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  1. Book ; Online: Is the U.S. Legal System Ready for AI's Challenges to Human Values?

    Cheong, Inyoung / Caliskan, Aylin / Kohno, Tadayoshi

    2023  

    Abstract: Our interdisciplinary study investigates how effectively U.S. laws confront the challenges posed ...

    Abstract Our interdisciplinary study investigates how effectively U.S. laws confront the challenges posed by Generative AI to human values. Through an analysis of diverse hypothetical scenarios crafted during an expert workshop, we have identified notable gaps and uncertainties within the existing legal framework regarding the protection of fundamental values, such as privacy, autonomy, dignity, diversity, equity, and physical/mental well-being. Constitutional and civil rights, it appears, may not provide sufficient protection against AI-generated discriminatory outputs. Furthermore, even if we exclude the liability shield provided by Section 230, proving causation for defamation and product liability claims is a challenging endeavor due to the intricate and opaque nature of AI systems. To address the unique and unforeseeable threats posed by Generative AI, we advocate for legal frameworks that evolve to recognize new threats and provide proactive, auditable guidelines to industry stakeholders. Addressing these issues requires deep interdisciplinary collaborations to identify harms, values, and mitigation strategies.

    Comment: 25 pages, 7 figures
    Keywords Computer Science - Computers and Society ; Computer Science - Artificial Intelligence ; Computer Science - Computation and Language
    Subject code 303
    Publishing date 2023-08-30
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Design of S-S bond containing maleimide-conjugated closo-dodecaborate (SSMID): identification of unique modification sites on albumin and investigation of intracellular uptake.

    Ishii, Satomu / Sato, Shinichi / Asami, Hiroya / Hasegawa, Tomoko / Kohno, Jun-Ya / Nakamura, Hiroyuki

    Organic & biomolecular chemistry

    2019  Volume 17, Issue 22, Page(s) 5496–5499

    Abstract: An S-S bond containing maleimide-conjugated closo-dodecaborate (SSMID) was synthesised ...

    Abstract An S-S bond containing maleimide-conjugated closo-dodecaborate (SSMID) was synthesised for identification of albumin binding sites. Three Lys residues, Lys221, Lys413 and Lys431, were identified as SSMID modification sites in addition to Cys34 in bovin serum albumin (BSA). Fluorescent-labelled MID-BSA was found to be accumulated in the cytosol of HeLa cells.
    MeSH term(s) Animals ; Binding Sites ; Boron Compounds/chemical synthesis ; Boron Compounds/chemistry ; Cattle ; Disulfides/chemistry ; HeLa Cells ; Humans ; Maleimides/chemistry ; Molecular Structure ; Serum Albumin, Bovine/chemistry
    Chemical Substances Boron Compounds ; Disulfides ; Maleimides ; dodecaborate (12008-78-5) ; maleimide (2519R1UGP8) ; Serum Albumin, Bovine (27432CM55Q)
    Language English
    Publishing date 2019-04-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/c9ob00584f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Newly developed self-expandable Niti-S MD colonic metal stent for malignant colonic obstruction.

    Miyasako, Yuki / Kuwai, Toshio / Ishaq, Sauid / Tao, Kanae / Konishi, Hirona / Miura, Ryoichi / Sumida, Yuki / Kuroki, Kazutaka / Tamaru, Yuzuru / Kusunoki, Ryusaku / Yamaguchi, Atsushi / Kouno, Hirotaka / Kohno, Hiroshi

    World journal of gastrointestinal surgery

    2020  Volume 12, Issue 4, Page(s) 138–148

    Abstract: ... The WallFlex and Niti-S D type stents are the commonly used self-expandable metallic stents available in Japan ... S D type stent has a risk of obstructive colitis because of its weaker radial force. Niti-S MD type ... smaller-caliber colonoscopes.: Aim: To compare the efficacy and safety of the newly developed Niti-S MD ...

    Abstract Background: Colonic stents are increasingly used to treat acute malignant colonic obstructions. The WallFlex and Niti-S D type stents are the commonly used self-expandable metallic stents available in Japan since 2012. WallFlex stent has a risk of stent-related perforation because of its axial force, while the Niti-S D type stent has a risk of obstructive colitis because of its weaker radial force. Niti-S MD type stents not only overcome these limitations but also permit delivery through highly flexible-tipped smaller-caliber colonoscopes.
    Aim: To compare the efficacy and safety of the newly developed Niti-S MD type colonic stents.
    Methods: This single-center retrospective observational study included 110 patients with endoscopic self-expandable metallic stents placed between November 2011 and December 2018: WallFlex (Group W,
    Results: The technical success rate was 100% in Groups W, N, and MD, and the overall clinical success rate was 89.2% (33/37), 96.2% (51/53), and 100% (20/20) in Groups W, N, and MD, respectively. Early adverse events included pain (3/37, 8.1%), poor expansion (1/37, 2.7%), and fever (1/37, 2.6%) in Group W and perforation due to obstructive colitis (2/53, 3.8%) in Group N (likely due to poor expansion). Late adverse events (after 7 d) included stent-related perforations (4/36, 11.1%) and stent occlusion (1/36, 2.8%) in Group W and stent occlusion (2/51, 3.9%) in Group N. The stent-related perforation rate in Group W was significantly higher than that in Group N (
    Conclusion: In our early and limited experience, the newly developed Niti-S MD type colonic stent was effective and safe for treating acute malignant colonic obstruction.
    Language English
    Publishing date 2020-05-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573700-4
    ISSN 1948-9366
    ISSN 1948-9366
    DOI 10.4240/wjgs.v12.i4.138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Correction to: Analysis of glutathione S-transferase and cytochrome P450 gene polymorphism in recipients of dose-adjusted busulfan-cyclophosphamide conditioning.

    Terakura, Seitaro / Onizuka, Makoto / Fukumoto, Mariko / Kuwatsuka, Yachiyo / Kohno, Akio / Ozawa, Yukiyasu / Miyamura, Koichi / Inagaki, Yuichiro / Sawa, Masashi / Atsuta, Yoshiko / Suzuki, Ritsuro / Naoe, Tomoki / Morishita, Yoshihisa / Murata, Makoto

    International journal of hematology

    2019  Volume 111, Issue 1, Page(s) 159–160

    Abstract: In the original article of Terakura et al., the COI disclosure were missing. ...

    Abstract In the original article of Terakura et al., the COI disclosure were missing.
    Language English
    Publishing date 2019-11-26
    Publishing country Japan
    Document type Published Erratum
    ZDB-ID 1076875-0
    ISSN 1865-3774 ; 0917-1258 ; 0925-5710
    ISSN (online) 1865-3774
    ISSN 0917-1258 ; 0925-5710
    DOI 10.1007/s12185-019-02783-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Analysis of glutathione S-transferase and cytochrome P450 gene polymorphism in recipients of dose-adjusted busulfan-cyclophosphamide conditioning.

    Terakura, Seitaro / Onizuka, Makoto / Fukumoto, Mariko / Kuwatsuka, Yachiyo / Kohno, Akio / Ozawa, Yukiyasu / Miyamura, Koichi / Inagaki, Yuichiro / Sawa, Masashi / Atsuta, Yoshiko / Suzuki, Ritsuro / Naoe, Tomoki / Morishita, Yoshihisa / Murata, Makoto

    International journal of hematology

    2019  Volume 111, Issue 1, Page(s) 84–92

    Abstract: ... influence of glutathione S-transferase (GST) and cytochrome P450 (CYP) genotypes on plasma BU concentration ...

    Abstract Sporadic incidence of veno-occlusive disease (VOD) continues to occur, despite achievement of recommended busulfan (BU) concentrations after real-time BU dose adjustment. To explore the potential influence of glutathione S-transferase (GST) and cytochrome P450 (CYP) genotypes on plasma BU concentration, subsequent VOD, and transplant outcome, we assessed the polymorphisms of multiple GST and CYP genes. Fifty-five patients were included (median age 38 years; range 21-67). Of these, 49 received dose-adjusted BU/CY therapy. Twenty-six patients received transplants from human leukocyte antigen-identical siblings, 26 from unrelated donors. The GSTA1*A/*A genotype was significantly associated with lower BU first-dose area under curve (AUC1st). We found that patients with higher AUC1st showed a significantly higher serum total bilirubin during the first month after transplantation, but this was not necessarily associated with subsequent development of VOD. We further analyzed a possible association of GST and CYP polymorphisms and VOD development, and found none of the polymorphisms investigated was associated with VOD incidence. Regarding transplant outcomes, GSTM1-positive patients showed lower relapse rates and better overall survival in multivariate analyses. These results suggest that a GSTM1-positive genotype in patients receiving BU/CY conditioning protects against relapse of hematological malignancies after allogeneic hematopoietic stem cell transplantation.
    MeSH term(s) Adult ; Aged ; Alleles ; Area Under Curve ; Busulfan/administration & dosage ; Busulfan/pharmacokinetics ; Cyclophosphamide/administration & dosage ; Cytochrome P-450 Enzyme System/genetics ; Female ; Glutathione Transferase/genetics ; Haplotypes ; Hematologic Neoplasms/blood ; Hematologic Neoplasms/genetics ; Hematologic Neoplasms/mortality ; Hematologic Neoplasms/therapy ; Hematopoietic Stem Cell Transplantation ; Hepatic Veno-Occlusive Disease/complications ; Hepatic Veno-Occlusive Disease/genetics ; Humans ; Japan ; Male ; Middle Aged ; Polymorphism, Genetic ; Prospective Studies ; Recurrence ; Survival Rate ; Transplantation Conditioning ; Young Adult
    Chemical Substances Cyclophosphamide (8N3DW7272P) ; Cytochrome P-450 Enzyme System (9035-51-2) ; GSTA1 protein, human (EC 2.5.1.18) ; Glutathione Transferase (EC 2.5.1.18) ; glutathione S-transferase M1 (EC 2.5.1.18) ; Busulfan (G1LN9045DK)
    Language English
    Publishing date 2019-09-25
    Publishing country Japan
    Document type Clinical Trial, Phase II ; Journal Article
    ZDB-ID 1076875-0
    ISSN 1865-3774 ; 0917-1258 ; 0925-5710
    ISSN (online) 1865-3774
    ISSN 0917-1258 ; 0925-5710
    DOI 10.1007/s12185-019-02741-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Intermolecular binding between bulk water and dissolved gases in earth’s magnetic field

    Masahiro Kohno / Toshiaki Kamachi / Koji Fukui

    PLoS ONE, Vol 17, Iss

    2022  Volume 5

    Abstract: ... is related to excitation by the Earth’s magnetic field. Using quantum theories such as those used ... of oxygen, nitrogen and hydrogen dissolved in water. The results indicate that the Earth’s magnetic field is ... charge and van der Waals forces results from excitation in the Earth’s magnetic field. ...

    Abstract Elucidation of the static states and dynamic behavior of oxygen and nitrogen dissolved in water is one of the most important issues in the life sciences. In the present study, experimental trials and theoretical calculations were performed based on the hypothesis that the dissolution of gas molecules in water is related to excitation by the Earth’s magnetic field. Using quantum theories such as those used to describe electro magnetic resonance and nuclear magnetic resonance, this study investigated the states of oxygen, nitrogen and hydrogen dissolved in water. The results indicate that the Earth’s magnetic field is involved in the bonding and dissociation of molecules at the gas-liquid interface. These calculations assessed the effect of a field strength of 1.0 x 10−4 T and reproduced the influences of temperature changes on dissolved gas concentrations. Molecular interactions caused by electromagnetic properties and the external geomagnetic field were found to affect intermolar bonding associated with water cluster structures. It is concluded that the binding between molecules typically attributed to Coulomb coupling by magnetic charge and van der Waals forces results from excitation in the Earth’s magnetic field.
    Keywords Medicine ; R ; Science ; Q
    Subject code 541
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Decline of forced expiratory volume in 1 s after allogeneic hematopoietic cell transplantation is a good indicator for pulmonary damage and is associated with busulfan use.

    Sagou, Ken / Ukai, Shun / Adachi, Yoshitaka / Fukushima, Nobuaki / Ozeki, Kazutaka / Kohno, Akio

    International journal of hematology

    2019  Volume 109, Issue 3, Page(s) 299–308

    Abstract: ... s and other parameters. We focused on %FEV1, calculated decline of %FEV1 from pretransplant ...

    Abstract Reduced pulmonary function is commonly observed after allogeneic hematopoietic stem cell transplantation (HSCT); however, its relationship with the development of noninfectious pulmonary complications (NIPCs) is unclear, and the impact of changes in pulmonary function test (PFT) values on HSCT outcome remains controversial. We conducted a retrospective study including 150 patients to investigate changes in PFTs and impact on clinical outcome. PFT data at around 1 year after HSCT were available in 84 patients, and showed a significant time-dependent decline in percentage predicted forced expiratory volume in 1 s and other parameters. We focused on %FEV1, calculated decline of %FEV1 from pretransplant to around 1 year after HSCT (Δ%FEV1), and divided patients into good-Δ%FEV1 or poor-Δ%FEV1 groups, using a cut-off point of 20% decline of Δ%FEV1. In the poor-Δ%FEV1 group, half of the patients developed NIPCs. In the good-Δ%FEV1 group, PFT values were maintained, whereas those of the poor-Δ%FEV1 group declined significantly. Multivariate analysis showed that busulfan use was a risk factor for %FEV1 decline, and poor-Δ%FEV1 was a risk factor for overall survival. These data indicate that decline of %FEV1 may be a useful indicator of pulmonary damage after HSCT, and is strongly associated with busulfan use.
    MeSH term(s) Adult ; Aged ; Allografts ; Busulfan/administration & dosage ; Busulfan/adverse effects ; Disease-Free Survival ; Female ; Forced Expiratory Volume ; Hematopoietic Stem Cell Transplantation ; Humans ; Lung Diseases/chemically induced ; Lung Diseases/mortality ; Lung Diseases/physiopathology ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Survival Rate
    Chemical Substances Busulfan (G1LN9045DK)
    Language English
    Publishing date 2019-01-02
    Publishing country Japan
    Document type Clinical Trial ; Journal Article
    ZDB-ID 1076875-0
    ISSN 1865-3774 ; 0917-1258 ; 0925-5710
    ISSN (online) 1865-3774
    ISSN 0917-1258 ; 0925-5710
    DOI 10.1007/s12185-018-02581-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Adjuvant chemotherapy with S-1 after curative chemoradiotherapy in patients with locoregionally advanced squamous cell carcinoma of the head and neck: Reanalysis of the ACTS-HNC study.

    Kubota, Akira / Nakatani, Eiji / Tsukahara, Kiyoaki / Hasegawa, Yasuhisa / Takemura, Hideki / Terada, Tomonori / Taguchi, Takahide / Nagahara, Kunihiko / Nakatani, Hiroaki / Yoshino, Kunitoshi / Higaki, Yuichiro / Iwae, Shigemichi / Beppu, Takeshi / Hanamure, Yutaka / Tomita, Kichinobu / Kohno, Naoyuki / Kawabata, Kazuyoshi / Teramukai, Satoshi / Fujii, Masato

    PloS one

    2018  Volume 13, Issue 6, Page(s) e0198391

    Abstract: ... increasing CRT intensity has not been shown to improve OS. In the Adjuvant ChemoTherapy with S-1 after ... locoregional treatments improved more with adjuvant chemotherapy with S-1 (tegafur gimeracil oteracil potassium ... than with tegafur/uracil (UFT). ACTS HNC study showed the significant efficacy of S-1 after curative radiotherapy ...

    Abstract Background: Chemoradiotherapy (CRT) has improved organ preservation or overall survival (OS) of locoregionally advanced head and neck squamous cell cancer (LAHNSCC), but in clinical trials of conventional CRT, increasing CRT intensity has not been shown to improve OS. In the Adjuvant ChemoTherapy with S-1 after curative treatment in patients with Head and Neck Cancer (ACTS-HNC) phase III study, OS of curative locoregional treatments improved more with adjuvant chemotherapy with S-1 (tegafur gimeracil oteracil potassium) than with tegafur/uracil (UFT). ACTS HNC study showed the significant efficacy of S-1 after curative radiotherapy in sub-analysis. We explored the efficacy of S-1 after curative CRT in a subset of patients from the ACTS-HNC study.
    Methods: Patients with stage III, IVA, or IVB LAHNSCC were enrolled in this study to evaluate the efficacy of S-1 compared with UFT as adjuvant chemotherapy after curative CRT in the ACTS-HNC study. Patients received S-1 at 80-120 mg/day in two divided doses for 2 weeks, followed by a 1-week rest, or UFT 300 or 400 mg/day in two or three divided doses daily, for 1 year. The endpoints were OS, disease-free survival, locoregional relapse-free survival, distant metastasis-free survival (DMFS), and post-locoregional relapse survival.
    Results: One hundred eighty patients (S-1, n = 87; UFT, n = 93) were included in this study. Clinical characteristics of the S-1 and UFT arms were similar. S-1 after CRT significantly improved OS (hazard ratio [HR], 0.46; 95% confidence interval [CI], 0.22-0.93) and DMFS (HR, 0.50; 95% CI, 0.26-0.97) compared with UFT.
    Conclusion: As adjuvant chemotherapy, S-1 demonstrated better efficacy for OS and DMFS than UFT in patients with LAHNSCC after curative CRT and may be considered a treatment option following curative CRT. For this study was not preplanned in the ACTS-HNC study, the results is hypothesis generating but not definitive.
    MeSH term(s) Adult ; Aged ; Antimetabolites, Antineoplastic/administration & dosage ; Antimetabolites, Antineoplastic/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Chemoradiotherapy ; Chemotherapy, Adjuvant ; Disease-Free Survival ; Drug Administration Schedule ; Drug Combinations ; Female ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/pathology ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Oxonic Acid/administration & dosage ; Oxonic Acid/therapeutic use ; Squamous Cell Carcinoma of Head and Neck/drug therapy ; Squamous Cell Carcinoma of Head and Neck/pathology ; Tegafur/administration & dosage ; Tegafur/therapeutic use ; Treatment Outcome ; Uracil/administration & dosage ; Uracil/therapeutic use
    Chemical Substances Antimetabolites, Antineoplastic ; Drug Combinations ; S 1 (combination) (150863-82-4) ; Tegafur (1548R74NSZ) ; Uracil (56HH86ZVCT) ; Oxonic Acid (5VT6420TIG)
    Keywords covid19
    Language English
    Publishing date 2018-06-08
    Publishing country United States
    Document type Clinical Trial, Phase III ; Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0198391
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A Phase II Study of S-1 for Previously Untreated Elderly Patients with Advanced Non-Small Cell Lung Cancer.

    Kasai, Takashi / Nakamura, Yoichi / Fukuda, Minoru / Kitazaki, Takeshi / Nagashima, Seiji / Takatani, Hiroshi / Nakano, Hirofumi / Nakatomi, Katsumi / Ikeda, Takaya / Yamaguchi, Hiroyuki / Tsukamoto, Kazuhiro / Oka, Mikio / Kohno, Shigeru

    Chemotherapy

    2016  Volume 61, Issue 2, Page(s) 93–98

    Abstract: Background: S-1, a novel oral fluoropyrimidine, is active in the treatment ... of non-small cell lung cancer (NSCLC). However, data on S-1 for elderly patients with NSCLC are insufficient.: Methods ... and adequate hematological, hepatic, and renal functions. Patients received S-1 (40 mg/m(2) twice ...

    Abstract Background: S-1, a novel oral fluoropyrimidine, is active in the treatment of non-small cell lung cancer (NSCLC). However, data on S-1 for elderly patients with NSCLC are insufficient.
    Methods: Eligibility criteria were no prior chemotherapy, stage IIIB or IV NSCLC, performance status 0-1, age >70 years, and adequate hematological, hepatic, and renal functions. Patients received S-1 (40 mg/m(2) twice a day) for 28 consecutive days. This schedule was repeated every 6 weeks. The primary end point was the tumor response rate.
    Results: Thirty-two patients were enrolled and 31 patients were evaluable for response. The patients' median age was 80 years (range: 71-88). The response rate was 22.6% (95% CI: 11-38). Neutropenia, anemia, thrombocytopenia, febrile neutropenia, and diarrhea of grade ≥ 3 occurred in 6, 6, 10, 3, and 3%, respectively.
    Conclusions: In elderly patients with previously untreated advanced NSCLC, S-1 appears to be well tolerated and demonstrates encouraging activity.
    MeSH term(s) Aged ; Aged, 80 and over ; Anemia/chemically induced ; Antimetabolites, Antineoplastic/adverse effects ; Antimetabolites, Antineoplastic/therapeutic use ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/mortality ; Drug Administration Schedule ; Drug Combinations ; Female ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/mortality ; Male ; Nausea/chemically induced ; Neutropenia/chemically induced ; Oxonic Acid/adverse effects ; Oxonic Acid/therapeutic use ; Tegafur/adverse effects ; Tegafur/therapeutic use ; Treatment Outcome ; Vomiting/chemically induced
    Chemical Substances Antimetabolites, Antineoplastic ; Drug Combinations ; S 1 (combination) (150863-82-4) ; Tegafur (1548R74NSZ) ; Oxonic Acid (5VT6420TIG)
    Language English
    Publishing date 2016
    Publishing country Switzerland
    Document type Clinical Trial, Phase II ; Journal Article
    ZDB-ID 6708-8
    ISSN 1421-9794 ; 0009-3157
    ISSN (online) 1421-9794
    ISSN 0009-3157
    DOI 10.1159/000441486
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: [Response to S-1+paclitaxel in far-advanced gastric cancer].

    Aizaki, Kazuo / Kohno, Satoru / Sasaki, Kazunori / Fujihira, Daisuke / Koike, Takuya / Norimatsu, Tohgo / Funatsu, Kentaro / Ohya, Yoshiaki / Shino, Miwa / Yoshida, Toru / Tanaka, Tomohiro / Matsushita, Tsunehisa / Hokari, Takao / Kawakami, Shinjiro / Takano, Seigo / Kazama, Akio

    Gan to kagaku ryoho. Cancer & chemotherapy

    2009  Volume 36, Issue 11, Page(s) 1877–1880

    Abstract: The patient was a 55-year-old man who was treated with S-1 and paclitaxel(PTX ... dissemination, pancreatic invasion, and ascites. A total of 15 courses of S-1 120 mg/day for 2 weeks followed ...

    Abstract The patient was a 55-year-old man who was treated with S-1 and paclitaxel(PTX)combination chemotherapy for inoperable advanced gastric cancer in whom an abdominal CT examination had revealed peritoneal dissemination, pancreatic invasion, and ascites. A total of 15 courses of S-1 120 mg/day for 2 weeks followed by a 2-week rest period and PTX 90 mg/ body on day 1, 8, and 15 were administered. The CT examination after the completion of chemotherapy showed resolution of the ascites, and no evidence of peritoneal dissemination was observed on the images. The tumor marker values had also decreased, but because of severe manifestations of pyloric stenosis, distal gastrectomy and D1 lymph node dissection were performed. Intraoperative exploration revealed total scarring of the peritoneal dissemination and no evidence of pancreatic invasion. We reported this case because of the long-term combination chemotherapy with no major adverse effects and the fact that resection was possible.
    MeSH term(s) Adenocarcinoma/diagnostic imaging ; Adenocarcinoma/drug therapy ; Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Antimetabolites, Antineoplastic/administration & dosage ; Antineoplastic Agents, Phytogenic/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Drug Combinations ; Humans ; Male ; Middle Aged ; Oxonic Acid/administration & dosage ; Paclitaxel/administration & dosage ; Stomach Neoplasms/diagnostic imaging ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery ; Tegafur/administration & dosage ; Tomography, X-Ray Computed
    Chemical Substances Antimetabolites, Antineoplastic ; Antineoplastic Agents, Phytogenic ; Drug Combinations ; S 1 (combination) (150863-82-4) ; Tegafur (1548R74NSZ) ; Oxonic Acid (5VT6420TIG) ; Paclitaxel (P88XT4IS4D)
    Language Japanese
    Publishing date 2009-11
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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