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  1. Article ; Online: Insomnie : les 10 messages clés.

    Léger, Damien

    La Revue du praticien

    2024  Volume 74, Issue 3, Page(s) 303

    Title translation Insomnia: 10 key messages.
    MeSH term(s) Humans ; Sleep Initiation and Maintenance Disorders/diagnosis ; Sleep Initiation and Maintenance Disorders/therapy
    Language French
    Publishing date 2024-03-29
    Publishing country France
    Document type Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Impact économique de l’insomnie.

    Léger, Damien / Pitron, Victor

    La Revue du praticien

    2024  Volume 74, Issue 3, Page(s) 269–270

    Title translation Economic impact of insomnia.
    MeSH term(s) Humans ; Sleep Initiation and Maintenance Disorders/diagnosis ; Sleep Initiation and Maintenance Disorders/epidemiology ; Sleep Initiation and Maintenance Disorders/etiology
    Language French
    Publishing date 2024-03-29
    Publishing country France
    Document type Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Premières consultations pour insomnie et démarche en médecine générale.

    Léger, Damien / Taïeb, Jonathan

    La Revue du praticien

    2024  Volume 74, Issue 3, Page(s) 266–267

    Title translation First consultations for insomnia and gait in general practice.
    MeSH term(s) Humans ; Sleep Initiation and Maintenance Disorders/diagnosis ; Sleep Initiation and Maintenance Disorders/therapy ; Family Practice ; General Practice ; Gait ; Referral and Consultation
    Language French
    Publishing date 2024-03-29
    Publishing country France
    Document type Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Traitements médicamenteux de l’insomnie.

    Vecchierini, Marie-Françoise / Léger, Damien

    La Revue du praticien

    2024  Volume 74, Issue 3, Page(s) 297–302

    Abstract: PHARMACOTHERAPIES FOR INSOMNIA. The first line of treatment in adult chronic insomnia is cognitive behavioral therapy (CBT). However, its difficult accessibility limited its use and medications are still often prescribed. Considering the drugs with ... ...

    Title translation Pharmacotherapies for insomnia.
    Abstract PHARMACOTHERAPIES FOR INSOMNIA. The first line of treatment in adult chronic insomnia is cognitive behavioral therapy (CBT). However, its difficult accessibility limited its use and medications are still often prescribed. Considering the drugs with marketing authorization, Z-drugs (zolpidem and zopiclone) if taken at the right hour and dosage promote sleep initiation and have less deleterious effects than benzodiazepines, especially the long-acting ones which should be avoided. This class of drugs cannot be prescribed longer than 28 days. Some antihistaminic licensed drugs are authorized as hypnotics, with a low proof of efficacy and a risk of adverse event as sedation and somnolence the next day. Their prescription should be avoided in old subjects. Some clinicians used antidepressant sedative medications, at low dosage, as hypnotic drugs but "off label", outside authorization. Now melatonin, an endogenous synchronizer of biologic rhythms, has obtained the authorization for the treatment of insomniac troubles, in subjects of at least 55 years old, in its slow- release formula, replacing the physiological decline of this hormone with aging. Melatonin is not a hypnotic, but has soporific properties, inducing sleep, improving sleep efficacy, sometimes sleep duration and morning alertness. When discontinued, it induced no withdrawal syndrome. It has shown no risk of abuse potential and no deleterious side-effects, if used at the right dose and in the absence of hepatic interaction with other compounds. Finally, a new class of hypnotics, "the orexin antagonists" has its first representative on the French market: daridorexant. The place of these molecules in the therapeutic strategy for chronic insomnia needs to be clarified.
    MeSH term(s) Adult ; Humans ; Middle Aged ; Sleep Initiation and Maintenance Disorders/drug therapy ; Melatonin/therapeutic use ; Melatonin/adverse effects ; Hypnotics and Sedatives/therapeutic use ; Benzodiazepines/therapeutic use ; Sleep ; Antidepressive Agents/therapeutic use
    Chemical Substances Melatonin (JL5DK93RCL) ; Hypnotics and Sedatives ; Benzodiazepines (12794-10-4) ; Antidepressive Agents
    Language French
    Publishing date 2024-03-29
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: Sleep disorders

    Léger, Damien

    their impact on public health

    2007  

    Author's details ed. by Damien Léger
    Language English
    Size XV, 245 S.
    Publisher Informa Healthcare
    Publishing place Abingdon
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT014853085
    ISBN 1-84184-535-3 ; 978-1-84184-535-7
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2007 A 267 order for loan Magazin

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  6. Article ; Online: Insomnie et environnement de sommeil.

    Pitron, Victor / Faraut, Brice / Léger, Damien

    La Revue du praticien

    2024  Volume 74, Issue 3, Page(s) 283–284

    Title translation Insomnia and sleep environment.
    MeSH term(s) Humans ; Sleep Initiation and Maintenance Disorders/diagnosis ; Sleep Initiation and Maintenance Disorders/etiology ; Sleep Initiation and Maintenance Disorders/therapy ; Sleep
    Language French
    Publishing date 2024-03-29
    Publishing country France
    Document type Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Insomnie : définitions, épidémiologie et évolution avec l’âge.

    Dubois, Julie Margrethe / Rouen, Alexandre / Léger, Damien

    La Revue du praticien

    2024  Volume 74, Issue 3, Page(s) 260–265

    Abstract: Insomnia: DEFINITIONS, EPIDEMIOLOGY AND CHANGES WITH AGE. Chronic insomnia is a disorder defined as a subjective complaint relating to the quality and/or quantity of sleep associated with daytime impact, and which must be present 3 nights per week for a ...

    Title translation Insomnia: definitions, epidemiology and changes with age.
    Abstract Insomnia: DEFINITIONS, EPIDEMIOLOGY AND CHANGES WITH AGE. Chronic insomnia is a disorder defined as a subjective complaint relating to the quality and/or quantity of sleep associated with daytime impact, and which must be present 3 nights per week for a period of at least 3 months. This is a common sleep problem in the general population and represents a significant proportion of reasons for consultation in the general practice. It requires early identification at all ages of life to allow the establishment of adequate care, which will have the benefit of both improving the quality of life of these patients in the short term and preventing the consequences of chronic insomnia.
    MeSH term(s) Humans ; Sleep Initiation and Maintenance Disorders/epidemiology ; Sleep Initiation and Maintenance Disorders/therapy ; Quality of Life
    Language French
    Publishing date 2024-03-29
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Cette horloge qui nous gouverne.

    Léger, Damien

    Presse medicale (Paris, France : 1983)

    2018  Volume 47, Issue 11-12 Pt 1, Page(s) 962–963

    Title translation This clock that governs us.
    MeSH term(s) Circadian Clocks ; Humans
    Language French
    Publishing date 2018-11-03
    Publishing country France
    Document type Editorial
    ZDB-ID 120943-7
    ISSN 2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
    ISSN (online) 2213-0276
    ISSN 0032-7867 ; 0755-4982 ; 0301-1518
    DOI 10.1016/j.lpm.2018.10.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Insomnie et horloge biologique.

    Léger, Damien / Rouen, Alexandre / Vecchierini, Marie-Françoise / Pitron, Victor

    La Revue du praticien

    2024  Volume 74, Issue 3, Page(s) 271–274

    Abstract: INSOMNIA AND THE BIOLOGICAL CLOCK. Multiple physiological and biological rhythms known as «circadian» are generated by the biological clock that controls them within the suprachiasmatic nuclei of the hypothalamus. However, the most emblematic circadian ... ...

    Title translation Insomnia and the biological clock.
    Abstract INSOMNIA AND THE BIOLOGICAL CLOCK. Multiple physiological and biological rhythms known as «circadian» are generated by the biological clock that controls them within the suprachiasmatic nuclei of the hypothalamus. However, the most emblematic circadian rhythm is that of sleep and awakening. It is therefore crucial to check how the clock may be involved in chronic insomnia. What is the influence of the clock on the time and quality of sleep? What are the typical clock disorders that explain insomnia in adolescents, shift and night workers, the elderly and the blind individuals? What are the tools to recommend in general and specialized medicine in the evaluation of the clock in insomnia? What influence finally of the light on the clock and the light therapy to recommend? So many questions and elements of understanding often-poorly known of chronic insomnia.
    MeSH term(s) Humans ; Adolescent ; Aged ; Sleep Initiation and Maintenance Disorders/therapy ; Biological Clocks ; Sleep/physiology ; Circadian Rhythm/physiology ; Hypothalamus
    Language French
    Publishing date 2024-03-29
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Sleep deprivation detected by voice analysis.

    Thoret, Etienne / Andrillon, Thomas / Gauriau, Caroline / Léger, Damien / Pressnitzer, Daniel

    PLoS computational biology

    2024  Volume 20, Issue 2, Page(s) e1011849

    Abstract: Sleep deprivation has an ever-increasing impact on individuals and societies. Yet, to date, there is no quick and objective test for sleep deprivation. Here, we used automated acoustic analyses of the voice to detect sleep deprivation. Building on ... ...

    Abstract Sleep deprivation has an ever-increasing impact on individuals and societies. Yet, to date, there is no quick and objective test for sleep deprivation. Here, we used automated acoustic analyses of the voice to detect sleep deprivation. Building on current machine-learning approaches, we focused on interpretability by introducing two novel ideas: the use of a fully generic auditory representation as input feature space, combined with an interpretation technique based on reverse correlation. The auditory representation consisted of a spectro-temporal modulation analysis derived from neurophysiology. The interpretation method aimed to reveal the regions of the auditory representation that supported the classifiers' decisions. Results showed that generic auditory features could be used to detect sleep deprivation successfully, with an accuracy comparable to state-of-the-art speech features. Furthermore, the interpretation revealed two distinct effects of sleep deprivation on the voice: changes in slow temporal modulations related to prosody and changes in spectral features related to voice quality. Importantly, the relative balance of the two effects varied widely across individuals, even though the amount of sleep deprivation was controlled, thus confirming the need to characterize sleep deprivation at the individual level. Moreover, while the prosody factor correlated with subjective sleepiness reports, the voice quality factor did not, consistent with the presence of both explicit and implicit consequences of sleep deprivation. Overall, the findings show that individual effects of sleep deprivation may be observed in vocal biomarkers. Future investigations correlating such markers with objective physiological measures of sleep deprivation could enable "sleep stethoscopes" for the cost-effective diagnosis of the individual effects of sleep deprivation.
    MeSH term(s) Humans ; Sleep Deprivation ; Voice ; Sleep ; Voice Quality ; Wakefulness
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2193340-6
    ISSN 1553-7358 ; 1553-734X
    ISSN (online) 1553-7358
    ISSN 1553-734X
    DOI 10.1371/journal.pcbi.1011849
    Database MEDical Literature Analysis and Retrieval System OnLINE

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