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Article: Sulfated polysaccharides act as baits to interfere with the binding of the spike protein (SARS-CoV-2) to the ACE2 receptor and can be administered through food.

Barbosa, Jhonatas Rodrigues / de Fátima Henriques Lourenço, Lúcia

2023 Volume 104, Page(s) 105532

Abstract: Human civilization is experiencing a global crisis involving an unprecedented viral pandemic, with a high mortality rate, uncontrolled spread, and few effective drugs for treatment. Here, we critically evaluate how sulfated polysaccharides can be applied ...

Abstract	Human civilization is experiencing a global crisis involving an unprecedented viral pandemic, with a high mortality rate, uncontrolled spread, and few effective drugs for treatment. Here, we critically evaluate how sulfated polysaccharides can be applied via foods to reduce the infectious process and increase the chances of an adequate immune response. The approach is directed to the infectious process by SARS-CoV-2 and protein S as a therapeutic focus. We discuss the antiviral activities of certain natural and specific sulfated polysaccharides that bind tightly to protein S. Finally, we identified that sulfated polysaccharides act as baits to interfere with the binding of the spike protein (SARS-CoV-2) to the ACE2 receptor and can be administered through food.
Language	English
Publishing date	2023-04-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2511964-3
ISSN	1756-4646
ISSN	1756-4646
DOI	10.1016/j.jff.2023.105532
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Article ; Online: Sulfated polysaccharides act as baits to interfere with the binding of the spike protein (SARS-CoV-2) to the ACE2 receptor and can be administered through food

Barbosa, Jhonatas Rodrigues / de Fátima Henriques Lourenço, Lúcia

Journal of Functional Foods. 2023 May, v. 104 p.105532-

2023

Abstract	Human civilization is experiencing a global crisis involving an unprecedented viral pandemic, with a high mortality rate, uncontrolled spread, and few effective drugs for treatment. Here, we critically evaluate how sulfated polysaccharides can be applied via foods to reduce the infectious process and increase the chances of an adequate immune response. The approach is directed to the infectious process by SARS-CoV-2 and protein S as a therapeutic focus. We discuss the antiviral activities of certain natural and specific sulfated polysaccharides that bind tightly to protein S. Finally, we identified that sulfated polysaccharides act as baits to interfere with the binding of the spike protein (SARS-CoV-2) to the ACE2 receptor and can be administered through food.
Keywords	Severe acute respiratory syndrome coronavirus 2 ; humans ; immune response ; mortality ; pandemic ; polysaccharides ; therapeutics
Language	English
Dates of publication	2023-05
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2511964-3
ISSN	1756-4646
ISSN	1756-4646
DOI	10.1016/j.jff.2023.105532
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Occurrence and Possible Roles of Polysaccharides in Fungi and their Influence on the Development of New Technologies

Barbosa, Jhonatas Rodrigues

Carbohydr Polym

Abstract: The article summarizes the roles of polysaccharides in the biology of fungi and their relationship in the development of new technologies. The comparative approach between the evolution of fungi and the chemistry of glycobiology elucidated relevant ... ...

Abstract	The article summarizes the roles of polysaccharides in the biology of fungi and their relationship in the development of new technologies. The comparative approach between the evolution of fungi and the chemistry of glycobiology elucidated relevant aspects about the role of polysaccharides in fungi. Also, based on the knowledge of fungal glycobiology, it was possible to address the development of new technologies, such as the production of new anti-tumor drugs, vaccines, biomaterials, and applications in the field of robotics. We conclude that polysaccharides activate pathways of apoptosis, secretion of pro-inflammatory substances, and macrophage, inducing anticancer activity. Also, the activation of the immune system, which opens the way for the production of vaccines. The development of biomaterials and parts for robotics is a promising and little-explored field. Finally, the article is multidisciplinary, with a different and integrated approach to the role of nature in the sustainable development of new technologies.
Keywords	covid19
Publisher	Elsevier; PMC
Document type	Article ; Online
DOI	10.1016/j.carbpol.2020.116613
Database	COVID19

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Article: Food sustainability trends - How to value the açaí production chain for the development of food inputs from its main bioactive ingredients?

Barbosa, Jhonatas Rodrigues / Carvalho Junior, Raul Nunes de

Trends in food science & technology. 2022 June, v. 124

2022

Abstract: The growth of the market for products derived from the açaí production chain, and the problems of the accumulation of residues from the process, intensified the demand for innovative strategies based on a circular bioeconomy model to value the industry, ... ...

Abstract	The growth of the market for products derived from the açaí production chain, and the problems of the accumulation of residues from the process, intensified the demand for innovative strategies based on a circular bioeconomy model to value the industry, preserve the forest and the people who live in the Amazon. Thus, the demand for food inputs has stimulated the approach of full use of the açaí production chain for the production of mannose, polyphenols, and fatty acids. The objective of this brief comment is to update the reader on the potential of the açaí production chain for the development of food inputs, addressing its impacts, the development of technologies, and the challenges to implementing ecologies strategies and innovative in the Amazon region. The approach is centered on valuing the açaí production chain, based on a circular bioeconomy model, and applying ecological strategies to encourage the sustainable development of food inputs. Products derived from the entire açaí production chain, for applications as food input, are very promising, as they have a global consumer market, with the potential to be competitive and attractive to investors. The circular bioeconomy model should leverage new routes for the recovery of waste for the production of mannose and polyphenols. Therefore, there are business, investment, and research opportunities to reduce environmental problems and increase the value of the açaí production chain.
Keywords	bioeconomics ; food science ; forests ; industry ; mannose ; markets ; models ; polyphenols ; sustainable agriculture ; technology ; wastes ; Amazonia
Language	English
Dates of publication	2022-06
Size	p. 86-95.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1049246-x
ISSN	1879-3053 ; 0924-2244
ISSN (online)	1879-3053
ISSN	0924-2244
DOI	10.1016/j.tifs.2022.04.005
Database	NAL-Catalogue (AGRICOLA)

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Article: Polysaccharides obtained from natural edible sources and their role in modulating the immune system: Biologically active potential that can be exploited against COVID-19.

Barbosa, Jhonatas Rodrigues / de Carvalho Junior, Raul Nunes

Trends in food science & technology

2021 Volume 108, Page(s) 223–235

Abstract: Background: The global crisis caused by the outbreak of severe acute respiratory syndrome caused by the SARS-CoV-2 virus, better known as COVID-19, brought the need to improve the population's immunity. The foods rich in polysaccharides with ... ...

Abstract	Background: The global crisis caused by the outbreak of severe acute respiratory syndrome caused by the SARS-CoV-2 virus, better known as COVID-19, brought the need to improve the population's immunity. The foods rich in polysaccharides with immunomodulation properties are among the most highly rated to be used as immune response modulators. Thus, the use of polysaccharides obtained from food offers an innovative strategy to prevent serious side effects of viral infections. Scope and approach: This review revisits the current studies on the pathophysiology of SARS-CoV-2, its characteristics, target cell interactions, and the possibility of using polysaccharides from functional foods as activators of the immune response. Several natural foods are explored for the possibility of being used to obtain polysaccharides with immunomodulatory potential. And finally, we address expectations for the use of polysaccharides in the development of potential therapies and vaccines. Key findings and conclusions: The negative consequences of the SARS-CoV-2 pandemic across the world are unprecedented, thousands of lives lost, increasing inequalities, and incalculable economic losses. On the other hand, great scientific advances have been made regarding the understanding of the disease and forms of treatment. Polysaccharides, due to their characteristics, have the potential to be used as potential drugs with the ability to modulate the immune response. In addition, they can be used safely, as they have no toxic effects, are biocompatible and biodegradable. Finally, these biopolymers can still be used in the development of new therapies and vaccines.
Language	English
Publishing date	2021-01-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1049246-x
ISSN	1879-3053 ; 0924-2244
ISSN (online)	1879-3053
ISSN	0924-2244
DOI	10.1016/j.tifs.2020.12.026
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Occurrence and possible roles of polysaccharides in fungi and their influence on the development of new technologies.

Barbosa, Jhonatas Rodrigues / Carvalho Junior, Raul Nunes de

Carbohydrate polymers

2020 Volume 246, Page(s) 116613

Abstract	The article summarizes the roles of polysaccharides in the biology of fungi and their relationship in the development of new technologies. The comparative approach between the evolution of fungi and the chemistry of glycobiology elucidated relevant aspects about the role of polysaccharides in fungi. Also, based on the knowledge of fungal glycobiology, it was possible to address the development of new technologies, such as the production of new anti-tumor drugs, vaccines, biomaterials, and applications in the field of robotics. We conclude that polysaccharides activate pathways of apoptosis, secretion of pro-inflammatory substances, and macrophage, inducing anticancer activity. Also, the activation of the immune system, which opens the way for the production of vaccines. The development of biomaterials and parts for robotics is a promising and little-explored field. Finally, the article is multidisciplinary, with a different and integrated approach to the role of nature in the sustainable development of new technologies.
MeSH term(s)	Antineoplastic Agents/chemistry ; Antineoplastic Agents/classification ; Antineoplastic Agents/isolation & purification ; Antineoplastic Agents/pharmacology ; Biocompatible Materials/isolation & purification ; Biocompatible Materials/pharmacology ; Biotechnology/methods ; Electronics/methods ; Fungal Polysaccharides/chemistry ; Fungal Polysaccharides/classification ; Fungal Polysaccharides/isolation & purification ; Fungal Polysaccharides/pharmacology ; Fungi/chemistry ; Fungi/metabolism ; Glycomics/methods ; Humans ; Immunologic Factors/chemistry ; Immunologic Factors/classification ; Immunologic Factors/isolation & purification ; Immunologic Factors/pharmacology ; Macrophages/cytology ; Macrophages/drug effects ; Macrophages/immunology ; Rheology ; Robotics/methods ; Signal Transduction ; Vaccines/administration & dosage ; Vaccines/chemical synthesis
Chemical Substances	Antineoplastic Agents ; Biocompatible Materials ; Fungal Polysaccharides ; Immunologic Factors ; Vaccines
Keywords	covid19
Language	English
Publishing date	2020-06-13
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2020.116613
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Article ; Online: K-Nearest Neighbor algorithm for selection of new gelatin-carboxymethylcellulose films with TiO₂ nanoparticles and propolis extract with antioxidant and light barrier activity

Brito, Raíra Sá de / Costa, Marcos Jhony Almeida / Barbosa, Jhonatas Rodrigues / Filho, Adilson Ferreira Santos / de Souza Farias, Fabricio / Lourenço, Lúcia de Fátima Henriques

Food Packaging and Shelf Life. 2023 Sept., v. 38 p.101119-

2023

Abstract: Nanoparticles associated with antioxidant ingredients emerge as a new strategy to improve food packaging properties. In this study, we developed gelatin-carboxymethylcellulose films containing propolis extract and TiO₂ nanoparticles (1 % and 5 %), and ... ...

Abstract	Nanoparticles associated with antioxidant ingredients emerge as a new strategy to improve food packaging properties. In this study, we developed gelatin-carboxymethylcellulose films containing propolis extract and TiO₂ nanoparticles (1 % and 5 %), and the K-Nearest Neighbor algorithm was used to select the best packaging composition. Films showed excellent antioxidant activity and those mixed with nanoparticles performed better with light and water barrier properties. The film with propolis and 5 % TiO₂ nanoparticles showed higher antioxidant activity and opacity, lower water vapor permeability, solubility, water activity, moisture content, and thickness. These results indicate that the KNN algorithm, an artificial intelligence tool, is promising for classifying and selecting films with properties of interest. The films containing propolis extract and TiO₂ nanoparticles have excellent properties that validate their application as food packaging.
Keywords	algorithms ; antioxidant activity ; antioxidants ; artificial intelligence ; nanoparticles ; opacity ; permeability ; propolis ; shelf life ; solubility ; water activity ; water content ; water vapor ; K-Nearest Neighbor algorithm ; Propolis extract ; Food packaging
Language	English
Dates of publication	2023-09
Publishing place	Elsevier Ltd
Document type	Article ; Online
ISSN	2214-2894
DOI	10.1016/j.fpsl.2023.101119
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A new edible coating of fish gelatin incorporated into açaí oil to increase the post-harvest shelf life of tomatoes.

da Silva, Ana Caroline Pereira / Barbosa, Jhonatas Rodrigues / da Silva Araújo, Cleidiane / Sousa Batista, Jáira Thayse / Xavier Neves, Eleda Maria Paixão / Pereira Cardoso, Dilson Nazareno / Peixoto Joele, Maria Regina Sarkis / de Fátima Henriques Lourenço, Lúcia

Food chemistry

2023 Volume 438, Page(s) 138047

Abstract: Açaí oil (Euterpe oleracea) is a new active ingredient, originating from the Amazon Forest, which offers numerous benefits as an antioxidant and antimicrobial agent. Here, we report how açaí oil can be used as an active ingredient in gelatin coatings to ... ...

Abstract	Açaí oil (Euterpe oleracea) is a new active ingredient, originating from the Amazon Forest, which offers numerous benefits as an antioxidant and antimicrobial agent. Here, we report how açaí oil can be used as an active ingredient in gelatin coatings to increase the shelf life of tomatoes. The optimized viscosity and gel strength conditions were 5.40 % gelatin, 17.25 % açaí oil and 18 % plasticizer. FTIR, XRD and zeta potential analysis reveals that repulsive forces dominate the interactions between açaí oil and gelatin. The optimized coating (GAO) reduced mass loss by 8 % and achieved greater firmness (25 N), proving its effectiveness in maintaining tomato quality during storage. For the first time, it was found that the addition of açaí oil to fish gelatin improves the percentage of acidity and firmness of the tomato, delaying ripening, making it a promising alternative as packaging for climacteric fruits.
MeSH term(s)	Animals ; Solanum lycopersicum ; Gelatin ; Edible Films ; Antioxidants ; Fruit ; Euterpe
Chemical Substances	Gelatin (9000-70-8) ; Antioxidants
Language	English
Publishing date	2023-11-24
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2023.138047
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Geographical Discrimination of Ground Amazon Cocoa by Near-Infrared Spectroscopy: Influence of Sample Preparation

Negrão Ferreira, Fabielle / Albuquerque Chagas-Junior, Gilson Celso / Santana de Oliveira, Mozaniel / Rodrigues Barbosa, Jhonatas / Chaves Oliveira, Marcos Enê / Santos Lopes, Alessandra

Journal of food quality. 2022 July 31, v. 2022

2022

Abstract: This work presents the application of the NIR technique associated with exploratory analysis of spectral data by main principal components for the discrimination of Amazon cocoa ground seeds. Cocoa samples from different geographic regions of the state ... ...

Abstract	This work presents the application of the NIR technique associated with exploratory analysis of spectral data by main principal components for the discrimination of Amazon cocoa ground seeds. Cocoa samples from different geographic regions of the state of Pará, Brazil (Medicilândia, Tucumã, and Tomé-Açu), were evaluated. The samples collected from each region were divided into four groups distinguished by the treatment applied to the samples, which were fermented (1-with fat and 2-fat-free) and unfermented (3-with moisture and 4-dried). Each set of samples was analyzed separately to identify the influence of moisture, fermentation, and fat on the geographical differentiation of the three regions. From the results obtained, it can be observed that it was not possible to differentiate the samples of seeds not fermented by geographic origin. However, fermentation was crucial for efficient discrimination, providing more defined clusters for each geographic region. The presence of fat in the seeds was a determinant to obtain the best model of geographic discrimination.
Keywords	fermentation ; food quality ; models ; near-infrared spectroscopy ; provenance ; spectral analysis ; Brazil
Language	English
Dates of publication	2022-0731
Publishing place	Hindawi
Document type	Article
ZDB-ID	2175284-9
ISSN	1745-4557
ISSN	1745-4557
DOI	10.1155/2022/8126810
Database	NAL-Catalogue (AGRICOLA)

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Article: From waste to sustainable industry: How can agro-industrial wastes help in the development of new products?

Freitas, Lucas Cantão / Barbosa, Jhonatas Rodrigues / da Costa, Ana Laura Caldas / Bezerra, Fernanda Wariss Figueiredo / Pinto, Rafael Henrique Holanda / Carvalho Junior, Raul Nunes de

Resources, conservation, and recycling. 2021 June, v. 169

2021

Abstract: Demand for food production has been promoting an increase in the generation of agro-industrial wastes. Although in the past these wastes were mainly seen as a big issue, in the current scenario they are seen as the key strategy for the development of ... ...

Abstract	Demand for food production has been promoting an increase in the generation of agro-industrial wastes. Although in the past these wastes were mainly seen as a big issue, in the current scenario they are seen as the key strategy for the development of sustainable industrial processes. In this context, several new environmentally friendly technologies such as supercritical fluid extraction (SFE), microwave-assisted extraction (MAE) and ultrasound-assisted extraction (UAE) have been studied and applied to obtain products with high added value in order to supply the chemical, pharmaceutical and food industries. Similarly, the energy generation from biomass and production of new biomaterials such as bionanofilms, bioaerogels, hydrogels and nanocomposites have been intensely studied in order to cross the barriers of the laboratory scale. Therefore, this review aims to update the scientific community, industries, governments and society on the sustainable applications, latest advances and trends in the valorization of agro-industrial wastes for new product development, highlighting the new possibilities for the progress of sustainable production.
Keywords	biocompatible materials ; biomass ; energy ; food production ; hydrogels ; microwave treatment ; nanocomposites ; product development ; supercritical fluid extraction ; ultrasonic treatment
Language	English
Dates of publication	2021-06
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1498716-8
ISSN	0921-3449
ISSN	0921-3449
DOI	10.1016/j.resconrec.2021.105466
Database	NAL-Catalogue (AGRICOLA)

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