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  1. Book ; Online: Multi-Functional Collagen-Based Biomaterials for Biomedical Applications

    Gallo, Nunzia / Madaghiele, Marta / Quarta, Alessandra / Barca, Amilcare

    2023  

    Keywords Medicine ; collagen ; hydrogel ; stability ; transmission electron microscopy ; methacrylation ; rheology ; gelatin methacrylate ; type I collagen ; tilapia ; skin ; aquaponic ; biomaterials ; fish scale ; hydroxyapatite ; bone marrow mesenchymal stem cells ; osteogenic differentiation ; scaffold ; collagen vitrigel ; tissue engineering ; cornea ; corneal endothelium ; dentin-pulp complex regeneration ; signalling molecules ; stem cell from human exfoliated deciduous teeth (SHED) ; gelatin ; fibronectin-binding ; peptides ; HPLC-MS ; electrospinning ; ICOS-Fc ; cell migration ; bone remodelling ; osteoporosis ; viscoll collagen membrane ; cornea regeneration ; stromal replacement ; polyelectrolyte multilayer ; cross-linking ; bone tissue engineering ; drug release ; drug reservoir ; BMP-2 ; composite material ; controlled release ; vancomycin ; swelling ; pH dependence ; rose bengal ; crosslinking ; injectable collagen ; medical devices ; collagen scaffolds ; mechanical properties ; physicochemical properties ; morphology ; composition ; cell viability ; molecular structure ; Dosidicus gigas ; X-ray tomography ; SynchrotronLike
    Language English
    Size 1 electronic resource (234 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030376562
    ISBN 9783036570723 ; 3036570721
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Materials Engineering to Help Pest Control: A Narrative Overview of Biopolymer-Based Entomopathogenic Fungi Formulations.

    Friuli, Marco / Pellegrino, Rebecca / Lamanna, Leonardo / Nitti, Paola / Madaghiele, Marta / Demitri, Christian

    Journal of fungi (Basel, Switzerland)

    2023  Volume 9, Issue 9

    Abstract: Biopolymer-based formulations show great promise in enhancing the effectiveness of entomopathogenic fungi as bioinsecticides. Chitosan and starch, among other biopolymers, have been utilized to improve spore delivery, persistence, and adherence to target ...

    Abstract Biopolymer-based formulations show great promise in enhancing the effectiveness of entomopathogenic fungi as bioinsecticides. Chitosan and starch, among other biopolymers, have been utilized to improve spore delivery, persistence, and adherence to target insects. These formulations offer advantages such as target specificity, eco-friendliness, and sustainability. However, challenges related to production costs, stability, and shelf life need to be addressed. Recently, biomimetic lure and kill approaches based on biopolymers offer cost-effective solutions by leveraging natural attractants. Further research is needed to optimize these formulations and overcome challenges. Biopolymer-based formulations have the potential to revolutionize pest control practices, providing environmentally friendly and sustainable solutions for agriculture.
    Language English
    Publishing date 2023-09-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof9090918
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Cell-Tissue Interaction: The Biomimetic Approach to Design Tissue Engineered Biomaterials.

    Nitti, Paola / Narayanan, Athira / Pellegrino, Rebecca / Villani, Stefania / Madaghiele, Marta / Demitri, Christian

    Bioengineering (Basel, Switzerland)

    2023  Volume 10, Issue 10

    Abstract: The advancement achieved in Tissue Engineering is based on a careful and in-depth study of cell-tissue interactions. The choice of a specific biomaterial in Tissue Engineering is fundamental, as it represents an interface for adherent cells in the ... ...

    Abstract The advancement achieved in Tissue Engineering is based on a careful and in-depth study of cell-tissue interactions. The choice of a specific biomaterial in Tissue Engineering is fundamental, as it represents an interface for adherent cells in the creation of a microenvironment suitable for cell growth and differentiation. The knowledge of the biochemical and biophysical properties of the extracellular matrix is a useful tool for the optimization of polymeric scaffolds. This review aims to analyse the chemical, physical, and biological parameters on which are possible to act in Tissue Engineering for the optimization of polymeric scaffolds and the most recent progress presented in this field, including the novelty in the modification of the scaffolds' bulk and surface from a chemical and physical point of view to improve cell-biomaterial interaction. Moreover, we underline how understanding the impact of scaffolds on cell fate is of paramount importance for the successful advancement of Tissue Engineering. Finally, we conclude by reporting the future perspectives in this field in continuous development.
    Language English
    Publishing date 2023-09-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering10101122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Current Trends in Gelatin-Based Drug Delivery Systems.

    Milano, Francesca / Masi, Annalia / Madaghiele, Marta / Sannino, Alessandro / Salvatore, Luca / Gallo, Nunzia

    Pharmaceutics

    2023  Volume 15, Issue 5

    Abstract: Gelatin is a highly versatile natural polymer, which is widely used in healthcare-related sectors due to its advantageous properties, such as biocompatibility, biodegradability, low-cost, and the availability of exposed chemical groups. In the biomedical ...

    Abstract Gelatin is a highly versatile natural polymer, which is widely used in healthcare-related sectors due to its advantageous properties, such as biocompatibility, biodegradability, low-cost, and the availability of exposed chemical groups. In the biomedical field, gelatin is used also as a biomaterial for the development of drug delivery systems (DDSs) due to its applicability to several synthesis techniques. In this review, after a brief overview of its chemical and physical properties, the focus is placed on the commonly used techniques for the development of gelatin-based micro- or nano-sized DDSs. We highlight the potential of gelatin as a carrier of many types of bioactive compounds and its ability to tune and control select drugs' release kinetics. The desolvation, nanoprecipitation, coacervation, emulsion, electrospray, and spray drying techniques are described from a methodological and mechanistic point of view, with a careful analysis of the effects of the main variable parameters on the DDSs' properties. Lastly, the outcomes of preclinical and clinical studies involving gelatin-based DDSs are thoroughly discussed.
    Language English
    Publishing date 2023-05-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15051499
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Development of PVA Electrospun Nanofibers for Fabrication of Bacteriological Swabs.

    Pellegrino, Rebecca / Villani, Stefania / Spagnolo, Daniela / Carofalo, Irene / Carrino, Nico / Calcagnile, Matteo / Alifano, Pietro / Madaghiele, Marta / Demitri, Christian / Nitti, Paola

    Biology

    2023  Volume 12, Issue 11

    Abstract: In recent years, the enormous demand for swabs for clinical use has promoted their relevance and, consequently, brought the environmental issues due to their single use and lack of biodegradability to the attention of the healthcare industry. Swabs ... ...

    Abstract In recent years, the enormous demand for swabs for clinical use has promoted their relevance and, consequently, brought the environmental issues due to their single use and lack of biodegradability to the attention of the healthcare industry. Swabs consist of a stick that facilitates their easy handling and manoeuvrability even in complex districts and an absorbent tip designed to uptake and release biological samples. In this study, we focused on the fabrication of an innovative biodegradable poly(vinyl alcohol) (PVA) nanofiber swab tip using the electrospinning technique. The innovative swab tip obtained showed comparable uptake and release capacity of protein and bacterial species (
    Language English
    Publishing date 2023-11-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12111404
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The accuracy of intra-oral scanners in full arch implant rehabilitation: a narrative review.

    De Rubertis, Chiara / Ferrante, Franco / Stefanelli, Nicolò / Friuli, Marco / Madaghiele, Marta / Demitri, Christian / Palermo, Andrea

    British dental journal

    2023  Volume 235, Issue 11, Page(s) 887–891

    Abstract: This narrative review aims to study the accuracy of different intra-oral scanner (IOS) devices already available on the market. The accuracy emerged during in vitro, in vivo and ex vivo studies made with IOS devices during the scan of a full arch implant ...

    Abstract This narrative review aims to study the accuracy of different intra-oral scanner (IOS) devices already available on the market. The accuracy emerged during in vitro, in vivo and ex vivo studies made with IOS devices during the scan of a full arch implant rehabilitation that have been analysed to evaluate which device may be the most suitable in this clinical situation. The literature review was performed by searching topics and keywords using the PubMed and Medline databases, for example, 'digital workflow', 'full arch', 'full arch implant rehabilitation' and 'accuracy of IOS'. Inclusion and exclusion criteria for studies were: correct IMRAD (introduction, methods, results and discussion) structure; article with clear and detailed objectives; consistency of the articles with the purpose of the review; two-year range from the year of publication of the article; reproducible materials and methods; and correct follow-up. Most of the intra-oral scanners employed in vitro provided acceptable accuracy (below a threshold of 150 μm). The main parameters identified for their influence on precision were interim plant distance, body scan design, scanning pattern and operator experience. Even though literature is limited, significant differences emerged between the different models of intra-oral scanners evaluated in the studies considered within this review.
    MeSH term(s) Dental Implants ; Imaging, Three-Dimensional ; Dental Impression Technique ; Computer-Aided Design ; Models, Dental ; Dental Arch
    Chemical Substances Dental Implants
    Language English
    Publishing date 2023-12-08
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/s41415-023-6550-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 447: Show issues

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  7. Article: Mimicking the Hierarchical Organization of Natural Collagen: Toward the Development of Ideal Scaffolding Material for Tissue Regeneration.

    Salvatore, Luca / Gallo, Nunzia / Natali, Maria Lucia / Terzi, Alberta / Sannino, Alessandro / Madaghiele, Marta

    Frontiers in bioengineering and biotechnology

    2021  Volume 9, Page(s) 644595

    Abstract: Biological materials found in living organisms, many of which are proteins, feature a complex hierarchical organization. Type I collagen, a fibrous structural protein ubiquitous in the mammalian body, provides a striking example of such a hierarchical ... ...

    Abstract Biological materials found in living organisms, many of which are proteins, feature a complex hierarchical organization. Type I collagen, a fibrous structural protein ubiquitous in the mammalian body, provides a striking example of such a hierarchical material, with peculiar architectural features ranging from the amino acid sequence at the nanoscale (primary structure) up to the assembly of fibrils (quaternary structure) and fibers, with lengths of the order of microns. Collagen plays a dominant role in maintaining the biological and structural integrity of various tissues and organs, such as bone, skin, tendons, blood vessels, and cartilage. Thus, "artificial" collagen-based fibrous assemblies, endowed with appropriate structural properties, represent ideal substrates for the development of devices for tissue engineering applications. In recent years, with the ultimate goal of developing three-dimensional scaffolds with optimal bioactivity able to promote both regeneration and functional recovery of a damaged tissue, numerous studies focused on the capability to finely modulate the scaffold architecture at the microscale and the nanoscale in order to closely mimic the hierarchical features of the extracellular matrix and, in particular, the natural patterning of collagen. All of these studies clearly show that the accurate characterization of the collagen structure at the submolecular and supramolecular levels is pivotal to the understanding of the relationships between the nanostructural/microstructural properties of the fabricated scaffold and its macroscopic performance. Several studies also demonstrate that the selected processing, including any crosslinking and/or sterilization treatments, can strongly affect the architecture of collagen at various length scales. The aim of this review is to highlight the most recent findings on the development of collagen-based scaffolds with optimized properties for tissue engineering. The optimization of the scaffolds is particularly related to the modulation of the collagen architecture, which, in turn, impacts on the achieved bioactivity.
    Language English
    Publishing date 2021-04-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2021.644595
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Author Correction: Biomimetic cellulose-based superabsorbent hydrogels for treating obesity.

    Madaghiele, Marta / Demitri, Christian / Surano, Ivo / Silvestri, Alessandra / Vitale, Milena / Panteca, Eliana / Zohar, Yishai / Rescigno, Maria / Sannino, Alessandro

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 24533

    Language English
    Publishing date 2021-12-29
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-04527-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Mechanical and Biological Properties of Magnesium- and Silicon-Substituted Hydroxyapatite Scaffolds.

    Kunjalukkal Padmanabhan, Sanosh / Nitti, Paola / Stanca, Eleonora / Rochira, Alessio / Siculella, Luisa / Raucci, Maria Grazia / Madaghiele, Marta / Licciulli, Antonio / Demitri, Christian

    Materials (Basel, Switzerland)

    2021  Volume 14, Issue 22

    Abstract: Magnesium (Mg)- and silicon (Si)-substituted hydroxyapatite (HA) scaffolds were synthesized using the sponge replica method. The influence of ... ...

    Abstract Magnesium (Mg)- and silicon (Si)-substituted hydroxyapatite (HA) scaffolds were synthesized using the sponge replica method. The influence of Mg
    Language English
    Publishing date 2021-11-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma14226942
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Recent Advances in Functionalized Electrospun Membranes for Periodontal Regeneration.

    Epicoco, Luana / Pellegrino, Rebecca / Madaghiele, Marta / Friuli, Marco / Giannotti, Laura / Di Chiara Stanca, Benedetta / Palermo, Andrea / Siculella, Luisa / Savkovic, Vuk / Demitri, Christian / Nitti, Paola

    Pharmaceutics

    2023  Volume 15, Issue 12

    Abstract: Periodontitis is a global, multifaceted, chronic inflammatory disease caused by bacterial microorganisms and an exaggerated host immune response that not only leads to the destruction of the periodontal apparatus but may also aggravate or promote the ... ...

    Abstract Periodontitis is a global, multifaceted, chronic inflammatory disease caused by bacterial microorganisms and an exaggerated host immune response that not only leads to the destruction of the periodontal apparatus but may also aggravate or promote the development of other systemic diseases. The periodontium is composed of four different tissues (alveolar bone, cementum, gingiva, and periodontal ligament) and various non-surgical and surgical therapies have been used to restore its normal function. However, due to the etiology of the disease and the heterogeneous nature of the periodontium components, complete regeneration is still a challenge. In this context, guided tissue/bone regeneration strategies in the field of tissue engineering and regenerative medicine have gained more and more interest, having as a goal the complete restoration of the periodontium and its functions. In particular, the use of electrospun nanofibrous scaffolds has emerged as an effective strategy to achieve this goal due to their ability to mimic the extracellular matrix and simultaneously exert antimicrobial, anti-inflammatory and regenerative activities. This review provides an overview of periodontal regeneration using electrospun membranes, highlighting the use of these nanofibrous scaffolds as delivery systems for bioactive molecules and drugs and their functionalization to promote periodontal regeneration.
    Language English
    Publishing date 2023-12-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15122725
    Database MEDical Literature Analysis and Retrieval System OnLINE

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