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  1. Article ; Online: Medical Oncology Education in Egypt Over the Past 50 Years: the Experience of the National Cancer Institute of Cairo University.

    Khaled, Hussein M / Soliman, Amr S

    Journal of cancer education : the official journal of the American Association for Cancer Education

    2021  Volume 36, Issue Suppl 1, Page(s) 87–94

    Abstract: This manuscript outlines the progress of education in the field of medical oncology in Egypt over the past 50 years. The manuscript illustrates the origin of the Egyptian medical oncology program since the creation of the only specialized cancer center ... ...

    Abstract This manuscript outlines the progress of education in the field of medical oncology in Egypt over the past 50 years. The manuscript illustrates the origin of the Egyptian medical oncology program since the creation of the only specialized cancer center in the country, the National Cancer Institute of Cairo University (NCI-Cairo) in 1969, from Cairo University Medical School. The manuscript also outlines the NCI-Cairo's educational program for developing a cadre of academic medical oncologists for NCI-Cairo, other Egyptian medical institutions, and countries in the Middle East and Africa. We also emphasize the capacity building that resulted over the past 50 years from academic and professional standpoints, the changing curriculum in medical oncology, and the differences between the medical oncology and clinical oncology education programs in the country. Medical oncology research resulted from international collaborations and highlighted needs for cancer prevention and control. Finally, we propose possible future directions for medical oncology education and research in the country and a roadmap for low- and middle-income countries (LMICs) that are developing their medical oncology programs.
    MeSH term(s) Developing Countries ; Educational Status ; Egypt ; Humans ; Medical Oncology ; National Cancer Institute (U.S.) ; Neoplasms ; United States ; Universities
    Language English
    Publishing date 2021-06-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 632898-2
    ISSN 1543-0154 ; 0885-8195 ; 1543-1154
    ISSN (online) 1543-0154
    ISSN 0885-8195 ; 1543-1154
    DOI 10.1007/s13187-021-02038-7
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2185: Show issues Location:
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  2. Article ; Online: Outlining the Clinical Profile of

    El-Kamah, Ghada Y / Mehrez, Mennat I / Taher, Mohamed B / El-Bassyouni, Hala T / Gaber, Khaled R / Amr, Khalda S

    Genes

    2023  Volume 14, Issue 4

    Abstract: ... ...

    Abstract TCIRG1
    MeSH term(s) Humans ; Bone Density ; Egypt ; Mutation ; Osteopetrosis/genetics ; Phenotype ; Vacuolar Proton-Translocating ATPases/genetics
    Chemical Substances TCIRG1 protein, human ; Vacuolar Proton-Translocating ATPases (EC 3.6.1.-)
    Language English
    Publishing date 2023-04-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14040900
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  3. Article ; Online: Novel sulfonamide derivatives as multitarget antidiabetic agents: design, synthesis, and biological evaluation.

    Ayoup, Mohammed Salah / Khaled, Nourhan / Abdel-Hamid, Hamida / Ghareeb, Doaa A / Nasr, Samah A / Omer, Ahmed / Sonousi, Amr / Kassab, Asmaa E / Eltaweil, Abdelazeem S

    RSC advances

    2024  Volume 14, Issue 11, Page(s) 7664–7675

    Abstract: A series of new sulfonamide derivatives connected through an imine linker to five or seven membered heterocycles were designed and synthesized. All synthesized derivatives were characterized using a variety of spectroscopic methods, including IR, ...

    Abstract A series of new sulfonamide derivatives connected through an imine linker to five or seven membered heterocycles were designed and synthesized. All synthesized derivatives were characterized using a variety of spectroscopic methods, including IR,
    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d4ra01060d
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  4. Article: A single-stage computer-guided gap arthroplasty with simultaneous patient-specific total joint replacement with a novel flat fossa design: A case report.

    Shawky, Mohamed / Elbehairy, Mohamed S / Atef, Mohammed / Amr, Khaled

    International journal of surgery case reports

    2021  Volume 79, Page(s) 440–449

    Abstract: Introduction and importance: The computer-guided approach for the patient-specific TMJ replacement is considered an ultimate reliable option in advanced cases. However, dislocation of the condylar head could happen with the concave fossa design. A flat ... ...

    Abstract Introduction and importance: The computer-guided approach for the patient-specific TMJ replacement is considered an ultimate reliable option in advanced cases. However, dislocation of the condylar head could happen with the concave fossa design. A flat design was described and used in this case.
    Case presentation: A 15 years old male patient with mandibular asymmetry and class IV recurrent ankylosis of the right TMJ received a patient-specific artificial joint with computer-guided gap arthroplasty and orthognathic corrective mandibular surgery for the left side. The fossa component was made entirely flat, and the patient was followed up over the next year.
    Clinical discussion: Customized TMJ prosthetic solutions are reliable in advanced cases, especially when facial corrections are indicated; however, the commonly used concave design showed reported dislocations requiring some design modifications as proposed in the presented case.
    Conclusion: The flat fossa design of the artificial TMJ secures the same results as the anatomical fossa design without the incidence of dislocation.
    Language English
    Publishing date 2021-01-22
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2021.01.078
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  5. Article ; Online: The impact of membrane perforation and L-PRF for vertical ridge augmentation with a xenogeneic block graft: an experimental study in a canine model.

    Eldabe, Abdelrahman K / Abdel-Ghaffar, Khaled A / Amr, Ahmed E / Abu-Seida, Ashraf M / Abdelhamid, Ehab S / Gamal, Ahmed Y

    Clinical oral investigations

    2023  Volume 27, Issue 7, Page(s) 3949–3960

    Abstract: Objectives: This study evaluated clinically and histologically the efficacy of modified perforated collagen membrane (PCM) and/or leukocyte- and platelet-rich fibrin (L-PRF) in combination with xenogeneic block bone graft in the vertical alveolar ridge ... ...

    Abstract Objectives: This study evaluated clinically and histologically the efficacy of modified perforated collagen membrane (PCM) and/or leukocyte- and platelet-rich fibrin (L-PRF) in combination with xenogeneic block bone graft in the vertical alveolar ridge augmentation.
    Materials and methods: Six adult mongrel dogs were enrolled in this randomized blinded study. After defect preparation, xenogeneic screw-fixed block graft was covered by an occlusive collagen membrane in group 1 that represented the control group (Block + CM). In group 2, L-PRF membrane was added first before top coverage by occlusive collagen membrane (Block + L-PRF + CM). Groups 3 (Block + PCM) and 4 (Block + L-PRF + PCM) were identical to the first two groups except that the occlusive collagen membrane was replaced by a perforated one. Following a healing period of 2 months, the dogs were submitted to the surgical reentry phase for clinical and histological evaluation.
    Results: Clinically, no significant differences were found among all groups regarding vertical and horizontal ridge dimensions (p = 0.155, 0.492, respectively). Histomorphometric analysis revealed that the percentage of the total bone area and mature bone was significantly higher in group 4 (69.36 ± 2.72, 33.11 ± 5.18) compared to the control group (59.17 ± 4.27, 21.94 ± 2.86) (p = 0. 027, p = 0.029).
    Conclusion: The use of xenogenic block grafts in combination with a double-layered perforated collagen L-PRF membrane in vertical ridge augmentation appeared to improve the inductive power of this challenging defect type.
    Clinical relevance: Size and number of perforations may affect the mechanical and handling properties of the membrane.
    MeSH term(s) Animals ; Dogs ; Alveolar Ridge Augmentation/methods ; Bone Regeneration ; Bone Transplantation/methods ; Collagen ; Platelet-Rich Fibrin
    Chemical Substances Collagen (9007-34-5)
    Language English
    Publishing date 2023-04-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1364490-7
    ISSN 1436-3771 ; 1432-6981
    ISSN (online) 1436-3771
    ISSN 1432-6981
    DOI 10.1007/s00784-023-05018-x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4788: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article: Metastasizing Malignant Granular Cell Tumor (Abrikossoff Tumor) of the Anterior Abdominal Wall, with Prolonged Survival.

    Alnashwan, Yara A / Ali, Khaled A H / Amr, Samir S

    Case reports in pathology

    2019  Volume 2019, Page(s) 9576487

    Abstract: Malignant granular cell tumor (MGCT) is a rare high-grade mesenchymal tumor of Schwann cell origin. MGCTs commonly affect thigh, extremity, and trunk; however, involvement of the abdominal wall is quite rare. It has poor prognosis with 39% mortality rate ...

    Abstract Malignant granular cell tumor (MGCT) is a rare high-grade mesenchymal tumor of Schwann cell origin. MGCTs commonly affect thigh, extremity, and trunk; however, involvement of the abdominal wall is quite rare. It has poor prognosis with 39% mortality rate in 3-year interval. We report a 50-year-old female who had MGCT arising in the anterior abdominal wall and developed massive metastatic deposits in both lungs and in the right inguinal lymph nodes, with prolonged survival for 11 years. A brief review of the literature is presented.
    Language English
    Publishing date 2019-04-07
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2648758-5
    ISSN 2090-679X ; 2090-6781
    ISSN (online) 2090-679X
    ISSN 2090-6781
    DOI 10.1155/2019/9576487
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  7. Article ; Online: Mass spectrometry and two-dimensional electrophoresis in prenatal diagnosis of mucopolysaccharidosis type VI

    Aly A. Aboulnasr / Khaled R. Gaber / Gamal Abdel Sameea / Amr S. Gouda / Mona M. Ibrahim / Taghreed A. Shalabi / Amr Elnouri

    Egyptian Journal of Medical Human Genetics, Vol 23, Iss 1, Pp 1-

    2022  Volume 6

    Abstract: Abstract Background Mucopolysaccharidosis VI (MPS VI) or Maroteaux–Lamy syndrome is an autosomal recessive lysosomal storage disorder. Clinical manifestations are related to progressive accumulation of dermatan sulfate (DS). Two-dimensional ... ...

    Abstract Abstract Background Mucopolysaccharidosis VI (MPS VI) or Maroteaux–Lamy syndrome is an autosomal recessive lysosomal storage disorder. Clinical manifestations are related to progressive accumulation of dermatan sulfate (DS). Two-dimensional electrophoresis has traditionally been used for the diagnosis of MPS disorders. The method is only qualitative and is time consuming. For prenatal diagnosis of MPS, 6–8 ml of amniotic fluid is required and 5 working days to complete. It needs personal experience to do the test and to interpret the results. Mass spectrometry (MS) is now available as a quantitative method and for prenatal diagnosis of MPS it needs less amniotic fluid and takes only 2 working days. It is more accurate, less person dependent, but it costs more. Our aim was to introduce quantitative determination of dermatan sulfate using mass spectrometry in the prenatal diagnosis of MPS VI in Egypt and to compare this technique to the classical qualitative diagnosis using two-dimensional electrophoresis (2-DEP) of the glycosaminoglycans (GAGs) in amniotic fluid. Thirty pregnant females each with single fetus were subjected to amniocentesis at 16 weeks gestation. Ten with a previously affected MPS VI infant and twenty served as controls. Prenatal diagnosis (PD) was done by both MS and 2-DEP. Results MS verified 2-DEP results which showed 5 affected and 5 non-affected fetuses with MPS VI. Conclusion Two-dimensional electrophoresis of the GAGs in amniotic fluid is a good qualitative method and MS was an accurate quantitative method for prenatal diagnosis of MPS type VI. Quantitative determination of GAGs in AF by mass spectrometry is quicker. Where prenatal diagnosis is recommended for at risk pregnancies, mass spectrometry could be used more in the future as it gives rapid and accurate results.
    Keywords Mass spectrometry (MS) ; Two-dimensional electrophoresis (2-DEP) ; Prenatal diagnosis of MPS VI ; Amniocentesis ; Medicine (General) ; R5-920 ; Genetics ; QH426-470
    Subject code 150 ; 610
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher SpringerOpen
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Screening of Apoptosis Pathway-Mediated Anti-Proliferative Activity of the Phytochemical Compound Furanodienone against Human Non-Small Lung Cancer A-549 Cells.

    Al Saqr, Ahmed / Khafagy, El-Sayed / Aldawsari, Mohammed F / Almansour, Khaled / Abu Lila, Amr S

    Life (Basel, Switzerland)

    2022  Volume 12, Issue 1

    Abstract: Furanodienone (FDN), a major bioactive component of sesquiterpenes produced ... ...

    Abstract Furanodienone (FDN), a major bioactive component of sesquiterpenes produced from
    Language English
    Publishing date 2022-01-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12010114
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  9. Article ; Online: Correction to: Feasibility and outcomes of living‑donor liver transplantation utilizing the right hemi‑liver graft with portal vein anatomical variations.

    Shehta, Ahmed / Elshobari, Mohamed / Salah, Tarek / Sultan, Ahmad M / Yasen, Amr / Shiha, Usama / El-Saadany, Mohamed / Monier, Ahmed / Said, Rami / Habl, Mohamed S / Adly, Reham / Ged, Basma Abd Elmoaem El / Karam, Rasha / Khaled, Reem / Razek, Hassan Magdy Abd El / Abdel-Khalek, Ehab E / Wahab, Mohamed Abdel

    Langenbeck's archives of surgery

    2024  Volume 409, Issue 1, Page(s) 34

    Language English
    Publishing date 2024-01-10
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 1423681-3
    ISSN 1435-2451 ; 1435-2443
    ISSN (online) 1435-2451
    ISSN 1435-2443
    DOI 10.1007/s00423-024-03226-x
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  10. Article: Carriere Motion Appliance with Miniscrew Anchorage for Treatment of Class II, Division 1 Malocclusion.

    Fouda, Ahmed S / Aboulfotouh, Mai H / Attia, Khaled H / Aboulezezz, Amr M

    Journal of clinical orthodontics : JCO

    2021  Volume 54, Issue 10, Page(s) 633–641

    MeSH term(s) Cephalometry ; Humans ; Malocclusion, Angle Class II/therapy ; Orthodontic Anchorage Procedures ; Orthodontic Appliance Design ; Orthodontic Appliances, Functional ; Tooth Movement Techniques
    Language English
    Publishing date 2021-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410668-4
    ISSN 0022-3875
    ISSN 0022-3875
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