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Article ; Online: Widening how we see the impact of culture on learning, practice and identity development in clinical environments.

Sheehan, Dale / Wilkinson, Tim J

2021 Volume 56, Issue 1, Page(s) 110–116

Abstract: As part of this State of the Science series on Self, Society and Situation, we focus on how we might see the situation of the workplace as a learning environment in the future. Research to date into how health professionals learn while working in ... ...

Abstract	As part of this State of the Science series on Self, Society and Situation, we focus on how we might see the situation of the workplace as a learning environment in the future. Research to date into how health professionals learn while working in clinical workplace environments has mostly focused on the supervisor-trainee relationship or on the interaction between the affordances of a workplace and the receptiveness of trainees. However, the wider environment has not received as much focus-though frequently mentioned, it is seldom investigated. We suggest there is a need to embrace the wider institution factors, recognise and acknowledge an organisation's values and culture as they impact on clinical learning in order to work with these, not around them or ignore them, to make what may be tacit visible through reflection and observation and to embrace a range of perspectives on culture.
MeSH term(s)	Clinical Competence ; Education, Medical, Graduate ; Health Personnel ; Humans ; Learning ; Workplace
Language	English
Publishing date	2021-09-02
Publishing country	England
Document type	Journal Article
ZDB-ID	195274-2
ISSN	1365-2923 ; 0308-0110
ISSN (online)	1365-2923
ISSN	0308-0110
DOI	10.1111/medu.14630
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Article ; Online: Shifting fire regimes cause continent-wide transformation of threatened species habitat.

Doherty, Tim S / Macdonald, Kristina J / Nimmo, Dale G / Santos, Julianna L / Geary, William L

Proceedings of the National Academy of Sciences of the United States of America

2024 Volume 121, Issue 18, Page(s) e2316417121

Abstract: Human actions are causing widespread increases in fire size, frequency, and severity in diverse ecosystems globally. This alteration of fire regimes is considered a threat to numerous animal species, but empirical evidence of how fire regimes are ... ...

Abstract	Human actions are causing widespread increases in fire size, frequency, and severity in diverse ecosystems globally. This alteration of fire regimes is considered a threat to numerous animal species, but empirical evidence of how fire regimes are shifting within both threatened species' ranges and protected areas is scarce, particularly at large spatial and temporal scales. We used a big data approach to quantify multidecadal changes in fire regimes in southern Australia from 1980 to 2021, spanning 415 reserves (21.5 million ha) and 129 threatened species' ranges including birds, mammals, reptiles, invertebrates, and frogs. Most reserves and threatened species' ranges within the region have experienced declines in unburnt vegetation (≥30 y without fire), increases in recently burnt vegetation (≤5 y since fire), and increases in fire frequency. The mean percentage of unburnt vegetation within reserves declined from 61 to 36% (1980 to 2021), whereas the mean percentage of recently burnt vegetation increased from 20 to 35%, and mean fire frequency increased by 32%, with the latter two trends primarily driven by the record-breaking 2019 to 2020 fire season. The strongest changes occurred for high-elevation threatened species, and reserves of high elevation, high productivity, and strong rainfall decline, particularly in the southeast of the continent. Our results provide evidence for the widely held but poorly tested assumption that threatened species are experiencing widespread declines in unburnt habitat and increases in fire frequency. This underscores the imperative for developing management strategies that conserve fire-threatened species in an increasingly fiery future.
MeSH term(s)	Endangered Species/trends ; Animals ; Ecosystem ; Fires ; Conservation of Natural Resources ; Australia ; Reptiles ; Mammals ; Humans ; Birds/physiology ; Biodiversity
Language	English
Publishing date	2024-04-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2316417121
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Article ; Online: Reflections on the impact of time and context in clinical learning.

Sheehan, Dale / Wilkinson, Tim J

Medical education

2018 Volume 52, Issue 7, Page(s) 690–691

MeSH term(s)	Learning ; Students, Nursing
Language	English
Publishing date	2018-06-07
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	195274-2
ISSN	1365-2923 ; 0308-0110
ISSN (online)	1365-2923
ISSN	0308-0110
DOI	10.1111/medu.13600
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Article ; Online: Size Isn't Everything: Geometric Tuning in Polycyclic Aromatic Hydrocarbons and Its Implications for Carbon Nanodots.

Scott, James M / Dale, Stephen G / McBroom, James / Gould, Tim / Li, Qin

The journal of physical chemistry. A

2024 Volume 128, Issue 11, Page(s) 2003–2014

Abstract: Recent developments in light-emitting carbon nanodots and molecular organic semiconductors have seen renewed interest in the properties of polycyclic aromatic hydrocarbons (PAHs) as a family. The networks of delocalized π electrons in ... ...

Abstract	Recent developments in light-emitting carbon nanodots and molecular organic semiconductors have seen renewed interest in the properties of polycyclic aromatic hydrocarbons (PAHs) as a family. The networks of delocalized π electrons in sp
Language	English
Publishing date	2024-03-12
Publishing country	United States
Document type	Journal Article
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/acs.jpca.3c07416
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Article ; Online: Novel Hendra Virus Variant Circulating in Black Flying Foxes and Grey-Headed Flying Foxes, Australia.

Peel, Alison J / Yinda, Claude Kwe / Annand, Edward J / Dale, Adrienne S / Eby, Peggy / Eden, John-Sebastian / Jones, Devin N / Kessler, Maureen K / Lunn, Tamika J / Pearson, Tim / Schulz, Jonathan E / Smith, Ina L / Munster, Vincent J / Plowright, Raina K

Emerging infectious diseases

2022 Volume 28, Issue 5, Page(s) 1043–1047

Abstract: A novel Hendra virus variant, genotype 2, was recently discovered in a horse that died after acute illness and in Pteropus flying fox tissues in Australia. We detected the variant in flying fox urine, the pathway relevant for spillover, supporting an ... ...

Abstract	A novel Hendra virus variant, genotype 2, was recently discovered in a horse that died after acute illness and in Pteropus flying fox tissues in Australia. We detected the variant in flying fox urine, the pathway relevant for spillover, supporting an expanded geographic range of Hendra virus risk to horses and humans.
MeSH term(s)	Animals ; Australia/epidemiology ; Chiroptera ; Hendra Virus/genetics ; Henipavirus Infections/epidemiology ; Henipavirus Infections/veterinary ; Horses
Language	English
Publishing date	2022-04-21
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid2805.212338
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Article ; Online: Shear shock wave injury in vivo: High frame-rate ultrasound observation and histological assessment.

Chandrasekaran, Sandhya / Santibanez, Francisco / Long, Tyler / Nichols, Tim / Kait, Jason / Bruegge, Ruth Vorder / 'Dale' Bass, Cameron R / Pinton, Gianmarco

Journal of biomechanics

2024 Volume 166, Page(s) 112021

Abstract: Using high frame-rate ultrasound and ¡1μm sensitive motion tracking we previously showed that shear waves at the surface of ex vivo and in situ brains develop into shear shock waves deep inside the brain, with destructive local accelerations. However ... ...

Abstract	Using high frame-rate ultrasound and ¡1μm sensitive motion tracking we previously showed that shear waves at the surface of ex vivo and in situ brains develop into shear shock waves deep inside the brain, with destructive local accelerations. However post-mortem tissue cannot develop injuries and has different viscoelastodynamic behavior from in vivo tissue. Here we present the ultrasonic measurement of the high-rate shear shock biomechanics in the in vivo porcine brain, and histological assessment of the resulting axonal pathology. A new biomechanical model of brain injury was developed consisting of a perforated mylar surface attached to the brain and vibrated using an electromechanical shaker. Using a custom sequence with 8 interleaved wide beam emissions, brain imaging and motion tracking were performed at 2900 images/s. Shear shock waves were observed for the first time in vivo wherein the shock acceleration was measured to be 2.6 times larger than the surface acceleration ( 95g vs. 36g). Histopathology showed axonal damage in the impacted side of the brain from the brain surface, accompanied by a local shock-front acceleration of >70g. This shows that axonal injury occurs deep in the brain even though the shear excitation was at the brain surface, and the acceleration measurements support the hypothesis that shear shock waves are responsible for deep traumatic brain injuries.
MeSH term(s)	Animals ; Swine ; Ultrasonography ; Brain/diagnostic imaging ; Motion ; Brain Injuries/diagnostic imaging ; Elasticity Imaging Techniques/methods
Language	English
Publishing date	2024-02-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	218076-5
ISSN	1873-2380 ; 0021-9290
ISSN (online)	1873-2380
ISSN	0021-9290
DOI	10.1016/j.jbiomech.2024.112021
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Article: Artificial habitat structures for animal conservation: design and implementation, risks and opportunities

Watchorn, Darcy J / Cowan, Mitchell A / Driscoll, Don A / Nimmo, Dale G / Ashman, Kita R / Garkaklis, Mark J / Wilson, Barbara A / Doherty, Tim S

Frontiers in ecology and the environment. 2022 June, v. 20, no. 5

2022

Abstract: Habitat loss and degradation, and their interaction with other threats, are driving declines in animal populations worldwide. One potential approach for mitigating these threats is to create artificial habitat structures as substitutes for lost or ... ...

Abstract	Habitat loss and degradation, and their interaction with other threats, are driving declines in animal populations worldwide. One potential approach for mitigating these threats is to create artificial habitat structures as substitutes for lost or degraded natural structures. Here, we provide – to the best of our knowledge – the first general definition of artificial habitat structures and synthesize important considerations for their effective use. We show that such structures represent a versatile conservation tool that has been trialed in a variety of contexts globally, albeit with varying degrees of success. The design of these structures must be well informed by the drivers of natural habitat selection, and their use should be part of an experimental framework to enable evaluation and refinement. We highlight possible ecological risks associated with the use of artificial habitat structures and urge that they not be exploited as inappropriate biodiversity offsets or for greenwashing. Looking forward, cross‐disciplinary collaborations will facilitate the development of sophisticated and effective structures to assist animal conservation in this era of rapid global change.
Keywords	animals ; artificial habitats ; biodiversity ; environment ; global change ; habitat destruction ; habitat preferences
Language	English
Dates of publication	2022-06
Size	p. 301-309.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	REVIEW
ZDB-ID	2110853-5
ISSN	1540-9309 ; 1540-9295
ISSN (online)	1540-9309
ISSN	1540-9295
DOI	10.1002/fee.2470
Database	NAL-Catalogue (AGRICOLA)

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Z 7542: Show issues

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Article: Animal mortality during fire

Jolly, Chris J. / Dickman, Chris R. / Doherty, Tim S. / van Eeden, Lily M. / Geary, William L. / Legge, Sarah M. / Woinarski, John C. Z. / Nimmo, Dale G.

Global change biology. 2022 Mar., v. 28, no. 6

2022

Abstract: Earth's rapidly warming climate is propelling us towards an increasingly fire‐prone future. Currently, knowledge of the extent and characteristics of animal mortality rates during fire remains rudimentary, hindering our ability to predict how animal ... ...

Abstract	Earth's rapidly warming climate is propelling us towards an increasingly fire‐prone future. Currently, knowledge of the extent and characteristics of animal mortality rates during fire remains rudimentary, hindering our ability to predict how animal populations may be impacted in the future. To address this knowledge gap, we conducted a global systematic review of the direct effects of fire on animal mortality rates, based on studies that unequivocally determined the fate of animals during fire. From 31 studies spanning 1984–2020, we extracted data on the direct impacts of fire on the mortality of 31 species from 23 families. From these studies, there were 43 instances where direct effects were measured by reporting animal survival from pre‐ to post‐fire. Most studies were conducted in North America (52%) and Oceania (42%), focused largely on mammals (53%) and reptiles (30%), and reported mostly on animal survival in planned (82%) and/or low severity (70%) fires. We found no studies from Asia, Europe or South America. Although there were insufficient data to conduct a formal meta‐analysis, we tested the effect of fire type, fire severity, fire regime, animal body mass, ecological attributes and class on survival. Only fire severity affected animal mortality, with a higher proportion of animals being killed by high than low severity fires. Recent catastrophic fires across the globe have drawn attention to the plight of animals exposed to wildfire. Yet, our systematic review suggests that a relatively low proportion of animals (mean predicted mortality [95% CI] = 3% [1%–9%]) are killed during fire. However, our review also underscores how little we currently know about the direct effects of fire on animal mortality, and highlights the critical need to understand the effects of high severity fire on animal populations.
Keywords	body weight ; climate ; fire regime ; fire severity ; global change ; meta-analysis ; mortality ; systematic review ; wildfires ; Asia ; Europe ; North America ; Pacific Ocean Islands ; South America
Language	English
Dates of publication	2022-03
Size	p. 2053-2065.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	1281439-8
ISSN	1365-2486 ; 1354-1013
ISSN (online)	1365-2486
ISSN	1354-1013
DOI	10.1111/gcb.16044
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Novel Hendra Virus Variant Circulating in Black Flying Foxes and Grey-Headed Flying Foxes, Australia

Alison J. Peel / Claude Kwe Yinda / Edward J. Annand / Adrienne S. Dale / Peggy Eby / John-Sebastian Eden / Devin N. Jones / Maureen K. Kessler / Tamika J. Lunn / Tim Pearson / Jonathan E. Schulz / Ina L. Smith / Vincent J. Munster / Raina K. Plowright

Emerging Infectious Diseases, Vol 28, Iss 5, Pp 1043-

2022 Volume 1047

Abstract	A novel Hendra virus variant, genotype 2, was recently discovered in a horse that died after acute illness and in Pteropus flying fox tissues in Australia. We detected the variant in flying fox urine, the pathway relevant for spillover, supporting an expanded geographic range of Hendra virus risk to horses and humans.
Keywords	Hendra virus ; henipavirus ; viruses ; reservoir host ; Pteropus ; flying foxes ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Centers for Disease Control and Prevention
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Genomic Predictors Associated With Exceptional Response to Systemic Therapy in Advanced Pancreatic Cancer.

Kamath, Suneel / Roopkumar, Joanna / Ni, Ying / Shen, Minqian / Bejarano, Pablo / Allende, Daniela / Nagarajan, Arun / Nguyen, Tim / Dergham, Bachar / Shepard, Dale / Shapiro, Marc A / McNamara, Michael J / Estfan, Bassam N / Nair, Kanika G / Khorana, Alok A

Oncology (Williston Park, N.Y.)

2023 Volume 37, Issue 12, Page(s) 488–495

Abstract: Introduction: Exceptional response to therapy is rare in patients with advanced pancreatic cancer. This study explored potential genomic differences between typical and exceptional responses that could confer more favorable biology.: Methods: We ... ...

Abstract	Introduction: Exceptional response to therapy is rare in patients with advanced pancreatic cancer. This study explored potential genomic differences between typical and exceptional responses that could confer more favorable biology. Methods: We included exceptional responders and controls with advanced pancreatic cancer from Cleveland Clinic from April 2013 to August 2017. Exceptional responders were defined as patients with an overall survival of more than 18 months for metastatic disease and more than 24 months for locally advanced disease. Clinical data were obtained, and next-generation sequencing was performed. Statistical analyses comparing the 2 groups were performed using descriptive statistics, the Kaplan-Meier method, and the log-rank test. Results: The study comprised 4 exceptional responders and 6 controls. Both groups were well balanced in age, sex, race, and treatment regimens. Exceptional responders had significantly fewer nonsynonymous mutations than controls (2.25 vs 5.17; P = .014). A mutation count of less than 3 was associated with significantly better progression-free survival (17.2 vs 2.3 months; P = .002) and overall survival (29.4 vs 4.6 months; P = .013). Tumor mutational burden did not differ between exceptional responders and controls (4.88 vs 5.70 mut/Mb; P = .39). Conclusion: A lower number of nonsynonymous mutations may correlate with exceptional outcomes in patients with pancreatic cancer. These findings should encourage future studies into genomic signatures of exceptional response.
MeSH term(s)	Humans ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/genetics ; Genomics ; Progression-Free Survival ; Mutation ; Biomarkers, Tumor/genetics
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2023-12-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1067950-9
ISSN	0890-9091
ISSN	0890-9091
DOI	10.46883/2023.25921008
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