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Article: Emerging new evidence for the treatment of pulmonary sarcomatoid carcinoma.

Akaba, Tomohiro / Arimura, Ken / Tagaya, Etsuko

2023 Volume 15, Issue 3, Page(s) 953–955

Language	English
Publishing date	2023-02-23
Publishing country	China
Document type	Editorial ; Comment
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd-22-1775
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Article ; Online: Neuronal and astrocytic protein connections and associated adhesion molecules.

Dewa, Ken-Ichi / Arimura, Nariko

Neuroscience research

2022 Volume 187, Page(s) 14–20

Abstract: Astrocytes are morphologically complex, with a myriad of processes which allow contact with other astrocytes, blood vessels, and neurons. Adhesion molecules expressed by these cells regulate this connectivity. Adhesion molecules are required to form and ... ...

Abstract	Astrocytes are morphologically complex, with a myriad of processes which allow contact with other astrocytes, blood vessels, and neurons. Adhesion molecules expressed by these cells regulate this connectivity. Adhesion molecules are required to form and maintain functional neural circuits, but their importance and mechanisms of action, particularly in astrocyte-neuron contact, remain unresolved. Several studies of neuron-astrocyte connections have demonstrated the vital functions of adhesion molecules, including neuron-glia cell adhesion molecules, astrotactins, and protocadherins. In this review, we provide an overview and perspective of astrocyte-neuron contacts mediated by adhesion molecules in developing neural circuits and synapse formation, especially in the cerebellum. We also outline a novel mechanism of interaction between neurons and astrocytes in the tripartite synapses that has been recently found by our group.
MeSH term(s)	Astrocytes/metabolism ; Neurons/physiology ; Synapses/physiology ; Cerebellum ; Neurogenesis
Language	English
Publishing date	2022-10-03
Publishing country	Ireland
Document type	Journal Article ; Review
ZDB-ID	605842-5
ISSN	1872-8111 ; 0168-0102 ; 0921-8696
ISSN (online)	1872-8111
ISSN	0168-0102 ; 0921-8696
DOI	10.1016/j.neures.2022.09.014
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Article ; Online: Effect of Alkali Metal Cations on the Unilamellar Vesicle of a Squalene Bearing 18-Crown-6.

Ngoc Linh, Tran / Arimura, Takashi / Tominaga, Ken-Ichi / Isoda, Hiroko / Kawasaki, Masato / Adachi, Naruhiko

ACS omega

2023 Volume 8, Issue 12, Page(s) 11583–11587

Abstract: Squalene bearing 18-crown-6 was synthesized and formed unilamellar vesicles with a membrane thickness of about 6 nm and a diameter of about 0.32 μm. In the wake of the recognition of alkali metal cations, squalene unilamellar vesicles become larger as ... ...

Abstract	Squalene bearing 18-crown-6 was synthesized and formed unilamellar vesicles with a membrane thickness of about 6 nm and a diameter of about 0.32 μm. In the wake of the recognition of alkali metal cations, squalene unilamellar vesicles become larger as multilamellar vesicles or smaller while maintaining unilamellar vesicles depending on cations.
Language	English
Publishing date	2023-03-17
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c00744
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Article ; Online: Effect of Alkali Metal Cations on the Unilamellar Vesicle of a Squalene Bearing 18-Crown‑6

Tran Ngoc Linh / Takashi Arimura / Ken-Ichi Tominaga / Hiroko Isoda / Masato Kawasaki / Naruhiko Adachi

ACS Omega, Vol 8, Iss 12, Pp 11583-

2023 Volume 11587

Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	American Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Less airway inflammation and goblet cell metaplasia in an IL-33-induced asthma model of leptin-deficient obese mice.

Kurokawa, Atsushi / Kondo, Mitsuko / Arimura, Ken / Ashino, Shigeru / Tagaya, Etsuko

Respiratory research

2021 Volume 22, Issue 1, Page(s) 166

Abstract: Background: Obesity-associated asthma is a phenotype of severe asthma. Late-onset, non-eosinophilic and female-dominant phenotype is highly symptomatic and difficult to treat. Leptin, an adipokine, exerts an immunomodulatory effect. IL-33 associated ... ...

Abstract	Background: Obesity-associated asthma is a phenotype of severe asthma. Late-onset, non-eosinophilic and female-dominant phenotype is highly symptomatic and difficult to treat. Leptin, an adipokine, exerts an immunomodulatory effect. IL-33 associated with innate immunity induces type 2 inflammation and is present in adipose tissue. The purpose of this study was to elucidate the pathogenesis of obesity-associated asthma by focusing on the interaction between leptin and IL-33. Methods: In leptin-deficient obese (ob/ob) and wild-type mice, IL-33 was instilled intranasally on three consecutive days. In part of the mice, leptin was injected intraperitoneally prior to IL-33 treatment. The mice were challenged with methacholine, and airway hyperresponsiveness (AHR) was assessed by resistance (Rrs) and elastance (Ers) of the respiratory system using the forced oscillation technique. Cell differentiation, IL-5, IL-13, eotaxin, keratinocyte-derived chemokine (KC) in bronchoalveolar lavage fluid (BALF) and histology of the lung were analyzed. For the in vitro study, NCI-H292 cells were stimulated with IL-33 in the presence or absence of leptin. Mucin-5AC (MUC5AC) levels were measured using an enzyme-linked immunosorbent assay. Results: Ob/ob mice showed greater Rrs and Ers than wild-type mice. IL-33 with leptin, but not IL-33 alone, enhanced Ers rather than Rrs challenged with methacholine in ob/ob mice, whereas it enhanced Rrs alone in wild-type mice. IL-33-induced eosinophil numbers, cytokine levels in BALF, eosinophilic infiltration around the bronchi, and goblet cell metaplasia were less in ob/ob mice than in wild-type mice. However, leptin pretreatment attenuated these changes in ob/ob mice. MUC5AC levels were increased by co-stimulation with IL-33 and leptin in vitro. Conclusions: Ob/ob mice show innate AHR. IL-33 with leptin, but not IL-33 alone, induces airway inflammation and goblet cell metaplasia and enhances AHR involving peripheral airway closure. This is presumably accelerated by mucus in ob/ob mice. These results may explain some aspects of the pathogenesis of obesity-associated asthma.
MeSH term(s)	Animals ; Asthma/chemically induced ; Asthma/complications ; Asthma/pathology ; Bronchi/metabolism ; Bronchi/pathology ; Bronchoalveolar Lavage Fluid/cytology ; Disease Models, Animal ; Female ; Goblet Cells/metabolism ; Goblet Cells/pathology ; Inflammation/metabolism ; Inflammation/pathology ; Interleukin-33/toxicity ; Leptin/deficiency ; Leptin/metabolism ; Metaplasia ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Obesity/complications ; Obesity/metabolism ; Obesity/pathology
Chemical Substances	Il33 protein, mouse ; Interleukin-33 ; Leptin
Language	English
Publishing date	2021-06-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2041675-1
ISSN	1465-993X ; 1465-9921
ISSN (online)	1465-993X
ISSN	1465-9921
DOI	10.1186/s12931-021-01763-3
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Article ; Online: The efficacy of neutralizing monoclonal antibodies in transplant recipients with mild-to-moderate COVID-19.

Arimura, Ken / Tagaya, Etsuko / Kikuchi, Ken / Mitsuda, Toshihiro / Ebihara, Fumiya / Maruyama, Takumi / Hamada, Yukihiro / Unagami, Kohei / Kanzawa, Taichi / Sekiguchi, Haruki / Shimamoto, Ken / Ishida, Hideki / Egawa, Hiroto / Tanaka, Junji / Kawana, Masatoshi

Transplant immunology

2022 Volume 77, Page(s) 101777

Abstract: Introduction: Transplant recipients (TRs) are at high risk for severe coronavirus disease 2019 (COVID-19). Neutralizing monoclonal antibodies (mAbs) are used for treating mild-to-moderate COVID-19. However, reports comparing the efficacy of COVID-19 ... ...

Abstract	Introduction: Transplant recipients (TRs) are at high risk for severe coronavirus disease 2019 (COVID-19). Neutralizing monoclonal antibodies (mAbs) are used for treating mild-to-moderate COVID-19. However, reports comparing the efficacy of COVID-19 treatment without/with mAbs in TRs are limited. We assessed the efficacy of casirivimab/imdevimab against mild-to-moderate COVID-19 in TRs. Methods: Forty-one patients were retrospectively evaluated. The duration until defervescence, oxygen (O Results: Casirivimab/imdevimab was correlated with shorter duration until defervescence and non-requirement of O Conclusion: Casirivimab/imdevimab was effective and increased the neutralizing antibody in TRs with mild-to-moderate COVID-19, it may contribute toward preventing the progression.
MeSH term(s)	Humans ; Antibodies, Monoclonal/therapeutic use ; Transplant Recipients ; COVID-19 Drug Treatment ; Retrospective Studies ; COVID-19 ; Antibodies, Neutralizing/therapeutic use ; Oxygen
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Neutralizing ; Oxygen (S88TT14065)
Language	English
Publishing date	2022-12-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1160846-8
ISSN	1878-5492 ; 0966-3274
ISSN (online)	1878-5492
ISSN	0966-3274
DOI	10.1016/j.trim.2022.101777
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Article ; Online: Elucidating the role of EPPK1 in lung adenocarcinoma development.

Arimura, Ken / Kammer, Michael / Rahman, S M Jamshedur / Sheau-Chiann, Chen / Zhao, Shilin / Heidi, Chen / Eisenberg, Rosana / Zou, Yong / Antic, Sanja / Richmond, Bradley / Tagaya, Etsuko / Grogan, Eric / Massion, Pierre / Maldonado, Fabien

BMC cancer

2024 Volume 24, Issue 1, Page(s) 441

Abstract: Background: We recently found that epiplakin 1 (EPPK1) alterations were present in 12% of lung adenocarcinoma (LUAD) cases and were associated with a poor prognosis in early-stage LUAD when combined with other molecular alterations. This study aimed to ... ...

Abstract	Background: We recently found that epiplakin 1 (EPPK1) alterations were present in 12% of lung adenocarcinoma (LUAD) cases and were associated with a poor prognosis in early-stage LUAD when combined with other molecular alterations. This study aimed to identify a probable crucial role for EPPK1 in cancer development. Methods: EPPK1 mRNA and protein expression was analyzed with clinical variables. Normal bronchial epithelial cell lines were exposed to cigarette smoke for 16 weeks to determine whether EPPK1 protein expression was altered after exposure. Further, we used CRISPR-Cas9 to knock out (KO) EPPK1 in LUAD cell lines and observed how the cancer cells were altered functionally and genetically. Results: EPPK1 protein expression was associated with smoking and poor prognosis in early-stage LUAD. Moreover, a consequential mesenchymal-to-epithelial transition was observed, subsequently resulting in diminished cell proliferation and invasion after EPPK1 KO. RNA sequencing revealed that EPPK1 KO induced downregulation of 11 oncogenes, 75 anti-apoptosis, and 22 angiogenesis genes while upregulating 8 tumor suppressors and 12 anti-cell growth genes. We also observed the downregulation of MYC and upregulation of p53 expression at both protein and RNA levels following EPPK1 KO. Gene ontology enrichment analysis of molecular functions highlighted the correlation of EPPK1 with the regulation of mesenchymal cell proliferation, mesenchymal differentiation, angiogenesis, and cell growth after EPPK1 KO. Conclusions: Our data suggest that EPPK1 is linked to smoking, epithelial to mesenchymal transition, and the regulation of cancer progression, indicating its potential as a therapeutic target for LUAD.
MeSH term(s)	Humans ; Lung Neoplasms/pathology ; Epithelial-Mesenchymal Transition/genetics ; Prognosis ; Adenocarcinoma of Lung/pathology ; Adenocarcinoma/pathology ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Cell Line, Tumor
Language	English
Publishing date	2024-04-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-024-12185-x
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Article ; Online: Serum VEGF-A levels on admission in COVID-19 patients correlate with SP-D and neutrophils, reflecting disease severity: A prospective study.

Tsuji, Mayoko / Kondo, Mitsuko / Sato, Yasuto / Miyoshi, Azusa / Kobayashi, Fumi / Arimura, Ken / Yamashita, Kaoru / Morimoto, Satoshi / Yanagisawa, Naoko / Ichihara, Atsuhiro / Tagaya, Etsuko

Cytokine

2024 Volume 178, Page(s) 156583

Abstract: Background and objective: The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in significant global morbidity and mortality. This study aimed to investigate the clinical ... ...

Abstract	Background and objective: The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in significant global morbidity and mortality. This study aimed to investigate the clinical significance of serum vascular endothelial growth factor A (VEGF-A) in COVID-19 patients and its association with disease severity and pulmonary injury. Methods: We prospectively collected data from 71 hospitalized COVID-19 patients between June 2020 and January 2021. Patients were classified as either mild or severe based on their oxygen requirements during hospitalization. Serum VEGF-A levels were measured using an ELISA kit. Results: In comparison to mild cases, significantly elevated serum VEGF-A levels were observed in severe COVID-19 patients. Furthermore, VEGF-A levels exhibited a positive correlation with white blood cell count, neutrophil count, and lymphocyte count. Notably, serum surfactant protein-D (SP-D), an indicator of alveolar epithelial cell damage, was significantly higher in patients with elevated VEGF-A levels. Conclusion: These results suggest that elevated serum VEGF-A levels could serve as a prognostic biomarker for COVID-19 as it is indicative of alveolar epithelial cell injury caused by SARS-CoV-2 infection. Additionally, we observed a correlation between VEGF-A and neutrophil activation, which plays a role in the immune response during endothelial cell injury, indicating a potential involvement of angiogenesis in disease progression. Further research is needed to elucidate the underlying mechanisms of VEGF-A elevation in COVID-19.
MeSH term(s)	Humans ; COVID-19 ; Vascular Endothelial Growth Factor A ; Pulmonary Surfactant-Associated Protein D ; Prospective Studies ; SARS-CoV-2 ; Neutrophils ; Patient Acuity
Chemical Substances	Vascular Endothelial Growth Factor A ; Pulmonary Surfactant-Associated Protein D
Language	English
Publishing date	2024-03-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1018055-2
ISSN	1096-0023 ; 1043-4666
ISSN (online)	1096-0023
ISSN	1043-4666
DOI	10.1016/j.cyto.2024.156583
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Article ; Online: Emergency upper gastrointestinal endoscopy performed safely in a patient with COVID-19 with suspected hemorrhagic shock.

Misumi, Yoshitsugu / Nitta, Yuki / Nonaka, Kouichi / Kawana, Masatoshi / Arimura, Ken / Tokushige, Katsutoshi / Tanabe, Kazunari

DEN open

2021 Volume 1, Issue 1, Page(s) e2

Abstract: Coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 has spread explosively throughout the world and has since been declared a pandemic by the World Health Organization. Although it is recommended that upper gastrointestinal ...

Abstract	Coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 has spread explosively throughout the world and has since been declared a pandemic by the World Health Organization. Although it is recommended that upper gastrointestinal endoscopies either be postponed or canceled during the pandemic because of their high risk of aerosol generation, this does not apply in emergency cases, which may include patients with coronavirus disease. In this case report, we describe the safe undertaking of an emergency upper gastrointestinal endoscopy in a patient with suspected hemorrhagic shock who tested positive for the severe acute respiratory syndrome coronavirus 2 using the polymerase chain reaction. We performed the procedure in the contamination zone of a specialized coronavirus disease ward with prespecified zones. Full personal protective equipment was worn during the procedure, as recommended by various academic societies, and careful attention was paid to the sterilization of all equipment after the procedure. Thus, emergency endoscopies can be performed safely in patients with coronavirus disease in a suitable environment by using appropriate personal protective equipment and by handling the equipment appropriately.
Language	English
Publishing date	2021-04-28
Publishing country	Australia
Document type	Case Reports
ISSN	2692-4609
ISSN (online)	2692-4609
DOI	10.1002/deo2.2
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Article ; Online: Evaluation of Ministry of Health, Labour and Welfare diagnostic criteria for antineutrophil cytoplasmic antibody-associated vasculitis compared to ACR/EULAR 2022 classification criteria.

Sada, Ken-Ei / Nagasaka, Kenji / Kaname, Shinya / Higuchi, Tomoaki / Furuta, Shunsuke / Nanki, Toshihiro / Tsuboi, Naotake / Amano, Koichi / Dobashi, Hiroaki / Hiromura, Keiju / Bando, Masashi / Wada, Takashi / Arimura, Yoshihiro / Makino, Hirofumi / Harigai, Masayoshi

Modern rheumatology

2023 Volume 34, Issue 3, Page(s) 551–558

Abstract: Objective: This study aimed to evaluate the Ministry of Health, Labour and Welfare (MHLW) diagnostic criteria for antineutrophil cytoplasmic antibody-associated vasculitis compared to the new American College of Rheumatology/European Alliance of ... ...

Abstract	Objective: This study aimed to evaluate the Ministry of Health, Labour and Welfare (MHLW) diagnostic criteria for antineutrophil cytoplasmic antibody-associated vasculitis compared to the new American College of Rheumatology/European Alliance of Associations for Rheumatology 2022 criteria. Methods: Two nationwide cohort studies were used, and participants were categorised as having eosinophilic granulomatosis with polyangiitis, granulomatosis with polyangiitis (GPA), or microscopic polyangiitis (MPA) according to the American College of Rheumatology/European Alliance of Associations for Rheumatology 2022 and MHLW criteria. Results: Of the entire patient population, only 10 (2.1%) were unclassifiable according to the MHLW probable criteria, while a significant number of patients (71.3%) met at least two criteria. The MHLW probable criteria for MPA had some challenges in differentiating between MPA and eosinophilic granulomatosis with polyangiitis, and the same was true for MHLW probable criteria for GPA in differentiating MPA from GPA. Nevertheless, improved classification results were obtained when the MHLW probable criteria were applied in the order of eosinophilic granulomatosis with polyangiitis, MPA, and GPA. Conclusions: The application of MHLW criteria could categorise a substantial number of patients with antineutrophil cytoplasmic antibody-associated vasculitis into one of the three antineutrophil cytoplasmic antibody-associated vasculitis diseases. The classification was in accordance with the American College of Rheumatology/European Alliance of Associations for Rheumatology 2022 criteria when considering the order of application.
MeSH term(s)	Humans ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/diagnosis ; Granulomatosis with Polyangiitis/diagnosis ; Granulomatosis with Polyangiitis/complications ; Churg-Strauss Syndrome/complications ; Churg-Strauss Syndrome/diagnosis ; Churg-Strauss Syndrome/epidemiology ; Antibodies, Antineutrophil Cytoplasmic ; Microscopic Polyangiitis/diagnosis ; Microscopic Polyangiitis/complications
Chemical Substances	Antibodies, Antineutrophil Cytoplasmic
Language	English
Publishing date	2023-05-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2078157-X
ISSN	1439-7609 ; 1439-7595
ISSN (online)	1439-7609
ISSN	1439-7595
DOI	10.1093/mr/road052
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