. Article: [Prognostic analysis of definitive radiotherapy for early esophageal carcinoma(T1-2N0M0): a multi-center retrospective study of Jing-Jin-ji Esophageal and Esophagogastric Cancer Radiotherapy Oncology Group].

    Lu, N / Wang, X / Li, C / Wang, L / Chen, J Q / Zhang, W C / Wang, X M / Ge, X L / Shen, W B / Hu, M M / Yuan, Q Q / Xu, Y G / Hao, C L / Zhou, Z G / Qie, S / Xiao, Z F / Zhu, S C / Han, C / Qiao, X Y /
    Pang, Q S / Wang, P / Zhao, Y D / Sun, X C / Zhang, K X / Li, L / Li, G F / Liu, M L / Wang, Y D

    Zhonghua zhong liu za zhi [Chinese journal of oncology

    2020  Volume 42, Issue 2, Page(s) 139–144

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Antineoplastic Agents/therapeutic use ; Chemoradiotherapy ; Dose-Response Relationship, Radiation ; Esophageal Neoplasms/drug therapy ; Esophageal Neoplasms/mortality ; Esophageal Neoplasms/pathology ; Esophageal Neoplasms/radiotherapy ; Esophageal Squamous Cell Carcinoma/drug therapy ; Esophageal Squamous Cell Carcinoma/mortality ; Esophageal Squamous Cell Carcinoma/pathology ; Esophageal Squamous Cell Carcinoma/radiotherapy ; Humans ; Prognosis ; Radiotherapy Dosage ; Radiotherapy, Conformal ; Radiotherapy, Intensity-Modulated ; Retrospective Studies
    Chemical Substances Antineoplastic Agents
    Language Chinese
    Publishing date 2020-03-02
    Publishing country China
    Document type Journal Article ; Multicenter Study
    ZDB-ID 603424-x
    ISSN 0253-3766
    ISSN 0253-3766
    DOI 10.3760/cma.j.issn.0253-3766.2020.02.010
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  10. Article: [Efficacy analysis of the radiotherapy and chemotherapy in patients with stage Ⅳ esophageal squamous carcinoma: a multicenter retrospective study of Jing-Jin-Ji Esophageal and Esophagogastric Cancer Radiotherapy Oncology Group (3JECROG R-01F)].

    Hu, M M / Yuan, Q Q / Zhang, X S / Yang, S / Wang, X / Wang, L / Chen, J Q / Zhang, W C / Wang, X M / Ge, X L / Shen, W B / Xu, Y G / Hao, C L / Zhou, Z G / Qie, S / Lu, N / Pang, Q S / Zhao, Y D / Sun, X C /
    Li, G F / Li, L / Qiao, X Y / Liu, M L / Wang, Y D / Li, C / Zhu, S C / Han, C / Zhang, K X / Xiao, Z F

    Zhonghua zhong liu za zhi [Chinese journal of oncology

    2020  Volume 42, Issue 8, Page(s) 676–681

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Chemoradiotherapy/methods ; China/epidemiology ; Esophageal Neoplasms/drug therapy ; Esophageal Neoplasms/mortality ; Esophageal Neoplasms/pathology ; Esophageal Neoplasms/radiotherapy ; Esophageal Squamous Cell Carcinoma/drug therapy ; Esophageal Squamous Cell Carcinoma/mortality ; Esophageal Squamous Cell Carcinoma/pathology ; Esophageal Squamous Cell Carcinoma/radiotherapy ; Humans ; Neoplasm Staging ; Radiotherapy, Intensity-Modulated/methods ; Retrospective Studies ; Treatment Outcome
    Language Chinese
    Publishing date 2020-08-20
    Publishing country China
    Document type Journal Article
    ZDB-ID 603424-x
    ISSN 0253-3766
    ISSN 0253-3766
    DOI 10.3760/cma.j.cn112152-20190327-00197
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