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  1. Article ; Online: Identification of highly conserved

    Majeau, Alicia / Dumonteil, Eric / Herrera, Claudia

    Emerging microbes & infections

    2024  Volume 13, Issue 1, Page(s) 2315964

    Abstract: Chagas Disease is an important neglected tropical disease caused ... ...

    Abstract Chagas Disease is an important neglected tropical disease caused by
    MeSH term(s) Humans ; Trypanosoma cruzi/genetics ; Trypanosoma cruzi/chemistry ; Antigens, Protozoan/genetics ; Chagas Disease/diagnosis ; Chagas Disease/parasitology ; Epitopes/genetics ; Enzyme-Linked Immunosorbent Assay ; Peptides
    Chemical Substances Antigens, Protozoan ; Epitopes ; Peptides
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2681359-2
    ISSN 2222-1751 ; 2222-1751
    ISSN (online) 2222-1751
    ISSN 2222-1751
    DOI 10.1080/22221751.2024.2315964
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Report of the fourth TDR/IDRI Meeting on Second-Generation Vaccines against Leishmaniasis, 1-3 May 2001, Universidad Autónoma de Yucatán, Mexico / Eric Dumonteil, Diane McMahon-Pratt and Virginia L. Price

    TDR/IDRI Meeting on Second-Generation Vaccines against Leishmaniasis (4th : 2001: Yucatan, Mexico) / Dumonteil, Eric / McMahon-Pratt, Diane / Price, Virginia L / UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases / Infectious Diseases Research Institute (U.S.)

    2001  

    Abstract: TDR/PRD/LEISH/VAC/01.1 ... 13 p. ...

    Abstract TDR/PRD/LEISH/VAC/01.1

    13 p.
    Keywords Leishmaniasis ; Leishmania ; Vaccines ; Parasitic Diseases and their Control ; prevention and control congresses ; immunology ; chemistry
    Language English
    Publisher Geneva
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  3. Book ; Online: Report of the fourth TDR/IDRI Meeting on Second-Generation Vaccines against Leishmaniasis, 1-3 May 2001, Universidad Autónoma de Yucatán, Mexico / Eric Dumonteil, Diane McMahon-Pratt and Virginia L. Price

    TDR/IDRI Meeting on Second-Generation Vaccines against Leishmaniasis (4th : 2001: Yucatan, Mexico) / Dumonteil, Eric / McMahon-Pratt, Diane / Price, Virginia L / UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases / Infectious Diseases Research Institute (U.S.)

    2001  

    Abstract: TDR/PRD/LEISH/VAC/01.1 ... 13 p. ...

    Abstract TDR/PRD/LEISH/VAC/01.1

    13 p.
    Keywords Leishmaniasis ; Leishmania ; Vaccines ; Parasitic Diseases and their Control ; prevention and control congresses ; immunology ; chemistry
    Language English
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  4. Article ; Online: Chagas Disease Diagnostic Testing in Two Academic Hospitals in New Orleans, Louisiana: A Call to Action.

    Proaño, Alvaro / Dumonteil, Eric / Herrera, Claudia

    Tropical medicine and infectious disease

    2023  Volume 8, Issue 5

    Abstract: Chagas disease, caused by the protozoa ... ...

    Abstract Chagas disease, caused by the protozoa parasite
    Language English
    Publishing date 2023-05-15
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2414-6366
    ISSN (online) 2414-6366
    DOI 10.3390/tropicalmed8050277
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Ecological interactions of Triatoma sanguisuga (Hemiptera: Reduviidae) and risk for human infection with Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae) in Illinois and Louisiana.

    Dumonteil, Eric / Tu, Weihong / Jiménez, F Agustín / Herrera, Claudia

    Journal of medical entomology

    2024  

    Abstract: Triatoma sanguisuga (Leconte) is one of the most widely distributed kissing bugs in the United States, associated with an extensive zoonotic circulation of Trypanosoma cruzi, the agent of Chagas disease, in a large part of the country. However, the ... ...

    Abstract Triatoma sanguisuga (Leconte) is one of the most widely distributed kissing bugs in the United States, associated with an extensive zoonotic circulation of Trypanosoma cruzi, the agent of Chagas disease, in a large part of the country. However, the actual risk for human infection in the United States is poorly understood. Here, we further assessed the ecology of T. sanguisuga bugs collected in residents' houses in Illinois and Louisiana, using a metagenomic approach to identify their blood-feeding sources, T. cruzi parasites and gut microbiota. Blood meal analysis revealed feeding on domestic animals (dogs, cats, pigs, goats, and turkeys), synanthropic species (raccoons, opossums, and squirrels), as well as the more sylvatic white-tail deer. Human blood was identified in 11/14 (78%) of bugs, highlighting a frequent vector-human contact. The infection rate with T. cruzi was 53% (8/15), and most infected bugs (6/8) had fed on humans. A total of 41 bacterial families were identified, with significant differences in microbiota alpha and beta diversity between bugs from Louisiana and Illinois. However, predicted metabolic functions remained highly conserved, suggesting important constraints to fulfill their role in bug biology. These results confirmed a significant risk for vector-borne transmission of T. cruzi to humans in Louisiana and Illinois, which warrants more active screening for human infections. Also, while there is broad plasticity in the bacterial composition of T. sanguisuga microbiota, there are strong constraints to preserve metabolic profile and function, making it a good target for novel vector control strategies.
    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 410635-0
    ISSN 1938-2928 ; 0022-2585
    ISSN (online) 1938-2928
    ISSN 0022-2585
    DOI 10.1093/jme/tjae017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 303: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Monkeypox Virus Evolution before 2022 Outbreak.

    Dumonteil, Eric / Herrera, Claudia / Sabino-Santos, Gilberto

    Emerging infectious diseases

    2023  Volume 29, Issue 2, Page(s) 451–453

    Abstract: Phylogenetic analysis of monkeypox virus genomes showed statistically significant divergence and nascent subclades during the 2022 mpox outbreak. Frequency of G>A/C>T transitions has increased in recent years, probably resulting from apolipoprotein B ... ...

    Abstract Phylogenetic analysis of monkeypox virus genomes showed statistically significant divergence and nascent subclades during the 2022 mpox outbreak. Frequency of G>A/C>T transitions has increased in recent years, probably resulting from apolipoprotein B mRNA editing enzyme catalytic polypeptide 3G (APOBEC3) deaminase editing. This microevolutionary pattern most likely reflects community spread of the virus and adaptation to humans.
    MeSH term(s) Humans ; Monkeypox virus/genetics ; Mpox (monkeypox)/epidemiology ; Phylogeny ; Disease Outbreaks
    Language English
    Publishing date 2023-01-24
    Publishing country United States
    Document type Letter
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2902.220962
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4778: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Percolation properties of the neutron population in nuclear reactors.

    Dechenaux, Benjamin / Delcambre, Thomas / Dumonteil, Eric

    Physical review. E

    2023  Volume 106, Issue 6-1, Page(s) 64126

    Abstract: Reactor physics aims at studying the neutron population in a reactor core under the influence of feedback mechanisms, such as the Doppler temperature effect. Numerical schemes to calculate macroscopic properties emerging from such coupled stochastic ... ...

    Abstract Reactor physics aims at studying the neutron population in a reactor core under the influence of feedback mechanisms, such as the Doppler temperature effect. Numerical schemes to calculate macroscopic properties emerging from such coupled stochastic systems, however, require us to define intermediate quantities (e.g., the temperature field), which are bridging the gap between the stochastic neutron field and the deterministic feedback. By interpreting the branching random walk of neutrons in fissile media under the influence of a feedback mechanism as a directed percolation process and by leveraging on the statistical field theory of birth death processes, we will build a stochastic model of neutron transport theory and of reactor physics. The critical exponents of this model, combined with the analysis of the resulting field equation involving a fractional Laplacian, will show that the critical diffusion equation cannot adequately describe the spatial distribution of the neutron population and shifts instead to a critical superdiffusion equation. The analysis of this equation will reveal that nonnegligible departure from mean-field behavior might develop in reactor cores, questioning the attainable accuracy of the numerical schemes currently used by the nuclear industry.
    MeSH term(s) Neutrons ; Nuclear Reactors
    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2844562-4
    ISSN 2470-0053 ; 2470-0045
    ISSN (online) 2470-0053
    ISSN 2470-0045
    DOI 10.1103/PhysRevE.106.064126
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  8. Article ; Online: Trypanosoma cruzi amastigote transcriptome analysis reveals heterogenous populations with replicating and dormant parasites.

    Desale, Hans / Herrera, Claudia / Dumonteil, Eric

    Microbes and infection

    2023  Volume 26, Issue 1-2, Page(s) 105240

    Abstract: Trypanosoma cruzi is a protozoan parasite causing Chagas disease, with a complex life cycle involving different stages in insect vectors and mammalian hosts. Amastigotes are an intracellular form that replicates in the cytoplasm of host cells, and recent ...

    Abstract Trypanosoma cruzi is a protozoan parasite causing Chagas disease, with a complex life cycle involving different stages in insect vectors and mammalian hosts. Amastigotes are an intracellular form that replicates in the cytoplasm of host cells, and recent studies suggested that dormant forms may be contributing to parasite persistence, suggesting cellular heterogeneity among amastigotes. We investigated here if a transcriptomic approach could identify some heterogeneity in intracellular amastigotes and identify a dormant population. We used gene expression data derived from bulk RNA-sequencing of T. cruzi infection of human fibroblasts for deconvolution using CDSeq, which allows to simultaneously estimate amastigote cell-type proportions and cell-type-specific expression profiles. Six amastigote subpopulations were identified, confirming intracellular amastigotes heterogeneity, and one population presented characteristics of non-replicative dormant parasites, based on replication markers and TcRAD51 expression. Transcriptomic approaches appear to be powerful to understand T. cruzi cell differentiation and expansion of these studies could provide further insight on the role different cell types in parasite persistence and Chagas disease pathogenesis.
    MeSH term(s) Animals ; Humans ; Trypanosoma cruzi/genetics ; Parasites/genetics ; Chagas Disease/parasitology ; Gene Expression Profiling ; Cytoplasm/metabolism ; Mammals
    Language English
    Publishing date 2023-10-20
    Publishing country France
    Document type Journal Article
    ZDB-ID 1465093-9
    ISSN 1769-714X ; 1286-4579
    ISSN (online) 1769-714X
    ISSN 1286-4579
    DOI 10.1016/j.micinf.2023.105240
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5014: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Metabolomics of developmental changes in Triatoma sanguisuga gut microbiota.

    Teal, Evan / Herrera, Claudia / Dumonteil, Eric

    PloS one

    2023  Volume 18, Issue 2, Page(s) e0280868

    Abstract: Triatoma sanguisuga is one of the major vectors of Trypanosoma cruzi in the southeastern US, where it sustains a robust zoonotic parasite transmission cycle and occasional human infections. A better understanding of triatomine development may allow for ... ...

    Abstract Triatoma sanguisuga is one of the major vectors of Trypanosoma cruzi in the southeastern US, where it sustains a robust zoonotic parasite transmission cycle and occasional human infections. A better understanding of triatomine development may allow for alternative approaches to insecticide-based vector control. Indeed, the role of the gut microbiota and bacterial endosymbionts in triatomine development and in their vectorial capacity is emerging. We investigated here the differences in microbiota among nymph and adult T. sanguisuga, to shed light on the metabolomic interactions occurring during development. Microbiota composition was assessed by 16s gene amplification and deep sequencing from field-caught adult bugs and their laboratory-raised progeny. Significant differences in microbiota bacterial diversity and composition were observed between nymphs and adults. Laboratory-raised nymphs showed a higher taxonomic diversity, and at least seven families predominated. On the other hand, field-caught adults had a lower bacterial diversity and four families comprised most of the microbiota. These differences in compositions were associated with differences in predicted metabolism, with laboratory-raised nymphs microbiota metabolizing a limited diversity of carbon sources, with potential for resource competition between bacterial families, and the production of lactic acid as a predominant fermentation product. On the other hand, field-caught adult microbiota was predicted to metabolize a broader diversity of carbon sources, with complementarity rather than competition among taxa, and produced a diverse range of products in a more balanced manner. The restricted functionality of laboratory-raised nymph microbiota may be associated with their poor development in captivity, and further understanding of the metabolic interactions at play may lead to alternative vector control strategies targeting triatomine microbiota.
    MeSH term(s) Animals ; Humans ; Triatoma/genetics ; Gastrointestinal Microbiome ; Trypanosoma cruzi/genetics ; Microbiota ; Metabolomics ; Bacteria/genetics ; Nymph ; Chagas Disease/parasitology
    Language English
    Publishing date 2023-02-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0280868
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  10. Article ; Online: The Case for the Development of a Chagas Disease Vaccine: Why? How? When?

    Dumonteil, Eric / Herrera, Claudia

    Tropical medicine and infectious disease

    2021  Volume 6, Issue 1

    Abstract: Chagas disease is a major neglected tropical disease, transmitted predominantly by triatomine insect vectors, but also through congenital and oral routes. While endemic in the Americas, it has turned into a global disease. Because of the current drug ... ...

    Abstract Chagas disease is a major neglected tropical disease, transmitted predominantly by triatomine insect vectors, but also through congenital and oral routes. While endemic in the Americas, it has turned into a global disease. Because of the current drug treatment limitations, a vaccine would represent a major advancement for better control of the disease. Here, we review some of the rationale, advances, and challenges for the ongoing development of a vaccine against Chagas disease. Recent pre-clinical studies in murine models have further expanded (i) the range of vaccine platforms and formulations tested; (ii) our understanding of the immune correlates for protection; and (iii) the extent of vaccine effects on cardiac function, beyond survival and parasite burden. We further discuss outstanding issues and opportunities to move Chagas disease development forward in the near future.
    Language English
    Publishing date 2021-01-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2414-6366
    ISSN (online) 2414-6366
    DOI 10.3390/tropicalmed6010016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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