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Article: An unusual case of infectious spondylodiscitis.

Kroot, E J A / Wouters, J M W G

2007 Volume 46, Issue 8, Page(s) 1296

MeSH term(s)	Adult ; Bacterial Infections/diagnosis ; Candidiasis/diagnosis ; Crohn Disease/complications ; Crohn Disease/diagnosis ; Discitis/etiology ; Discitis/microbiology ; Humans ; Magnetic Resonance Imaging ; Male ; Positron-Emission Tomography
Language	English
Publishing date	2007-08
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/kem110
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Article ; Online: Hepcidin in human iron disorders: diagnostic implications.

Kroot, Joyce J C / Tjalsma, Harold / Fleming, Robert E / Swinkels, Dorine W

Clinical chemistry

2011 Volume 57, Issue 12, Page(s) 1650–1669

Abstract: ... 25, and 2 smaller forms, i.e., hepcidin-22 and -20; however, only hepcidin-25 has been shown ...

Abstract	Background: The peptide hormone hepcidin plays a central role in regulating dietary iron absorption and body iron distribution. Many human diseases are associated with alterations in hepcidin concentrations. The measurement of hepcidin in biological fluids is therefore a promising tool in the diagnosis and management of medical conditions in which iron metabolism is affected. Content: We describe hepcidin structure, kinetics, function, and regulation. We moreover explore the therapeutic potential for modulating hepcidin expression and the diagnostic potential for hepcidin measurements in clinical practice. Summary: Cell-culture, animal, and human studies have shown that hepcidin is predominantly synthesized by hepatocytes, where its expression is regulated by body iron status, erythropoietic activity, oxygen tension, and inflammatory cytokines. Hepcidin lowers serum iron concentrations by counteracting the function of ferroportin, a major cellular iron exporter present in the membrane of macrophages, hepatocytes, and the basolateral site of enterocytes. Hepcidin is detected in biologic fluids as a 25 amino acid isoform, hepcidin-25, and 2 smaller forms, i.e., hepcidin-22 and -20; however, only hepcidin-25 has been shown to participate in the regulation of iron metabolism. Reliable assays to measure hepcidin in blood and urine by use of immunochemical and mass spectrometry methods have been developed. Results of proof-of-principle studies have highlighted hepcidin as a promising diagnostic tool and therapeutic target for iron disorders. However, before hepcidin measurements can be used in routine clinical practice, efforts will be required to assess the relevance of hepcidin isoform measurements, to harmonize the different assays, to define clinical decision limits, and to increase assay availability for clinical laboratories.
MeSH term(s)	Animals ; Antimicrobial Cationic Peptides/analysis ; Antimicrobial Cationic Peptides/deficiency ; Antimicrobial Cationic Peptides/physiology ; Biomarkers/analysis ; Erythropoiesis ; Hepcidins ; Humans ; Hypoxia/metabolism ; Inflammation/metabolism ; Iron/blood ; Iron Metabolism Disorders/diagnosis ; Iron Metabolism Disorders/drug therapy ; Iron Metabolism Disorders/metabolism ; Molecular Targeted Therapy ; Protein Conformation ; Reference Values
Chemical Substances	Antimicrobial Cationic Peptides ; Biomarkers ; HAMP protein, human ; Hepcidins ; Iron (E1UOL152H7)
Language	English
Publishing date	2011-10-11
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	80102-1
ISSN	1530-8561 ; 0009-9147
ISSN (online)	1530-8561
ISSN	0009-9147
DOI	10.1373/clinchem.2009.140053
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Article ; Online: The iron regulatory hormone hepcidin is decreased in pregnancy: a prospective longitudinal study.

van Santen, Susanne / Kroot, Joyce J C / Zijderveld, Gerard / Wiegerinck, Erwin T / Spaanderman, Marc E A / Swinkels, Dorine W

Clinical chemistry and laboratory medicine

2013 Volume 51, Issue 7, Page(s) 1395–1401

Abstract: Background: Iron deficiency is a commonly encountered problem in pregnancy and a frequently observed cause of pregnancy-associated anemia. We longitudinally assessed the iron regulatory hormone hepcidin during gestation and postpartum and related ... ...

Abstract	Background: Iron deficiency is a commonly encountered problem in pregnancy and a frequently observed cause of pregnancy-associated anemia. We longitudinally assessed the iron regulatory hormone hepcidin during gestation and postpartum and related hepcidin to conventional indicators of iron status and inflammation. Methods: Thirty-one healthy pregnant women were included and 81 blood samples from the three trimesters, directly and 6 weeks postpartum were analyzed for hemoglobin, the iron parameters: iron, total iron binding capacity, transferrin saturation, ferritin, soluble transferrin receptor and hepcidin, and CRP and leucocytes as markers of inflammation. Results: Hepcidin concentration decreased gradually from the first to the second and third trimester to undetectable levels (≤ 0.5 nmol/L) which was paralleled by decreasing hemoglobin levels and changes in iron parameters indicative for iron deficiency. During gestation hepcidin levels correlated with iron parameters, but not with inflammatory markers. Postpartum, hepcidin increased immediately to levels similar as assessed at early pregnancy. Conclusions: We conclude that hepcidin levels were suppressed during the second and third trimester of pregnancy, which was likely determined by the occurrence of iron deficiency. These data give insight in iron homeostasis during normal pregnancy.
MeSH term(s)	Adult ; Anemia, Iron-Deficiency/blood ; Biomarkers/blood ; C-Reactive Protein/analysis ; Female ; Ferritins/blood ; Hepcidins/blood ; Humans ; Iron/blood ; Postpartum Period/blood ; Pregnancy ; Pregnancy Trimesters/blood ; Prospective Studies ; Receptors, Transferrin/blood ; Time Factors
Chemical Substances	Biomarkers ; Hepcidins ; Receptors, Transferrin ; C-Reactive Protein (9007-41-4) ; Ferritins (9007-73-2) ; Iron (E1UOL152H7)
Language	English
Publishing date	2013-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2012-0576
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Article ; Online: Time-course analysis of serum hepcidin, iron and cytokines in a C282Y homozygous patient with Schnitzler's syndrome treated with IL-1 receptor antagonist.

van Deuren, Marcel / Kroot, Joyce J C / Swinkels, Dorine W

Haematologica

2009 Volume 94, Issue 9, Page(s) 1297–1300

Abstract: ... hemochromatosis who was treated for an auto-inflammatory condition, i.e. variant Schnitzler's syndrome ...

Abstract	It is currently unknown if the increase of the hepatic iron regulatory hormone hepcidin during inflammation in man depends on an intact HFE-protein. Here we describe the temporal relationship of serum hepcidin, serum iron and cytokines in a patient with HFE-related (C282Y homozygous) hereditary hemochromatosis who was treated for an auto-inflammatory condition, i.e. variant Schnitzler's syndrome, with the potent anti-inflammatory cytokine inter-leukin-1 receptor antagonist (IL-1ra, anakinra). The patient had bouts of fever with peaking serum IL-6 concentrations followed by peaking serum hepcidin levels, while serum iron was low. Upon treatment, these peaks disappeared and hepcidin levels became non-detectable, consistent with HFE deficiency. In conclusion, this in vivo human model: i) supports the importance of an HFE-independent IL-6-hepcidin axis in the development of hypoferremia and anemia of inflammation; and ii) suggests that chronic inflammation protects patients with HFE-related hereditary hemochromatosis from iron accumulation.
MeSH term(s)	Antimicrobial Cationic Peptides/blood ; Antimicrobial Cationic Peptides/genetics ; Antirheumatic Agents/administration & dosage ; Hemochromatosis/blood ; Hemochromatosis/drug therapy ; Hemochromatosis/genetics ; Hemochromatosis Protein ; Hepcidins ; Histocompatibility Antigens Class I/blood ; Histocompatibility Antigens Class I/genetics ; Homozygote ; Humans ; Interleukin 1 Receptor Antagonist Protein/administration & dosage ; Interleukin-6/blood ; Iron/blood ; Male ; Membrane Proteins/blood ; Membrane Proteins/genetics ; Middle Aged ; Mutation, Missense ; Schnitzler Syndrome/blood ; Schnitzler Syndrome/drug therapy ; Schnitzler Syndrome/genetics ; Time Factors
Chemical Substances	Antimicrobial Cationic Peptides ; Antirheumatic Agents ; HAMP protein, human ; HFE protein, human ; Hemochromatosis Protein ; Hepcidins ; Histocompatibility Antigens Class I ; IL6 protein, human ; Interleukin 1 Receptor Antagonist Protein ; Interleukin-6 ; Membrane Proteins ; Iron (E1UOL152H7)
Language	English
Publishing date	2009-07-16
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	2333-4
ISSN	1592-8721 ; 0017-6567 ; 0390-6078
ISSN (online)	1592-8721
ISSN	0017-6567 ; 0390-6078
DOI	10.3324/haematol.2009.005975
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Article ; Online: Physical activity and body composition in patients with ankylosing spondylitis.

Plasqui, G / Boonen, A / Geusens, P / Kroot, E J / Starmans, M / van der Linden, S

Arthritis care & research

2012 Volume 64, Issue 1, Page(s) 101–107

Abstract: Objective: Patients with ankylosing spondylitis (AS) are at risk for accelerated muscle loss and reduced physical activity. Accurate data are needed on body composition and physical activity in this patient group. The purpose of this study was to ... ...

Abstract	Objective: Patients with ankylosing spondylitis (AS) are at risk for accelerated muscle loss and reduced physical activity. Accurate data are needed on body composition and physical activity in this patient group. The purpose of this study was to investigate body composition and objectively assessed physical activity in patients with AS. Methods: Twenty-five AS patients (15 men, mean ± SD age 48 ± 11 years) were compared with 25 healthy adults matched for age, sex, and body mass index. Body composition was measured using a 3-compartment model based on air-displacement plethysmography to assess body volume and deuterium dilution to assess total body water. The fat-free mass index (FFMI; fat-free mass divided by height squared) and the percent fat mass (%FM) were calculated. Daily physical activity was assessed for 7 days using a triaxial accelerometer and physical fitness with an incremental test until exertion on a bicycle ergometer. Blood samples were taken to determine C-reactive protein (CRP) level and tumor necrosis factor α. Results: Accelerometer output (kilocounts/day) showed the same physical activity level for patients and controls (mean ± SD 319 ± 105 versus 326 ± 66). There was no difference in the FFMI or %FM between the patients and controls. Physical activity was positively related to the FFMI (partial R = 0.38, P = 0.01) and inversely related to CRP level (R = -0.39, P < 0.01), independent of group. CRP level was inversely related to the FFMI, but the effect was less strong than with physical activity (partial R = -0.31, P = 0.03). Conclusion: Daily physical activity may help preserve fat-free mass in patients with AS.
MeSH term(s)	Actigraphy/instrumentation ; Adolescent ; Adult ; Aged ; Analysis of Variance ; Biomarkers/blood ; Body Composition ; Body Mass Index ; Body Water/metabolism ; C-Reactive Protein/analysis ; Case-Control Studies ; Exercise Test ; Female ; Humans ; Inflammation Mediators/blood ; Linear Models ; Male ; Middle Aged ; Motor Activity ; Netherlands ; Plethysmography ; Spondylitis, Ankylosing/blood ; Spondylitis, Ankylosing/diagnosis ; Spondylitis, Ankylosing/physiopathology ; Tumor Necrosis Factor-alpha/blood ; Young Adult
Chemical Substances	Biomarkers ; Inflammation Mediators ; Tumor Necrosis Factor-alpha ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2012-01
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	645059-3
ISSN	2151-4658 ; 0893-7524 ; 2151-464X
ISSN (online)	2151-4658
ISSN	0893-7524 ; 2151-464X
DOI	10.1002/acr.20566
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Article: Poncet's disease: reactive arthritis accompanying tuberculosis. Two case reports and a review of the literature.

Kroot, E J A / Hazes, J M W / Colin, E M / Dolhain, R J E M

Rheumatology (Oxford, England)

2007 Volume 46, Issue 3, Page(s) 484–489

Abstract: Objective: Reactive arthritis (ReA) in tuberculosis (TB) is known as Poncet's disease. It is a rare aseptic form of arthritis observed in patients with active TB. We present two such patients and review the literature on Poncet's disease.: Methods: ... ...

Abstract	Objective: Reactive arthritis (ReA) in tuberculosis (TB) is known as Poncet's disease. It is a rare aseptic form of arthritis observed in patients with active TB. We present two such patients and review the literature on Poncet's disease. Methods: Two patients who were identified with Poncet's disease at the Department of Rheumatology of Erasmus MC, Rotterdam University Hospital, during the last 5 yrs are reported. In addition, a review of the literature on Poncet's disease is given: the PubMed/MEDLINE database was studied up to December 2005 using the term 'Poncet's disease' and the terms 'arthritis', 'reactive' and 'tuberculosis'. Results: After careful work-up, the polyarthritis and erythema nodosum in both presented patients with active TB could be diagnosed as Poncet's disease. Resolution of the arthritis with anti-TB drugs occurred in just a few days. Reviewing the literature, 50 case reports were found. In most reports 'Poncet's disease' was described as an aseptic polyarthritis, presumably ReA arthritis developing in the presence of active TB elsewhere. However, no uniform characterization of the term 'Poncet's disease' could be abstracted from these reports. Conclusion: Both presented patients and the review of the literature demonstrate that active TB may be complicated by ReA known as Poncet's disease. Early recognition of this rare complication of TB is of major importance to avoid delayed initiation of appropriate treatment.
MeSH term(s)	Adult ; Antitubercular Agents/therapeutic use ; Arthritis, Reactive/diagnosis ; Arthritis, Reactive/drug therapy ; Diagnosis, Differential ; Erythema Nodosum/diagnosis ; Erythema Nodosum/microbiology ; Humans ; Male ; Middle Aged ; Tuberculosis, Osteoarticular/diagnosis ; Tuberculosis, Osteoarticular/drug therapy
Chemical Substances	Antitubercular Agents
Language	English
Publishing date	2007-03
Publishing country	England
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/kel268
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Article: Methotrexate toxicity causing pseudomembraneous laryngotracheitis.

Kroot, E J A / van Nederveen, F H / Ten Koppel, P G J

European journal of internal medicine

2006 Volume 17, Issue 7, Page(s) 526

Language	English
Publishing date	2006-11
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1038679-8
ISSN	0953-6205
ISSN	0953-6205
DOI	10.1016/j.ejim.2006.02.027
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Article: Sarcoidosis in a clinically unaffected joint demonstrated by somatostatin receptor scintigraphy.

Kroot, Eric-Jan A / Dolhain, R J E M / van Hagen, P M / Kwekkeboom, D J

Clinical nuclear medicine

2006 Volume 31, Issue 8, Page(s) 501–503

MeSH term(s)	Adult ; Female ; Humans ; Indium Radioisotopes ; Knee Joint/diagnostic imaging ; Lymphatic Diseases/diagnostic imaging ; Octreotide/analogs & derivatives ; Pentetic Acid/analogs & derivatives ; Radionuclide Imaging ; Radiopharmaceuticals ; Receptors, Somatostatin/metabolism ; Sarcoidosis/diagnostic imaging
Chemical Substances	111In-octreotide, DTPA(0)- ; Indium Radioisotopes ; Radiopharmaceuticals ; Receptors, Somatostatin ; Pentetic Acid (7A314HQM0I) ; Octreotide (RWM8CCW8GP)
Language	English
Publishing date	2006-08
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/01.rlu.0000227653.88404.9b
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Article ; Online: Development of a scale for estimating procedural distress in the newborn intensive care unit: the Procedural Load Index.

Schiavenato, Martin / Antos, Stephen A / Bell, Frances A / Freedman, Benjamin R / Kozak, Adam J / Kroot, Travis B / Lam, Eric H / Ross, Kirsten E / Sternfield, Brett A / Carney, Laurel H

Early human development

2013 Volume 89, Issue 9, Page(s) 615–619

Abstract: Background: Infants in the newborn intensive care unit (NICU) are exposed to routine procedures that often cause distress and carry a negative burden or load on the infant's neurodevelopment.: Aim: A ratio level index is introduced to estimate ... ...

Abstract	Background: Infants in the newborn intensive care unit (NICU) are exposed to routine procedures that often cause distress and carry a negative burden or load on the infant's neurodevelopment. Aim: A ratio level index is introduced to estimate procedural load so as to begin to develop a system to monitor the intensity of distress associated with common NICU procedures. Study design: Two psychophysical methods, magnitude estimation (ME) and the general labeled magnitude scale (gLMS) were used to survey 86 clinicians via the internet to estimate the distress associated with 55 common NICU procedures. Results: gLMS and ME estimations correlated highly across all procedures (r = 0.97). gLMS values were used to derive the procedural load index (PLI) as a ratio level estimation of procedural distress. Conclusion: The PLI ranks and differentiates distress among common NICU procedures more precisely than current tools. This methodology, if correlated with infant physiological indices and health outcomes, may be operationalized at the bedside to measure procedural distress, and help to guide the ideal timing to perform procedures and minimize their negative consequence.
MeSH term(s)	Data Collection ; Humans ; Infant, Newborn ; Intensive Care Units, Neonatal/standards ; Intensive Care Units, Neonatal/statistics & numerical data ; Intensive Care, Neonatal/methods ; Intensive Care, Neonatal/standards ; Pain Measurement ; Process Assessment, Health Care
Language	English
Publishing date	2013-05-11
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	752532-1
ISSN	1872-6232 ; 0378-3782
ISSN (online)	1872-6232
ISSN	0378-3782
DOI	10.1016/j.earlhumdev.2013.04.007
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Article ; Online: Second round robin for plasma hepcidin methods: first steps toward harmonization.

Kroot, Joyce J C / van Herwaarden, Antonius E / Tjalsma, Harold / Jansen, Rob T P / Hendriks, Jan C M / Swinkels, Dorine W

American journal of hematology

2012 Volume 87, Issue 10, Page(s) 977–983

Abstract: Measurements of the iron regulatory hormone hepcidin by various methodologies and laboratories are not harmonized. As a result different numeric results are obtained for the same clinical sample. We investigated whether better agreement between plasma ... ...

Abstract	Measurements of the iron regulatory hormone hepcidin by various methodologies and laboratories are not harmonized. As a result different numeric results are obtained for the same clinical sample. We investigated whether better agreement between plasma hepcidin methods can be achieved by harmonization. Native plasma pools (n = 11) of a variety of hepcidin concentrations and blank plasma spiked with three different quantities of synthetic hepcidin-25 purchased from two different commercial sources (n = 6), were distributed in duplicate among 21 methods worldwide. We assessed commutability by comparing results from synthetic hepcidin with those from native samples in various method couples by Bland-Altman plots. Methods differed substantially in absolute values and reproducibility. For the majority of methods we found that samples with synthetic hepcidin-25 were noncommutable with the native samples. In an attempt to harmonize by using native hepcidin results, we selected two methods that showed good mutual agreement of native results and calculated consensus values as the medians for the 11 duplicate native samples obtained by these two methods. Finally, we constructed algorithms enabling the laboratories to calculate the hepcidin consensus (HEPCON) value using their own native hepcidin results. We found that the use of these algorithms substantially reduced the between-method CV. Until commutable materials are defined, hepcidin harmonization can be achieved by exploiting specific algorithms, allowing each lab to report their native hepcidin concentrations in HEPCON values. This study represents the first step toward harmonization of plasma hepcidin methods and facilitates aggregation of hepcidin data from different research investigations.
MeSH term(s)	Algorithms ; Antimicrobial Cationic Peptides/blood ; Calibration ; Chromatography, High Pressure Liquid ; Enzyme-Linked Immunosorbent Assay ; Hepcidins ; Humans ; Immunochemistry/methods ; Laboratories ; Ligands ; Mass Spectrometry/methods ; Prospective Studies ; Radioimmunoassay ; Reference Standards ; Reproducibility of Results ; Single-Blind Method ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Chemical Substances	Antimicrobial Cationic Peptides ; HAMP protein, human ; Hepcidins ; Ligands ; hepcidin 25, human
Language	English
Publishing date	2012-10
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	196767-8
ISSN	1096-8652 ; 0361-8609
ISSN (online)	1096-8652
ISSN	0361-8609
DOI	10.1002/ajh.23289
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